Review
Immunology
Angela Ju, Rosanna Cazzolli, Martin Howell, Nicole Scholes-Robertson, Germaine Wong, Allison Jaure
Summary: While solid organ transplantation improves the survival and quality of life for patients with organ failure, the complications and side effects of treatment can be debilitating. Patient-reported outcome measures (PROMs) directly assess the feelings and functions of patients, including their quality of life, symptoms, and side effects. However, PROMs are rarely reported in solid organ transplantation trials due to various barriers including uncertainty in selecting appropriate PROMs, concerns about resource limitations and patient burden, and limited evidence supporting their use in transplant recipients. Efforts have been made to include patient-reported outcomes in trials to provide patient-centered information, and this article provides an overview of PROMs, discusses important patient-reported outcomes for solid organ transplant recipients, and outlines approaches for selecting PROMs in clinical trials.
Article
Health Care Sciences & Services
Rasa Ruseckaite, Claire Bavor, Lucy Marsh, Joanne Dean, Oliver Daly, Dora Vasiliadis, Susannah Ahern
Summary: This study aimed to assess the feasibility and acceptability of incorporating patient-reported outcome measures (PROMs) into the Australian Pelvic Floor Procedure Registry (APFPR). The study found that most women and clinicians supported the incorporation of PROMs in the APFPR, believing that PROMs have the potential for use in individual care and provide useful aggregate health-related quality of life (HRQoL) data.
QUALITY OF LIFE RESEARCH
(2022)
Review
Psychiatry
Alix Morel, Pierre Lebard, Alexandra Dereux, Julien Azuar, Frank Questel, Frank Bellivier, Cynthia Marie-Claire, Melina Fatseas, Florence Vorspan, Vanessa Bloch
Summary: This study reviewed the outcome measures, surrogate endpoints, and biomarkers in published and ongoing randomized clinical trials of CBD for substance use disorders. The primary outcomes were withdrawal symptoms and drug use reduction, while short-term or crossover studies used various measures and endpoints to assess treatment efficacy. Ongoing studies are incorporating peripheral biomarkers to predict treatment response, showing improvement in outcome measures in CBD trials for substance use disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Surgery
K. Paige Mihalsky, Rachel Tran, Fernando Moreno-Garcia, Caitlin Stenberg, Fernando Mier Giraud, Adam Hare, Lieschen H. Quiroz, Laura E. Fischer
Summary: Obesity is a known risk factor for urinary incontinence. Bariatric surgery can lead to significant weight loss and improvement in obesity-related chronic diseases. Therefore, bariatric surgery may significantly improve urinary incontinence symptoms and quality of life.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
K. Paige Mihalsky, Rachel Tran, Fernando Moreno-Garcia, Caitlin Stenberg, Fernando Mier Giraud, Adam Hare, Lieschen H. Quiroz, Laura E. Fischer
Summary: Bariatric surgery can significantly improve obesity-related urinary incontinence symptoms and quality of life. Over time, UI symptoms improve and are associated with BMI and the percentage of weight loss.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Medical Informatics
Finlay J. Pearce, Samantha Cruz Rivera, Xiaoxuan Liu, Elaine Manna, Alastair K. Denniston, Melanie J. Calvert
Summary: This systematic evaluation examines the use of patient-reported outcome measures (PROMs) in clinical trials for artificial intelligence (AI) technologies. The study found that although there is an increase in the number of clinical trials for AI health technologies, the use of PROMs is still lacking. The most common clinical areas where PROMs are used include digestive system health and musculoskeletal health.
LANCET DIGITAL HEALTH
(2023)
Review
Medicine, General & Internal
Alba Nicolas-Boluda, Anne Oppenheimer, Jerome Bouaziz, Arnaud Fauconnier
Summary: Patient Reported Outcome Measures (PROM) allow capturing patients' perspectives on their condition in the context of endometriosis care. Despite their extensive use in research and clinical trials, PROMs are rarely used in clinical practice. The development of digital tools can help facilitate the integration of PROMs into routine endometriosis care, improving patient-centered communication and quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Kathleen C. Kobashi, Sandip Vasavada, Aaron Bloschichak, Linnea Hermanson, Janice Kaczmarek, Sennett K. Kim, Erin Kirkby, Rena Malik
Summary: The purpose of this guideline is to provide a clinical approach for the diagnosis, counseling, and treatment of female patients with stress urinary incontinence (SUI). The guideline has been amended to reflect changes in and additions to the literature since 2017. Differentiation between index and non-index patients is maintained, with non-index patients having factors that may affect their treatment options and outcomes. Future reviews of this guideline will be conducted to ensure the highest levels of patient care.
JOURNAL OF UROLOGY
(2023)
Article
Medicine, General & Internal
Claire Snyder, Alexandra Gilbert, David Moher, Derek Kyte, Ellie Daniels, Madeleine King, Melanie Calvert, Ronald C. Chen, Michael Brundage
Summary: This paper offers practical recommendations from an international consortium of experts on patient reported outcomes to guide grant applicants in preparing their research strategies and grant reviewers in evaluating applications.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Sport Sciences
Elena Sonsoles Rodriguez-Lopez, Sofia Olivia Calvo-Moreno, Angel Basas-Garcia, Fernando Gutierrez-Ortega, Jesus Guodemar-Perez, Maria Barbano Acevedo-Gomez
Summary: The prevalence of urinary incontinence among elite athletes was found to be 33%, with higher rates in females compared to males and variations depending on the type of sports practiced.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Review
Multidisciplinary Sciences
L. Santisteban, M. Teremetz, J. Irazusta, P. G. Lindberg, A. Rodriguez-Larrad
Summary: In 46 RCTs, 69 different outcome measures were identified. The most commonly used outcome measures were the 6-minute walking test and the Timed Up and Go test, used in 37% of the studies. Gait spatiotemporal parameters (35%) were also frequently used, primarily to assess gait speed, cadence, and step length. Fatigue was measured in 39% of the studies, while participation was assessed in 50% of the studies using a variety of scales.
Review
Oncology
Ainhoa Madariaga, Rodrigo Sanchez-Bayona, Fernanda G. Herrera, Pedro T. Ramirez, Antonio Gonzalez Martin
Summary: Drug development plays a crucial role in improving outcomes for patients with gynecologic cancers. Clinical trials should measure whether new interventions result in clinically relevant improvements compared to standard care, using reproducible and appropriate endpoints. Overall survival and quality of life are the gold standards for measuring the benefits of new therapeutic strategies. Alternative endpoints, such as progression-free survival, provide early insights into the effects of new drugs but their correlation with overall survival or quality of life in gynecologic malignancies is unclear. Additionally, time-to-event endpoints like progression-free survival two and time to second subsequent treatment are valuable for assessing disease control in the longer term.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Obstetrics & Gynecology
Amerigo Ferrari, Manila Bonciani, Eleonora Russo, Paolo Mannella, Tommaso Simoncini, Milena Vainieri
Summary: This study aimed to investigate the prevalence and risk factors of pregnancy-related urinary/fecal incontinence (UI/FI) in a large Italian population. The results showed that highly educated, aged >30, and overweight/obese women had higher incidence and severity of UI. Spontaneous tears or episiotomy were risk factors for postpartum UI, while cesarean section and pelvic floor muscle training during pregnancy were protective, especially in specific groups. Higher prevalence and severity of FI were found in overweight, aged >40, highly educated, non-Italian women, and those undergoing tears.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, General & Internal
Saangyoung E. Lee, Zainab Farzal, Adam J. Kimple, Ramon Moreno-Luna, Brent A. Senior, Brian D. Thorp, Charles S. Ebert
Summary: This study aims to evaluate the accessibility and readability of Spanish PROMs used to evaluate rhinosinusitis. The results indicate that most Spanish PROMs used for assessment of rhinosinusitis are above the recommended readability level. Future development of PROMs should ensure appropriate readability levels to provide good patient-centered care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Pervez Sultan, Nadir Sharawi, Lindsay Blake, Kazuo Ando, Ellile Sultan, Nima Aghaeepour, Brendan Carvalho, Nishant Sadana
Summary: This study evaluated patient-reported outcome measures (PROMs) for outpatient postpartum recovery and found that the best-performing PROMs currently available are the Maternal Concerns Questionnaire, the Postpartum Quality of Life tool, and the World Health Organization Quality of Life-BREF. Future research should focus on developing and validating a new comprehensive PROM for evaluating outpatient postpartum recovery.