Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 370, Issue 19, Pages 1861-1862Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMc1402692
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To the Editor: Wunderink and Waterer (Feb. 6 issue)(1) summarize antimicrobial agents, including fluoroquinolones, that are safe and effective for the treatment of community-acquired pneumonia. However, the appropriateness of antimicrobial therapy also depends on the spectrum of activity. In this context, the routine use of fluoroquinolones to treat community-acquired pneumonia is inappropriate. Fluoroquinolones are the only oral antibiotics with reliable activity against gram-negative bacilli, yet increasing resistance is rapidly eliminating them as the last oral treatment option for common community-associated infections (e.g., kidney, abdominal, and prostate infections) and health care-associated gram-negative infections (including pneumonia). The routine use of these active ...
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