News Item
Biochemistry & Molecular Biology
Paul Webster
Summary: Cancer immunotherapy has generated significant excitement, but the potential lies in antibody-drug conjugates, proteolysis-targeting chimeras, and liquid biopsy for early detection.
Article
Cardiac & Cardiovascular Systems
Yngvar Nilssen, Steinar Solberg, Odd Terje Brustugun, Bjorn Moller, Arve Sundset, Sissel Gyrid Freim Wahl, Aslaug Helland
Summary: The aim of this study was to provide updated national data on the incidence, characteristics, treatment and outcome for patients with tracheal cancer. The findings showed that the incidence of tracheal cancer is low and the prognosis is still poor despite improved survival. Increasing awareness and early diagnosis of tracheal cancer are crucial.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
News Item
Biochemistry & Molecular Biology
Sofia Moutinho
Summary: Risk-based screening approaches can decrease excessive detection, while self-testing and new diagnostics can detect diseases at an early stage.
Article
Medicine, General & Internal
Rachel White, Fintan Stanley, Jen Than, Archie Macnair, Joanna Pethick, Gregory Fallica, Luke Hounsome, Jane Maher
Summary: This study estimated the prevalence of cancers categorized as treatable but not curable in England and provided a framework for identifying this group to design tailored support services. It identified a large population living with TbnC cancer that requires personalized treatment and support.
Article
Clinical Neurology
Dale J. Langford, Raissa Lou, Soun Sheen, Dagmar Amtmann, Luana Colloca, Robert R. Edwards, John T. Farrar, Nathaniel P. Katz, Michael P. McDermott, Bryce B. Reeve, Ajay D. Wasan, Dennis C. Turk, Robert H. Dworkin, Jennifer S. Gewandter
Summary: Variability in pain outcomes can hinder the sensitivity of chronic pain clinical trials. Participants' expectations may contribute to this variability and impede the development of new pain treatments. Measurement and management of expectations in clinical trials need to be optimized and standardized. This article provides an overview of research findings on the relationship between baseline expectations and pain outcomes, emphasizing the potential benefit of adjusting for participants' expectations in trial analyses.
Review
Radiology, Nuclear Medicine & Medical Imaging
Francesco Alessandrino, Daniel A. Smith, Angela Spierling, Elias Kikano, Bhanusupriya Somarouthu, Sree Harsha Tirumani, Nikhil H. Ramaiya
Summary: Understanding the structure and clinical relevance of modern clinical trials is beneficial for radiologists in the field of oncologic imaging.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Bob T. Li, Bobby Daly, Mary Gospodarowicz, Monica M. Bertagnolli, Otis W. Brawley, Bruce A. Chabner, Lola Fashoyin-Aje, R. Angelo de Claro, Elizabeth Franklin, Jennifer Mills, Jeff Legos, Karen Kaucic, Mark Li, Lydia The, Tina Hou, Ting-Hui Wu, Bjorn Albrecht, Yi Shao, Justin Finnegan, Jing Qian, Javad Shahidi, Eduard Gasal, Craig Tendler, Geoffrey Kim, James Yan, Phuong Khanh Morrow, Charles S. Fuchs, Lianshan Zhang, Robert LaCaze, Stefan Oelrich, Martin J. Murphy, Richard Pazdur, Kevin Rudd, Yi-Long Wu
Summary: The Bloomberg New Economy International Cancer Coalition is an organization that brings together academia, industry, government, patient advocacy, and policy think tanks to leverage technology and collaboration. Their goal is to improve patient access to clinical trials and harmonize regulations, aiming to accelerate cancer cures and prevention worldwide in the post-pandemic era.
Review
Pharmacology & Pharmacy
Pedro Novais, Patricia M. A. Silva, Isabel Amorim, Hassan Bousbaa
Summary: Mitosis is a promising target for inhibiting cancer cell proliferation, with traditional antimitotics facing limitations such as resistance and toxicity. Second-generation antimitotics, targeting mitotic and SAC components, have attracted interest for overcoming these limitations. While many inhibitors have entered clinical trials, their efficacy as monotherapy is limited, leading to emerging interest in combination therapies.
Article
Medicine, General & Internal
Katarzyna Szlezinger, Katarzyna Pogoda, Agnieszka Jagiello-Gruszfeld, Danuta Klosowska, Andrzej Gorski, Jan Borysowski
Summary: This study assessed the eligibility criteria in recent clinical trials for breast cancer. It found that many of these trials exclude large groups of patients, especially older adults, individuals with comorbidities, and those with poor performance status. Therefore, careful modification of these criteria is needed to evaluate the benefits and harms of investigational treatments in patients with characteristics commonly encountered in clinical practice.
Editorial Material
Biochemistry & Molecular Biology
Thomas U. Marron, Matthew D. Galsky, Bachir Taouli, Maria Isabel Fiel, Stephen Ward, Edward Kim, David Yankelevitz, Deborah Doroshow, Emma Guttman, Benjamin Ungar, Saurabh Mehandru, Benjamin J. Golas, Daniel Labow, John Sfakianos, Sujit S. Nair, Dimple Chakravarty, Michael Buckstein, Xiaoyu Song, Effi Kenigsberg, Sacha Gnjatic, Brian D. Brown, Joseph Sparano, Ashutosh Tewari, Myron Schwartz, Nina Bhardwaj, Miriam Merad
Summary: Window-of-opportunity trials offer a platform to understand the mechanisms of short-duration pre-surgical therapies, but there is a need for a paradigm shift in trial design, specimen collection, and analysis.
Review
Gastroenterology & Hepatology
Sumita Verma, Jay Hingwala, Joseph T. S. Low, Arpan A. Patel, Manisha Verma, Stephen Bremner, Yazan Haddadin, Myrick C. Shinall, Paul Komenda, Nneka N. Ufere
Summary: This article reviews past and ongoing palliative interventional trials in advanced chronic liver disease, identifies barriers and facilitators, and offers guidance on addressing these challenges, aiming to reduce inequities in palliative care provision for patients.
JOURNAL OF HEPATOLOGY
(2023)
Review
Oncology
M. Cisneros-Villanueva, L. Hidalgo-Perez, M. Rios-Romero, A. Cedro-Tanda, C. A. Ruiz-Villavicencio, K. Page, R. Hastings, D. Fernandez-Garcia, R. Allsopp, M. A. Fonseca-Montano, S. Jimenez-Morales, V Padilla-Palma, J. A. Shaw, A. Hidalgo-Miranda
Summary: Cell-free DNA analysis is a promising method for the diagnosis and treatment selection of cancer patients. Despite the need for standardization and technical validation, numerous clinical trials have shown its potential in early cancer detection and treatment improvement.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Charlotte Ouimet, Gauthier Bouche, Jonathan Kimmelman
Summary: This study compares the clinical impact of research efforts on cancer drugs before and after approval, and finds that secondary approvals are less likely to result from post-approval research efforts and tend to have a smaller impact compared to those originating from pre-approval research.
Review
Biochemistry & Molecular Biology
Chiara Benvenuti, Mariangela Gaudio, Flavia Jacobs, Giuseppe Saltalamacchia, Rita De Sanctis, Rosalba Torrisi, Armando Santoro, Alberto Zambelli
Summary: Visceral crisis is a life-threatening condition in advanced breast cancer, but its clinical definition is unclear, making it challenging to manage. Chemotherapy is recommended as first-line treatment, but its effectiveness is limited and the prognosis is poor. The available evidence is mainly from retrospective studies, and the role of chemotherapy is questioned with the introduction of innovative drugs. This article aims to critically discuss the management of visceral crisis and explore future treatment perspectives.
Article
Medicine, General & Internal
Connie M. Ulrich, Kathleen Knafl, Anessa M. Foxwell, Qiuping Zhou, Cynthia Paidipati, Deborah Tiller, Sarah J. Ratcliffe, Gwenyth R. Wallen, Therese S. Richmond, Mary Naylor, Thomas F. Gordon, Christine Grady, Victoria Miller
Summary: Patient-participants who withdrew from cancer clinical trials described intense symptoms and emotions, as well as a sense of limited options and short life span awareness. Communication focusing on posttrial needs is crucial throughout the trial to help patients navigate posttrial steps effectively. Research should target responsible and ethical transitions post clinical trial, including timing and types of discussions and who should initiate these discussions with patients and their families.