Article
Environmental Sciences
Chun Pan, Minghao Yan, Haibo Jin, Hongqian Guo, Xiaodong Han
Summary: The study found that microcystins play an important role in human hematological parameters, potentially leading to microcytic anemia, and identified the related signaling pathway for the first time.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Hiroshi Kimura, Kenichi Tanaka, Hirotaka Saito, Tsuyoshi Iwasaki, Sakumi Kazama, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama
Summary: This study reveals that the red blood cell distribution width-albumin ratio (RAR) is associated with adverse renal outcomes in patients with chronic kidney disease (CKD), making it a convenient and useful prognostic marker for assessing renal prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Lidia Romero-Cortadellas, Gonzalo Hernandez, Xenia Ferrer-Cortes, Laura Zalba-Jadraque, Jose Luis Fuster, Mar Bermudez-Cortes, Ana Maria Galera-Minarro, Santiago Perez-Montero, Cristian Tornador, Mayka Sanchez
Summary: DMT1, encoded by SLC11A2 gene, plays a crucial role in iron homeostasis. Mutations in SLC11A2 can lead to AHMIO1, a rare form of anemia with iron overload. This study reports two novel cases of AHMIO1, one with a new SLC11A2 splicing variant and the other with a previously reported DMT1 G75R mutation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Anteneh Omer, Dejene Hailu, Gezahegn Nigusse, Afework Mulugeta
Summary: This study found that the prevalence of anemia among children aged 6-59 months in Ethiopia is 44.7%. Microcytic hypochromic anemia with high red cell distribution width is the most common type, primarily affecting children under the age of two. Normocytic normochromic anemia is significantly more prevalent among children aged 24-59 months, while macrocytic anemia is not related to age.
Article
Medicine, General & Internal
Yi-Kai Fu, Hsueng-Mei Liu, Li-Hsuan Lee, Ying-Ju Chen, Sheng-Hsuan Chien, Jeong-Shi Lin, Wen-Chun Chen, Ming-Hsuan Cheng, Po-Heng Lin, Jheng-You Lai, Chyong-Mei Chen, Chun-Yu Liu
Summary: A new classifier combining indices and machine-learning techniques was developed to discriminate thalassemia and non-thalassemia microcytic anemia, showing better performance than other indices.
Article
Medical Laboratory Technology
Fan Zhang, Jing Yang, Yang Wang, Manyi Cai, Juan Ouyang, JunXun Li
Summary: This study aimed to develop a machine learning algorithm to differentiate between iron deficiency anemia (IDA) and thalassemia trait (TT). Laboratory data from 798 patients with microcytic hypochromic anemia (MHA) were collected, and the performance of six existing discriminant formulas was compared. The random forest model was chosen as the discriminant algorithm, and a webpage tool was developed to assist healthcare providers in rural areas.
CLINICA CHIMICA ACTA
(2023)
Article
Hematology
Zainab Mukhtar, Sabatino Valente, Loredana Masi, Gabriella Lakos, Fabrizio Papa
Summary: The study demonstrated that the Abbott Alinity hq advanced optical RBC technology is effective in differentiating between iron deficiency anemia and beta-thalassemia carrier status. Various red cell parameters and mathematical formulas showed high discriminative power, highlighting the diagnostic utility of extended red cell analysis for these two common microcytic anemias.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Ginga Suzuki, Ryo Ichibayashi, Yuka Masuyama, Saki Yamamoto, Hibiki Serizawa, Yoshimi Nakamichi, Masayuki Watanabe, Mitsuru Honda
Summary: This study investigates the association between blood transfusion and the occurrence of PIICS, finding that RBC and PLT transfusions are significantly associated with PIICS.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Senta Jorinde Raasveld, Sanne de Bruin, Merijn C. Reuland, Claudia Van den Oord, Jimmy Schenk, Cecile Aubron, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Marcella C. A. Mueller, Thomas W. L. Scheeren, Zoe Mcquilten, Andrew Flint, Tarikul Hamid, Michael Piagnerelli, Tina Tomic Mahecic, Jan Benes, Lene Russell, Hernan Aguirre-Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V. Llau, Manual Quintana-Diaz, Maria Cronhjort, Carmen A. Pfortmueller, Nihan Yapici, Nathan D. Nielsen, Akshay Shah, Harm-Jan de Grooth, Alexander P. J. Vlaar, InPUT Study Grp
Summary: Red blood cell transfusion was common among patients admitted to the intensive care unit (ICU) between 2019 and 2022, with high variability in transfusion practices across centers.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Hematology
Stacey Uter, Hyun Hyung An, Grace E. Linder, Stephan Kadauke, Deborah Sesok-Pizzini, Haewon C. Kim, David F. Friedman, Stella T. Chou
Summary: The study successfully reduced the number of red blood cell units required by patients undergoing chronic red cell exchange during the COVID-19 pandemic by implementing two measures, maintaining pretransfusion HbS% target goals and minimizing iron accumulation.
Article
Hematology
Huihui Li, Jacob S. Kazmi, Sungkyun Lee, Dachuan Zhang, Xin Gao, Maria Maryanovich, Lidiane Torres, Divij Verma, Libusha Kelly, Yelena Z. Ginzburg, Paul S. Frenette, Deepa Manwani
Summary: Sickle cell disease (SCD) is a genetic disorder characterized by erythrocyte sickling, vaso-occlusive episodes (VOE), and organ damage. Red blood cell transfusions cause iron overload in some SCD patients, while others exhibit iron deficiency. In this study, an iron-restricted diet (IRD) was shown to reduce iron availability, hemolysis, and VOE, and improve organ damage in SCD mice. Furthermore, IRD altered the gut microbiota and improved gut integrity, preventing crosstalk between the microbiome and inflammatory factors, and ultimately ameliorating SCD pathophysiology.
Article
Infectious Diseases
Xiao-Yan Yang, Lin Chen, Ji -Na Gu, Cheng-Jun Zeng, Dan-Mei Pan
Summary: This study reported a case of a 68-year-old woman who developed PRCA after treatment with LZD, highlighting the importance of monitoring bone marrow suppression during long-term LZD therapy, especially in patients over 58 and/or with pre-existing anemia, chronic infections, and renal insufficiency.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Pediatrics
Theodore S. Kocoshis, Theodosia A. Kalfa, Alexander G. Miethke, William F. Balistreri, Katie G. Seu, Crystal G. Slaughter, Ruchi Singh, Mary Mullen, Samuel A. Kocoshis
Summary: This study investigates the impact of cholestasis on red blood cell osmotic fragility and deformability in pediatric patients. It shows that even in the absence of spur cells, cholestasis can alter these red blood cell measures, increasing the risk of hemolysis under oxidative stress. The findings suggest the importance of minimizing pro-oxidant exposure and maximizing antioxidant exposure in this patient population.
PEDIATRIC RESEARCH
(2023)
Article
Hematology
France Pirenne, Aline Floch, Saliou Diop
Summary: Sickle cell disease is a commonly inherited disorder in sub-Saharan Africa and high-income countries, and transfusion is a crucial treatment. However, alloimmunisation against red blood cell antigens and post-transfusion haemolysis often occur, posing life-threatening risks. The prevention of alloimmunisation is important, but the reasons behind high alloimmunisation rates differ between high-income countries and low-income countries, and further research is needed to address this issue.
LANCET HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Yi-Pang Lee, Ching-Hui Loh, Ming-Jay Hwang, Chun-Pin Lin
Summary: LVs have significantly higher frequencies of microcytosis, macrocytosis, blood Hb, RBC, and serum vitamin B12 deficiencies than HCSs. Normocytic and microcytic anemias are the two most common types of anemia in LVs.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)