Article
Medicine, General & Internal
Daniel Boron, Jakub Kornacki, Ewa Wender-Ozegowska
Summary: Intima-media thickness (IMT) measurement is a non-invasive method to assess arterial wall, and it is associated with atherosclerosis and endothelial dysfunction. Pre-existing conditions like diabetes, chronic hypertension, and obesity may impair the adaptation to pregnancy and influence fetal IMT. Increased fetal abdominal aorta IMT (aIMT) has been correlated with placental dysfunctions, which may lead to gestational hypertension, preeclampsia, and fetal growth restriction. Understanding the underlying pathomechanism is crucial for developing targeted therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Piotr Tousty, Magda Fraszczyk-Tousty, Anna Golara, Adrianna Zahorowska, Michal Slawinski, Sylwia Dzidek, Hanna Jasiak-Jozwik, Magda Nawceniak-Balczerska, Agnieszka Kordek, Ewa Kwiatkowska, Aneta Cymbaluk-Ploska, Andrzej Torbe, Sebastian Kwiatkowski
Summary: This study aimed to evaluate the implementation of low-dose acetylsalicylic acid (ASA) for the prevention of pregnancy-induced hypertension (PE) and fetal growth restriction (FGR) in a Polish population. The results showed that patients in the high-risk group were more likely to experience complications during pregnancy, including pre-eclampsia, fetal growth restriction, gestational diabetes, and cesarean section. The conclusion is that the first-trimester screening is crucial in identifying high-risk pregnancies, and ASA prophylaxis may have the most beneficial effect on these high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Biochemistry & Molecular Biology
Kayo Tanaka, Hiroaki Tanaka, Ryota Tachibana, Kento Yoshikawa, Takuya Kawamura, Sho Takakura, Hiroki Takeuchi, Tomoaki Ikeda
Summary: This study aimed to investigate the effects of tadalafil as an intrauterine treatment for fetal growth restriction (FGR). The results showed that tadalafil improved placental mTOR signaling and facilitated fetal growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Xianglan Peng, Dong He, Rui Peng, Jianyang Feng, Dunjin Chen, Hongkai Xie, Qixuan Li, Yitong Guo, Jiaxiong Zhou, Yang Chen, Hong He
Summary: IGFBP1 gene single nucleotide polymorphism is associated with preeclampsia susceptibility. The GG or AG genotypes are associated with a decreased risk of preeclampsia. Women in the preeclampsia group with the G allele have higher fetal birth weight, lower diastolic blood pressure, and lower levels of ALT and AST. Rs1065780A>G raises the level of IGFBP1 protein in plasma and decidua in the preeclampsia group.
HYPERTENSION RESEARCH
(2023)
Review
Medicine, General & Internal
Sylwia Slawek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Cieplucha, Maciej Lesiak, Mariola Ropacka-Lesiak
Summary: Cardiovascular diseases (CVDs) are the top cause of death in women worldwide. Traditional risk factors and pregnancy-related complications both impact a woman's future CVD risk. Some pregnancy complications and CVDs may share common pathophysiological pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ciara N. Murphy, Catherine A. Cluver, Susan P. Walker, Emerson Keenan, Roxanne Hastie, Teresa M. MacDonald, Natalie J. Hannan, Fiona C. Brownfoot, Ping Cannon, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: This study is the first to demonstrate significantly reduced SPINT1 levels in pregnancies with co-existing FGR and preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Eun Hui Joo, Young Ran Kim, Nari Kim, Jae Eun Jung, Seon Ha Han, Hee Young Cho
Summary: Oxidative stress, caused by the imbalance between ROS production and detoxification ability, is associated with pregnancy complications. Maintaining normal placental function and vascular network is crucial for a healthy pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jakub Staniczek, Maisa Manasar-Dyrbus, Agnieszka Drosdzol-Cop, Rafal Stojko
Summary: Beckwith-Wiedemann Syndrome (BWS) is an imprinting disorder characterized by overgrowth and susceptibility to embryonal tumors. The relationship between maternal complications such as HELLP syndrome and preeclampsia with the development of BWS in offspring is rarely documented. This case report highlights the complex nature of BWS and its potential association with maternal complications, as well as the atypical presence of fetal growth restriction and the absence of CDKN1C gene mutations in the newborn, which have not been previously reported in BWS cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Siv Boon Mundal, Johanne Johnsen Rakner, Gabriela Brettas Silva, Lobke Marijn Gierman, Marie Austdal, Purusotam Basnet, Mattijs Elschot, Siril Skaret Bakke, Jenny Ostrop, Liv Cecilie Vestrheim Thomsen, Eric Keith Moses, Ganesh Acharya, Line Bjorge, Ann-Charlotte Iversen
Summary: Utero-placental development in pregnancy depends on direct maternal-fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are associated with preeclampsia and fetal growth restriction (FGR).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo Garcia-Montero, Miguel A. Saez, Miguel Angel alvarez-Mon, Diego Torres-Carranza, Melchor alvarez-Mon, Julia Bujan, Natalio Garcia-Honduvilla, Coral Bravo, Luis G. Guijarro, Juan A. De Leon-Luis
Summary: The placenta is a crucial organ in pregnancy, with various functions. Understanding its development and role is essential for comprehending pregnancy and related diseases.
Article
Immunology
Antonio Braga, Esmeralda Neves, Judite Guimaraes, Jorge Braga, Carlos Vasconcelos
Summary: This study evaluated the number of Tregs and Th17 cells in patients with preeclampsia (PE) and fetal growth restriction (FGR). The results showed that PE patients had a higher number of Th17 cells and a lower number of Treg cells, indicating a proinflammatory profile. In the FGR group, there was an increase in Th17 cells during the third trimester. These findings suggest that inflammation may play a significant role in the development of PE and FGR.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Maxwell B. Zeigler, Emily E. Fay, Sue L. Moreni, Jennie Mao, Rheem A. Totah, Mary F. Hebert
Summary: This study aimed to investigate the changes in plasma levels of hydrogen sulfide (H2S), nitric oxide (NO), and related metabolites during pregnancy progression. The results showed significant decreases in plasma levels of NO and thiocyanate (SCN-) at 25-28 weeks and 28-32 weeks gestation, while plasma H2S levels significantly decreased at 28-32 weeks gestation. Methanethiol (CH3SH) levels did not show significant differences. These findings are important for understanding the role of these gasotransmitters in normal and pathological progression of pregnancy.
Review
Pharmacology & Pharmacy
Ayala Hirsch, Reut Rotem, Natali Ternovsky, Bruria Hirsh Raccah
Summary: Treatment with statins in women with uteroplacental insufficiency disorders can significantly prolong pregnancy duration and reduce neonatal intensive care unit admissions. Meta-analysis showed that an earlier initiation of treatment is associated with a lower risk of developing preeclampsia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Usman M. Ashraf, Dalton L. Hall, Nathan Campbell, Jamarius P. Waller, Adam Z. Rawls, Dylan Solise, Kathy Cockrell, Gene L. Bidwell III, Damian G. Romero, Norma B. Ojeda, Babbette LaMarca, Barbara T. Alexander
Summary: This study demonstrates that the use of "n7AAc" can improve uterine blood flow and fetal growth, and reduce the elevated expression of placental miRNAs associated with PE and FGR.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Asif Ahmed, Keqing Wang, Shakil Ahmad, Homira Rezai
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Review
Acoustics
R. Townsend, A. Khalil, Y. Premakumar, J. Allotev, K. I. E. Snell, C. Chan, L. C. Chappell, R. Hooper, M. Green, B. W. Mol, B. Thilaganathan, S. Thangaratinam, J. Allotey, K. Snell, J. Dodds, E. Rogozinska, K. Khan, L. Poston, L. Kenny, J. Myers, L. Chappell, P. Von Dadelszen, A. Ahmed, K. Moons, R. D. Riley
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Francisco Leyva, Abbasin Zegard, Osita Okafor, Joseph de Bono, David McNulty, Asif Ahmed, Howard Marshall, Daniel Ray, Tian Qiu
Article
Cell Biology
Xuefei Gao, Monika Nowak-Imialek, Xi Chen, Dongsheng Chen, Doris Herrmann, Degong Ruan, Andy Chun Hang Chen, Melanie A. Eckersley-Maslin, Shakil Ahmad, Yin Lau Lee, Toshihiro Kobayashi, David Ryan, Jixing Zhong, Jiacheng Zhu, Jian Wu, Guocheng Lan, Stoyan Petkov, Jian Yang, Liliana Antunes, Lia S. Campos, Beiyuan Fu, Shengpeng Wang, Yu Yong, Xiaomin Wang, Song-Guo Xue, Liangpeng Ge, Zuohua Liu, Yong Huang, Tao Nie, Peng Li, Donghai Wu, Duanqing Pei, Yi Zhang, Liming Lu, Fengtang Yang, Susan J. Kimber, Wolf Reik, Xiangang Zou, Zhouchun Shang, Liangxue Lai, Azim Surani, Patrick P. L. Tam, Asif Ahmed, William Shu Biu Yeung, Sarah A. Teichmann, Heiner Niemann, Pentao Liu
NATURE CELL BIOLOGY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Swati Agrawal, Homira Rezai, Catalin S. Buhimschi, Irina A. Buhimschi, Asif Ahmed
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
A. Ahmed, D. J. Williams, V. Cheed, L. J. Middleton, S. Ahmad, K. Wang, A. T. Vince, P. Hewett, K. Spencer, K. S. Khan, J. P. Daniels, Katherine Barber, Mark Kilby, Ellen Knox, Tara Sellman, Paula Trinham, Derek Tuffnell, Vicky Jones, Jennifer Syson, Neil Shah, Laurie Deeks, Wendy Carter, Ed Dorman, Susannah Thomas, Deborah Harrington, Nicola Higgins, Mirriam Wilmott-Powell, Nigel Simpson, Vivian Dolby, Leanne Bricker, Steve Walkinshaw, Gillian Houghton, Heather Longworth, Catherine Williamson, Mandish Dhanjal, Muna Noori, Mavis Machirori, Richard Howard, Rebecca Murray, Sarah Weist, Fiona Denison, Isobel Crawford, Stephen Robson, Carly Allan, Jenny Myers, Giovanna Bernatavicius, Lynsey Moorhead, Lucy Chappell, Catherine Nelson-Piercy, David Williams, Rebecca Daley, Miguel Rosas, Ian Greer, Libor Vitek, Andy Shennan, Neil Marlow, Ann Marie Barnard, Jim Thornton, Janet Rennie, Janet Peacock, Fang Gao Smith, Carolyn Hyde, Isobel Crawford, Melissa Cudmore, Alex Furmston, Leanne Fulcher, Leanne Homer, Andrew Howman, Nicholas Hilken, Stephen Brown
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Lissette Carolina Sanchez-Aranguren, Homira Rezai, Shakil Ahmad, Faisal A. Alzahrani, Anna Sparatore, Keqing Wang, Asif Ahmed
Article
Multidisciplinary Sciences
Lissette Carolina Sanchez-Aranguren, Shakil Ahmad, Irundika H. K. Dias, Faisal A. Alzahrani, Homira Rezai, Keqing Wang, Asif Ahmed
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Homira Rezai, Shakil Ahmad, Faisal A. Alzahrani, Lissette Sanchez-Aranguren, Irundika H. K. Dias, Swati Agrawal, Anna Sparatore, Keqing Wang, Asif Ahmed
Summary: Preeclampsia is a common and serious complication affecting millions of pregnant women worldwide. This study found that a novel H2S-releasing aspirin can ameliorate preeclampsia by reducing hypertension and renal damage through possibly stimulating antioxidant genes, improving fetal outcomes compared to aspirin alone.
Article
Health Care Sciences & Services
John Allotey, Kym I. E. Snell, Melanie Smuk, Richard Hooper, Claire L. Chan, Asif Ahmed, Lucy C. Chappell, Peter von Dadelszen, Julie Dodds, Marcus Green, Louise Kenny, Asma Khalil, Khalid S. Khan, Ben W. Mol, Jenny Myers, Lucilla Poston, Basky Thilaganathan, Anne C. Staff, Gordon C. S. Smith, Wessel Ganzevoort, Hannele Laivuori, Anthony O. Odibo, Javier A. Ramirez, John Kingdom, George Daskalakis, Diane Farrar, Ahmet A. Baschat, Paul T. Seed, Federico Prefumo, Fabricio da Silva Costa, Henk Groen, Francois Audibert, Jacques Masse, Ragnhild B. Skrastad, Kjell A. Salvesen, Camilla Haavaldsen, Chie Nagata, Alice R. Rumbold, Seppo Heinonen, Lisa M. Askie, Luc J. M. Smits, Christina A. Vinter, Per M. Magnus, Kajantie Eero, Pia M. Villa, Anne K. Jenum, Louise B. Andersen, Jane E. Norman, Akihide Ohkuchi, Anne Eskild, Sohinee Bhattacharya, Fionnuala M. McAuliffe, Alberto Galindo, Ignacio Herraiz, Lionel Carbillon, Kerstin Klipstein-Grobusch, SeonAe Yeo, Helena J. Teede, Joyce L. Browne, Karel G. M. Moons, Richard D. Riley, Shakila Thangaratinam
HEALTH TECHNOLOGY ASSESSMENT
(2020)
Article
Biochemistry & Molecular Biology
Jaimy Saif, Shakil Ahmad, Homira Rezai, Karina Litvinova, Anna Sparatore, Faisal A. Alzahrani, Keqing Wang, Asif Ahmed
Summary: An imbalanced angiogenic growth factors and poor utero-placental perfusion are strongly correlated with preeclampsia. A refined RUPP model in C57B1/6 J mice was developed to test the efficacy of MZe786 as a potential inhibitor of soluble Flt-1 for preeclampsia therapy. The study demonstrated that MZe786 treatment successfully prevented the development of preeclampsia by reducing maternal MAP and kidney nitrotyrosine staining, and improving fetal outcomes.
Review
Pharmacology & Pharmacy
Allyah Abbas-Hanif, Homira Rezai, Syed Faraz Ahmed, Asif Ahmed
Summary: Emerging data suggest that pregnant women with COVID-19 face higher risks of severe outcomes compared to non-pregnant women of similar age. Clinical studies have shown that COVID-19 may predispose pregnant women to conditions like pre-eclampsia, with mRNA vaccines offering a novel approach to vaccination in this population.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Manal A. Babaker, Fadwa A. Aljoud, Faris Alkhilaiwi, Abdulrahman Algarni, Asif Ahmed, Mohammad Imran Khan, Islam M. Saadeldin, Faisal A. Alzahrani
Summary: Colorectal cancer is a prevalent and deadly form of cancer. Current chemotherapy treatments are not selective, causing harm to healthy cells. Milk-derived extracellular vesicles offer potential as a natural alternative with the ability to suppress tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Peripheral Vascular Disease
Mohammed Hameed, Sarah Hopkins, Shakil Ahmed, Sayeed Haque, Asif Ahmed, Paramjit Gill, Indranil Dasgupta
JOURNAL OF HUMAN HYPERTENSION
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Rahul Potluri, Paul Carter, Amir Aziz, Minh Vo, Ranjit More, Jaydeep Sarma, Asif Ahmed, David Adlam, Robert Welsh, Kevin Bainey
