Article
Entomology
Ingrid S. Kaiser, Rubens H. Kanno, Anderson Bolzan, Fernando S. A. Amaral, Ewerton C. Lira, Aline S. Guidolin, Celso Omoto
Summary: The study demonstrated that Spodoptera frugiperda in Brazil exhibited low resistance to the sodium channel blocker insecticides indoxacarb and metaflumizone, with no cross-resistance observed with other insecticides and Bt proteins. This suggests that these insecticides could be important tools in resistance management strategies for S. frugiperda in Brazil.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2021)
Article
Entomology
Xingliang Wang, Jianheng Zhang, Yihua Yang, Yidong Wu
Summary: Two point mutations in the voltage-gated sodium channel gene of Plutella xylostella were found to be involved in resistance to sodium channel blocker insecticides. The resistance was determined to be inherited in different modes for each mutation. This study contributes to the understanding of resistance mechanisms and inheritance patterns in P. xylostella.
Article
Agronomy
Yu-Jie Wu, Bing-Jie Wang, Meng-Ru Wang, Ying-Chuan Peng, Hai-Qun Cao, Cheng-Wang Sheng
Summary: The study found that metaflumizone demonstrated stronger insecticidal effect than indoxacarb on fall armyworm larvae. The mixture of metaflumizone and chlorantraniliprole showed the highest synergistic effect against fall armyworm with a co-toxicity coefficient of 317.18, while the best synergistic effect for mixtures of metaflumizone and indoxacarb was observed at a ratio of 1:9 with a CTC of 185.98. The field trial results showed that metaflumizone mixed with chlorantraniliprole or indoxacarb at a 50% reduction in application rate effectively controlled fall armyworm with efficacy ranging from 77.73% to 94.65% within 1-7 days postapplication.
PEST MANAGEMENT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Fen Li, Xueyan Gong, Linlin Yuan, Xuelian Pan, Haifeng Jin, Rongcai Lu, Shaoying Wu
Summary: Liriomyza trifolii, a pest recently prevalent in China, has caused harm to over 300 plant species, particularly cowpea in Hainan. The field population of L. trifolii has developed high resistance to the insecticide indoxacarb, with a mutation in the sodium channel being responsible for this resistance. This study is significant for understanding the evolution of resistance and developing resistance management practices.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Molly O'Reilly, Laura C. Sommerfeld, C. O'Shea, S. Broadway-Stringer, S. Andaleeb, J. S. Reyat, S. N. Kabir, D. Stastny, A. Malinova, D. Delbue, L. Fortmueller, K. Gehmlich, D. Pavlovic, B. Skryabin, A. P. Holmes, P. Kirchhof, L. Fabritz
Summary: This study found that the point mutation M1875T in the SCN5A gene is associated with familial AF. A new mouse model was used to show that this mutation causes gain-of-function of the cardiac sodium channel, resulting in increased atrial excitability.
Article
Entomology
Shao-Hung Lee, Dong-Hwan Choe, Michael K. Rust, Chow-Yang Lee
Summary: Gel bait insecticides are commonly used to control German cockroaches, but their effectiveness is decreasing. This study found multiple resistance to all tested commercial bait insecticides except Optigard in field strains of German cockroaches.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beata Niklas, Jakub Rydzewski, Bruno Lapied, Wieslaw Nowak
Summary: Diseases spread by mosquitoes cause 700,000 deaths each year. The most effective method to reduce transmission is to prevent mosquito bites with chemicals, but the commonly used insecticides are becoming less effective due to resistance. This study identified the most probable entry route of an insecticide to the mosquito sodium channel, providing insights into its mechanism of action and resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zachery M. Wolfe, Michael E. Scharf
Summary: This study investigates the metabolic processes inside the gut of German cockroaches after treatment with antibiotics and insecticides, revealing the potential role of gut microbes in insecticide activation.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Environmental Sciences
Xi Yang, Muhammad Hafeez, Hong-Yu Chen, Wan-Ting Li, Rong-Jie Ren, Yu-Sen Luo, Yousif Abdelrahman Yousif Abdellah, Rui-Long Wang
Summary: This study assessed the multi-resistance and resistance mechanisms of Spodoptera litura to indoxacarb, a novel oxadiazine insecticide. The researchers found that DIMBOA-pretreated larvae also developed high resistance to other insecticides. The study further highlighted the importance of detoxification enzymes in S. litura gene expression and their role in responses to insecticides and pest management approaches.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Clinical Neurology
Kristopher M. Kahlig, Liam Scott, Robert J. Hatch, Andrew Griffin, Gabriel Martinez Botella, Zoe A. Hughes, Marion Wittmann
Summary: This study investigated the effects of PRAX-562 on sodium current, neuronal excitability, and protection from evoked seizures. PRAX-562 demonstrated potent inhibition of persistent sodium current and significantly improved tolerability compared to standard sodium channel blockers. It showed robust preclinical anticonvulsant activity and potentially represents a differentiated therapeutic option for hyperexcitability disorders.
Article
Parasitology
Daniel N. Munywoki, Elizabeth D. Kokwaro, Joseph M. Mwangangi, Ephantus J. Muturi, Charles M. Mbogo
Summary: The study found that Anopheles arabiensis was the dominant species in coastal Kenya, showing resistance to deltamethrin and fenitrothion. A low level of the L1014S kdr mutation was detected in some An. gambiae (s.s.), which may contribute to the resistance to pyrethroids. These findings could inform insecticide resistance management strategies in the Kenyan Coast.
PARASITES & VECTORS
(2021)
Review
Chemistry, Medicinal
James R. Groome
Summary: This article reviews the study of marine toxins, particularly on their actions on sodium ion channels regulated by transmembrane voltage and neurotransmitters. The focus is on the diverse conotoxin peptides and their potential applications in evolutionary relationships, biological actions, disease therapy, and understanding the structure of ion channels at the atomic level.
Article
Behavioral Sciences
Takeshi Suzuki, Jun Natsume, Sumire Kumai, Yuki Maki, Hiroyuki Yamamoto, Shingo Numoto, Sho Narahara, Tetsuo Kubota, Takeshi Tsuji, Toru Kato, Keitaro Yamada, Koichi Maruyama, Akihisa Okumura, Yoshiyuki Takahashi, Hiroyuki Kidokoro
Summary: In this multicenter study, lacosamide was found to be effective in 30% of children and young adults with epilepsy who had not responded to other sodium channel blockers. The effectiveness and tolerability of lacosamide differed when used concurrently with different sodium channel blockers.
EPILEPSY & BEHAVIOR
(2021)
Article
Entomology
Huan-Huan Wang, Rui Zhao, Shuai Zhang, Jie Gao, Xing Xiao, Xin-Yao Tian, Pei Liang, Shao-Hua Gu
Summary: The fall armyworm (FAW) is a destructive agricultural pest that poses a serious threat to global food security. Current control measures in China rely on chemical insecticides, but this may lead to insecticide resistance in FAW. This study found that a new insecticide called broflanilide was effective against FAW, but resistance was detected in some populations. Combining broflanilide with other insecticides showed promising results in improving FAW control and delaying resistance development.
ENTOMOLOGIA GENERALIS
(2023)
Article
Cardiac & Cardiovascular Systems
Greg J. Mellor, Lennart J. Blom, Sanne A. Groeneveld, Bo G. Winkel, Bode Ensam, Johannes Bargehr, Bianca van Rees, Chiara Scrocco, Ingrid P. C. Krapels, Paul G. A. Volders, Jacob Tfelt-Hansen, Andrew D. Krahn, Rutger J. Hassink, Elijah R. Behr
Summary: While family screening in relatives of IVF probands yield low results when the proband is comprehensively investigated, the significance of J wave syndromes in relatives and the role for systematic sodium channel blocker provocation are uncertain and require further research.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Review
Agronomy
Anastasia M. W. Cooper, Kristopher Silver, Jianzhen Zhang, Yoonseong Park, Kun Yan Zhu
PEST MANAGEMENT SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Jiao Liu, Haihua Wu, Xueyao Zhang, Wen Ma, Wenya Zhu, Kristopher Silver, Enbo Ma, Jianzhen Zhang, Kun Yan Zhu
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Xiaojian Liu, Anastasia M. W. Cooper, Zhitao Yu, Kristopher Silver, Jianzhen Zhang, Kun Yan Zhu
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2019)
Article
Entomology
Jianxiu Yao, Chengyu Chen, Hua Wu, Jing Chang, Kristopher Silver, James F. Campbell, Frank H. Arthur, Kun Yan Zhu
JOURNAL OF STORED PRODUCTS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Anastasia M. W. Cooper, Zhitao Yu, Marie Biondi, Huifang Song, Kristopher Silver, Jianzhen Zhang, Kun Yan Zhu
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2020)
Article
Agronomy
Anastasia M. W. Cooper, Huifang Song, Zhitao Yu, Marie Biondi, Jun Bai, Xuekai Shi, Zhaoyang Ren, Sahani M. Weerasekara, Duy H. Hua, Kristopher Silver, Jianzhen Zhang, Kun Yan Zhu
Summary: The study found that while certain reagents can enhance the stability of dsRNA in ECB insects, they do not significantly improve RNAi efficiency. In vivo and ex vivo experiments showed variations in RNAi efficiency among different target genes, with some refractory genes remaining unaffected by nuclease inhibitors.
PEST MANAGEMENT SCIENCE
(2021)
Article
Entomology
Anastasia M. W. Cooper, Huifang Song, Xuekai Shi, Zhitao Yu, Marce Lorenzen, Kristopher Silver, Jianzhen Zhang, Kun Yan Zhu
Article
Entomology
Yun-He Fan, Hui-Fang Song, Mureed Abbas, Yan-Li Wang, Tao Li, En-Bo Ma, Anastasia M. W. Cooper, Kristopher Silver, Kun Yan Zhu, Jian-Zhen Zhang
Summary: The study identified four dsRNase genes from the Asian corn borer transcriptome database, with OfdsRNase2 exclusively expressed in the midgut of larvae. It was found that OfdsRNase2 contributes to low RNAi efficiency in larvae by degrading dsRNA, confirmed through RNAi-of-RNAi experiments and in vitro luciferase assays.
Review
Agronomy
Kristopher Silver, Anastasia M. W. Cooper, Kun Yan Zhu
Summary: The article provides a comprehensive review of strategies for enhancing RNAi efficiency in insect pests, focusing on target gene selection and dsRNA delivery technologies. Recent research has focused on genome-wide screening for target gene selection and designing dsRNA constructs for maximal efficiency. In terms of dsRNA delivery, research has explored complexing or encapsulating dsRNA using various agents to enhance stability and uptake, as well as genetic engineering of microbes and plants for insect-specific dsRNA production.
PEST MANAGEMENT SCIENCE
(2021)
Article
Entomology
Anastasia M. W. Cooper, Huifang Song, Xuekai Shi, Zhitao Yu, Marce Lorenzen, Kristopher Silver, Jianzhen Zhang, Kun Yan Zhu
Summary: The efficiency and variability of RNAi in the European corn borer have been hindered by differences in the expression and function of core RNAi pathway genes, potentially leading to low efficiency. Variations in amino acid sequences in specific domains of core RNAi proteins in the European corn borer may contribute to functional differences, affecting RNAi efficiency.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anastasia M. W. Cooper, Huifang Song, Xuekai Shi, Zhitao Yu, Young Ho Kim, Kristopher Silver, Jianzhen Zhang, Kun Yan Zhu
Summary: High specificity for silencing target genes and single-copy target genes that yield clear phenotypes are crucial for successful RNA interference (RNAi). While the lethal giant larvae (Lgl) gene seems to be an ideal target for RNAi in insects, the study found that RNAi-mediated suppression of DvLgl in Diabrotica virgifera virgifera did not produce a phenotype, highlighting the variability in RNAi response among insects.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Entomology
Mureed Abbas, Yun-He Fan, Xue-Kai Shi, Lu Gao, Yan-Li Wang, Tao Li, Anastasia M. W. Cooper, Kristopher Silver, Kun Yan Zhu, Jian-Zhen Zhang
Summary: Analysis of Rab family genes in migratory locusts reveals their conservation and tissue-specific expression patterns. RNA interference experiments demonstrate that certain Rab genes are essential for survival and development in insects, with different genes contributing to RNAi efficiency in different tissues.
Article
Agronomy
Xuekai Shi, Xiaojian Liu, Anastasia Mw Cooper, Kristopher Silver, Hans Merzendorfer, Kun Yan Zhu, Jianzhen Zhang
Summary: This study identified and characterized the V-ATPase-c gene in Locusta migratoria and found that it is primarily expressed in the Malpighian tubules. The silencing of LmV-ATPase-c resulted in severe molting defects and impaired RNA interference efficiency in the insect. These findings suggest that LmV-ATPase-c plays a crucial role in cuticle formation and dsRNA escape.
PEST MANAGEMENT SCIENCE
(2022)
Article
Entomology
Haoliang Chen, Chengyu Chen, Zhitao Yu, Kristopher Silver, James F. Campbell, Frank H. Arthur, Yong Huang, Fei Hu, Kun Yan Zhu
Summary: This study revealed that genes such as CYP4G7, CYP9Z5, CYP4BR3, and CYP345A1 contribute significantly to the differential insecticide susceptibilities between the red flour beetle and the confused flour beetle. This is the first study to uncover the molecular mechanisms behind the different insecticide susceptibilities between these two Tribolium species.
JOURNAL OF STORED PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lu Gao, Yanli Wang, Yunhe Fan, Mureed Abbas, Enbo Ma, Anastasia M. W. Cooper, Kristopher Silver, Kun Yan Zhu, Jianzhen Zhang
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2020)