Article
Biochemistry & Molecular Biology
Haelim Jeong, Jun Young Park, Ji-Hyun Lee, Ja-Hyun Baik, Chae-Yeon Kim, Jin-Young Cho, Monica Driscoll, Young-Ki Paik
Summary: The discovery of rcat-1 as a novel negative transcriptional regulator for dopamine metabolism genes has provided insights into the regulation of food search-associated locomotion. The mutants of rcat-1 exhibit abnormal movement behaviors and potential deficiencies in food sensing or locomotion toward food. This finding not only identifies a new subtype of dopamine-related behaviors but also suggests a potential therapeutic target in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
V. Mesa-Infante, D. Afonso-Oramas, J. Salas-Hernandez, J. Rodriguez-Nunez, P. Barroso-Chinea
Summary: Research suggests that short-term GDNF treatment enhances rat midbrain neuronal activity, whereas long-term or high-dose continuous treatment can lead to degeneration. The need for more effective long-acting therapeutic approaches to manage the beneficial effects of GDNF in relevant diseases is highlighted.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Yifei Yang, Dawei Yu, Xiaoyin Zhu, Guangying Du, Wenyan Wang, Fangxia Zou, Hongbo Wang, Rui Zhang, Liang Ye, Jingwei Tian
Summary: A novel series of dihydrotetrabenazine derivative analogs were synthesized and evaluated for their effects on VMAT2, with compound 13e showing promising affinity and inhibition. This compound also exhibited increased stability compared to other VMAT2 inhibitors and effectively suppressed locomotor activity in rats, suggesting its potential as a lead compound for TD treatment development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Virology
George Mpekoulis, Vassilina Tsopela, Anna Chalari, Katerina Kalliampakou, Georgios Panos, Efseveia Frakolaki, Raphaela S. Milona, Diamantis C. Sideris, Dido Vassilacopoulou, Niki Vassilaki
Summary: This study reveals the association between catecholamine biosynthesis/metabolism and Dengue virus replication. The production and uptake of biogenic amines impede DV replication, while the virus reduces catecholamine biosynthesis, metabolism, and transport. Altering the expression of L-Dopa decarboxylase (DDC) enhances virus replication, suggesting a negative effect of DDC on DV. In addition, the study demonstrates that dopamine uptake, rather than dopamine signaling, is responsible for the negative effect on DV.
Review
Behavioral Sciences
Gabriella E. DiCarlo, Mark T. Wallace
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted interests/repetitive behaviors. Over 1000 genes and 2000 copy number variants have been implicated in ASD. It is believed that there is not a single genetic cause or neurobiological basis for ASD, but rather multiple subtypes with different genetic and neurobiological perturbations. Dopamine dysfunction may be one potential subtype associated with ASD. This research provides a framework for subcategorizing ASD based on genetic changes, neurobiological differences, and behavioral features.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Maxime Fougere, Cornelis Immanuel van der Zouwen, Joel Boutin, Dimitri Ryczko
Summary: Recent studies have identified three distinct expression patterns in dopamine neurons in mice along the rostrocaudal brain axis, providing insights into the homology of dopamine nuclei across vertebrate species.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Vindhya Nawaratne, Sean P. McLaughlin, Felix P. Mayer, Zayna Gichi, Alyssa Mastriano, Lucia Carvelli
Summary: The dopamine 2 receptors (D2R) play an important role in mediating the effects of amphetamine, which primarily rely on the ability of amphetamine to increase extracellular dopamine. This study found that prolonged exposure to amphetamine can decrease or increase endogenous hD2R at the cellular membrane in HEK293 cells. Moreover, the effects of amphetamine on D2R expression may occur independently of dopamine and DAT.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Fei Zeng, Yan Fan, Russell W. Brown, Wesley Drew Gill, Jennifer B. Price, Thomas C. Jones, Meng-Yang Zhu
Summary: This study found that enhancing noradrenergic activity in the brain can improve the function of dopaminergic neurons in aged animals, potentially indicating biochemical therapeutic benefits but not necessarily behavioral improvements.
Article
Biochemistry & Molecular Biology
Hyomin Ahn, Kichul Park, Dongyoung Kim, Sung-Gil Chi, Kee-Hyun Choi, Seo-Jung Han, Chiman Song
Summary: This study examines the pharmacological properties of selective reuptake inhibitors for dopamine, norepinephrine, and serotonin and finds antagonistic effects when they are used in combination. Furthermore, it suggests the presence of a potential secondary inhibitor binding site that affects inhibition.
Article
Neurosciences
Isabel Perez-Santos, Nicola Palomero-Gallagher, Karl Zilles, Carmen Cavada
Summary: The study reveals that Noradrenaline (NA) plays important roles in modulating thalamic functions related to consciousness, emotion, cognition, and executive functions, with different levels of innervation and receptor densities across thalamic nuclei. The findings suggest a close relationship between NA axonal densities and Alpha adrenoceptor densities in the thalamus.
Article
Biochemistry & Molecular Biology
Matheus C. Bianchini, Luiz F. W. Soares, Joao M. F. M. Sousa, Bruna P. Ramborger, Mateus C. Gayer, Jessika C. Bridi, Rafael Roehrs, Simone Pinton, Michael Aschner, Daiana S. Avila, Robson L. Puntel
Summary: This study found that exposure to methylmercury in fruit flies led to reduced survival rate, decreased levels of dopamine and octopamine, and changes in behavior. These effects were associated with inhibition of acetylcholinesterase and tyrosine hydroxylase, increased oxidative stress, and altered glutathione-S-transferase activity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma O'Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan W. Logan, Jill R. Glausier, Kenneth N. Fish, David A. Lewis, J. Timothy Greenamyre, Brian D. McCabe, Claire E. J. Cheetham, Thomas S. Hnasko, Zachary Freyberg
Summary: The study revealed the impact of age and sex differences on dopamine neuron vulnerability, with males exhibiting greater decreases in neuron number and locomotion during aging, and dynamic changes in VGLUT expression in dopamine neurons possibly serving as a compensatory mechanism. Female fruit flies were found to possess higher levels of VGLUT expression in dopamine neurons compared to males, and diminishing VGLUT expression eliminated their greater resilience to neuron loss. Optimal control over VGLUT expression in dopamine neurons was identified as essential for neuron survival and a potential therapeutic target for age- and PD-related neurodegeneration.
Article
Neurosciences
Maddison Reed, Wen Pan, Lina Musa, Stefania Arlotta, Jan A. Mennigen, Michael G. Jonz
Summary: Dopamine plays a role in oxygen sensing and autonomous ventilation control in aquatic vertebrates. This study provides evidence that dopamine is synthesized and stored by sensory nerve terminals that innervate chemoreceptive neuroepithelial cells (NECs) in the gills. The D2 receptors on NECs act as a feedback mechanism to attenuate the chemoreceptor response to hypoxia. These findings suggest a fundamental, modulatory role for dopamine in oxygen sensing early in vertebrate evolution.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Review
Clinical Neurology
Emily Behling, Luis C. Farhat, Angeli Landeros-Weisenberger, Michael H. Bloch
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy, acceptability, and tolerability of Vesicular monoamine transporter type 2 (VMAT2) inhibitors for chronic tic disorders (CTD), including Tourette syndrome (TS). The results showed that VMAT2 inhibitors did not have a significant effect on the short-term treatment of tic disorders and had no clinically meaningful impact on tic symptoms, but there were some adverse effects on tolerability and acceptability.
MOVEMENT DISORDERS
(2022)
Article
Cell Biology
Joseph J. Lebowitz, Aditi Banerjee, Claire Qiao, James R. Bunzow, John T. Williams, Pascal S. Kaeser
Summary: In this study, mouse genetics and whole-cell electrophysiology were used to demonstrate that the fast calcium sensor Synaptotagmin-1 (Syt-1) plays a crucial role in somatodendritic dopamine release. Ablation of Syt-1 from dopamine neurons significantly reduced stimulus-evoked D2 receptor-mediated inhibitory postsynaptic currents (D2-IPSCs), while D2-IPSCs evoked by paired stimuli exhibited less depression and high-frequency trains restored dopamine release.
Article
Biochemistry & Molecular Biology
Miguel Cabanillas-Gamez, Ulises Bardullas, Mario A. Galaviz, Sergio Rodriguez, Veronica M. Rodriguez, Lus M. Lopez
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2020)
Article
Behavioral Sciences
Pamela Reyes-Ortega, Durairaj Ragu Varman, Veronica M. Rodriguez, Daniel Reyes-Haro
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Toxicology
M. E. Chavez-Pichardo, D. Y. Reyes-Bravo, M. S. Mendoza-Trejo, A. G. Marin-Lopez, M. Giordano, N. Hernandez-Chan, K. Dominguez-Marchan, L. C. Ortega-Rosales, V. M. Rodriguez
ARCHIVES OF TOXICOLOGY
(2020)
Article
Environmental Sciences
Isela Hernandez-Plata, Veronica M. Rodriguez, Efrain Tovar-Sanchez, Leticia Carrizalez, Patricia Villalobos, Maria Soledad Mendoza-Trejo, Patricia Mussali-Galante
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Neurosciences
Fernando Lizcano-Cortes, Jalil Rasgado-Toledo, Averi Giudicessi, Magda Giordano
Summary: This study did not find statistically significant associations between Theory of Mind (ToM) performance and brain structural measures after correction. Results suggest that in neurotypical and homogeneous populations, a reliable association between brain anatomy measures and ToM performance, as measured with specific tasks, may be unlikely to be found.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Guillermo Valera-Marin, Larry J. Young, Francisco Camacho, Raul G. Paredes, Veronica M. Rodriguez, Nestor F. Diaz, Wendy Portillo
Summary: The study compared the effects of biparental and monoparental care on the offspring of prairie voles, finding that voles raised by a single parent showed a delay in pair bond formation. Despite no developmental differences, the monoparental voles received less licking/grooming behavior, which may lead to the sexual interaction being less rewarding.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Jalil Rasgado-Toledo, Fernando Lizcano-Cortes, Victor Enrique Olalde-Mathieu, Giovanna Licea-Haquet, Miguel Angel Zamora-Ursulo, Magda Giordano, Azalea Reyes-Aguilar
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Neurosciences
Maribel Delgado-Herrera, Azalea Reyes-Aguilar, Magda Giordano
Summary: This study systematically examined deception tasks and classified them based on their ecological validity. The results showed that intention to lie was the least included component, while monetary reward was the most common motivator. Meta-analysis revealed that tasks with high ecological validity recruited fewer brain areas, suggesting they may be more natural and realistic.
Article
Neurosciences
G. L. Licea-Haquet, A. Reyes-Aguilar, S. Alcauter, M. Giordano
Summary: Pragmatic competence requires linguistic, communicative, social, and cognitive competence. Successful language use in social interaction necessitates mutual understanding of the speaker's intentions, with speech act recognition involving inferring intention, executive functions, and activation of social cognition areas.
Correction
Linguistics
G. L. Licea-Haquet, E. P. Velasquez-Upegui, T. Holtgraves, M. Giordano
JOURNAL OF PRAGMATICS
(2021)
Article
Behavioral Sciences
Pamela Reyes-Ortega, Maria Berenice Soria-Ortiz, Veronica M. Rodriguez, Eva Olivia Vazquez-Martinez, Mauricio Diaz-Munoz, Daniel Reyes-Haro
Summary: In this study, researchers found that anorexia disrupts glutamate-glutamine homeostasis associated with astrocyte dysfunction in the prefrontal cortex of young female rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Elizabeth Valles-Capetillo, Cristian Ibarra, Domingo Martinez, Magda Giordano
Summary: An irony identification task was created and evaluated for use in neuroimaging studies. The study found that contextual discrepancy, prosody, and facial expression were relevant cues for detecting ironic statements. However, the correlation between irony comprehension and cognitive functions did not yield consistent results.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jorge Humberto Limon Pacheco, Guillermo Elizondo
Summary: Breast cancer is a common malignancy among women worldwide, and estrogen exposure as well as the dysregulation of AHR and IDO/TDO/KYN pathways play important roles in its development. The interaction between E2-AHR-IDO/TDO/KYN pathways has an immunosuppressive effect on the immune system in breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Toxicology
D. Y. Reyes-Bravo, P. Villalobos-Aguilera, J. T. Almonte-Zepeda, M. S. Mendoza-Trejo, M. Giordano, A. Orozco, V. M. Rodriguez
Summary: The herbicide atrazine has effects on the GABAergic and glutamatergic systems in rats, leading to increased expression of related genes. These findings suggest that the GABAergic and glutamatergic systems are targets of ATR exposure.
FRONTIERS IN TOXICOLOGY
(2022)