Review
Endocrinology & Metabolism
Chermaine Hung, Amal Shibli-Rahhal
Summary: Fibrous dysplasia (FD) is a bone disorder caused by a genetic mutation, resulting in bone pain and fracture risk. Bisphosphonates have been traditionally used, but with mixed results. This study reports the use of denosumab in FD patients and summarizes the existing literature.
ENDOCRINE PRACTICE
(2022)
Article
Chemistry, Medicinal
Sarang Jang, Hyo Geun Choi, Mi Jung Kwon, Ji Hee Kim, Joo-Hee Kim, So Young Kim
Summary: This study evaluated the association between long-term statin use and diagnosis and mortality of esophageal cancer in a Korean population. The results showed no significant relationship between the duration of statin use and the occurrence or mortality of esophageal cancer in the overall study population.
Article
Otorhinolaryngology
Yi-Hsun Chen, Chi-Mei Ho, Meng-Shieh Wu, Wen-Hung Hsu, Winnie Yen-Yun Wang, Shyng-Shiou F. Yuan, Hui-Min Hsieh, I-Chen Wu
Summary: This study aimed to compare the 5-year mortality between endoscopically screened and non-screened patients with oral cavity cancer and second primary esophageal cancer. The results showed that endoscopic screening significantly improved early detection of second primary esophageal cancer and reduced all-cause mortality.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Oncology
Sonja B. Vliek, Iris Noordhoek, Elma Meershoek-Klein Kranenbarg, Annelot G. J. van Rossum, Vincent O. Dezentje, Agnes Jager, J. W. Esmeralda Hokken, Hein Putter, Annette W. G. van der Velden, Mathijs P. Hendriks, Sandra D. Bakker, Yvonne E. A. van Riet, Vivianne C. G. Tjan-Heijnen, Johanneke E. A. Portielje, Judith R. Kroep, Johan W. R. Nortier, Cornelis J. H. van de Velde, Sabine C. Linn
Summary: This study investigated the efficacy of ibandronate in postmenopausal women with ER+ breast cancer and found that daily oral ibandronate 50 mg for 5 years did not improve disease-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Liping Yang, Jing Gao, Yan Zhou, Zhenchao Tao, Jian He, Jing Yang, Ru Wang, Yangyang Zhang, Yifan Huang, Lingran Zhou, Bin Sun
Summary: Oral nutritional supplements can reduce weight loss and improve the nutritional status of patients with esophageal cancer during radiotherapy. Additionally, they can also reduce adverse reactions such as radiation esophagitis, myelosuppression, nausea, and vomiting.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Cardiac & Cardiovascular Systems
Erin M. Corsini, Wayne L. Hofstetter
Summary: Recent evidence suggests a possible association between postoperative ketorolac use and anastomotic leak after esophagectomy, but further research is needed to determine the extent of this relationship.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Hyung-Youl Park, Ki-Won Kim, Ji-Hyun Ryu, Geon-U Kim, Ho-Young Jung, Youn-Sung Jung, Jun-Seok Lee
Summary: The aim of this study was to investigate the effect of lumbar spinal stenosis (LSS) on bone mineral density (BMD) in patients treated with oral bisphosphonates for osteoporosis. The study found that LSS had a negative impact on BMD increase. Ibandronate and alendronate were more effective in treating osteoporosis compared to risedronate, especially in patients with both osteoporosis and LSS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Haley M. Zylberberg, Sheila D. Rustgi, Anthony Yang, Anne Aronson, Elizabeth Kessel, Sunil Amin, Aimee L. Lucas
Summary: The study found that the use of bisphosphonates, either alone or in combination with statins, did not result in a survival advantage for patients with pancreatic cancer.
Article
Oncology
Pilar Lopez-Nieva, Laura Gonzalez-Sanchez, Maria angeles Cobos-Fernandez, Raul Cordoba, Javier Santos, Jose Fernandez-Piqueras
Summary: The NOTCH1 gene encodes a transmembrane receptor protein with activating mutations observed in various leukemias and lymphomas, leading to interest in targeting NOTCH1 signaling for cancer therapy. Multiple classes of Notch inhibitors have been developed, but current treatments with gamma-secretase inhibitors (GSIs) have faced challenges due to side effects. Further research is needed to identify alternative targets and improve the efficacy of anti-NOTCH1 therapies.
Article
Oncology
Machiko Kawasaki, Yuichi Ikeda, Eri Ikeda, Momoko Takahashi, Daiki Tanaka, Yasuaki Nakajima, Shinichi Arakawa, Yuichi Izumi, Satoshi Miyake
Summary: This study found that high levels of periodontopathic bacteria and Streptococcus anginosus were detected in cancer tissue from patients with esophageal cancer. The prevalence and abundance of certain oral bacteria were significantly higher in the cancer group compared to the control group, suggesting a potential association between oral microbiota and esophageal cancer, with implications for early diagnosis.
Article
Nutrition & Dietetics
Xuemei Li, Tingting Dai, Zhiyong Rao, Wen Hu
Summary: This study compared the outcomes between patients with esophageal cancer who received oral nutrition supplementation (ONS) and a control group. The results showed that ONS was associated with a lower incidence of myelosuppression, especially in patients with a lower BMI. However, ONS was also found to increase hospitalization time and cost.
FRONTIERS IN NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Kristen E. Rhodin, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Norma E. Farrow, David H. Harpole, Betty C. Tong, Thomas A. D'Amico
Summary: This study examined the patterns of use of induction therapy for patients with cT2N0M0 esophageal cancer, revealing differences in patient characteristics between those receiving induction therapy and upfront surgery, without any survival benefit associated with induction therapy.
ANNALS OF THORACIC SURGERY
(2021)
Article
Pharmacology & Pharmacy
Ian R. Reid, Jingyuan Wen, Anna Mellar, Mengyang Liu, Amani Jabr, Anne M. Horne
Summary: The aim of this study was to assess the safety and efficacy of two oral zoledronate preparations in postmenopausal women. The results showed that oral zoledronate had a smaller and less sustained anti-resorptive effect compared to intravenous zoledronate. However, oral zoledronate could be a viable option with dosing intervals of weeks to months.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Surgery
Fabrizio Rebecchi, Elettra Ugliono, Marco Ettore Allaix, Mario Morino
Summary: Esophagectomy is the preferred treatment for resectable esophageal cancer. Robot-assisted Minimally Invasive Esophagectomy (RAMIE) has shown to have better postoperative outcomes compared to traditional methods.
UPDATES IN SURGERY
(2023)
Article
Endocrinology & Metabolism
Nobuhiro Ueda, Kumiko Aoki, Hiroko Shimotsuji, Chie Nakashima, Mao Kawakami, Yuichiro Imai, Tadaaki Kirita
Summary: Our study found that patients with alveolar bone loss involving more than half the root on panoramic radiographs and torus mandibularis are at high risk for developing MRONJ. Early dental intervention before BMA administration and oral management during treatment are important for preventing MRONJ.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
