MR evaluation of response to targeted treatment in cancer cells

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of a Novel Histone Deacetylase Inhibitor, LAQ824, in Human Colon Carcinoma Cells and Xenografts

(2015) Yuen-Li Chung et al.   NEOPLASIA

Nuclear Magnetic Resonance Detects Phosphoinositide 3-Kinase/Akt-Independent Traits Common to Pluripotent Murine Embryonic Stem Cells and Their Malignant Counterparts

(2015) Hanna M. Romanska et al.   NEOPLASIA

A Comparison between Radiolabeled Fluorodeoxyglucose Uptake and Hyperpolarized 13C-Labeled Pyruvate Utilization as Methods for Detecting Tumor Response to Treatment

(2015) Timothy H. Witney et al.   NEOPLASIA

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of Phosphatidylcholine Cycle Enzymes in Human Epithelial Ovarian Cancer Cells

(2010) E. Iorio et al.   CANCER RESEARCH

Noninvasive Detection of Target Modulation following Phosphatidylinositol 3-Kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

(2010) C. S. Ward et al.   CANCER RESEARCH

Magnetic Resonance Spectroscopy in Metabolic and Molecular Imaging and Diagnosis of Cancer

(2010) Kristine Glunde et al.   CHEMICAL REVIEWS

Everolimus

(2010) P. J. Houghton   CLINICAL CANCER RESEARCH

Radionuclide Molecular Imaging Using Affibody Molecules

(2010) Sara Ahlgren et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Activation of P-glycoprotein (Pgp)-mediated drug efflux by extracellular acidosis: in vivo imaging with 68Ga-labelled PET tracer

(2010) Oliver Thews et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Radionuclide imaging of perfusion and hypoxia

(2010) George Laking et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A robust coregistration method forin vivostudies using a first generation simultaneous PET/MR scanner

(2010) Thomas S. C. Ng et al.   MEDICAL PHYSICS

Metabolic oxidation regulates embryonic stem cell differentiation

(2010) Oscar Yanes et al.   Nature Chemical Biology

Phenylbutyrate induces apoptosis and lipid accumulations via a peroxisome proliferator-activated receptor gamma-dependent pathway

(2010) Matthew Milkevitch et al.   NMR IN BIOMEDICINE

Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer

(2009) Andrea L Merz et al.   Biomarkers in Medicine

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

(2009) M Beloueche-Babari et al.   BRITISH JOURNAL OF CANCER

Molecular classification of solid tumours: towards pathway-driven therapeutics

(2009) C Swanton et al.   BRITISH JOURNAL OF CANCER

A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy

(2009) C P Lee et al.   BRITISH JOURNAL OF CANCER

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

Noninvasive Detection of Lentiviral-Mediated Choline Kinase Targeting in a Human Breast Cancer Xenograft

(2009) B. Krishnamachary et al.   CANCER RESEARCH

V-ATPase inhibitors and implication in cancer treatment

(2009) Mario Pérez-Sayáns et al.   CANCER TREATMENT REVIEWS

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Abnormalities in Glucose Uptake and Metabolism in Imatinib-Resistant Human BCR-ABL-Positive Cells

(2009) D. J. Kominsky et al.   CLINICAL CANCER RESEARCH

Clinical Applications of Metabolomics in Oncology: A Review

(2009) J. L. Spratlin et al.   CLINICAL CANCER RESEARCH

HSP90 Inhibitors: Multi-Targeted Antitumor Effects and Novel Combinatorial Therapeutic Approaches in Cancer Therapy

(2009) Misun Hwang et al.   CURRENT MEDICINAL CHEMISTRY

Predictors of response to interferon therapy

(2009) Helen Gogas et al.   CURRENT OPINION IN ONCOLOGY

Molecular imaging of hypoxia with radiolabelled agents

(2009) Gilles Mees et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PET/CT for the staging and follow-up of patients with malignancies

(2009) T.D. Poeppel et al.   EUROPEAN JOURNAL OF RADIOLOGY

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

(2009) Boon Chua et al.   Molecular Cancer

Changes in choline metabolism as potential biomarkers of phospholipase C 1 inhibition in human prostate cancer cells

(2009) M. Beloueche-Babari et al.   MOLECULAR CANCER THERAPEUTICS

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

(2009) Arun Sreekumar et al.   NATURE

Modulation of choline kinase activity in human cancer cells observed by dynamic31P NMR

(2009) Cristina Gabellieri et al.   NMR IN BIOMEDICINE

Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

(2009) A Yalcin et al.   ONCOGENE

A critical role for choline kinase-α in the aggressiveness of bladder carcinomas

(2009) E Hernando et al.   ONCOGENE

Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI

(2009) S. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomedical applications of hyperpolarized 13C magnetic resonance imaging

(2009) F.A. Gallagher et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Intrinsic Susceptibility MR Imaging of Chemically Induced Rat Mammary Tumors: Relationship to Histologic Assessment of Hypoxia and Fibrosis

(2009) Lesley D. McPhail et al.   RADIOLOGY

Biofunctionalized, Phosphonate-Grafted, Ultrasmall Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Multimodal Imaging

(2009) Manasmita Das et al.   Small

Phosphatidylcholine-Specific Phospholipase C Activation in Epithelial Ovarian Cancer Cells

(2008) F. Spadaro et al.   CANCER RESEARCH

Hypoxia Regulates Choline Kinase Expression through Hypoxia-Inducible Factor-1  Signaling in a Human Prostate Cancer Model

(2008) K. Glunde et al.   CANCER RESEARCH

Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading

(2008) M. J. Albers et al.   CANCER RESEARCH

Many Roads Lead to the Lipid Droplet

(2008) Andrew S. Greenberg et al.   Cell Metabolism

Heat Shock Protein 90 as a Drug Target: Some Like It Hot

(2008) U. Banerji   CLINICAL CANCER RESEARCH

Choline Kinase Alpha Depletion Selectively Kills Tumoral Cells

(2008) Monica Banez-Coronel et al.   CURRENT CANCER DRUG TARGETS

Pluripotent stem cell lines

(2008) J. Yu et al.   GENES & DEVELOPMENT

Thematic Review Series: Glycerolipids.Phosphatidylcholine and choline homeostasis

(2008) Zhaoyu Li et al.   JOURNAL OF LIPID RESEARCH

Causes and Consequences of Increased Glucose Metabolism of Cancers

(2008) R. J. Gillies et al.   JOURNAL OF NUCLEAR MEDICINE

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

(2008) A. Toschi et al.   MOLECULAR AND CELLULAR BIOLOGY

Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine

(2008) J. Ross et al.   MOLECULAR CANCER THERAPEUTICS

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

(2008) Ferdia A. Gallagher et al.   NATURE

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway

(2008) David L. Morse et al.   NMR IN BIOMEDICINE

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

(2008) C Garcia-Echeverria et al.   ONCOGENE

Cooperation of phosphatidylcholine-specific phospholipase C and basic fibroblast growth factor in the neural differentiation of mesenchymal stem cells in vitro

(2007) Nan Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY