Review
Cell Biology
Ezekiel Mecha, Roselydiah Makunja, Jane B. Maoga, Agnes N. Mwaura, Muhammad A. Riaz, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: Thoracic endometriosis (TE) is a rare form of endometriosis where endometrial tissue is found in or around the lungs, often presenting as catamenial pneumothorax (CP). Immunohistochemical evaluation is considered crucial for diagnosing and classifying the disease effectively.
Editorial Material
Obstetrics & Gynecology
Liron Bar-El, Amanda Chu, Karli Goldstein, Serin Seckin, Tamer Seckin
Summary: This article presents a case of endometriosis within an isthmocele membrane and diffuse peritoneal endometriosis after cesarean sections. A unique surgical repair technique is described, and a possible correlation between isthmocele formation and endometriosis is proposed.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Ming-Yao Qiu, Ya-Ping Wang, Ran Ren, Yan-Ru Sun, Shu-Qin Xiao, Lu Han
Summary: This study aims to investigate the clinical and histopathological features of peritoneal endometriosis (PEM) and deep infiltrating endometriosis (DIE). The main distribution of PEM and DIE was located in the posterior pelvic cavity, and different morphological lesions had different invasiveness rates and depths of invasion to the peritoneum. The Ki-67 expression of DIE in endometrioid glandular epithelium was significantly higher than that in other PEM lesions.
ANNALS OF MEDICINE
(2023)
Article
Medical Laboratory Technology
Anuja Pant, Kareena Moar, Taruna K. Arora, Pawan Kumar Maurya
Summary: Endometriosis is a severe reproductive disorder affecting a significant percentage of women. The current diagnostic approaches are invasive, leading to delayed treatment. Finding sensitive and specific biomarkers for early diagnosis is a research priority. Non-invasive detection of biomarkers may provide early diagnosis, and future advancements in science and technology may result in a potent remedy for endometriosis.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Qihui Guan, Renata Voltolini Velho, Jalid Sehouli, Sylvia Mechsner
Summary: Endometriosis is a common gynecological disease that causes chronic pelvic pain and infertility in the majority of patients. The exact pathogenic mechanisms are still unclear, and there is currently no curative therapy available. Optimal pain management for endometriosis includes non-steroidal anti-inflammatory drugs, metamizole, and opioids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O'Malley, Sang Jun Han
Summary: In this study, researchers identified a natural product called oleuropein that selectively inhibits ER beta activity without affecting ER alpha activity, thus suppressing the progression of endometriosis and improving fertility in patients.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Cell Biology
Yangshuo Li, Yalun He, Wen Cheng, Zhihao Zhou, Zhexin Ni, Chaoqin Yu
Summary: Endometriosis is strongly associated with infertility, and the mechanisms by which it affects fertility have not been fully elucidated. Iron overload may be one of the mechanisms that lead to endometriosis-related infertility, causing damage to ovarian granulosa cells, oocytes, and embryos. This article summarizes the possible mechanisms of iron overload and explores its impact on endometriosis-related infertility.
CELL DEATH DISCOVERY
(2023)
Article
Obstetrics & Gynecology
Paul Pirtea, Nicolas Vulliemoz, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Endometriosis was traditionally diagnosed through laparoscopic surgery, but modern imaging techniques have provided a reliable alternative. In cases of infertility, endometriosis can be diagnosed or excluded based on past medical history and physical examination.
FERTILITY AND STERILITY
(2022)
Review
Biochemistry & Molecular Biology
Philippa T. K. Saunders, Andrew W. Horne
Summary: Endometriosis is a common condition associated with infertility that causes chronic pain in women. The exact cause and natural history are still uncertain, but hormonal, neurological, and immunological factors are believed to play a role in the development of symptoms. Current interventions have limited efficacy with high rates of symptom recurrence.
Review
Biochemistry & Molecular Biology
Marie-Madeleine Dolmans, Jacques Donnez
Summary: Endometriosis is a chronic inflammatory disease that requires lifelong management. This review evaluates the pathways involved in endometriosis and explores new therapies. Inflammation and inflammatory molecules play a crucial role in the disease, and targeting inflammation, nuclear factor kappa B and cytokines, as well as pathways related to apoptosis and autophagy, may offer new perspectives for non-hormonal treatment.
Review
Biochemistry & Molecular Biology
Soo Youn Song, Ye Won Jung, WonKyo Shin, Mia Park, Geon Woo Lee, Soohwa Jeong, Sukjeong An, Kyoungmin Kim, Young Bok Ko, Ki Hwan Lee, Byung Hun Kang, Mina Lee, Heon Jong Yoo
Summary: Endometriosis, a common gynecologic disease, often leads to various pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. Inflammatory responses, nervous system sensitization, and altered distribution of nerve fibers may contribute to chronic pain in these patients. Understanding these mechanisms is crucial in guiding treatment decisions for endometriosis-related pain symptoms.
Review
Pharmacology & Pharmacy
Grace J. Lee, Frank Porreca, Edita Navratilova
Summary: Women are more susceptible to chronic pain, with specific pain conditions being more prevalent among women. Prolactin, a neuropeptide hormone with higher levels in women, has been found to sensitize nociceptive sensory neurons in a sexually dimorphic manner. Dysregulation of prolactin and prolactin receptors may be responsible for increased pain in female predominant conditions such as migraine, fibromyalgia, and pelvic pain. In this review, the role of prolactin in endometriosis, a condition characterized by pelvic pain and infertility, is discussed, along with different sources of prolactin secretion and their contribution to the disease. Clinical studies indicate that serum prolactin levels are increased in patients with endometriosis, suggesting a possible association between high levels of prolactin and pelvic pain in these patients.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Genetics & Heredity
Marcos A. S. Fonseca, Marcela Haro, Kelly N. Wright, Xianzhi Lin, Forough Abbasi, Jennifer Sun, Lourdes Hernandez, Natasha L. Orr, Jooyoon Hong, Yunhee Choi-Kuaea, Horacio M. Maluf, Bonnie L. Balzer, Aaron Fishburn, Ryan Hickey, Ilana Cass, Helen S. Goodridge, Mireille Truong, Yemin Wang, Margareta D. Pisarska, Huy Q. Dinh, Amal EL-Naggar, David G. Huntsman, Michael S. Anglesio, Marc T. Goodman, Fabiola Medeiros, Matthew Siedhoff, Kate Lawrenson
Summary: Endometriosis is a common condition in women that causes chronic pain and infertility. The study found differences in cellular and molecular signatures across different tissue types, suggesting a role for cellular restructuring and transcriptional reprogramming in the disease.
Article
Medicine, General & Internal
Paola Ciriaco, Piergiorgio Muriana, Angelo Carretta, Jessica Ottolina, Massimo Candiani, Giampiero Negri
Summary: Menstrual-related catamenial pneumothorax (CP) can be the initial manifestation of thoracic endometriosis syndrome (TES) and pelvic endometriosis (PE). A multidisciplinary approach is crucial for optimal management of this disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
L. Maulitz
Summary: Endometriosis patients often have comorbid mental disorders, potentially requiring psychological treatment. Neuroimaging studies on endometriosis patients show that brain regions related to pain processing as well as emotion, cognition, self-regulation, and reward may constitute the "endometriosis brain." However, it is unclear whether the observed neurobiological changes are caused by chronic pain, mental comorbidities, or endometriosis itself.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
