Article
Medicine, General & Internal
Hueih-Ling Ong, Hann-Chorng Kuo
Summary: This study evaluated the long-term effectiveness of transurethral incision of the bladder neck (TUI-BN) with or without an additional procedure for female voiding dysfunction. The success rate of the first TUI-BN was 29.4% and increased to 66.7% after combining TUI-BN and an additional procedure. TUI-BN alone or in combination with an additional procedure was safe, effective, and durable in patients with detrusor underactivity to resume spontaneous voiding.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Lori A. Birder, Amanda S. Wolf-Johnston, Irina Zabbarova, Youko Ikeda, Anne M. Robertson, Ricardo Cardozo, Fatemeh Azari, Anthony J. Kanai, George A. Kuchel, Edwin K. Jackson
Summary: This study found that chronic exposure to hypoxanthine in drinking water caused changes in voiding behavior and bladder structure in adult rats, resembling alterations observed with aging. Increased levels of hypoxanthine were associated with ROS/oxidative stress-induced cellular damage, which may play a key role in the development of age-related LUTS.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hsiang-Ying Lee, Chien-Sheng Wang, Yung-Shun Juan
Summary: This article focuses on detrusor underactivity (DU) with bladder outlet obstruction (BOO) in male patients, discussing the pathophysiology, evaluation, treatment and predictors for successful BOO surgery. The article highlights the lack of understanding and research on DU from BOO, as well as the need for effective and safe medication to restore bladder contractility. Further research to explore the unknown aspects of DU is deemed valuable.
Article
Physiology
Lipeng Chen, Linchen Lv, Lekai Zhang, Zhengdong Gao, Yaxiao Liu, Shuai Wang, Nan Zhou, Yangyang Xia, Jianfeng Cui, Xuewen Jiang, Xiulin Zhang, Yan Li, Benkang Shi
Summary: The study demonstrates that oral administration of metformin can alleviate inflammation in the bladder during the early phase of partial bladder outlet obstruction and improve bladder fibrosis and dysfunction in the long term. Metformin is suggested as a potential drug to inhibit bladder remodeling and alleviate bladder dysfunction, with the need for future clinical trials to validate its effects.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Yung-Hsiang Hsu, Hann-Chorng Kuo
Summary: The study investigated the diagnostic and prognostic value of urine biomarkers in female patients with dysfunctional voiding. The results showed that patients with DV had distinct profiles of oxidative stress biomarkers and inflammatory markers in urine, which correlated with clinical characteristics and treatment outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Tien-Lin Chang, Sheng-Fu Chen, Hann-Chorng Kuo
Summary: This study investigated the surgical outcome of patients with chronic central nervous system disorders after bladder outlet surgery. Overall, bladder outlet surgery was effective in relieving voiding dysfunction, but had limited effect on improving storage symptoms.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guangdong Liu, Cui Yang, Xin Wang, Xi Chen, Yanjiang Wang, Weidong Le
Summary: Abnormalities in oxygen metabolism play a crucial role in the development of Alzheimer's disease (AD). Chronic hypoxia, oxidative stress, and mitochondrial dysfunction exacerbate the pathological components of AD. Hyperbaric oxygen therapy shows promise in attenuating these abnormalities, but further investigation is needed to determine the optimal treatment parameters.
Article
Gastroenterology & Hepatology
Kentaro Yamao, Masayuki Kitano, Yasutaka Chiba, Takeshi Ogura, Takaaki Eguchi, Ichiro Moriyama, Yukitaka Yamashita, Hironari Kato, Takahisa Kayahara, Noriyuki Hoki, Yoshinobu Okabe, Hideyuki Shiomi, Yoshitaka Nakai, Yoshinori Kushiyama, Yoshifumi Fujimoto, Shiro Hayashi, Shigeki Bamba, Yasushi Kudo, Nobuaki Azemoto, Toshiharu Ueki, Norimitsu Uza, Masanori Asada, Kazuya Matsumoto, Hiroko Nebiki, Hiroshi Takihara, Chisio Noguchi, Hideki Kamada, Kojiro Nakase, Daisuke Goto, Tsuyoshi Sanuki, Tetsuya Koga, Shinichi Hashimoto, Hidefumi Nishikiori, Masahiro Serikawa, Keiji Hanada, Ken Hirao, Masaya Ohana, Imakiire Kazuyuki, Takao Kato, Motoyuki Yoshida, Hirofumi Kawamoto
Summary: In patients with mGOO, although overall survival rates are low, there is no significant difference in survival between covered and uncovered stents. However, the proportion of stent dysfunction is significantly higher in uncovered stents, especially in patients with extrinsic tumors. Subgroup analysis suggests using covered stents for intrinsic tumors and uncovered stents for extrinsic malignancies.
Article
Cell Biology
Ye Gao, Peilin Liu, Fan He, Xingliang Yang, Ronghua Wu, Wei Chen, Longkun Li, Zhenxing Yang
Summary: Non-invasive biomarkers are still needed to identify patients with bladder outlet obstruction (BOO)-related dysfunction. In a study involving rats and BPH patients, it was found that FGF2 is involved in the development of bladder hypertrophy in partial BOO and is positively correlated with prostate volume in BPH patients. BDNF, on the other hand, showed no correlation with prostate volume, age, or BMI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Jae Heon Kim, Hee Jo Yang, Hong J. Lee, Yun Seob Song
Summary: This study found that chronic bladder outlet obstruction in rats lead to bladder hypoxia which resulted in the upregulation and downregulation of certain genes involved in hypoxia response, indicating the important role of hypoxia in decompensated bladder in bladder outlet obstruction.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Health Care Sciences & Services
Guy Verhovsky, Ilia Baberashvili, Yishai H. Rappaport, Dorit E. Zilberman, Amos Neheman, Jonathan Gal, Amnon Zisman, Kobi Stav
Summary: The objective of this study was to assess the objective association between bladder outlet obstruction (BOO) and abnormal sensation parameters during filling cystometry in men. The results indicated a strong association between bladder oversensitivity and BOO in men. Men with first desire to void (FDV) <140 mL had a significantly increased probability of being obstructed.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Andrology
Ecem Kaya-Sezginer, Didem Yilmaz-Oral, Omer Faruk Kirlangic, Sercan Yilmaz, Fatma Zeynep Ozen, Melih Asan, Serap Gur
Summary: In a rat model of partial bladder outlet obstruction (PBOO), sodium butyrate (NaBu) was found to improve erectile function, prevent penile fibrosis, and normalize the expression of certain proteins and genes. NaBu may be a promising target for preventing erectile dysfunction (ED) in patients with benign prostate hyperplasia (BPH).
Article
Medicine, General & Internal
Jessica Jay Fang, Ming-Ping Wu, Yu-Chun Yen, Jeng-Cheng Wu, Hung-Yen Chin
Summary: The study found that nulliparous women with OAB had a significantly higher prevalence of abnormal voiding patterns, DO, and MUCP compared to parous women. Especially in nulliparous women, abnormal voiding patterns were significantly associated with DO and MUCP.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Review
Urology & Nephrology
Suzanne M. Biers, Chris Harding, Mo Belal, Nikesh Thiruchelvam, Rizwan Hamid, Arun Sahai, Richard Parkinson, Rachel Barratt, Ased Ali, Sheilagh Reid
Summary: The BAUS has issued guidelines on the assessment and management of female voiding dysfunction, covering a wide range of conditions that can cause this issue. The aim is to optimize assessment and treatment pathways for patients with voiding dysfunction, providing guidance in the absence of a known underlying neurological condition.
Review
Medicine, General & Internal
Iruru Maetani
Summary: Although endoscopic stenting is a less-invasive method for palliating malignant gastric outlet obstruction, it has some issues and controversies. Various aspects need to be assessed before treatment, and the ideal structure and mechanical properties of stents are still unclear. Chemotherapy and biliary intervention should also be considered. Many remaining issues need to be clarified in the future.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Beverly Rosa Williams, Jesse Nodora, Diane K. Newman, Lisa Kane Low, Aimee S. James, Deepa R. Camenga, Jeni Hebert-Beirne, Sonya S. Brady, Cecilia T. Hardacker, Ariana L. Smith, Shayna D. Cunningham, Kathryn L. Burgio
NEUROUROLOGY AND URODYNAMICS
(2020)
Article
Urology & Nephrology
Ariana L. Smith, Steven J. Weissbart, Siobhan M. Hartigan, Michel Bilello, Diane K. Newman, Alan J. Wein, Anna P. Malykhina, Guray Erus, Yong Fan
NEUROUROLOGY AND URODYNAMICS
(2020)
Editorial Material
Obstetrics & Gynecology
Alison Weidner
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2020)
Article
Urology & Nephrology
Giulia I. Lane, Ariana L. Smith, Hanna Stambakio, George Lin, Omar Al Hussein Alawamlh, Jennifer T. Anger, Eileen R. Brandes, Maude E. Carmel, Doreen E. Chung, Lindsey Cox, Jessica DeLong, Christopher S. Elliott, Ehab Eltahawy, Wagner Aparecido Franca, Angelo Gousse, Priyanka Gupta, Judith C. Hagedorn, Rachel A. High, Aqsa Khan, Casey Kowalik, Richard K. Lee, Una J. Lee, Alvaro Lucioni, Susan MacDonald, Bahaa Malaeb, Scotty McKay, Priya Padmanabhan, Charles R. Powell, Kamran P. Sajadi, Suzette E. Sutherland, Didi Theva, Annah Vollstedt, Blayne Welk, Yu Zheng, Anne P. Cameron
NEUROUROLOGY AND URODYNAMICS
(2020)
Article
Neurosciences
Rita J. Valentino, Raymond J. Dingledine
Summary: The cholinergic regulation of hippocampal circuit activity, characterized by diverse cellular actions of acetylcholine in different sites within hippocampal circuitry, plays a crucial role in optimizing the encoding of new information, promoting consolidation, and coordinating with recall of prior memories. Through decades of research, the foundational findings on the inhibitory effects of acetylcholine on Schaffer collaterals have become integral in understanding the cholinergic modulation of hippocampal function in learning and memory.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Urology & Nephrology
Giulia I. Lane, Alyssa Gracely, Pansy Uberoi, Una Lee, Ariana L. Smith, Jennifer T. Anger, Didi Theva, Jessica DeLong, Casey Kowalik, Priya Padmanabhan, Charles R. Powell, Maude E. Carmel, J. Quentin Clemens, Anne P. Cameron, Priyanka Gupta
Summary: The study shows that women with urethral strictures experience improvement in lower urinary tract symptoms and quality of life after surgery.
NEUROUROLOGY AND URODYNAMICS
(2021)
Article
Urology & Nephrology
Ariana L. Smith, Jingwen Chen, Jean F. Wyman, Diane K. Newman, Amanda Berry, Kathryn Schmitz, Ann E. Stapleton, Heather Klusaritz, George Lin, Hanna Stambakio, Siobhan Sutcliffe
Summary: A national online survey of bladder health was conducted among registry volunteers, revealing a high prevalence of lower urinary tract symptoms (LUTS) in women, similar to other population-based samples. The new LURN-SI-29 demonstrated its ability to detect associations with demographic and health characteristics.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Nursing
Jean F. Wyman, Charles H. Cain, C. Neill Epperson, Colleen M. Fitzgerald, Sheila Gahagan, Diane K. Newman, Kyle Rudser, Ariana L. Smith, Camille P. Vaughan, Siobhan Sutcliffe
Summary: This study used data from the BACH Survey to estimate normative reference ranges for urination frequencies in healthy women and examine the effects of age, race/ethnicity, and fluid intake. The results showed a wide range of normal urination frequencies, with some differences based on these factors. The study highlights the need for further research on urination frequencies in minority women and the impact of fluid intake on lower urinary tract symptoms.
Article
Urology & Nephrology
Ariana L. Smith, Kyle Rudser, Bernard L. Harlow, Gerald McGwin, Julia Barthold, Sonya S. Brady, Linda Brubaker, Shayna D. Cunningham, James W. Griffith, Kim Kenton, Heather Klusaritz, Cora E. Lewis, Emily S. Lukacz, Julia Maki, Alayne D. Markland, Elizabeth R. Mueller, Diane K. Newman, Jesse Nodora, Leslie M. Rickey, Todd Rockwood, Melissa Simon, Jean F. Wyman, Siobhan Sutcliffe
Summary: This study aims to understand the distribution of bladder health and the factors that promote bladder health and prevent LUTS in women. It is a population-based longitudinal cohort study conducted in the United States, involving community-dwelling women. Data collection includes self-administered surveys and objective measures. The findings will contribute to the development of interventions for bladder health promotion and LUTS prevention in women.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Pediatrics
David A. Ostrowski, Joseph R. Logan, Maria Antony, Reilly Broms, Dana A. Weiss, Jason Van Batavia, Christopher J. Long, Ariana L. Smith, Stephen A. Zderic, Rebecca C. Edwins, Raymond J. Pominville, Jessica H. Hannick, Lynn L. Woo, Yong Fan, Gregory E. Tasian, John K. Weaver
Summary: This study aimed to develop an automated CNN model to classify hydronephrosis on renal ultrasound imaging according to the SFU system. The machine learning model predicted hydronephrosis grade with 82.0% overall accuracy and classified 97.6% of the patients correctly or within one grade of the radiologist grade.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Article
Urology & Nephrology
Connie N. Wang, Irene W. Su, Ariana L. Smith, Gina M. Badalato, Doreen E. Chung
Summary: Little is known about the exposure of contemporary US urology residents to Female Pelvic Medicine and Reconstructive Surgery (FPMRS) faculty. A study found that 30% of US urology residents lack FPMRS training, and even when trained, the representation of FPMRS faculty is relatively low.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Alayne Markland, Tamara Bavendam, Charles Cain, C. Neill Epperson, Colleen M. Fitzgerald, D. Yvette LaCoursiere, David A. Shoham, Ariana L. Smith, Siobhan Sutcliffe, Kyle Rudser
Summary: This study investigated the prevalence of lower urinary tract symptoms (LUTS) across occupational groups in the Boston Area Community Health Survey and found that the workplace toileting environment may impact urination frequency. Women in Computing, Engineering, and Science were more likely to experience LUTS, while women in Education, Legal, Community Service, Arts, and Media, as well as Healthcare Practitioner and Technical Occupations, were less likely to experience frequent daytime urination.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Clinical Neurology
Rita J. Valentino, Sunila G. Nair, Nora D. Volkow
Summary: The prevention and treatment of addiction is challenging due to the complex interactions between biological and social determinants. The use of multiple drugs and different stages of addiction require a deep understanding of pharmacological interactions and neurobiological processes. Individual susceptibility to addiction varies based on multiple factors such as genetics, sex, drug exposure, and social and environmental factors. Understanding these interactions is crucial for identifying the biobehavioral basis of addiction and developing effective prevention and treatment strategies.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Urology & Nephrology
Katherine Shapiro, Jennifer Anger, Anne P. Cameron, Doreen Chung, Stephanie Daignault-Newton, Giulia M. Ippolito, Una Lee, Arthur Mourtzinos, Priya Padmanabhan, Ariana L. Smith, Anne M. Suskind, Christopher Tenggardjaja, Monica Van Til, Benjamin M. Brucker
Summary: This retrospective multi-institutional study reveals significant variations in antibiotic regimens and adherence to the 2008 AUA BPS among providers, with lower rates of concordant antibiotic use in the office setting. The incidence of UTI within 30 days following BTX-A injection did not significantly differ based on concordance with the BPS or procedure setting.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Public, Environmental & Occupational Health
Sonya S. Brady, Linda Brubaker, Cynthia S. Fok, Sheila Gahagan, Cora E. Lewis, Jessica Lewis, Jerry L. Lowder, Jesse Nodora, Ann Stapleton, Mary H. Palmer
HEALTH PROMOTION PRACTICE
(2020)
