Article
Food Science & Technology
Patricia Costa da Silva, Tassiele Toledo, Vandre Briao, Telma Elita Bertolin, Jorge Alberto Vieira Costa
Summary: The study focused on the development of products with bioactive peptides from Spirulina, showing their potential in enhancing antioxidant activity and physical properties when added to snacks, thus indicating a viable natural alternative for improving the quality of extruded foods.
Article
Food Science & Technology
Hesam Daliri, Raman Ahmadi, Akram Pezeshki, Hamed Hamishehkar, Maryam Mohammadi, Hossein Beyrami, Maryam Khakbaz Heshmati, Marjan Ghorbani
Summary: The study demonstrates that quinoa protein hydrolysate (QPH) prepared by pancreatin hydrolysis has better emulsifying, foaming, and antioxidant properties compared to quinoa protein concentrate (QPC). However, QPC showed better emulsion/foam stabilizing properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dewei Xie, Yaling Shen, Erzheng Su, Lei Du, Jingli Xie, Dongzhi Wei
Summary: The study found that VGINYW and LH-3k can effectively lower blood pressure and improve oxidative stress in hypertensive rats. Additionally, these substances control blood pressure by regulating the renin-angiotensin system and improving intestinal microbiota dysbiosis.
Article
Environmental Sciences
Amahle Bokveld, Nonso E. Nnolim, Tennison O. Digban, Anthony I. Okoh, Uchechukwu U. Nwodo
Summary: The valorization of keratinous biomass for value-added products is of high importance in ecological management and the advancement of the bio-economy. Through screening and identification of bacteria, as well as optimization of fermentation process conditions, chicken feathers can be converted into amino acid-rich hydrolysate, providing potential applications as dietary protein supplements in livestock feed.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Food Science & Technology
Feyisola Fisayo Ajayi, Priti Mudgil, Amie Jobe, Priya Antony, Ranjit Vijayan, Chee-Yuen Gan, Sajid Maqsood
Summary: Hypercholesterolemia is a serious global public health concern. Natural products have emerged as an alternative therapy for ameliorating this condition. This study aimed to produce novel bioactive peptides from quinoa protein hydrolysates using enzymatic hydrolysis methods and found that chymotrypsin-generated hydrolysates showed higher inhibitory potential against cholesterol esterase and pancreatic lipase. Several bioactive peptides were identified as potential inhibitors for these enzymes. The results suggest that quinoa protein hydrolysates can be considered as an alternative therapy for hypercholesterolemia.
Article
Polymer Science
Laura Olariu, Brindusa Georgiana Dumitriu, Carmen Gaidau, Maria Stanca, Luiza Mariana Tanase, Manuela Diana Ene, Ioana-Rodica Stanculescu, Cristina Tablet
Summary: This study aimed to investigate the molecular factors responsible for skin homeostasis restoration induced by low molecular weight keratin hydrolysates. The results showed that the hydrolysates increased the expression of α1 and α2 subunits, which promoted tight binding between cells and collagen/laminin 1, stimulated epidermal cell turnover, and inhibited VCAM over-expression under inflammatory conditions.
Review
Agriculture, Multidisciplinary
Pauline Duffuler, Khushwant S. Bhullar, Stepheny C. de Campos Zani, Jianping Wu
Summary: Food-derived bioactive peptides and protein hydrolysates have gained attention as diet-based strategies for preventing and mitigating chronic diseases, but their clinical translation is limited by a lack of understanding of their mechanisms of action and pharmacokinetics. Commercialization is also hindered by limited information on efficacy, safety, bitter taste, and cost-effective production methods.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Environmental Sciences
Ebru Gezgincioglu, Okkes Atici
Summary: Chicken feather waste is a significant problem in the poultry industry. However, chicken feather protein hydrolysate (CFPH) derived from these waste feathers has the potential to enhance cold stress tolerance in wheat by promoting physiological and antioxidative responses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Leila Najafian
Summary: The creation of bioactive peptides from dietary proteins offers great potential for the development of functional foods and nutraceuticals. These peptides have various important roles in the body, including antioxidative, antimicrobial, immunomodulatory, hypocholesterolaemic, antidiabetic, and antihypertensive properties. They can be used as food additives to maintain quality and microbiological safety, as well as functional components in the treatment and prevention of chronic and lifestyle-related disorders. This article highlights the functional, dietary, and health advantages of bioactive peptides in food items, discussing their mechanisms of action and medicinal uses, as well as their applications for enhancing food quality and shelf life.
Article
Environmental Sciences
Tunjung Mahatmanto, Nabilah Rizka Estiningtyas, Syafira Kintan Maharani, Ahmad Sultan Shalahuddin, Muhammad Yuda Dwitama Agustian, Untung Murdiyatmo
Summary: In this study, bacteria were screened from the rhizosphere of Mimosa pudica for their ability to degrade feathers and use them as a substrate. One isolate, identified as Chryseobacterium sp. A9.9, effectively degraded feathers and produced proteases with higher activity. Laboratory adaptation of Chryseobacterium sp. A9.9 using feathers as its sole carbon and nitrogen source improved its ability to degrade feathers and yielded higher total protein content. Furthermore, the production of flexirubin by Chryseobacterium sp. A9.9 may add value to the bioconversion process.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Food Science & Technology
Fatih Bozkurt, Hatice Bekiroglu, Kubra Dogan, Salih Karasu, Osman Sagdic
Summary: This study investigated the effects of different types of proteolytic enzymes on the technological and bioactive properties of glutenin hydrolysates. The results showed that hydrolysates with lower degree of hydrolysis had superior technological properties, while those with higher degree of hydrolysis exhibited better antioxidant and anti-diabetic activities. Additionally, the hydrolysates showed no cytotoxic effects on HEK293 healthy cell line but exhibited cytotoxic effects on MIA PaCa 2 and CaCo 2 cancer cell lines.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Srijana Mukhia, Anil Kumar, Rakshak Kumar
Summary: The cold-adapted bacterium-produced protease showed broad activity ranges for temperature and pH, generating antioxidant peptides with high radical scavenging activities. It is a promising catalyst for high-value functional food production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jing Zhang, Manyu Liang, Lijuan Wu, Yanhong Yang, Yingjie Sun, Qin Wang, Xiaowei Gao
Summary: This study developed a simple and cost-effective method to digest feathers using Bacillus licheniformis WHU, yielding a hydrolysate that can be directly used as a bioactive nutrient resource. In addition, supplementation with feather hydrolysate had positive effects on intestinal health, immune function, and microbial composition in mice.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Siddharthan Nagarajan, Balagurunathan Ramasamy, Hemalatha Natarajan
Summary: Feather waste can be effectively converted into bioactive peptides using keratinase producing bacteria, which exhibit antioxidant, antibacterial, anticancer, and wound healing properties.
PROCESS BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ezequiel R. Coscueta, Maria Emilia Brassesco, Manuela Pintado
Summary: This study aimed to optimize the production of bioactive hydrolysates from salt-cured cod skin using Bromelain, demonstrating their antioxidant and antihypertensive activities and biocompatibility with cells. It developed a sustainable process that conserves time and energy.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Rafael Lopes da Rosa, Tung Sheng Yang, Emanuela Fernanda Tureta, Laura Rascovetzki Saciloto de Oliveira, Amanda Naiara Silva Moraes, Juliana Miranda Tatara, Renata Pereira Costa, Julia Spier Borges, Camila Innocente Alves, Markus Berger, Jorge Almeida Guimaraes, Lucelia Santi, Walter Orlando Beys-da-Silva
Summary: The COVID-19 pandemic caused by the new coronavirus has accelerated research in the field, resulting in a large volume of clinical and experimental data, including changes in gene expression. The creation of the SARSCOVIDB database aims to integrate differential gene expression data and facilitate analysis from various experimental perspectives. This resource supports health workers and the scientific community in understanding the molecular impact of SARS-CoV-2 infection.
Letter
Virology
Andre Quincozes-Santos, Rafael L. da Rosa, Larissa D. Bobermin, Emanuela F. Tureta, Lucelia Santi, Walter O. Beys-da-Silva
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Diorge Jonatas Marmitt, Shanna Bitencourt, Chistiane Oliveira Coura, Markus Berger, Dalana Faleiro, Debora Mara Kich, Bruna Caye, Sheila Mariele Immich, Annyta Fernandes Frota, Walter O. Beys-da-Silva, Jorge Almeida Guimaraes, Norma Maria Barros Benevides, Stefan Laufer, Marcia Ines Goettert
Summary: This study evaluated the anti-inflammatory and anticoagulant activities of the ethanol leaf extract of Myrciaria plinioides. The results showed that the extract exhibited inhibitory effects on cell inflammation and blood clotting, suggesting the potential of Myrciaria plinioides as a source for developing anti-inflammatory and anticoagulant drugs.
INFLAMMOPHARMACOLOGY
(2022)
Review
Genetics & Heredity
Lavinia Schuler-Faccini, Miguel del Campo, Alfredo Garcia-Alix, Liana O. Ventura, Juliano Andre Boquett, Vanessa van der Linden, Andre Pessoa, Helio van der Linden Junior, Camila V. Ventura, Mariana Carvalho Leal, Thayne Woycinck Kowalski, Lais Rodrigues Gerzson, Carla Skilhan de Almeida, Lucelia Santi, Walter O. Beys-da-Silva, Andre Quincozes-Santos, Jorge A. Guimaraes, Patricia P. Garcez, Julia do Amaral Gomes, Fernanda Sales Luiz Vianna, Andre Anjos da Silva, Lucas Rosa Fraga, Maria Teresa Vieira Sanseverino, Alysson R. Muotri, Rafael Lopes da Rosa, Alberto Mantovani Abeche, Clairton Marcolongo-Pereira, Diogo O. Souza
Summary: This article reviews the identification of Zika virus as a human teratogen and its effects on congenital Zika syndrome (CZS). This syndrome is characterized by severe motor, cognitive, and language impairments, particularly in the form of cerebral palsy. However, some children may exhibit milder deficits, and those born without brain or eye abnormalities can have normal neurodevelopment. Vertical transmission and disruption in brain development are less frequent when maternal infection occurs in the second half of pregnancy. Experimental studies indicate the possibility of other behavioral outcomes in prenatally infected children, as well as in postnatal and adult infections. The development of CZS is influenced by various factors, including genetics, environment, nutrition, and social determinants.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Raul M. Rodrigues, Vanessa de Souza Valim, Markus Berger, Annelise P. M. da Silva, Flavia N. S. Fachel, Ianae I. Wilke, Walter O. B. da Silva, Lucelia Santi, Maria A. L. da Silva, Bruna Amorin, Filipe Sehn, John R. Yates, Jorge A. Guimaraes, Lucia Silla
Summary: This study analyzes the composition and reproducibility of a platelet lysate produced with a standardized method. Proteomics and dynamic light scattering are used to describe the protein and particle content of several batches. The study reveals a diverse protein content with proteins related to essential cellular processes, and it provides new data on two major particle populations that may play a role in protein trafficking. These findings contribute to defining the content and quality criteria of a cell supplement for clinical applications.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Kelly P. Zucatti, Paula P. Teixeira, Laura F. Wayerbacher, Giovana F. Piccoli, Poliana E. Correia, Natasha K. O. Fonseca, Karla S. Moresco, Bruno A. Guerra, Michelle G. Madure, Laura P. Farenzena, Anize D. Frankenberg, Elisa Brietzke, Bruno Halpern, Oscar Franco, Veronica Colpani, Fernando Gerchman
Summary: This study found that lifestyle interventions did not show superiority to usual care in reducing cardiovascular or all-cause mortality for individuals with prediabetes and type 2 diabetes. Factors such as the type of intervention, follow-up time, age, glycemic status, geographical location, risk of bias, and weight change did not influence the outcomes.
Article
Virology
Juliana M. M. Tatara, Rafael L. L. Rosa, Ana Paula M. Varela, Tais F. F. Teixeira, Patricia Sesterheim, Anderson Gris, David Driemeier, Amanda N. S. Moraes, Markus Berger, Ramon D. D. Pena, Paulo M. M. Roehe, Diogo O. G. Souza, Jorge A. A. Guimaraes, Alexandre R. R. Campos, Lucelia Santi, Walter O. O. Beys-da-Silva
Summary: This study compared the infections of Zika virus between the African strain MR766 and the Brazilian strain 17 SM. The results showed that the African strain activated immune system pathways, while the Brazilian strain caused neutrophil infiltration in the lungs of mice. The findings suggest that the African strain may lead to faster viral clearance by immune cells.
ARCHIVES OF VIROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Elton Rodrigo Ce, Audecir Giombelli, Jalusa Deon Kich, Karla Suzana Moresco, Andresa Miranda, Mayka Reghiany Pedrao, Gracielle Johann, Andrea Catia Leal Badaro, Elisabete Hiromi Hashimoto, Alessandra Machado-Lunkes
Summary: Pig production has economic importance in Brazil. The different stages of raising and slaughtering pigs affect the microbiological quality of pig products and by-products. Microbiological analysis and HACCP are tools for monitoring the quality of microorganisms. This study developed a predictive model to monitor the absence or presence of Salmonella based on variables such as distance and aerobic mesophilic. The model showed an accuracy of about 85% for monitoring the microbiological quality of pig slaughter.
JOURNAL OF FOOD PROTECTION
(2023)
Article
Genetics & Heredity
Cristine Dieter, Leticia de Almeida Brondani, Natalia Emerim Lemos, Ariell Freires Schaeffer, Caroline Zanotto, Denise Taurino Ramos, Eliandra Girardi, Felipe Mateus Pellenz, Joiza Lins Camargo, Karla Suzana Moresco, Lucas Lima da Silva, Mariana Rauback Aubin, Mayara Souza de Oliveira, Tatiana Helena Rech, Luis Henrique Canani, Fernando Gerchman, Cristiane Bauermann Leitao, Daisy Crispim
Summary: Although age, sex, and comorbidities play a role in the severity of COVID-19, genetic polymorphisms in ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4, TLR3, TMPRSS2, and TYK2 also contribute to the variation in disease severity. This study found that specific genotypes and alleles in these genes are associated with increased risk of ICU admission and death in COVID-19 patients, especially among females and non-white individuals. Moreover, interactions between these polymorphisms further increase the risk of worse outcomes.
Article
Mycology
Laura Rascovetzki Saciloto-de-Oliveira, Leonardo Broetto, Camila Innocente Alves, Rafael Lopes da Rosa, Yohana Porto Calegari Alves, Rodrigo Campos da Silva, Markus Berger, Alexandre Jose Macedo, Pedro Ferrari Dalberto, Cristiano Valim Bizarro, Jorge Almeida Guimara, John R. Yates, Lucelia Santi, Walter Orlando Beys-da-Silva
Summary: Using MudPIT technology, we analyzed the differential secretome of Metarhizium anisopliae E6 induced by its host, Rhipicephalus microplus cuticle. The proteomic results revealed changes in the expression of 194 proteins involved in adhesion, penetration, stress, and fungal defense. Comparative genomic analysis showed that M. anisopliae E6 had a higher expression level of certain protein families compared to Beauveria bassiana, another arthropod pathogen. In vivo toxicity assays confirmed that the M. anisopliae E6 secretome was more effective against cattle tick infections compared to other secretomes.
Review
Neurosciences
Andre Quincozes-Santos, Larissa Daniele Bobermin, Naithan Ludian Fernandes Costa, Natalie K. Thomaz, Romulo Rodrigo de Souza Almeida, Walter O. Beys-da-Silva, Lucelia Santi, Rafael L. Rosa, Daniela Capra, Juliana M. Coelho-Aguiar, Marcos Fabio DosSantos, Manoela Heringer, Elizabeth O. Cirne-Lima, Jorge Almeida Guimaraes, Lavinia Schuler-Faccini, Carlos-Alberto Goncalves, Vivaldo Moura-Neto, Diogo Onofre Souza
Summary: Zika virus infects glial cells in both the central and peripheral nervous systems, leading to neurological complications and potential neurodevelopmental disorders. Understanding the changes in glial cell functions, including inflammatory response, oxidative stress, mitochondrial dysfunction, calcium and glutamate homeostasis, neural metabolism, and neuron-glia communication, may contribute to the development of preventive and therapeutic strategies against Zika virus-induced neurodegeneration.
Article
Biology
Larissa Daniele Bobermin, Lara Scopel Medeiros, Fernanda Weber, Giancarlo Tomazzoni De Oliveira, Lucelia Santi, Walter Orlando Beys-Da-Silva, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: Glial cells play a crucial role in maintaining CNS homeostasis. Viral infections during pregnancy may affect neurodevelopment and lead to behavioral dysfunction later in life. SARS-CoV-2 infection during pregnancy is associated with more severe COVID-19 and higher preterm birth rates. It can also affect the CNS by inducing neurochemical remodeling in neural cells, compromising neuronal plasticity and synaptic function. However, the impact of SARS-CoV-2 infection during pregnancy on postnatal CNS development remains unclear. Considering the potential risk of neurological consequences, it is important to address long-term public health concerns associated with SARS-CoV-2 infection during pregnancy.
