Article
Biochemistry & Molecular Biology
Huayu Zheng, John M. Weaver, Changjian Feng
Summary: The study found that Hsp90 alpha can significantly increase superoxide generation from nNOS mu and nNOS alpha proteins under L-Arg-depleted conditions, and has varying effects on superoxide production by these two nNOS splice variants.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Ana C. Pena, Ana Pamplona
Summary: Transition metals, especially iron, play important roles in the chemistry of life. Hemoproteins, including hemoglobin, are common targets for binding with biologically active gases such as NO and CO. Heme oxygenases, particularly HO-1, are crucial enzymes involved in heme metabolism and have documented antioxidant and anti-inflammatory properties. However, their role in infection, such as malaria, can be dual, either limiting pathogen burden or promoting pathogen growth. CO-releasing molecules have been considered as a potential alternative to CO gas inhalation for therapeutic purposes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Plant Sciences
Nana Su, Ze Liu, Lu Wang, Yuanyuan Liu, Mengyang Niu, Xin Chen, Jin Cui
Summary: This study reveals that hemin treatment increases anthocyanin accumulation in radish sprouts through HO-1 and NO signaling network.
Article
Chemistry, Multidisciplinary
Xiaodi Rong, Yiyuan Peng, Caiyun Liu, Mingzhu Li, Jiafan Shi, Miaohui Yu, Shuaikang Ba, Wenlong Sheng, Baocun Zhu
Summary: In this study, the issues of sensitivity, selectivity, and water solubility of CO fluorescent probes were investigated. A probe named HS-CO was designed to greatly increase the rigid plane of the probe through intramolecular cyclization, resulting in high sensitivity for CO detection. The probe was successfully used to detect CO in HeLa cells and zebrafish, demonstrating its great potential as a tool for functional analysis of CO in organisms.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Oncology
Yinhua Zheng, Zhenlan Li, Min Yin, Xu Gong
Summary: HO-1 is an enzyme that can be induced by various stimuli, with its products having anti-inflammatory and antioxidant effects and providing protection to skin flaps.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ana Paula Magrini Iacopucci, Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Valeria Pittala, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: In this study, a mouse model was used to investigate the effect of intravascular hemolysis on corpus cavernosum smooth muscle relaxation and oxidative stress in the penis. The results showed that intravascular hemolysis promotes increased corpus cavernosum smooth muscle relaxation, accompanied by upregulation of HO-1 expression and oxidative stress. This study provides support for clinical studies that have shown a strong positive correlation between priapism and high levels of intravascular hemolysis in men with SCD.
Review
Plant Sciences
John T. Hancock, Tyler W. LeBaron, Jennifer May, Adam Thomas, Grace Russell
Summary: Although the use of molecular hydrogen (H-2) for enhanced plant growth and postharvest storage of crops has not been widely accepted in the UK, evidence shows that it can alleviate plant stress and slow crop senescence. The effects of H-2 treatment appear to be mediated by the alteration of plant cell antioxidant capacity, with potential benefits in agriculture if the costs are justified. Hydrogen-rich water (HRW) is considered safe and relatively easy to use, suggesting that it could potentially be widely adopted in the UK and help reduce food waste in the future.
Article
Chemistry, Multidisciplinary
Woo Jin Lee, Wan Yi Li, Sang Woo Lee, Sung Keun Jung
Summary: The extract of Soroseris hirsuta demonstrates anti-inflammatory and antioxidant effects on LPS-activated murine macrophages, inhibiting nitric oxide expression and key signaling pathways related to inflammation and oxidative stress.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Hernando Gomez, Hakon Haugaa, Daniel Escobar, Ana M. Botero, Rachel Pool, Gaspar Del Rio-Pertuz, Carlos L. Manrique-Caballero, Lisa Gordon, Alicia Frank, Jean-Louis Teboul, Brian S. Zuckerbraun, Michael R. Pinsky
Summary: The study found that guiding resuscitation based on macrohemodynamics during endotoxemic shock cannot predict tissue metabolic stress and microvascular response to resuscitation, nor can it prevent tubular injury and AKI. Microvascular flow index, PCO2 gap, and P(v-a)CO2/C(a-v)O-2 ratio outperformed macrohemodynamic parameters in predicting renal metabolic stress and tubular injury, suggesting potential as resuscitation targets.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Reiko Akagi
Summary: The gastrointestinal tract is lined with epithelial cells forming the mucosa, which acts as a selective barrier and plays important roles in nutrient absorption and protection against harmful agents. Heme oxygenases (HOs) are enzymes that degrade heme, a major nutritional source of iron, and produce beneficial substances. Recent studies have shown that the products of heme degradation have antioxidant, anti-inflammatory, and cytoprotective functions. This review summarizes the essential roles of HO in the gastrointestinal tract, focusing on nutrient absorption, cellular protection, and the regulation of tight junction proteins, highlighting their potential therapeutic implications.
Article
Biochemistry & Molecular Biology
Fernanda Tomiotto-Pellissier, Daniela Ribeiro Alves, Selene Maia de Morais, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Taylon Felipe Silva, Eliandro Reis Tavares, Lucy Megumi Yamauchi, Idessania Nazareth Costa, Emmanuel Silva Marinho, Marcia Machado Marinho, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: The study showed that extracts from Caryocar coriaceum fruit had antileishmanial effects by inducing apoptosis-like processes, causing damage to the mitochondria and plasma membrane of the parasite, and reducing infection rates in infected cells. Additionally, the extracts exhibited antioxidant properties and up-regulated Nrf2/HO-1/Ferritin expression, leading to a depletion of available iron for Leishmania replication. Molecular modeling experiments suggested that flavonoids in the extracts can act as synergistic inhibitors of Leishmania proteins, with rutin showing a preference for the active site.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Jakub Szyller, Mariusz Kozakiewicz, Piotr Siermontowski, Dorota Kaczerska
Summary: Simulated dives have significant effects on the antioxidant system, heat shock protein expression, and nitric oxide synthase, but these changes depend on the diving conditions. There is a relationship between the expression of heat shock proteins and the intensity of oxidative stress.
Article
Biochemistry & Molecular Biology
Na-Ra Han, Kyeoung-Cheol Kim, Ju-Sung Kim, Hi-Joon Park, Seong-Gyu Ko, Phil-Dong Moon
Summary: Sambu-Tang (SBT) and stigmasterol (Stig) have antioxidant and immunomodulatory activities, making them effective natural compounds for treating symptoms caused by immune dysregulation.
Review
Plant Sciences
Noushina Iqbal, Shahid Umar, Nafees A. Khan, Francisco J. Corpas
Summary: Under heat stress, the interaction between ABA and NO affects plant adaptation and provides insights into developing heat stress-resistant varieties.
PLANT CELL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Julia Claudiane da Veiga, Neidiquele Maria Silveira, Amedea Barozzi Seabra, Ilana Urbano Bron
Summary: This review investigates the strategy of using nitric oxide (NO) donors to extend postharvest shelf-life and improve fruit quality, discusses the interactions between NO and ethylene or reactive oxygen species, and highlights the potential of nanotechnology in NO applications.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2024)