Article
Radiology, Nuclear Medicine & Medical Imaging
Stig P. Cramer, Henrik B. W. Larsson, Maria H. Knudsen, Helle J. Simonsen, Mark B. Vestergaard, Ulrich Lindberg
Summary: This study investigates the reproducibility of DCE-MRI in healthy controls and evaluates the impact of arterial input function selection and manual region of interests delineation versus automated global segmentation. The results show excellent reproducibility of pharmacokinetic variables derived from DCE-MRI in healthy controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Inna Gertsenshteyn, Boris Epel, Amandeep Ahluwalia, Heejong Kim, Xiaobing Fan, Eugene Barth, Marta Zamora, Erica Markiewicz, Hsiu-Ming Tsai, Subramanian Sundramoorthy, Lara Leoni, John Lukens, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Mihai Giurcanu, Brian B. Roman, Gregory Karczmar, Chien-Min Kao, Howard Halpern, Chin-Tu Chen
Summary: This study compared FMISO PET images with pO(2) EPRI in mouse models to identify the optimal FMISO threshold for locating tumor hypoxia, showing a high overall hypoxia similarity between the two imaging methods. Additionally, the correlations between PET/EPRI hypoxia images and vascular permeability and extracellular-extravascular space from DCE-MRI were evaluated.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Clinical Neurology
Yong Jin, Hui Peng, Jie Peng
Summary: This study utilized DCE-MRI technology and its perfusion parameters to diagnose and differentially diagnose brain tumors, showing that DCE-MRI can accurately distinguish between HGG and LGG, with t-Ktrans value demonstrating higher specificity and sensitivity.
WORLD NEUROSURGERY
(2021)
Article
Biology
Jintao Ru, Beichen Lu, Buran Chen, Jialin Shi, Gaoxiang Chen, Meihao Wang, Zhifang Pan, Yezhi Lin, Zhihong Gao, Jiejie Zhou, Xiaoming Liu, Chen Zhang
Summary: Breast cancer is the most common cancer in women. Ultrasound and DCE-MRI are widely used for diagnosis, and we propose a segmentation network named Att-U-Node to address the challenges of current deep neural networks. The experiments show that the proposed model achieves competitive results for tumor segmentation and mitigates the common problems of deep neural networks.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Jennifer Hazel Elizabeth Baker, Firas Moosvi, Alastair Hugh Kyle, Judit Puspoky Banath, Katayoun Saatchi, Urs Otto Haefeli, Stefan Alexander Reinsberg, Andrew Ivor Minchinton
Summary: There is a need for a widely available, translatable, sensitive and non-invasive imaging biomarker for tumor hypoxia in radiation oncology. This study investigates the utility of dOE-MRI, a previously validated imaging approach, to detect VEGF-ablation treatment-induced changes in tumor oxygenation that result in radiosensitization. The results illustrate the effectiveness of dOE-MRI as a non-invasive biomarker for treatment response and tumor sensitivity during cancer interventions.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jerome Conq, Nicolas Joudiou, Bernard Ucakar, Kevin Vanvarenberg, Veronique Preat, Bernard Gallez
Summary: This study evaluated the value of methods to assess hemodynamic changes in the core and margins of GB using osmotic shock. The results showed that the fluorescent dye diffused more extensively outside the tumor area after osmotic shock. However, DCE-MRI did not reveal any changes in BBB permeability.
Article
Surgery
H. Tibermacine, P. Rouanet, M. Sbarra, R. Forghani, C. Reinhold, S. Nougaret
Summary: The study evaluated and compared different radiomics approaches for predicting disease-free survival in patients with locally advanced rectal cancer. The 3D radiomics model outperformed qualitative analysis and showed good performance in predicting DFS. Radiomics models have the potential to predict DFS more accurately than qualitative analysis.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Engineering, Biomedical
Jun Wang, Wei Tang, Meng Yang, Ying Yin, Hui Li, Fangfang Hu, Lin Tang, Xiaoyue Ma, Yu Zhang, Yazhou Wang
Summary: NEs-Exos system exhibits neutrophil-like chemotactic function and BBB penetration capability, efficiently suppressing tumor growth and prolonging survival time in a glioma mouse model.
Article
Biochemistry & Molecular Biology
Jonathan Pratt, Khadidja Haidara, Borhane Annabi
Summary: Modulations in cell surface receptor ectodomain proteolytic shedding impact on receptor function and cancer biomarker expression. LRP-1-mediated Angiopep-2 internalization is influenced by MT1-MMP expression. Inhibitors of MMP increase An2 internalization, while MT1-MMP overexpression reduces it. Combined administration of MMP inhibitors and An2-drug conjugates may enhance the treatment of high-MT1-MMP-expressing brain tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Xiaokai Li, Lei Li, Ke Zhou, Huixiang Zhang, Ali Abdi Maalim, Xingyu Chen, Ximiao He, Xinmin Ding, Chuanrui Xu, Yonghong Wang
Summary: In this study, the infiltration of BBB constituent cells in the glioma tumor microenvironment was investigated using statistical analysis. The results showed a close relationship between the infiltration proportions of BBB constituent cell types and BBB alterations. A BBB score was developed and found to be associated with more malignant tumor features, higher WHO grade, shorter survival time, and unfavorable prognosis in glioma patients. Furthermore, TME-related pathways were found to regulate BBB alterations and coinhibitory immune checkpoints were enriched in samples with higher BBB scores.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Computer Science, Artificial Intelligence
Edson Damasceno Carvalho, Otilio Paulo da Silva Neto, Mano Joseph Mathew, Antonio Oseas de Carvalho Filho
Summary: Predicting the response of breast tumors to treatment is crucial for patients undergoing neoadjuvant chemotherapy. This study presents a new methodology that effectively predicts tumor response using dynamic contrast magnetic resonance imaging (DCE-MRI) and achieved high accuracy in various steps such as tumor segmentation and classification of malignancy. The proposed methodology proves to be efficient and can be integrated into a support system for breast cancer treatment.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Biophysics
Seokha Jin, Hyung Joon Cho
Summary: This study demonstrates the robustness of model-free leakage index estimation in ischemic brains by using dual DSC-MRIs. The leakage index values correlated well with Delta T-1 and showed consistency in measuring inter-subject vascular permeability.
NMR IN BIOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin C. Musall, Abeer H. Abdelhafez, Beatriz E. Adrada, Rosalind P. Candelaria, Rania M. M. Mohamed, Medine Boge, Huong Le-Petross, Elsa Arribas, Deanna L. Lane, David A. Spak, Jessica W. T. Leung, Ken-Pin Hwang, Jong Bum Son, Nabil A. Elshafeey, Hagar S. Mahmoud, Peng Wei, Jia Sun, Shu Zhang, Jason B. White, Elizabeth E. Ravenberg, Jennifer K. Litton, Senthil Damodaran, Alastair M. Thompson, Stacy L. Moulder, Wei T. Yang, Mark D. Pagel, Gaiane M. Rauch, Jingfei Ma
Summary: The study aimed to investigate the use of fast DCE MRI to predict response to neoadjuvant systemic therapy in triple-negative breast cancer. Results showed that FTV measured at 1 minute after injection during C4 provided the best discrimination between patients who achieved a pathologic complete response and those who did not.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Mark Behar, Kyung K. Peck, Onur Yildirim, Jamie Tisnado, Atin Saha, Julio Arevalo-Perez, Eric Lis, Yoshiya Yamada, Andrei I. Holodny, Sasan Karimi
Summary: This study investigated the correlation between changes in dynamic contrast-enhanced MR imaging perfusion parameters and clinical outcomes following radiation therapy for spinal metastases. The study found that perfusion parameters outperformed traditional size measurements in discriminating treatment success and failure.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Biophysics
P. Suhail Parvaze, Rupsa Bhattacharjee, Yogesh Kumar Verma, Rakesh Kumar Singh, Virendra Yadav, Anup Singh, Gaurav Khanna, Sunita Ahlawat, Richa Trivedi, Rana Patir, Sandeep Vaishya, Tejas J. J. Shah, Rakesh K. K. Gupta
Summary: This study investigated the different characteristics of peritumoral vasogenic edema (PVE) in brain tumors using radiomics features in FLAIR images. The presence of tumor cells was found to influence the texture variation in PVE. Specifically, glioblastoma (GB) showed tumor cell infiltration in PVE, while brain metastasis (BM) and meningioma had few tumor cells. These findings may be valuable in distinguishing solitary metastasis from GB.
NMR IN BIOMEDICINE
(2023)
Editorial Material
Clinical Neurology
Michael Fiechter, Astrid Weyerbrock, Jean-Yves Fournier
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Jessica Guenzle, Harue Akasaka, Katharina Joechle, Wilfried Reichardt, Aina Venkatasamy, Jens Hoeppner, Claus Hellerbrand, Stefan Fichtner-Feigl, Sven A. Lang
Summary: This study demonstrates the significant reduction in migration, invasion, and proliferation of melanoma cells upon specific inhibition of mTORC2 using the novel inhibitor JR-AB2-011, leading to cell death through non-apoptotic pathways. In a syngeneic murine metastasis model, therapy with JR-AB2-011 showed a remarkable decrease in liver metastasis, highlighting the potential of pharmacological blockade of mTORC2 as a novel anti-cancer approach for melanoma liver metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Marketa Sosnova, Anna Maria Zeitlberger, Michal Ziga, Oliver P. Gautschi, Luca Regli, Astrid Weyerbrock, Oliver Bozinov, Martin N. Stienen, Nicolai Maldaner
Summary: The study found that the majority of patients preferred the smartphone-based outcome measure over conventional paper-based methods, considering it more suitable, convenient, and responsive to their symptoms. Patients also believed that the smartphone app was better at detecting changes in physical performance and differences in symptoms. Most patients indicated a preference for using a smartphone app for future assessment and monitoring of spine-related symptoms.
Article
Clinical Neurology
Eva M. Kesenheimer, Maria Janina Wendebourg, Matthias Weigel, Claudia Weidensteiner, Tanja Haas, Laura Richter, Laura Sander, Antal Horvath, Muhamed Barakovic, Philippe Cattin, Cristina Granziera, Oliver Bieri, Regina Schlaeger
Summary: This study aimed to develop normalization strategies for spinal cord metrics derived from rAMIRA imaging, using skull and spine-based metrics to reduce anatomical variability.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Tugba Akinci D'Antonoli, Francesco Santini, Xeni Deligianni, Meritxell Garcia Alzamora, Erich Rutz, Oliver Bieri, Reinald Brunner, Claudia Weidensteiner
Summary: The study utilized a combination of MRI fat fraction and texture analysis to differentiate affected muscles from healthy ones in cerebral palsy patients, with the combination model consistently outperforming individual models in performance.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Claudia Weidensteiner, Philipp Madoerin, Xeni Deligianni, Tanja Haas, Oliver Bieri, Tugba Akinci D'Antonoli, Katrin Bracht-Schweizer, Jacqueline Romkes, Enrico De Pieri, Francesco Santini, Erich Rutz, Reinald Brunner, Meritxell Garcia
Summary: A study of 6 pediatric CP patients undergoing MRI evaluation of the effect of BTX injections on calf muscle properties showed signal enhancement, increased T-2 values, increased FA, unchanged ADC in hyperintense ROIs, and a trend towards increased fat fraction at 12 weeks. Mean values in the reference ROIs remained stable.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Sarah Nasreen Schmidt, Wilfried Reichardt, Beat A. Kaufmann, Carolin Wadle, Dominik von Elverfeldt, Peter Stachon, Ingo Hilgendorf, Dennis Wolf, Timo Heidt, Daniel Duerschmied, Karlheinz Peter, Christoph Bode, Constantin von zur Muehlen, Alexander Maier
Summary: The study aimed to explore the detection of early myocarditis using molecular contrast-enhanced ultrasound of activated platelets in mouse models. It was found that platelets infiltrated the myocardium before a decline in cardiac function was detectable, and P2Y(12) receptor platelet inhibition showed potential as an early therapeutic intervention in myocarditis. Further research is needed to fully understand the implications of this inhibition in myocarditis treatment.
Article
Neurosciences
Vanessa Aires, Stephanie Ziegler-Waldkirch, Marina Friesen, Wilfried Reichardt, Daniel Erny, Desiree Loreth, Andrew Harborne, Oliver Kretz, Dominik von Elverfeldt, Melanie Meyer-Luehmann
Summary: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-beta peptide (A beta) and subsequent formation of A beta plaques. It has been found that AD patients also exhibit white matter anomalies and corpus callosum (CC) atrophy, which may be related to the reduction in oligodendrocyte progenitor cell (OPC) numbers during the initial stages of plaque formation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Enrico De Pieri, Johannes Cip, Reinald Brunner, Claudia Weidensteiner, Nathalie Alexander
Summary: This study aimed to compare the muscle contributions to hip joint moments and muscle forces in patients with increased femoral anteversion and an internally rotated gait pattern to a control group of typically developing children. The study found that despite the patients having a comparable net hip abduction moment, their gluteus medius abductive contribution was lower compared to controls. Furthermore, if the patients were modeled to walk straight, their muscle forces would increase. These findings provide important information for understanding and improving treatment recommendations for this condition.
Article
Oncology
A. Venkatasamy, E. Guerin, W. Reichardt, V. Devignot, M. P. Chenard, L. Miguet, B. Romain, A. C. Jung, I. Gross, C. Gaiddon, G. Mellitzer
Summary: By establishing patient-derived xenograft (PDX) models and using a morpho-functional approach combining high-resolution imaging with molecular analyses, we have successfully studied the complex pathology of gastric cancer. We have characterized the expression of important therapeutic biomarkers and observed the presence of muscle atrophy in the tumor ecosystem.
Article
Medicine, Research & Experimental
Philipp Seidel, Anne Rubarth, Kyra Zodel, Asin Peighambari, Felix Neumann, Yannick Federkiel, Hsin Huang, Rouven Hoefflin, Mojca Adlesic, Christian Witt, David J. Hoffmann, Patrick Metzger, Ralph K. Lindemann, Frank T. Zenke, Christoph Schell, Melanie Boerries, Dominik von Elverfeldt, Wilfried Reichardt, Marie Follo, Joachim Albers, Ian J. Frew
Summary: This study identifies ATR inhibition as a potential therapeutic option for ccRCC, showing that the drug M4344 induces antiproliferative effects in ccRCC cells by inhibiting the DNA damage-sensing kinase ATR. The combination of M4344 with chemotherapeutic drugs or a poly(ADP-ribose) polymerase inhibitor demonstrates better efficacy in both mouse and human ccRCC cells.
Article
Clinical Neurology
Michal Ziga, Marketa Sosnova, Anna M. Zeitlberger, Luca Regli, Oliver Bozinov, Astrid Weyerbrock, John K. Ratliff, Martin N. Stienen, Nicolai Maldaner
Summary: This study aimed to investigate the application of a smartphone-based 6-minute walking test in patients with degenerative lumbar disorders after surgery. The study found that this test could objectively assess patients' functional impairment and detect changes in their recovery after surgery. Additionally, a ceiling effect was observed in some patients, indicating that their patient-reported outcome measures could not further improve.
Article
Food Science & Technology
Reinald Brunner, Enrico De Pieri, Christian Wyss, Claudia Weidensteiner, Katrin Bracht-Schweizer, Jacqueline Romkes, Meritxell Garcia, Norine Ma, Erich Rutz
Summary: Local botulinum toxin (BTX-A, Botox (R)) injection is a standard treatment for overactive muscles in cerebral palsy patients. However, the effectiveness of BTX-A is reduced in older children, possibly due to limited muscle volume affected by the drug. This study found that injecting BTX-A into the muscles only affected 9-15% of the muscle volume, and had no significant impact on gait kinematics and kinetics. Multiple injection sites are recommended for better distribution of the drug.
Article
Chemistry, Multidisciplinary
Henri de Maissin, Philipp R. Gross, Obaid Mohiuddin, Moritz Weigt, Luca Nagel, Marvin Herzog, Zirun Wang, Robert Willing, Wilfried Reichardt, Martin Pichotka, Lisa Hess, Thomas Reinheckel, Henning J. Jessen, Robert Zeiser, Michael Bock, Dominik von Elverfeldt, Maxim Zaitsev, Sergey Korchak, Stefan Gloeggler, Jan-Bernd Hoevener, Eduard Y. Chekmenev, Franz Schilling, Stephan Knecht, Andreas B. Schmidt
Summary: Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is a non-invasive technique for diagnosing, staging, and monitoring response to treatment in various diseases. The Signal Amplification By Reversible Exchange (SABRE) method provides a fast and low-cost way to produce HP pyruvate. In this study, a novel routine to produce aqueous HP [1-C-13]pyruvate-d(3) for injection in 6 minutes was demonstrated, making HP pyruvate MRI available to a wide biomedical community for fast metabolic imaging of living organisms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Geoffrey Cotin, Cristina Blanco-Andujar, Francis Perton, Laura Asin, Jesus M. de la Fuente, Wilfried Reichardt, Denise Schaffner, Dinh-Vu Ngyen, Damien Mertz, Celine Kiefer, Florent Meyer, Simo Spassov, Ovidiu Ersen, Michael Chatzidakis, Gianluigi A. Botton, Celine Henoumont, Sophie Laurent, Jean-Marc Greneche, Francisco J. Teran, Daniel Ortega, Delphine Felder-Flesch, Sylvie Begin-Colin
Summary: Iron oxide nanoparticles (IONPs) are commonly used contrast agents for MRI and are being explored for theranostic applications. The study found that dendronized octopods, with a mean size of 18 nm, displayed superior properties as both MRI contrast agents and magnetic hyperthermia agents compared to dendronized nanospheres. The research emphasizes the importance of understanding the structure-property relationships in designing efficient theranostic nanoparticles.