Article
Nanoscience & Nanotechnology
Qi Dong, Xindi Yang, Xiao Liang, Jing Liu, Binyi Wang, Yanteng Zhao, Celine Huselstein, Xiaolin Feng, Zan Tong, Yun Chen
Summary: Peripheral nerve regeneration and functional recovery remain challenging in clinical practice. The utilization of nerve guidance conduits (NGCs) and platelet-rich plasma (PRP) can regulate the regenerative microenvironment and promote peripheral nerve repair. A composite nerve conduit, GelMA/SA-3/PRP-20 NGCs, incorporating PRP into a gelatin methacrylate (GelMA) and sodium alginate (SA) hydrogel, showed optimal mechanical properties and sustained release of growth factors (VEGF-A, PDGF-BB) from PRP, promoting axonal regeneration and functional recovery in peripheral nerves.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Enxing Yu, Zhiwu Chen, Yuye Huang, Yibing Wu, Zonghuan Wang, Fangfang Wang, Miaoben Wu, Kailei Xu, Wei Peng
Summary: Peripheral nerve injury (PNI) is a common and severe clinical disease with poor prognosis. Autologous nerve grafting is limited in availability and size, leading to the development of artificial nerve conduits. In this study, a novel composite neural conduit containing decellularized tissues and a grooved PLGA conduit was found to significantly promote nerve regeneration. This artificial nerve conduit could potentially be used in clinical practice.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Merav Antman-Passig, Jonathan Giron, Moshe Karni, Menachem Motiei, Hadas Schori, Orit Shefi
Summary: Nerve growth conduits play a crucial role in supporting and promoting axon regeneration following nerve injuries. A biomimetic regenerative gel enriched with magnetic nanoparticles coated with nerve growth factor has been developed, showing promising effects on enhancing nerve regeneration in in vivo rat models. The magnet-based therapeutic conduits demonstrate oriented and directed axonal growth, providing a novel therapeutic approach to overcoming current medical obstacles for nerve injuries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Hui Zhang, Han Zhang, Huan Wang, Yuanjin Zhao, Renjie Chai
Summary: A novel silk fibroin-derived nerve guidance conduit (NGC) with internal-facing inverse opal structures is developed for local neurotrophic factor delivery and effective nerve regeneration. The NGC demonstrates excellent biocompatibility, suitable biodegradability, and spatial control over the distribution of loading factors, leading to enhanced therapeutic efficacy.
APPLIED MATERIALS TODAY
(2022)
Review
Cell Biology
Ming-Li Zou, Si-Yu Liu, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Ying-Ying Teng, Yi Feng, Feng-Lai Yuan
Summary: The incidence of acute and chronic wound diseases is increasing, causing a significant burden on patients, their families, and society due to their complex pathogenesis, long course, and difficult treatment. Research is focusing on identifying new ideas and methods for treatment, with adipose stem cells potentially playing a key role in wound healing.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Chaoying Zhang, Jiaxing Gong, Jingyu Zhang, Ziyu Zhu, Ying Qian, Kejie Lu, Siyi Zhou, Tianyi Gu, Huiming Wang, Yong He, Mengfei Yu
Summary: The replacement of autograft with a nerve guidance conduit (NGC) in peripheral nerve injury is challenging due to the limited conductivity and biocompatibility of current NGCs in vivo. In this review, the authors explore the superior factors for nerve conduction, the construction of a more conductive regenerative scaffold, and the next steps in nerve regeneration for NGCs. The analysis of NGC-related references suggests that conductive materials, manufacturing technologies of neural scaffolds, and electrical stimulation (ES) play essential roles in accelerating nerve conduction.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Cell Biology
Tiam M. Saffari, Sara Saffari, Krishna S. Vyas, Samir Mardini, Alexander Y. Shin
Summary: Autologous fat grafting is commonly used in reconstructive surgery to improve functional form. Fat tissue enrichment with adipose-derived stem cells can increase the long-term stability of grafts. Basic science research suggests that adipose-derived stem cells can enhance nerve regeneration and revascularization, and reduce nerve fibrosis. Clinical studies show promising results in secondary carpal tunnel release revisions using autologous lipofilling.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Mahmut Muhsin Yilmaz, Ozge Ekin Akdere, Menemse Gumusderelioglu, Gokce Kaynak Bayrak, Sena Koc, Aysen Erdem, Meltem Tuncer, Ozbeyen Atalay, Gulnur Take Kaplanoglu, Saadet Ozen Akarca Dizakar, Mert Calis
Summary: In this study, a biological conduit consisting of AdMSCs sheet and AM was used for peripheral nerve defect reconstruction. The effects of this conduit on neural regeneration were compared with other repair methods using functional, histological, and immunohistochemical tests. The results showed that the AdMSCs + AM group exhibited better nerve regeneration compared to the other groups. Therefore, the biological conduit can be considered as an alternative treatment method to nerve autograft in clinical applications.
CELL AND TISSUE RESEARCH
(2023)
Article
Cell Biology
Julius M. Mayer, Christian Krug, Maximilian M. Saller, Annette Feuchtinger, Riccardo E. Giunta, Elias Volkmer, Thomas Holzbach
Summary: Recent research highlights the beneficial effects of hypoxia-preconditioned adipose-derived multipotent stem/progenitor cells (ADSPCs) in peripheral nerve regeneration. The study investigated the use of a custom-made fibrin conduit seeded with hypoxic pre-conditioned ADSPCs for autologous sciatic nerve graft in rats. Compared to other treatment modes, the hypoxic pre-conditioned group showed faster functional regeneration, increased axon outgrowth/branching and density, remyelination, and reduced connective tissue area. Further studies are needed to explore the cellular mechanism and potential clinical applications.
NEURAL REGENERATION RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Ryan Akman, Harsha Ramaraju, Adam Verga, Scott J. Hollister
Summary: This study developed a biodegradable shape memory polymer for 3D printing of biomaterial implants. Material extrusion and vat photopolymerization are two prevalent 3D printing modalities, and they have significant differences in the printed sample geometry, material properties, and mechanical properties.
APPLIED MATERIALS TODAY
(2022)
Article
Cell & Tissue Engineering
Zheng Yang, Yang Yang, Yichi Xu, Weiqian Jiang, Yan Shao, Jiahua Xing, Youbai Chen, Yan Han
Summary: In this study, engineered exosomes were used as carriers to efficiently deliver NT-3 mRNA to recipient cells and promote nerve regeneration in a rat sciatic nerve defect model, demonstrating the potential for improving nerve regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Polymer Science
Josefa Alarcon Apablaza, Maria Florencia Lezcano, Karina Godoy Sanchez, Gonzalo H. Oporto, Fernando Jose Dias
Summary: This scoping review summarizes the adequate quantitative/morphometric parameters of polymeric nerve guide conduits (NGCs) that provide a supportive environment for nerve regeneration. Optimal morphometric characteristics, such as wall thickness, fiber size, pore size, and porosity, are identified to enhance nerve regeneration and reduce the need for experimental studies.
Article
Cell Biology
Ya-Nan Zhao, Ping Wu, Zi-Yuan Zhao, Fei-Xiang Chen, Ao Xiao, Zhi-Yi Yue, Xin-Wei Han, Yong Zheng, Yun Chen
Summary: In this study, chitosan/graphene oxide (GO) films were prepared using an electrodeposition technique, and their effects on Schwann cell proliferation and adhesion abilities were evaluated. The results showed that the films promoted the expression of nerve regeneration-related factors and that a nerve guidance conduit with a GO content of 0.25% improved functional and histological outcomes in a rat sciatic nerve defect model.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Cell Biology
Bruna Andrade Aguiar Koga, Leticia Alves Fernandes, Paula Fratini, Mari Cleide Sogayar, Ana Claudia Oliveira Carreira
Summary: Mesenchymal stem cells (MSCs) secrete vesicles known as extracellular vesicles (EVs), which play a crucial role in tissue homeostasis, repair, and therapeutic applications. MSC-derived EVs have advantages such as low immunogenicity and the ability to pass through barriers, making them potential drug delivery agents for various diseases. Extensive in vitro studies have been conducted to understand the mechanisms and signaling pathways of EVs. Clinical trials are underway to explore the therapeutic potential of EVs in Alzheimer's disease, retina degeneration, and COVID-19. This review provides an overview of different EV isolation methods and highlights their therapeutic applications in tissue repair and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Vulvar squamous cell carcinoma is the most frequent vulvar neoplasia, and surgery is associated with the best overall survival. Age, pathological grade, stage at diagnosis, treatment sequence, and chemotherapy are identified as independent prognostic factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Dominique Schaakxs, Mikael Wiberg, Paul J. Kingham, Daniel F. Kalbermatten
Summary: This study investigated the use of bioengineering techniques to repair peripheral nerve injuries and treat associated muscle atrophy. The results showed that the use of poly-3-hydroxybutyrate strips seeded with differentiated adipose stem cells promoted nerve repair and reduced muscle atrophy.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Medicine, General & Internal
Vladimir Megevand, Domizio Suva, Morad Mohamad, Didier Hannouche, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: The meta-analysis compared muscle (M) and fasciocutaneous (FC) free flaps for lower limb reconstruction and found that FC flaps had better clinical outcomes, including lower donor site morbidity and total flap loss rates.Authors preferred FC flaps due to higher aesthetic satisfaction and lower rates of postoperative infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Matteo Scampa, Rastine Merat, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Head and neck porocarcinoma is a rare tumor with male predominance. The incidence of distant metastasis is low, and surgery is the main treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Ebai A. Eseme, Daniel Da Rocha, Mathias Tremp, Evangelia Tzika, Rastine Merat, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Nasal tip reconstruction is complex and aesthetically important. The traditional paramedian forehead flap may be refused by patients. Researchers propose a combination of Rintala flap and posterior perichondrial cutaneous graft as an alternative.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2022)
Article
Gastroenterology & Hepatology
Andrea Schlegel, Matteo Mueller, Xavier Mueller, Janina Eden, Rebecca Panconesi, Stefanie von Felten, Klaus Steigmiller, Richard X. Sousa Da Silva, Olivier de Rougemont, Jean-Yves Mabrut, Mickael Lesurtel, Miriam Cortes Cerisuelo, Nigel D. Heaton, Marc Antoine Allard, Rene Adam, Diethard Monbaliu, Ina Jochmans, Martijn P. D. Haring, Robert J. Porte, Alessandro Parente, Paolo Muiesan, Philipp Kron, Magdy Attia, Dagmar Kollmann, Gabriela Berlakovich, Xavier Rogiers, Karin Petterson, Anne L. Kranich, Stefanie Amberg, Beat Mullhaupt, Pierre-Alain Clavien, Philipp Dutkowski
Summary: Hypothermic oxygenated perfusion (HOPE) after cold storage of donated livers reduces the incidence of complications and graft failure in liver transplantation.
JOURNAL OF HEPATOLOGY
(2023)
Article
Obstetrics & Gynecology
Tabea Cincera, Natalia Conde, Stefanie von Felten, Brigitte Leeners, Stephanie von Orelli
Summary: This study found a significant reduction in the rate of cesarean deliveries during the early period of the COVID-19 pandemic, without major differences in maternal and infant health indicators or obstetric risk factors. The composition and behavior of the obstetric team and the increased burden on healthcare systems during the pandemic may have contributed to these results.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Surgery
Carlo M. Oranges, Vendela Grufman, Pietro G. di Summa, Elmar Fritsche, Daniel F. Kalbermatten
Summary: This study conducted a systematic literature review to analyze the outcomes and complications associated with different chin augmentation techniques. All techniques achieved satisfactory cosmetic outcomes, but caution is needed to avoid nerve injuries and overcorrection or undercorrection.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Infectious Diseases
Aline Wolfensberger, Lauren Clack, Stefanie von Felten, Mirjam Faes Hesse, Dirk Saleschus, Marie-Theres Meier, Katharina Kusejko, Roger Kouyos, Leonhard Held, Hugo Sax
Summary: This study aimed to test a prevention intervention for non-ventilator-associated hospital-acquired pneumonia and a multifaceted implementation strategy. The results showed that implementing the prevention intervention significantly reduced the incidence rate of nvHAP.
LANCET INFECTIOUS DISEASES
(2023)
Correction
Health Care Sciences & Services
Karin Zimmermann, Michael Simon, Katrin Scheinemann, Eva Maria Tinner Oehler, Michele Widler, Simone Keller, Gunther Fink, Stefan Mitterer, Anne-Kathrin Gerber, Stefanie von Felten, Eva Bergstraesser
BMC PALLIATIVE CARE
(2023)
Article
Medicine, General & Internal
Isabel Zucal, Mathias Tremp, Dominik Duscher, Raphael Wenny, Maximilian Zaussinger, Alexander Kutz, Andrea Pagani, Georg M. Huemer
Summary: Single-stage mastopexy-augmentation is safe, but revisions may be necessary. We evaluated 95 patients undergoing the procedure and introduced a modified dual plane technique. The overall complication rate was high, but the modified dual plane technique had a lower rate of complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Merkel cell carcinoma is an aggressive malignant skin tumor with high recurrence and low survival. Lymph nodal metastases are associated with a worse overall prognosis. Factors such as increasing age, tumor size, and truncal location are associated with higher positive lymph node rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jerome Martineau, Solange N. Walz, Matteo Scampa, Salvatore Giordano, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: This study analyzed the demographic and pathological characteristics, treatment patterns, and survival outcomes of patients with spiradenocarcinoma. The results showed that spiradenocarcinoma affects males and females equally, with low rates of regional and distant invasion. Surgical excision is the main treatment modality, and the overall and disease-specific survival rates are high for patients with spiradenocarcinoma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Samuel Martin Eckstein, Stefanie von Felten, Laura Perotto, Romana Brun, Denise Vorburger
Summary: The study found differences in protocol characteristics between hospitals and private practices in Switzerland regarding abortion services. Private practices have easier access to abortion services compared to hospitals. Hospitals providing abortion services should reduce protocol-based barriers and improve abortion rates.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Manuele Giuseppe Muraro, Andrea Mazzoleni, Evrim Ceren Kabak, Arnaud Scherberich, Ivan Martin
TISSUE ENGINEERING PART A
(2022)