Journal
NMR IN BIOMEDICINE
Volume 24, Issue 5, Pages 529-535Publisher
WILEY-BLACKWELL
DOI: 10.1002/nbm.1620
Keywords
glutamine; spectroscopy; MRS; simulations; 3 T
Funding
- The National Institutes of Health [1R21NS054303-01A2]
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A theoretical study was performed to determine the accuracy and repeatability of multiple one-dimensional pulse sequences in the quantification of glutamine concentration at 3 T. Variable repeatability (12% to > 50%) and significant absolute error (-50% to +70%) were noted for the eight pulse sequences considered. Data acquired in vivo using three of the pulse sequences used for simulation matched the predicted repeatability well; among the pulse sequences considered, point-resolved spectroscopy (TE = 80 ms) offered minimal error and acceptable repeatability (12%) for brain glutamine measurements. Following correction for the expected bias of each pulse sequence, consistent glutamine measurements, in the 1-mM range, were reported with the three sequences. An explanation for the mismatch between in vivo (1)H MRS and in vitro (13)C/(1)H MRS at high field was attempted. Copyright (C) 2011 John Wiley & Sons, Ltd.
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