Article
Multidisciplinary Sciences
Patricia Gonzalez-Rodriguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, Jose Lopez-Barneo, Paul T. Schumacker, D. James Surmeier
Summary: Loss of functional mitochondrial complex I in dopaminergic neurons can lead to a shift in metabolism in mice, causing Parkinson's disease-like symptoms. This study challenges the traditional paradigm of Parkinson's disease by showing that dysfunction of mitochondrial complex I alone is sufficient to cause progressive parkinsonism.
Article
Biology
Yolaine Rabat, Sandra Chanraud, Majd Abdallah, Igor Sibon, Sylvie Berthoz
Summary: This review examines the use of Magnetic Resonance Imaging (MRI) to predict smoking cessation outcomes and identifies the insula as a key factor in addiction. Despite the inability to conduct a meta-analysis, this research has the potential to pave the way for personalized prevention therapy for high-risk smokers.
Article
Biochemistry & Molecular Biology
Jillian L. Seiler, Caitlin Cosme, Venus N. Sherathiya, Michael D. Schaid, Joseph M. Bianco, Abigael S. Bridgemohan, Talia N. Lerner
Summary: Compulsive behavior is a defining feature of disorders, and little is known about the mechanisms regulating its development. This study suggests that dopamine signaling in the dorsomedial striatum plays a key role in controlling the emergence of compulsive reward seeking.
Article
Behavioral Sciences
Chuya Jing, Changxin Jing, Liangcheng Zheng, Ganji Hong, Jingjing Zheng, Lu Yu, Ningning Song, Tengkun Zhang, Qilin Ma, Jie Fang
Summary: By studying 11 smoking addicts with dorsal striatum damage and 20 controls, it was found that disruption of smoking addiction was significantly associated with the dorsal striatum. Patients with dorsal striatum damage were more likely to successfully quit smoking and reduce the urge to smoke.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Xin Pan, Zhaoxin Wang
Summary: In this study, the neural correlates of non-motor inhibitory control were investigated using fMRI and a simple Count Go/NoGo task. The results revealed a distinct pattern of activation in the subcortical basal ganglia during the Count NoGo task. Regression and mediation analyses demonstrated that these activations were modulated by specific cortical regions, including the right inferior frontal gyrus/insula, left inferior frontal gyrus/insula, and anterior cingulate cortex/supplementary motor area.
Article
Biochemistry & Molecular Biology
Yu Ohmura, Kentaro Iwami, Srikanta Chowdhury, Hitomi Sasamori, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Akihiro Yamanaka, Mitsuhiro Yoshioka
Summary: The article explores the strategy changes in decision making under different environmental conditions and the role of the central serotonergic system in model-based decision making. Through manipulation of serotonin neurons, it is demonstrated that their impact on model-based decision making has been confirmed.
Article
Substance Abuse
Amanda L. Persons, Brinda Desai Bradaric, Leo P. Kelly, Sharanya M. Kousik, Steven M. Graves, Bryan K. Yamamoto, T. Celeste Napier
Summary: The study suggests that self-administration of methamphetamine in rats leads to motor deficits and increased expression of GFAP and alpha-synuclein in brain and gut tissue, resembling features of prodromal and early-stage Parkinson's disease.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Neurosciences
E. Giorla, S. Nordmann, C. Vielle, Y. Pelloux, P. Roux, C. Protopopescu, C. Manrique, K. Davranche, C. Montanari, L. Giorgi, A. Vilotitch, P. Huguet, P. Carrieri, C. Baunez
Summary: This study investigated the influence of peer presence and familiarity on cocaine intake and its neurobiological basis. The results showed that the presence of a peer, whether they were abstinent or drug-taking, and whether they were familiar or not, reduced cocaine consumption. Furthermore, the presence of a non-familiar and cocaine-naive peer further diminished cocaine intake. These findings suggest that peer presence plays an important role in decreasing cocaine intake, and the subthalamic nucleus may be a neurobiological substrate of social influence on drug intake.
PSYCHOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Matthew Baker, Seungwoo Kang, Sa-Ik Hong, Minryung Song, Minsu Abel Yang, Lee Peyton, Hesham Essa, Sang Wan Lee, Doo-Sup Choi
Summary: The authors found that GPe arky neurons are involved in reward-seeking behaviors and primarily project to the dorsolateral striatum. Genetic ablation of this circuit shift behavior from goal-directed to habitual seeking.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Shinwoo Kang, Sa-Ik Hong, Seungwoo Kang, Minryung Song, Minsu Abel Yang, Hesham Essa, Matthew Baker, Jeyeon Lee, Robert A. Bruce, Sang Wan Lee, Doo-Sup Choi
Summary: A study found that astrocytic activity in the external globus pallidus (GPe) is attenuated during habitual learning compared to goal-directed learning. Increased expression of GABA transporter type 3 (GAT3) in astrocytes during habit learning inhibits the transition from habitual to goal-directed behavior.
Article
Clinical Neurology
Claudia C. Schmidt, Elisabeth I. S. Achilles, Katharina Bolte, Nina N. Kleineberg, Monika K. Richter, Natalie Schloss, Gereon R. Fink, Peter H. Weiss
Summary: The study investigated the association between subcortical gray matter lesions and apraxic deficits in LH stroke patients, finding that lesions in the caudate nucleus were significantly related to apraxic deficits, while lesions in the globus pallidus were associated with a lower likelihood of apraxia. Other subcortical structures did not show significant differences in lesion load between apraxic and nonapraxic patients.
Article
Peripheral Vascular Disease
Marieke van den Kerkhof, Merel M. van der Thiel, Alida A. Postma, Robert J. van Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Summary: This study found that patients with hypertension have higher pulsatility index (PI) and lower damping factor (DF) in small perforating arteries, which may be due to hypertension-induced arterial stiffening leading to increased blood flow pulsatility and decreased damping. These results highlight the impact of hypertension on cerebral blood vessel structure and function, and provide clues for further investigation into the relationship between hypertension and stroke and cerebral small vessel disease (cSVD).
Article
Cell Biology
Francesco Longo, Sameer Aryal, Paul G. Anastasiades, Marta Maltese, Corey Baimel, Federica Albanese, Joanna Tabor, Jeffrey D. Zhu, Mauricio M. Oliveira, Denise Gastaldo, Claudia Bagni, Emanuela Santini, Nicolas X. Tritsch, Adam G. Carter, Eric Klann
Summary: Individuals with fragile X syndrome (FXS) often have a dual diagnosis of autism spectrum disorder (ASD), which includes an increased risk of restricted and repetitive behaviors (RRBs). FXS model mice exhibit RRBs and hyperactivity that are similar to dysfunctional cortico-striatal circuits. Through a multi-disciplinary approach, researchers have identified dysregulated protein synthesis at cortico-striatal synapses as a molecular cause of synaptic and ASD-associated motor phenotypes in FXS model mice. Cell-type-specific translational profiling of the FXS mouse striatum has revealed differentially translated mRNAs, providing important information for potential therapeutic targets. These findings highlight the cell-type-specific impact of fragile X messenger ribonucleoprotein (FMRP) loss on translation and the sequence of neuronal events in the striatum that drive RRBs in FXS.
Article
Multidisciplinary Sciences
Yosuke Sato, Go Okada, Satoshi Yokoyama, Naho Ichikawa, Masahiro Takamura, Yuki Mitsuyama, Ayaka Shimizu, Eri Itai, Hotaka Shinzato, Mitsuo Kawato, Noriaki Yahata, Yasumasa Okamoto
Summary: This study aimed to develop a classifier for subthreshold depression (StD) and explore the underlying neural mechanisms. By using resting-state functional magnetic resonance imaging data, the study identified important functional connections related to StD. Future research should investigate whether modulating these connections can be an effective treatment for StD.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Pelin Kuzucu, Pinar Celtikci, Oguz Kagan Demirtas, Cagri Canbolat, Emrah Celtikci, Harun Demirci, Pinar Ozisik, R. Shane Tubbs, M. Necmettin Pamir, Abuzer Gungor
Summary: This study explains the arterial blood supply of the basal ganglia using white matter dissection. The results showed that the globus pallidus is supplied by the medial lenticulostriate, lateral lenticulostriate, and anterior choroidal arteries; the substantia nigra and subthalamic nucleus are supplied by branches of the posterior cerebral artery; the putamen is supplied by the lateral and medial lenticulostriate arteries; and the caudate nucleus is supplied by the lateral and medial lenticulostriate arteries and the recurrent artery of Heubner. Knowledge of the detailed anatomy and vascular supply of the basal ganglia is essential in surgeries related to the insula and opens doors to endovascular deep brain stimulation treatment.
OPERATIVE NEUROSURGERY
(2023)
Article
Psychology, Clinical
Molly Z. Meth, John P. K. Bernstein, Matthew Calamia, Daniel Tranel
CLINICAL NEUROPSYCHOLOGIST
(2019)
Article
Neuroimaging
Vita Droutman, Feng Xue, Emily Barkley-Levenson, Hei Yeung Lam, Antoine Bechara, Benjamin Smith, Zhong-Lin Lu, Gue Xue, Lynn C. Miller, Stephen J. Read
NEUROIMAGE-CLINICAL
(2019)
Article
Behavioral Sciences
Qinghua He, Dandan Li, Ofir Turel, Antoine Bechara, Yih-Ing Hser
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neuroimaging
Qinghua He, Ofir Turel, Lei Wei, Antoine Bechara
Summary: This study focused on extensive gamers who play about 3 hours per day and found that they have morphological alterations in brain regions associated with control and visuomotor skills. These findings suggest potential indicators for Internet Gaming Disorder development and highlight the impact of gaming on brain morphology.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Psychology, Biological
Tasha Poppa, Sara de Witte, Marie-Anne Vanderhasselt, Antoine Bechara, Chris Baeken
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ofir Turel, Qinghua He, Lei Wei, Antoine Bechara
Summary: This study aimed to investigate the neural etiology of Internet gaming disorder, with findings supporting stronger reward system activation and weaker prefrontal activation in gamers, as well as increased insula activation under deprivation conditions when exposed to video game cues.
Article
Behavioral Sciences
Haichao Zhao, Ofir Turel, Damien Brevers, Antoine Bechara, Qinghua He
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Multidisciplinary Sciences
Kanchna Ramchandran, Jess Fiedorowicz, Zhaoying Chen, Yilin Bu, Antoine Bechara, Nancy C. Andreasen
Article
Biochemistry & Molecular Biology
Damien Brevers, Chris Baeken, Antoine Bechara, Qinghua He, Pierre Maurage, Mathieu Petieau, Guillaume Sescousse, Claus Voegele, Joel Billieux
Summary: The study investigated the impact of sports betting on brain activity, finding that nonavailable sports betting cues elicited higher brain activity in problem bettors, and lower trait-self-control was associated with increased brain reactivity to sports events with high levels of winning confidence that were nonavailable for betting.
Article
Business
Ofir Turel, Antoine Bechara
Summary: This study expands on the neuro-marketing literature on normal consumption by describing a triple neural model of maladaptive consumption, highlighting the roles of reward, self-control/inhibition, and interoceptive awareness circuits in maladaptive consumption. Imbalance between these systems drives maladaptive consumption.
JOURNAL OF THE ASSOCIATION FOR CONSUMER RESEARCH
(2021)
Article
Clinical Neurology
Tasha Poppa, Lars Benschop, Paula Horczak, Marie-Anne Vanderhasselt, Evelien Carrette, Antoine Bechara, Chris Baeken, Kristl Vonck
Summary: This study investigated the impact of transcutaneous auricular vagus nerve stimulation (taVNS) on interoceptive mechanisms, revealing that taVNS can alter the amplitudes of heart-evoked potentials (HEP) and affect activity in brain regions such as the insula and operculum.
Article
Psychiatry
Florent Wyckmans, Nilosmita Banerjee, Melanie Saeremans, Ross Otto, Charles Kornreich, Laetitia Vanderijst, Damien Gruson, Vincenzo Carbone, Antoine Bechara, Tony Buchanan, Xavier Noel
Summary: This study investigated the influence of acute stress on the balance between habitual response and the goal-directed system in individuals with gambling disorder. The results showed that stress-induced cortisol response had a deleterious effect on the orchestration between model-based and model-free learning in healthy controls, but not in individuals with gambling disorder.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2022)
Article
Neurosciences
Qinghua He, Xiaolu Huang, Shuyue Zhang, Ofir Turel, Liangsuo Ma, Antoine Bechara
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2019)
Article
Psychology, Multidisciplinary
Antoine Bechara, Kent C. Berridge, Warren K. Bickel, Jose A. Moron, Sidney B. Williams, Jeffrey S. Stein
PSYCHOLOGICAL SCIENCE IN THE PUBLIC INTEREST
(2019)
Article
Audiology & Speech-Language Pathology
Amy M. Belfi, Anna Kasdan, Daniel Tranel