Article
Critical Care Medicine
Lei Wang, Hanyu Jia, Yiming Shen, Xin Chu, Zhenghua Chen, Yuqin Ren, Yi Zhang
Summary: The significance of calcitoninogen detection was discussed in the context of severe heatstroke among inpatients. The study analyzed the clinical characteristics of heatstroke patients and found that D-dimer, procalcitonin, and platelet count could serve as early sensitivity indicators for severe heatstroke.
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
(2023)
Review
Medicine, General & Internal
William F. Wright, Catharina M. Mulders-Manders, Paul G. Auwaerter, Chantal P. Bleeker-Rovers
Summary: Fever of unknown origin refers to prolonged fever of at least 3 weeks' duration, with a temperature of 38.3 degrees C or higher, that remains unexplained after preliminary investigations. Recent advancements in diagnosis, management, and diagnostic testing have prompted a revision of the definition and approaches to fever of unknown origin. The updated definition includes a lower temperature threshold and revised minimum testing criteria, providing a solid foundation for clinicians and future research.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Microbiology
Laurent Dembele, Jean-Francois Franetich, Valerie Soulard, Nadia Amanzougaghene, Shahin Tajeri, Teun Bousema, Geert-Jan van Gemert, Roger Le Grand, Nathalie Dereuddre-Bosquet, J. Kevin Baird, Dominique Mazier, Georges Snounou
Summary: This study found that chloroquine can potentiate the activity of 8-aminoquinoline compound primaquine against several malarial parasites in normal primary hepatocytes, but not in a hepatocarcinoma cell line.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jyoti Chhibber-Goel, Manickam Yogavel, Amit Sharma
Summary: Malaria, caused by parasitic protists, affects over 3 billion people globally with drug resistance posing a major threat to treatment. Targeting aminoacyl-tRNA synthetases (aaRSs) as antimalarial drug targets shows promising potential in killing malaria parasites selectively. This approach highlights the need for new alternatives in malaria treatment to combat drug resistance.
Article
Immunology
William F. Wright, Paul G. Auwaerter, Elizabeth H. Dibble, Steven P. Rowe, Philip A. Mackowiak
Summary: (18)FDG-PET/CT imaging technology helps localize the cause of FUO by identifying abnormal uptake in hypermetabolic cells. Further investigations based on uptake may lead to a final diagnosis. The technology has the potential to improve diagnostic efficiency and reduce costs.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Morgan Homan, Govind Warrier, Christopher D. Lao, Sarah Yentz, Shawna Kraft, Leslie A. Fecher
Summary: This study describes the treatment-related toxicities of adjuvant dabrafenib and trametinib combination therapy for patients with resected melanoma and finds that the majority of patients experience treatment-limiting toxicities. Therefore, close monitoring of patients is necessary during treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Veterinary Sciences
Melissa A. Mercer, Jennifer L. Davis, Harold C. McKenzie, Kristen M. Messenger, Emily Schaefer, R. McAlister Council-Troche, Stephen R. Werre
Summary: This study aimed to evaluate the pharmacokinetics and efficacy of acetaminophen as an antipyretic in horses. The results showed that acetaminophen significantly reduced rectal temperature in horses and had a similar antipyretic effect as flunixin meglumine. It can be used as an alternative for antipyresis in clinical cases, especially when traditional NSAIDs are contraindicated.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Oncology
Alia Thawer, Wilson H. Miller Jr, Nancy Gregorio, Joel Claveau, Sudha Rajagopal, Kerry J. Savage, Xinni Song, Teresa M. Petrella
Summary: The combination treatment of dabrafenib and trametinib for BRAF-mutated melanoma can lead to pyrexia syndrome in at least 50% of patients, which if not managed properly, can worsen and cause complications. Despite various therapeutic approaches suggested in the literature, a Canadian working group developed a pyrexia treatment algorithm to provide practical guidance for managing this side effect.
Article
Immunology
Perle Latre de Late, Elizabeth A. J. Cook, David Wragg, E. Jane Poole, Gideon Ndambuki, Antoinette Aluoch Miyunga, Maurine C. Chepkwony, Stephen Mwaura, Nicholas Ndiwa, Giles Prettejohn, Tatjana Sitt, Richard Van Aardt, W. Ivan Morrison, James G. D. Prendergast, Philip Toye
Summary: Descendants of a single Bos indicus bull showed inherited tolerance to T. parva, with a significantly higher survival rate compared to unrelated animals. These tolerant cattle displayed delayed and less severe parasitosis and febrile response after infection. The reduced proliferation of infected lymphocytes and lower expression of pro-inflammatory cytokines in tolerant animals may contribute to their decreased clinical reactions to T. parva.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bilal Aslam, Asif Hussain, Muhammad Usman Bari, Muhammad Naeem Faisal, Zia ud Din Sindhu, Rasha Alonaizan, Rasha K. Al-Akeel, Shabana Naz, Rifat Ullah Khan
Summary: This study evaluated the in vivo effects of meloxicam and curcumin co-encapsulated PLGA nanoparticles in acute models of pyrexia, nociception, and inflammation. The results showed that PLGA encapsulation significantly improved the in vivo activities of both compounds, and co-encapsulation of meloxicam and curcumin enhanced their anti-pyretic, anti-nociceptive, and anti-inflammatory effects in a dose-dependent manner. Therefore, the combination of meloxicam and curcumin in a biodegradable nanocarrier system could provide a promising therapeutic approach for acute conditions.
Review
Immunology
William F. Wright, Gayane Yenokyan, Patricia J. Simner, Karen C. Carroll, Paul G. Auwaerter
Summary: Patients from Southeastern Asia with fever of unknown origin (FUO) are more likely to have an infectious disease etiology compared to other regions. The main factor for this finding seems to be the differences in disease prevalence among various geographical locations or other factors such as access to timely care and diagnosis. Noting epidemiological disease factors in FUO investigations could improve diagnostic yields and clinical outcomes.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Review
Immunology
William F. Wright, Gayane Yenokyan, Paul G. Auwaerter
Summary: This systematic review and meta-analysis reveals that there are variations in noninfectious disease diagnostic outcomes for fever of unknown origin (FUO) based on World Health Organization-defined geographical regions. Evaluating FUO should take into account local variations in disease prevalence. Geographical location influences the diagnoses of noninfectious inflammatory disorders, with the highest prevalence in the Western Pacific region, and cancer, with the highest prevalence in the Eastern Mediterranean region.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Oncology
Ricky Frazer, Avinash Gupta, Christopher Herbert, Miranda Payne, Sergio Diaz-Mendoza, Sally-Anne Vincent, Elena Kovaleva
Summary: Consensus statements on the optimal management of dabrafenib and trametinib-related pyrexia in patients with melanoma were developed through a modified Delphi panel.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Chemistry, Physical
Alexander I. Lebedev
Summary: In this study, the microscopic mechanisms of spontaneous strain and folding in Janus CdSe nanoplatelets are investigated using first-principles calculations. Three mechanisms are identified, including two bulk mechanisms related to the electric field created by the difference in electronegativities of ligands and the depolarizing field resulting from potential jumps in electrical double layers, and a predominant mechanism associated with surface strain of nanoplatelets through bridging bonds.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Immunology
William F. Wright, Patricia J. Simner, Karen C. Carroll, Paul G. Auwaerter
Summary: Despite the continued prevalence of infectious diseases as the main cause of fever of unknown origin, advancements in molecular technologies offer hope in transforming the investigation of this condition by potentially replacing traditional microbial identification methods.
CLINICAL INFECTIOUS DISEASES
(2022)