Article
Pharmacology & Pharmacy
Amreen Mughal, Chengwen Sun, Stephen T. O'Rourke
Summary: The study indicates that apelin does not inhibit BKCa channel function in coronary arteries, and therefore does not interfere with NO-dependent relaxation in coronary arteries.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Siyuan Wu, Tomoki Ootawa, Ryoya Sekio, Henry Smith, Md. Zahorul Islam, Yasuhiro Uno, Mitsuya Shiraishi, Atsushi Miyamoto
Summary: This study aimed to investigate the response of poultry basilar arteries to noradrenaline and to characterize the adrenergic receptor subtypes involved. The presence of alpha and beta receptor subtypes in chicken basilar arteries was confirmed through evaluating the response to noradrenaline and using beta-AR and alpha-AR antagonists. Furthermore, the study suggested that beta(3)-ARs, especially those on the endothelium, play an important role in vasodilation via nitric oxide release.
Article
Pharmacology & Pharmacy
Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study demonstrates for the first time that the selective eEF2 kinase inhibitor A484954 can induce vasodilatation by inhibiting sympathetic nerve activity-induced vasoconstriction.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leonardo A. da Costa Marques, Simone A. Teixeira, Flavia N. de Jesus, Mark E. Wood, Roberta Torregrossa, Matthew Whiteman, Soraia K. P. Costa, Marcelo N. Muscara
Summary: This study aimed to investigate the effects and mechanisms of action of AP39 on in vitro vascular reactivity of mouse mesenteric artery. The results showed that AP39 and its H2S-releasing moiety promoted vasorelaxation, specifically dependent on NO-cGMP signaling and SKCa channel opening. Furthermore, endogenous H2S seems to be involved in the mechanism of action of AP39, suggesting that mitochondria-targeted H2S donors may provide a new perspective in the treatment of cardiovascular diseases.
Article
Plant Sciences
Jingmei Fang, Ran Li, Yue Zhang, Patrick Kwabena Oduro, Sa Li, Ling Leng, Zhimei Wang, Yao Rao, Lu Niu, Hong-Hua Wu, Qilong Wang
Summary: Nardostachys jatamansi is a medicinal herb commonly used for treating cardiovascular diseases, including hypertension. The main bioactive compounds, (-)-aristolone and kanshone H, have been found to promote vasorelaxation and reduce blood pressure. Their mechanism of action involves the activation of the PDK1-Akt-eNOS-NO pathway and the opening of KATP channels.
Article
Multidisciplinary Sciences
Jennifer Q. J. Zhang, Sayanthooran Saravanabavan, Kai Man Cheng, Aarya Raghubanshi, Ashley N. Chandra, Alexandra Munt, Benjamin Rayner, Yunjia Zhang, Katrina Chau, Annette T. Y. Wong, Gopala K. Rangan
Summary: The study found that L-arginine has a mild direct effect on reducing renal cyst growth in vitro, while long-term sodium nitrate supplementation was ineffective in vivo. This suggests that the bioconversion of dietary nitrate to NO through the entero-salivary pathway may not be sufficient to influence the progression of renal cyst growth in ADPKD.
Article
Pharmacology & Pharmacy
Esra Akcabag, Zeliha Bayram, Ikbal Ozen Kucukcetin, Gulbahar Uzun, Sebahat Ozdem, Sadi S. Ozdem
Summary: Visfatin can inhibit the endothelium-dependent relaxation responses of isolated rat small resistance arteries to acetylcholine, likely mediated by oxygen free radicals and a reduction in nitric oxide bioavailability. High levels of visfatin in systemic and/or local environments due to pathologies like obesity may contribute to vascular dysfunctions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peter Balis, Andrea Berenyiova, Anton Misak, Marian Grman, Zuzana Rostakova, Iveta Waczulikova, Sona Cacanyiova, Enrique Dominguez-Alvarez, Karol Ondrias
Summary: Phthalic selenoanhydride, when dissolved in physiological buffer, releases various reactive selenium species including H2Se. It is a potential compound for selenium supplementation and exerts various biological effects, although its effect on the cardiovascular system is still unknown. This study aimed to investigate the effects of R-Se on rat hemodynamic parameters and vasoactive properties in isolated arteries, and the results suggest that R-Se acts on vascular smooth muscle cells, which may explain its effects on rat hemodynamic parameters.
Article
Medicine, General & Internal
Yiwei Liu, Yifan Zhu, Chenyu Jiang, Zhanhao Su, Yi Yan, Bei Feng, Wen Mao, Yuyan Zhang, Xiaojian Wang, Zhuoming Xu, Hao Zhang
Summary: This study developed a novel portable device to produce nitric oxide (NO) for in-home inhalation therapy in patients with pulmonary artery hypertension (PAH). The device effectively reduced pulmonary arterial pressure and pulmonary vascular resistance in a pig model of PAH without causing major physiologic disruptions. This research paves the way for future clinical trials in PAH patients and other cardiopulmonary conditions.
Article
Physiology
Michaela L. Sundqvist, Jon O. Lundberg, Eddie Weitzberg, Mattias Carlstrom
Summary: The study aimed to investigate potential sex differences in renal nitrate handling during low and high dietary nitrate intake. It was hypothesized that renal clearance and excretion of nitrate are higher in men compared to women. Results showed that women had lower urinary nitrate concentration, amount of nitrate excreted, renal nitrate clearance, and fractional excretion of nitrate compared to men.
Article
Physiology
HongYu Li, LanLan Yang, Ying Jin, ChunXiang Jin
Summary: The study demonstrates that motilin-induced relaxation of the left gastric artery (LGA) in dogs is dependent on the endothelial motilin receptor (MLNR) through the G protein-PLC-IP3 pathway and Ca2+ influx. The NOS-NO-sGC-cGMP pathway, prostacyclin, myoendothelial gap junction (MEGJ), and K+ channels (especially K-Ca) are also involved in endothelial-dependent relaxation of vascular smooth muscle (VSM) cells.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Airlla Laana de Medeiros Cavalcanti, Patricia Keytth Lins Rocha, Zhengbing Zhuge, Marcelo F. Montenegro, Luciano Leite Paulo, Leonidas das Gracas Mendes-Junior, Maria Claudia Rodrigues Brandao, Petronio F. Athayde-Filho, Jon O. Lundberg, Eddie Weitsberg, Mattias Carlstrom, Valdir de Andrade Braga
Summary: This study investigates the cardiovascular effects of the new organic nitrate NDIBP, and finds that it has a blood pressure-lowering effect without inducing tolerance. These effects may be mediated through the activation of the NO-sGC-cGMP signaling pathway and positive modulation of K+ channels in vascular smooth muscle.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Physiology
Md Rahatullah Razan, Farjana Akther, Rifat A. Islam, James L. Graham, Kimber L. Stanhope, Peter J. Havel, Roshanak Rahimian
Summary: This study investigated the protective effects of the female hormone estrogen (E-2) on mesenteric arterial vasorelaxation in prediabetic female rats. The results showed that the vasorelaxation function of the mesenteric arteries was impaired in prediabetic rats, but E-2 treatment restored the vasorelaxation. Additionally, the response to phenylephrine was enhanced in prediabetic rats.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pablo Mendez-Albinana, Angel Martinez-Gonzalez, Laura Camacho-Rodriguez, Alvaro Ferreira-Lazarte, Mar Villamiel, Raquel Rodrigues-Diez, Gloria Balfagon, Ana B. Garcia-Redondo, Ma Isabel Prieto-Nieto, Javier Blanco-Rivero
Summary: This study investigated the relationship between gut dysbiosis and vascular innervation dysfunction, as well as altered nitric oxide (NO) production. The results suggest that Prodefen (R) may be a potential non-pharmacological approach to ameliorate hypertension by enhancing neuronal NO release and activity.
Article
Plant Sciences
Ursula Houngue, Claire Villette, Jean-Marie Tokoudagba, Ahmed B. Chaker, Lamia Remila, Cyril Auger, Dimitri Heintz, Fernand A. Gbaguidi, Valerie B. Schini-Kerth
Summary: This study investigated the vasoreactivity of Carissa edulis, Diodia scandens, and Cleome gynandra on isolated arteries and found that Carissa edulis leaf extract induced significant endothelium-dependent relaxations and inhibited the contraction of arteries by stimulating the endothelial formation of nitric oxide. LC-HRMS analysis revealed the presence of multiple compounds including polyphenols, terpenes, and alkaloids in the most active fraction of Carissa edulis.
Article
Food Science & Technology
Germana Freire Rocha Caldas, Mayara Marilia Ferreira Limeira, Alice Valenca Araujo, Giwellington Silva Albuquerque, Jacinto da Costa Silva-Neto, Teresinha Goncalves da Silva, Joao Henrique Costa-Silva, Irwin Rose Alencar de Menezes, Jose Galberto Martins da Costa, Almir Goncalves Wanderley
FOOD AND CHEMICAL TOXICOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Audrey N. de Andrade, Alice V. Araujo, Hugo B. W. Barbosa, Almir G. Wanderley, Oscar L. Malta, Janaina V. dos Anjos
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2017)
Article
Materials Science, Multidisciplinary
Vander Alkmin dos Santos Ribeiro, Amanda Carvalho Pereira, Adhimar Flavio Oliveira, Claudiney de Sales Pereira Mendonca, Manoel Ribeiro da Silva
MATERIA-RIO DE JANEIRO
(2016)
Article
Biochemistry & Molecular Biology
Amanda de Carvalho Pereira, Alice Valenca Araujo, Michele Paulo, Fernanda Aparecida de Andrade, Bruno Rodrigues Silva, Juliana Aparecida Vercesi, Roberto Santana da Silva, Lusiane Maria Bendhack
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Alice V. Araujo, Fernanda A. Andrade, Michele Paulo, Tiago D. de Paula, Simone R. Potje, Amanda C. Pereira, Lusiane M. Bendhack
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Savio dos Santos Barbosa, Ana Paula da Fonseca Arcoverde Cabral Mello, Viviane de Oliveira Nogueira, Ially Fabiane da Silva, Palloma Emanuelle Dornelas de Melo, Carlos Renato dos Santos, Joao Henrique da Costa-Silva, Alice Valenca Araujo
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Jose Wilson do Nascimento Correa, Cibele Maria Prado, Maria Elena Riul, Alice Valenca Araujo, Marcos Antonio Rossi, Lusiane Maria Bendhack
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Review
Biology
Gabriela Maria da Silva, Mirelly Cunha da Silva, Deborah Victoria Gomes Nascimento, Ellen Mayara Lima Silva, Fabiola Furtado Fialho Gouvea, Luiz Gonzaga de Franca Lopes, Alice Valenca Araujo, Kelli Nogueira Ferraz Pereira, Thyago Moreira de Queiroz
Summary: Nitric oxide plays crucial physiological roles in the cardiovascular system, and its deficiency can lead to cardiovascular diseases such as hypertension. Nitric oxide donors are clinically beneficial in treating cardiovascular disorders by modulating oxidative stress and inflammation, particularly in conditions like hypertension. Novel NO donors, especially those containing metal ions, show promising potential in improving vascular function and treating hypertension.
Article
Pharmacology & Pharmacy
Amanda de Carvalho Pereira, Alice Valenca Araujo, Michele Paulo, Roberto Santana da Silva, Lusiane Maria Bendhack
Summary: RuBPY decreases intracellular calcium concentration by blocking calcium influx and activating the guanylyl cyclase-cGMP-GK pathway, resulting in reduced vascular contraction. These findings suggest that RuBPY increases Ca2+ storage through SERCA activation and inhibition of capacitive Ca2+ influx.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Review
Chemistry, Medicinal
Sidiane B. da Silva, Sidney G. D. Feitosa, Silvia M. de L. Alves, Ruth C. A. Santos, Janaina dos Anjos, Alice Araujo
Summary: Adrenoceptors are receptors for catecholamines and play a role in regulating cellular responses. Alpha-adrenoceptors are used in the treatment of hypertension and benign prostatic hyperplasia, but their activation can also lead to adverse effects such as orthostatic hypotension. Understanding the structure-activity relationships can help in the development of drugs with improved selectivity and reduced side effects.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Isis Didier Lins, Leonardo Streck Raupp, Caio Bezerra Souto Maior, Felipe Cavalcanti de Barros Felipe, Marcio Jose das Chagas Moura, Joao Mateus Marques de Santana, Alexsandro dos Santos, Marcelo Victor de Arruda Freitas, Ramon Nascimento Silva, Ewerton Henrique da Conceicao, Jose Candido Ferraz, Alice Araujo, Mariana Fernandes, Ana Lisa Gomes
Summary: This paper introduces SerumCovid, a COVID-19 serological database that aims to understand the impact of COVID-19 on healthcare professionals. The study found that the majority of samples were from females and the most common age group was between 30 and 39 years old. The most reported symptoms were fatigue, headaches, and myalgia. Interestingly, some subjects still tested positive for antibodies after 130 days. Surprisingly, for over 80% of the samples, the results of IgA and IgG tests were consistent.
Article
Parasitology
Caio B. S. Maior, Isis D. Lins, Leonardo S. Raupp, Felipe Felipe, Mariana P. Fernandes, Alice V. Araujo, Ana L. V. Gomes
Summary: This study investigated the seroprevalence of health professionals in a Northeastern Brazilian city, using Bayesian analysis and IgA/IgG antibody levels, considering data availability from different sources and providing stratification by sex, age, and comorbidities.
Article
Food Science & Technology
Tafnes Oliveira, Isabella Ribeiro, Gabriela Jurema-Santos, Isabele Nobre, Ravi Santos, Camilla Rodrigues, Kevin Oliveira, Rafael Henrique, Wylla Ferreira-e-Silva, Alice Araujo
Article
Biochemistry & Molecular Biology
Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron
Summary: This review investigates the strategy of using nitric oxide (NO) donors to extend postharvest shelf-life and improve fruit quality, discusses the interactions between NO and ethylene or reactive oxygen species, and highlights the potential of nanotechnology in NO applications.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2024)