Review
Chemistry, Medicinal
Giusy Tassone, Marco Mazzorana, Cecilia Pozzi
Summary: Protozoan parasites are responsible for harmful diseases in humans, and new specific drug therapies are urgently needed. HSP90 plays a key role in parasite survival, with the N-terminal domain being a crucial target for inhibitor development.
Article
Chemistry, Multidisciplinary
Aaron T. Balana, Paul M. Levine, Timothy W. Craven, Somnath Mukherjee, Nichole J. Pedowitz, Stuart P. Moon, Terry T. Takahashi, Christian F. W. Becker, David Baker, Matthew R. Pratt
Summary: The study found that O-GlcNAc can activate the anti-amyloid activity of certain small heat shock proteins, inhibiting protein aggregation. Although O-GlcNAc levels are globally reduced in Alzheimer's disease brains, the modification of relevant small heat shock proteins is either maintained or increased, suggesting a mechanism to maintain these potentially protective O-GlcNAc modifications.
Review
Biochemistry & Molecular Biology
Kevin Reinle, Axel Mogk, Bernd Bukau
Summary: The protein quality control system maintains protein homeostasis through substrate degradation, refolding, and sequestration activities, in which small heat shock proteins play a crucial role and adapt to different tasks and stress conditions.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Environmental Sciences
Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu
Summary: This study revealed the important role of the sHSP family in Daphnia magna under heavy metal exposure, demonstrating the predominant role of DmsHSP1 in stress response and providing important insights into the survival mechanisms of D. magna in adverse environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Jieting Wu, Tian Gao, Jianing Hu, Lei Zhao, Chang Yu, Fang Ma
Summary: Plants respond to stresses by expressing sHSPs, which play significant roles in inhibiting protein aggregation, protecting cell integrity, and improving resistance. This review systematically summarizes the classification, structure, and functions of sHSPs in plants, with a focus on their roles in promoting fruit ripening and plant growth, protecting photosynthesis, and improving antioxidant activity. The production and regulatory mechanisms of sHSPs are also discussed, along with recent efforts to constitutively express sHSPs in transgenic plants to enhance stress resistance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
Deyang Yao, Yukun Li, Sheng Zeng, Zhifan Li, Zahir Shah, Bigui Song, Jinglei Liu, Yi Wu, Liang Yang, Qi Long, Wenqian Wang, Zhijuan Hu, Haite Tang, Xingguo Liu
Summary: Our study showed that S-OPA1 acts as a molecular chaperone in the intermembrane space (IMS) of mitochondria, protecting substrate proteins from aggregation and enhancing thermotolerance in E. coli. S-OPA1 also confers thermotolerance on IMS proteins such as neurolysin, suggesting its chaperone activity is crucial for maintaining IMS homeostasis within mitochondria.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Zhanwu Yang, Hui Du, Xinzhu Xing, Wenlong Li, Youbin Kong, Xihuan Li, Caiying Zhang
Summary: This study identified an important sHSP protein GmHSP17.9 in soybean nodules, revealing its significant role in nodule development and nitrogen fixation. GmHSP17.9 interacts with GmNOD100, influencing the function of soybean nodules.
PLANT BIOTECHNOLOGY JOURNAL
(2022)
Review
Cell Biology
Ying Liu, Lin Zhou, Yunfei Xu, Kexin Li, Yao Zhao, Haoduo Qiao, Qing Xu, Jie Zhao
Summary: This study systematically summarizes the roles of heat shock proteins in the occurrence of ferroptosis and predicts the possible mechanisms of different families of heat shock proteins in the development of ferroptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Xiaojing Sui, Dezerae Cox, Shuai Nie, Gavin E. Reid, Danny M. Hatters
Summary: During the recovery from heat shock, eukaryotic cells rapidly down-regulate prefoldins and translation machinery, while mobilizing protein quality control mechanisms, changing cellular energy metabolism, translational activity, and actin cytoskeleton. Long-term adaptation to stress involves the renewal of core cellular components.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sadia Sultana, Greg M. Anderson, Kevin Pierre Hoffmann, Jan-Ulrik Dahl
Summary: Exposure to environmental and cellular stresses can disrupt protein homeostasis, leading to protein aggregation in bacterial cells. This study presents an optimized method for extracting and visualizing aggregated and soluble proteins from different Escherichia coli strains.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Review
Microbiology
Seongjoon Moon, Soojeong Ham, Juwon Jeong, Heechan Ku, Hyunhee Kim, Changhan Lee
Summary: Temperature is critical for the survival of all living organisms. Bacteria, being unicellular organisms, have evolved sensitive mechanisms to sense and defend against temperature changes. This review focuses on the molecular perspective of cellular changes and bacterial responses, particularly in Escherichia coli, when subjected to temperature shifts.
JOURNAL OF MICROBIOLOGY
(2023)
Article
Microbiology
Emily S. Mathews, Andrew J. Jezewski, Audrey R. Odom John
Summary: During the malaria parasite's life cycle, farnesylation plays a crucial role in its survival through temperature changes. Loss of farnesylation of HSP40 affects its membrane attachment and interaction with essential proteins, impacting the parasite's ability to survive.
Article
Biochemistry & Molecular Biology
Xinmiao Fu, Anastasia N. Ezemaduka, Xinping Lu, Zengyi Chang
Summary: The study demonstrates that despite lacking chaperone activity, the Hsp12s from Caenorhabditis elegans play crucial physiological roles in suppressing dauer formation and promoting longevity and reproduction. Additionally, the identification of a unique sHSP gene from the Filarial nematode worm Brugia malayi provides insights into the evolutionary scenario for the Hsp12s subfamily.
Review
Biochemistry & Molecular Biology
Kalliopi Ziaka, Jacqueline van der Spuy
Summary: This review explores the role of Hsp90 in the proteostatic mechanisms of photoreceptors and elaborates on its function when retinal homeostasis is disturbed. It also discusses the impact of Hsp90 on retinal diseases through its interaction with specific client proteins.
Article
Biochemistry & Molecular Biology
Liang Liu, Jiyun Chen, Bo Yang, Yonghua Wang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Liang Liu, Jiyun Chen, Bo Yang, Yonghua Wang
Article
Multidisciplinary Sciences
Ji-Yun Chen, Liang Liu, Chun-Ling Cao, Mei-Jun Li, Kemin Tan, Xiaohan Yang, Cai-Hong Yun
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Liang Liu, Peng Chen, Min Wang, Xueyan Li, Jiuyu Wang, Maolu Yin, Yanli Wang
Article
Oncology
Xiao Zhao, Liang Liu, Jiayan Liang, Keman Cheng, Yongwei Wang, Xueyan Li, Jian Shi, Yanli Wang, Guangjun Nie
Article
Biochemistry & Molecular Biology
Lilan You, Jun Ma, Jiuyu Wang, Daria Artamonova, Min Wang, Liang Liu, Hua Xiang, Konstantin Severinov, Xinzheng Zhang, Yanli Wang
Article
Biochemistry & Molecular Biology
Liang Liu, Maolu Yin, Min Wang, Yanli Wang
Article
Biochemistry & Molecular Biology
Wei Sun, Jing Yang, Zhi Cheng, Nadia Amrani, Chao Liu, Kangkang Wang, Raed Ibraheim, Alireza Edraki, Xue Huang, Min Wang, Jiuyu Wang, Liang Liu, Gang Sheng, Yanhua Yang, Jizhong Lou, Erik J. Sontheimer, Yanli Wang
Article
Multidisciplinary Sciences
Jiyun Chen, Rong Hu, Ying Chen, Xiaofeng Lin, Wenwen Xiang, Hong Chen, Canglin Yao, Liang Liu
Summary: This study utilizes the crystal structures of ciliate methyltransferase complexes to reveal the molecular basis and mechanism of 6 mA methylation. The results demonstrate that MTA1 is the catalytically active subunit, p1 and p2 are involved in the formation of the substrate DNA-binding channel, and MTA9 plays a role in stabilizing substrate binding.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Liang Liu, Xueyan Li, Jun Ma, Zongqiang Li, Lilan You, Jiuyu Wang, Min Wang, Xinzheng Zhang, Yanli Wang
Article
Biochemistry & Molecular Biology
Liang Liu, Xueyan Li, Jiuyu Wang, Min Wang, Peng Chen, Maolu Yin, Jiazhi Li, Gang Sheng, Yanli Wang