4.6 Article

Transition-metal-free cross-dehydrogenative alkylation of pyridines under neutral conditions

Journal

NEW JOURNAL OF CHEMISTRY
Volume 37, Issue 6, Pages 1704-1706

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nj00095h

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Funding

  1. National Basic Research Program of China (973 Program) [2009CB825300]
  2. National NSF of China [20925207, 21002001]

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A mild and efficient method has been developed for the direct dehydrogenative alkylation of unprotonated pyridine derivatives. The avoidance of using acids and transition-metals makes this protocol greener and more practical for the synthesis of substituted pyridines.

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