Proprotein Convertases in Health and Disease

A Small-Molecule Furin Inhibitor Inhibits Cancer Cell Motility and Invasiveness

(2015) Julia M. Coppola et al.   NEOPLASIA

Proprotein Convertase Inhibition Results in Decreased Ski Proliferation, Tumorigenesis, and Metastasis

(2015) Daniel E. Bassi et al.   NEOPLASIA

What lies ahead for the proprotein convertases?

(2011) Nabil G. Seidah   Annals of the New York Academy of Sciences

Modulation of PC1/3 Activity by Self-Interaction and Substrate Binding

(2011) Akina Hoshino et al.   ENDOCRINOLOGY

Blockade of Furin Activity and Furin-Induced Tumor Cells Malignant Phenotypes By The Chemically Synthesized Human Furin Prodomain

(2010) A. Basak et al.   CURRENT MEDICINAL CHEMISTRY

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity

(2010) Albert G. Remacle et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inter-α Inhibitor Proteins

(2010) Steven M. Opal et al.   SHOCK

The role of furin in papillomavirus infection

(2009) Patricia M Day et al.   Future Microbiology

Serine proteases

(2009) Enrico Di Cera   IUBMB LIFE

Inhibition of Furin/Proprotein Convertase-catalyzed Surface and Intracellular Processing by Small Molecules

(2009) Tomoko Komiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model

(2009) Xiaowei Sun et al.   Molecular Cancer

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

(2009) J. C. Y. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Source of High Pathogenicity of an Avian Influenza Virus H5N1: Why H5 Is Better Cleaved by Furin

(2008) Panita Decha et al.   BIOPHYSICAL JOURNAL

Serine peptidases: Classification, structure and function

(2008) M. J. Page et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Knock-out mouse models of proprotein convertases: unique functions or redundancy?

(2008) John et al.   Frontiers in Bioscience-Landmark

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

(2008) D. Szumska et al.   GENES & DEVELOPMENT

The activation and physiological functions of the proprotein convertases

(2008) N SEIDAH et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels

(2008) Gaétan Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells

(2008) Nathalie Scamuffa et al.   JOURNAL OF CLINICAL INVESTIGATION

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

(2008) Marko Pesu et al.   NATURE