Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 25, Issue 1, Pages 1-10Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2011.05.001
Keywords
Cardiac non-uniformity; cGMP; Nitrosylation; Endocrine network; Cold-blooded vertebrates
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Funding
- MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca)
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During early ectotherm vertebrate evolution the heart was redesigned as a high pressure pump adapted to perfuse larger body sizes. To compensate the consequent higher organ complexity and heterogeneity (ventricular myoarchitecture and blood supply), conceivably the three principal cardiac cell components, the endocardium, the contractile myocardium and the epicardium recruited and diversified the cardiac NOS system for functioning not only as a major modulator, but also as a spatio-temporal integrator of heart function. In the context of NOS isoform evolution, we will use fish and amphibian paradigms to illustrate major aspects of cardiac spatial and temporal integration achieved by the NOS/NO systems. This may reveal a primordial cardiac NOS/NO function, allocating it in a wider biological framework than so far envisioned. (C) 2011 Elsevier Inc. All rights reserved.
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