Article
Biochemistry & Molecular Biology
Tomas J. Steeman, Andrea M. J. Weiner, Aldana P. David, Andres Binolfi, Nora B. Calcaterra, Pablo Armas
Summary: RNA guanine quadruplexes (G4s) formed within precursors of microRNAs (pre-miRNAs) regulate miRNA biogenesis during zebrafish embryogenesis. The G4 formed in the precursor of miRNA 150 (pre-miR-150) acts as a conserved regulatory structure competing with the stem-loop structure necessary for miRNA biogenesis, leading to knock-down phenotypes associated with the target gene myb. Inhibition of G4 formation and stabilization using a G4 ligand rescues the phenotypes related to myb knock-down.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Haitham G. Abo-Al-Ela, Mario A. Burgos-Aceves
Summary: The axolotl is extensively used in developmental biology research because of its unique ability to regenerate lost organs, particularly in the nervous system. While mammals rely on healing and scar formation for regeneration, other species like spiny mice, salamanders, and zebrafish are capable of regenerating damaged body components. Blastema formation, composed of progenitor cells or dedifferentiated cells, is crucial for regeneration in organisms, and the axolotl's introns, especially in development-associated genes, play a key role in this process by producing noncoding RNAs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hsiuying Wang, Ching Ho
Summary: MicroRNAs (miRNAs) play crucial roles in cell differentiation, development, gene regulation, and apoptosis. They have been identified as potential biomarkers for various diseases and can be used to explore disease associations. The phylogenetic tree analysis and distance distribution provide useful tools for investigating the similarity and association between different diseases and viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Candice Bohaud, Matt D. Johansen, Bela Varga, Rafael Contreras-Lopez, Audrey Barthelaix, Claire Hamela, Dora Sapede, Thierry Cloitre, Csilla Gergely, Christian Jorgensen, Laurent Kremer, Farida Djouad
Summary: This study investigated the role of macrophages in zebrafish embryos and found that exogenous infection can influence the macrophage response and tissue regenerative processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xixi Li, Guili Song, Yasong Zhao, Jing Ren, Qing Li, Zongbin Cui
Summary: The study revealed the essential role of SMC2 in zebrafish liver development, as its depletion led to a small liver phenotype, potentially linked to the activation of the p53-dependent apoptotic pathway.
Review
Cell Biology
Boya Peng, Poh Ying Theng, Minh T. N. Le
Summary: miR-125b, a key miRNA in cancer pathogenesis, is deregulated in various types of cancer and plays important roles in tumourigenesis and cancer progression. Its potential as a diagnostic and prognostic biomarker, as well as a therapeutic tool against cancer, is supported by emerging evidence on its essential functions.
CELL PROLIFERATION
(2021)
Article
Agriculture, Dairy & Animal Science
Qiongxian Yan, Lina Tian, Wenxun Chen, Jinhe Kang, Shaoxun Tang, Zhiliang Tan
Summary: The colon plays a crucial role in the fermentation and utilization of cell wall carbohydrates in ruminants. MicroRNAs have been found to regulate gastrointestinal development and maintain intestinal homeostasis in mammals. This study investigated the expression profiles of microRNAs in the colon of kid goats and identified different roles for DEmiRNAs, HEmiRNAs, and dynamic microRNAs in colon development. The targeted genes regulated by these microRNAs were associated with microbial invasion prevention, barrier maintenance, and cell damage surveillance. The study also revealed the impact of age on microRNA expression in the colon. Overall, this research provides new insights into the regulatory mechanism of colon development in goats.
Article
Engineering, Environmental
Sujin Lee, Ji-Su Lee, Younglim Kho, Kyunghee Ji
Summary: The study investigated the developmental toxicity and effects on the thyroid endocrine system in zebrafish embryos exposed to MIT and OIT. The results showed that exposure to these two isothiazolinones led to decreased hatchability, larvae survival, and body length in zebrafish larvae, as well as decreased levels of thyroid hormones. Significant gene expression changes and epigenetic deregulation of miRNAs were also observed. OIT exhibited higher toxicity compared to MIT.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Plant Sciences
Caitlin S. Byrt, Rose Y. Zhang, Isobel Magrath, Kai Xun Chan, Annamaria De Rosa, Samantha McGaughey
Summary: Maintenance of optimal leaf tissue humidity is vital for plant productivity and food security. The regulation of water and solute flux across plant cell membranes, influenced by aquaporin proteins, is crucial for achieving this optimal humidity. However, understanding the dynamics of aquaporin regulation and their influence on leaf cell solute flux and humidity remains challenging.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Sophie Wiszniak, Quenten Schwarz
Summary: VEGF-A is well-known for its roles in vascular development and angiogenesis, but it is also expressed in non-vascular cell types and various cancers. Intracellular VEGF has emerged as a key signalling molecule regulating cell growth, survival, and metabolism.
Article
Cell Biology
Cassia Michael, Sofia de Oliveira
Summary: Cell migration is a complex process that plays a crucial role in immune and inflammatory responses. The zebrafish, with its unique genetic and pharmacological manipulation capabilities and transparent body, provides an excellent model for studying cell migration dynamics, especially in leukocytes.
CURRENT OPINION IN CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tzahi Arazi, Jackson Khedia
Summary: This review provides a comprehensive annotation of tomato MIR genes and a non-redundant atlas of tomato MIR genes. The atlas includes 538 candidate and validated MIR genes, coding for various types of miRNAs. Additionally, a critical review of functional studies on tomato miRNAs is presented, creating a valuable resource for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shang-Wu Shih, Jia-Jiun Yan, Yi-Ling Tsou, Shao-Wei Lu, Min-Chen Wang, Ming-Yi Chou, Pung-Pung Hwang
Summary: Studies on fish ion regulation are crucial for understanding the molecular and physiological aspects of ionoregulatory organs. This study used the scanning ion-selective electrode technique to investigate the H+-excreting functions in adult fish gills, demonstrating an enhancement of H+ excretion capacity in response to acid acclimation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Tzu-Lun Tseng, Ying-Ting Wang, Chang-Yu Tsao, Yi-Teng Ke, Yi-Ching Lee, Hwei-Jan Hsu, Kenneth D. Poss, Chen-Hui Chen
Summary: Research identified a gene called pan in zebrafish that can suspend juvenile growth but resume a robust growth trajectory after release from restriction, with the mechanism being conserved in flies, zebrafish, and mice. This suggests that safe, reversible pauses of juvenile growth can be mediated by targeting the activity of a single gene.
Article
Biochemistry & Molecular Biology
Alejandro Valdivieso, Marta Caballero-Huertas, Javier Moraleda-Prados, Francesc Piferrer, Laia Ribas
Summary: Rearing density directly affects fish welfare and the epigenetic mechanisms of individuals exposed to confinement. The study found that high-density rearing of zebrafish resulted in significant masculinization and specific changes in DNA methylation and gene expression. These findings emphasize the importance of considering rearing densities in stocking protocols for fish hatcheries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
