Review
Medicine, General & Internal
Marcello Cottini, Carlo Lombardi, Giovanni Passalacqua, Diego Bagnasco, Alvise Berti, Pasquale Comberiati, Gianluca Imeri, Massimo Landi, Enrico Heffler
Summary: Asthma is a worldwide chronic disease in which small airways dysfunction (SAD) plays a significant role. SAD is associated with the severity, control, and exacerbation frequency of asthma, yet it is not adequately addressed in the Global Initiative for Asthma guidelines.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ameer Kakaje, Mohammad Marwan Alhalabi, Ayham Alyousbashi, Ayham Ghareeb
Summary: Allergic rhinitis (AR) and Laryngopharyngeal reflux (LPR) are common medical conditions that can overlap, especially in individuals with asthma. The presence of asthma is associated with higher likelihoods of developing AR and LPR, which can significantly impact quality of life. More research is needed to better understand the relationships between these conditions.
SCIENTIFIC REPORTS
(2021)
Review
Allergy
Narmeen Mallah, Julia May Turner, Francisco-Javier Gonzalez-Barcala, Bahi Takkouche
Summary: This systematic review and meta-analysis found a weak association between gastroesophageal reflux disease (GORD) and asthma exacerbation. Subgroup analyses revealed that GORD is associated with frequent asthma exacerbations and exacerbations needing oral corticosteroid therapy.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Respiratory System
Christos Chalitsios, Dominick E. Shaw, Tricia M. McKeever
Summary: Exposure to oral or inhaled corticosteroids is associated with bone health issues in asthma patients, with a dose-response relationship. It is recommended to administer steroids at the lowest possible level to maintain asthma control.
Article
Medicine, General & Internal
Gaia Pellegatta, Benedetto Mangiavillano, Rossella Semeraro, Francesco Auriemma, Elisa Carlani, Alessandro Fugazza, Edoardo Vespa, Alessandro Repici
Summary: Extraesophageal reflux symptoms are common in the Western population and their clinical management is controversial. This study evaluated a new treatment method for patients with GERD experiencing extraesophageal symptoms. The results showed that the treatment method reduced symptom frequency and severity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Allergy
Meghan D. Althoff, Alexander Ghincea, Lisa G. Wood, Fernando Holguin, Sunita Sharma
Summary: Asthma is a complex disease with heterogeneous phenotypes and endotypes. Common comorbidities such as obesity, obstructive sleep apnea, and gastroesophageal reflux disease may share inflammatory pathways and worsen asthma control.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Bronwyn K. Brew, Catarina Almqvist, Cecilia Lundholm, Anna Andreasson, Kelli Lehto, Nicholas J. Talley, Tong Gong
Summary: GERD is a common comorbidity in adults with asthma, hay fever, and/or eczema. There is evidence for shared mechanisms suggesting common underlying causes that may involve affective traits requiring further investigation.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Surgery
Karla Bernardi, Lauren Hawley, Vivian L. Wang, Anahita D. Jalilvand, Kelly R. Haisley, Kyle A. Perry
Summary: This retrospective cohort study evaluated 353 patients who underwent laparoscopic fundoplication (LF) for GERD between 2011 and 2017. The results showed that 16% of patients developed GERD-like symptoms after the surgery, and only 9% of these patients had recurrent pathologic acid reflux.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
Daniela Jodorkovsky, David A. Katzka, C. Prakash Gyawali
Summary: This review examines the clinical relevance and prognostic value of nonacid reflux (NAR) in esophageal reflux monitoring. The study finds that while NAR is associated with gastroesophageal reflux disease (GERD), its ability to explain symptom pathogenesis, meaningful manifestations of GERD, and predict treatment efficacy is limited.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Medicine, General & Internal
Han-Chung Lien, Ping-Huan Lee, Chen-Chi Wang
Summary: Laryngopharyngeal reflux (LPR) is a variant of gastroesophageal reflux disease (GERD) that causes airway symptoms or complications. LPR is prevalent and has negative effects on quality of life, medical expenses, and cancer risk. Diagnosis of LPR is challenging due to non-specific symptoms, and current diagnostic testing focuses on physiological measures. The validation of relevant pharyngeal acid reflux episodes for anti-reflux treatment is crucial.
Article
Allergy
Brandy M. Byrwa-Hill, Tricia L. Morphew, Albert A. Presto, James P. Fabisiak, Sally E. Wenzel
Summary: Living in an environmentally just tract increases the likelihood of severe and uncontrolled asthma, which is influenced by age at onset, disease duration, and traffic-related air pollution.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Daniel Sifrim, Sabine Roman, Edoardo Savarino, Serhat Bor, Albert J. Bredenoord, Donald Castell, Michele Cicala, Nicola de Bortoli, Marzio Frazzoni, Sutep Gonlachanvit, Katsuhiko Iwakiri, Osamu Kawamura, Anne Krarup, Yeong Yeh Lee, Chai Soon Ngiu, Eugene Ndebia, Tanisa Patcharatraku, Ans Pauwels, Julio Perez de la Serna, Rosa Ramos, Jose Maria Remes-Troche, Mentore Ribolsi, Alastair Sammon, Magnus Simren, Jan Tack, Radu Tutuian, Miguel Valdovinos, Yinglian Xiao, Frank Zerbib, C. Prakash Gyawali
Summary: The study aimed to establish new impedance-pH thresholds through expert consensus analysis and found significant differences in normal thresholds between different systems and regions. It highlights the importance of using appropriate normal thresholds for the system and world region used in clinical interpretation.
Article
Respiratory System
Ruben Andujar-Espinosa, Lourdes Salinero-Gonzalez, Fatima Illan-Gomez, Manuel Castilla-Martinez, Chunshao Hu-Yang, Francisco Jose Ruiz-Lopez
Summary: The study aimed to assess the efficacy of vitamin D supplementation in improving asthma control in adult patients with asthma and vitamin D deficiency. The intervention group receiving calcifediol showed significant clinical improvement in asthma control and quality of life compared to the control group receiving a placebo. Further research is needed to evaluate long-term efficacy and safety.
Article
Medicine, General & Internal
Rosana Camara Agondi, Natalia Menechino, Ana Karolina Barreto Berselli Marinho, Jorge Kalil, Pedro Giavina-Bianchi
Summary: This study evaluated the evolution of asthma in patients with and without COVID-19. The results showed that patients with COVID-19 had a significant worsening of asthma compared to those without the disease, requiring an increase in maintenance therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Shahid I. Sheikh, Nancy A. Ryan-Wenger, Judy Pitts, Rodney Britt, Grace Paul, Lisa Ulrich
Summary: This study compared asthma control over one year among AA and CA children managed per NAEPP guidelines, finding similar improvement in asthma control between the two groups over time, with a significant decrease in ED visits for AA children.
WORLD JOURNAL OF PEDIATRICS
(2021)
