Journal
NEW JOURNAL OF CHEMISTRY
Volume 37, Issue 9, Pages 2654-2662Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nj00317e
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Funding
- Department of Science and Technology (DST), New Delhi, India [SR/SO/HS-125/2010]
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A series of hybrid 4-aminoquinoline 1,3,5-triazine derivatives was synthesized and their chemical structure were confirmed by H-1-NMR, C-13-NMR, FT-IR and mass spectrometric analyses. In vitro antimalarial activity of these compounds was evaluated against chloroquine-sensitive (3D-7) and chloroquine resistant (RKL-2) strains of P. falciparum. Results showed that all compounds had considerable antimalarial activity against both the strains and further docking studies were performed on both wild type (1J3I.pdb) and quadruple mutant (N51I, C59R, S108 N, I164L, 3QG2.pdb) pf-DHFR-TS to quantify the structural parameter necessary for the activity.
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