Article
Agriculture, Multidisciplinary
Xiao-Qing Zhang, Ding-Ze Mang, Hui Liao, Jia Ye, Jia-Li Qian, Shuang-Lin Dong, Ya-Nan Zhang, Peng He, Qing-He Zhang, Endang R. Purba, Long-Wa Zhang
Summary: Hyphantria cunea is an invasive pest species in China that uses type II sex pheromone components. In this study, the binding mechanisms of its sex pheromone components to their respective pheromone-binding proteins were explored. The results showed that HcunPBPs have different selectivities for pheromone components with major and minor structural differences, providing insight into the olfactory mechanism of moths using type II pheromone components.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: This study discusses the role of fatty-acid-binding proteins (FABPs) in psoriasis and their potential as markers. Due to the different expressions and functions of FABPs in various tissues, they may be associated with psoriasis and its comorbidities.
Article
Nutrition & Dietetics
Guojun Wu, Hiba R. Tawfeeq, Atreju I. Lackey, Yinxiu Zhou, Zoe Sifnakis, Sophia M. Zacharisen, Heli Xu, Justine M. Doran, Harini Sampath, Liping Zhao, Yan Y. Lam, Judith Storch
Summary: This study investigated the effects of LFABP and IFABP deficiency on the gut microbiota in mice, and found that these changes were associated with phenotypic changes induced by a high-fat diet.
Article
Cell Biology
Liang-Ti Huang, Hsiu-Chu Chou, Chung-Ming Chen
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants characterized by interrupted alveologenesis and alveolar simplification due to oxygen therapy. The study found that the FABP4 inhibitor BMS309403 can regulate pulmonary fibrotic processes in newborn rats exposed to hyperoxia, reducing lung fibrosis and expression of TGF-beta 1. The inhibition of FABP4 showed potential clinical and therapeutic applications in attenuating hyperoxia-induced lung impairments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Physiology
Xia Guo, Ning Xuan, Guoxia Liu, Hongyan Xie, Qinian Lou, Philippe Arnaud, Bernard Offmann, Jean-Francois Picimbon
Summary: The study found that male responsiveness to female sex pheromone in silkmoths is not influenced by age, while the expression of OBPs varies with age. Exposure to insecticides affects the expression of OBPs, indicating potential non-olfactory functions for these proteins. Docking studies showed that PBP1 and GOBP2 can bind to vitamin K1 and multiple other vitamins.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiqiang Chen, Xu Zou, Weixing Zhu, Yanwei Duan, Hans Merzendorfer, Zhangwu Zhao, Qing Yang
Summary: Chitin is a major polysaccharide found in arthropods such as insects and mites, and its biosynthesis is not fully understood. This study reveals that fatty acid binding protein (Fabp) interacts with chitin synthase Kkv and plays an important role in chitin synthesis. Fabp knockdown in fruit flies resulted in developmental abnormalities and wing defects, indicating its significance in insect chitin biosynthesis.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Medicinal
Hamid Reza Kalhor, Elham Taghikhani
Summary: The study investigated the effect of commonly used drugs on the release of warfarin bound to HSA in silico. Both s-ibuprofen and ascorbic acid were found to exhibit allosteric effects on the release of warfarin from HSA, with ibuprofen showing a stabilizing effect and ascorbic acid aiding in the release through destabilization of HSA. Molecular dynamics simulations provided valuable insights into the interactions of drugs with the protein and the mechanism of anticoagulant release.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Biochemistry & Molecular Biology
Yongzhi Zhong, Minghui Xie, Zhongjuan Di, Fengqi Li, Jiaqi Chen, Xiangxin Kong, Lulu Lin, Weihua Su, Lina Xu, Feng Zhang, Rui Tang, Haoliang Chen
Summary: The study reveals that male adults of the Chinese population of Spodoptera frugiperda are more sensitive to the four components of sex pheromones compared to female adults. This difference may be attributed to the higher expression levels of SfruPBP1 and SfruPBP2 in male adults. SfruPBP1 plays a key role in sex pheromone discrimination. These findings contribute to the development of behavioral-mediating tools for integrated pest management.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yu-Xiao Si, Jin-Meng Guo, Hui Liao, Yu Li, Yu Ma, Yu-Wei Zhu, Zhi-Qiang Wei, Shuang-Lin Dong, Qi Yan
Summary: This study demonstrates for the first time the differential recognition of sex pheromone components by three pheromone-binding proteins (PBPs) in a moth using mixed-type sex pheromones. The PBPs in Orthaga achatina showed highly male-biased expression in antennae and different binding affinities to different sex pheromone components. Key amino acid residues involved in the binding of sex pheromone components were also identified in the PBPs.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
William George Warren, Myles Osborn, Andy Yates, Karen Wright, Saoirse E. O'Sullivan
Summary: Fatty acid binding protein 5 (FABP5) is an intracellular chaperone that regulates lipid metabolism and cell growth. Increased expression of FABP5 is associated with poor prognosis in tumors, and inhibiting FABP5 reduces protumoral markers, making it a potential therapeutic target. The strongest evidence base currently exists for liver, prostate, breast, brain cancers, and squamous cell carcinoma (SCC).
DRUG DISCOVERY TODAY
(2023)
Article
Engineering, Electrical & Electronic
Jun-Fei Zhang, Fan Wu, Ming-Zhu Tang, Dong-Xiao Chen, Jing Tan, Qing-Jun Liu, Hong-Liang Li
Summary: A biosensor specific for queen pheromone components was successfully constructed in this study, showing high sensitivity and specificity. The biosensor demonstrated a wide detection linear range and excellent detection capability for methyl p-hydroxy-benzoate (HOB) and vanillyl alcohol (HVA), with theoretical detection limits as low as 10(-8) mol/L. This biosensor is beneficial for the future protection and sustainability of honeybee resources.
IEEE SENSORS JOURNAL
(2021)
Article
Food Science & Technology
Vanderleia Botton, Luana Marcele Chiarello, Guilherme Alan Klunk, Dielen Marin, Luana Curbani, Marcel Jefferson Goncalves, Marcelo Diniz Vitorino
Summary: The study indicated that Cladomorphus phyllinum can be a potential source of insect-based protein, minerals, fatty acids, and amino acids. Experimental results showed that it is rich in protein and essential nutrients, and it is not toxic, suggesting that it can be used as a future food and nutritional supplement source.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Yang Zhang, Zhi Cao, Laidi Wang, Bingqiang Dong, Shangzong Qi, Xinlei Xu, Qiang Bao, Yu Zhang, Qi Xu, Guobin Chang, Guohong Chen
Summary: This study evaluated the effects of feeding time of a linseed oil diet on duck meat performance and gene expression. The results showed that linseed oil had no negative effect on duck performance or meat quality performance, but affected the composition of muscle fatty acids. Four weeks of feeding time may be a key factor in promoting the deposition of n-3 polyunsaturated fatty acids in duck meat.
Article
Biotechnology & Applied Microbiology
Djamila Onesime, Lea Vidal, Stephane Thomas, Celine Henry, Veronique Martin, Gwenaelle Andre, Piotr Kubiak, Philippe Minard, Ewelina Celinska, Jean-Marc Nicaud
Summary: Yarrowia lipolytica has been found to have a family of extracellular fatty acid binding proteins, proposed to be named eFbp1 to eFbp4. The exact mechanism of action of these proteins remains to be elucidated, but they are expected to have applications in lipid biotechnology, such as improving fatty acid production and bioconversion.
MICROBIAL CELL FACTORIES
(2022)
Article
Chemistry, Multidisciplinary
Kenshiro Hirata, Akito Kawai, Victor Tuan Giam Chuang, Keiki Sakurama, Koji Nishi, Keishi Yamasaki, Masaki Otagiri
Summary: The study found that myristate can affect the induced circular dichroism spectra of aripiprazole bound to human serum albumin, and can displace aripiprazole molecules from albumin.
Article
Developmental Biology
Thomas S. Muenz, Claudia Groh, Alban Maisonnasse, Yves Le Conte, Erika Plettner, Wolfgang Roessler
DEVELOPMENTAL NEUROBIOLOGY
(2015)
Review
Entomology
Erika Plettner, Nurit Eliash, Nitin K. Singh, Govardhana R. Pinnelli, Victoria Soroker
Article
Biochemistry & Molecular Biology
Jurgen T. Sanes, Erika Plettner
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Agriculture, Multidisciplinary
Govardhana R. Pinnelli, Nitin K. Singh, Victoria Soroker, Erika Plettner
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2016)
Article
Entomology
C. N. Hodson, Y. Yu, E. Plettner, B. D. Roitberg
MEDICAL AND VETERINARY ENTOMOLOGY
(2016)
Article
Multidisciplinary Sciences
Luis A. Alvarez, Lidija Kovacic, Javier Rodriguez, Jan-Hendrik Gosemann, Malgorzata Kubica, Gratiela G. Pircalabioru, Florian Friedmacher, Ada Cean, Alina Ghise, Mihai B. Sarandan, Prem Puri, Simon Daff, Erika Plettner, Alex von Kriegsheim, Billy Bourke, Ulla G. Knaus
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Shaima Kammoonah, Brinda Prasad, Priyadarshini Balaraman, Hemanshu Mundhadab, Ulrich Schwaneberg, Erika Plettner
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2018)
Article
Biotechnology & Applied Microbiology
Parisa Ebrahimi, Erika Plettner
Article
Entomology
Linda M. Cameron, Megan Rogers, Melissa Aalhus, Brendan Seward, Yang Yu, Erika Plettner
JOURNAL OF ECONOMIC ENTOMOLOGY
(2014)
Article
Entomology
Erin L. Clark, Rylee Isitt, Erika Plettner, Paul G. Fields, Dezene P. W. Huber
JOURNAL OF ECONOMIC ENTOMOLOGY
(2014)
Article
Multidisciplinary Sciences
Nurit Eliash, Nitin Kumar Singh, Yosef Kamer, Govardhana Reddy Pinnelli, Erika Plettner, Victoria Soroker
Article
Biochemistry & Molecular Biology
Priyadarshini Balaraman, Erika Plettner
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Article
Biochemistry & Molecular Biology
Mailyn Terrado, Mark Okon, Lawrence P. McIntosh, Erika Plettner
Article
Biochemistry & Molecular Biology
Govardhana R. Pinnelli, Erika Plettner
Summary: Fluorescent analogues of gypsy moth sex pheromone disparlure were synthesized and characterized for binding to pheromone-binding proteins LdisPBP1 and LdisPBP2. The fluorescence binding assay showed different affinities of disparlure enantiomers to the two proteins. Competitive binding assays demonstrated effective displacement of fluorescent disparlure by disparlure enantiomers.
JOURNAL OF CHEMICAL ECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuri Nagaoka, Kotone Oshiro, Yuta Yoshino, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Summary: This study investigated the effect of intercellular adhesion molecule CLDN1 on the anticancer drug sensitivity of small-cell lung cancer (SCLC) cells. It was found that overexpression of CLDN1 decreased the sensitivity of SCLC cells to anticancer drugs and enhanced their migratory capacity through the activation of the TGF-81/EMT signaling pathway. Treatment with EMT inhibitors showed potential in overcoming the reduced sensitivity to anticancer drugs in CLDN1-overexpressing SCLC cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2024)