Article
Clinical Neurology
Sophia Keins, Jessica R. Abramson, Akashleena Mallick, Juan Pablo Castello, Axana Rodriguez-Torres, Dominique Popescue, Danielle Hoffman, Christina Kourkoulis, M. Edip Gurol, Steven M. Greenberg, Christopher D. Anderson, Anand Viswanathan, Jonathan Rosand, Alessandro Biffi
Summary: Depressive symptoms after spontaneous intracerebral hemorrhage (ICH) are associated with inadequate blood pressure control. The use of selective serotonin reuptake inhibitors and norepinephrine-serotonin reuptake inhibitors antidepressants is independently associated with higher systolic blood pressure measurements.
Article
Cardiac & Cardiovascular Systems
Kristin Tveitan Larsen, Else Charlotte Sandset, Maiken Nordahl Selseth, Silje Holt Jahr, Nojoud Koubaa, Vigdis Hillestad, Espen Saxhaug Kristoffersen, Ole Morten Ronning
Summary: This study aimed to explore the interaction between antithrombotic treatment and prehospital blood pressure in patients with acute intracerebral hemorrhage. The findings showed that compared to patients without antithrombotic treatment, patients with antithrombotic treatment had stronger associations between high prehospital systolic blood pressure and in-hospital mortality, likelihood of disability improvement, and hematoma volume.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Kristin Tveitan Larsen, Maiken Nordahl Selseth, Silje Holt Jahr, Vigdis Hillestad, Nojoud Koubaa, Else Charlotte Sandset, Ole Morten Ronning, Espen Saxhaug Kristoffersen
Summary: This study investigated the relationship between prehospital blood pressure (BP) and clinical and radiological outcomes in acute intracerebral hemorrhage patients. The results showed that elevated prehospital BP parameters were associated with in-hospital death and hematoma expansion. Changes in prehospital BP were not consistently associated with outcome. A possible U-shaped association between prehospital BP and in-hospital death needs further investigation.
Article
Clinical Neurology
Jatinder S. Minhas, Tom J. Moullaali, Gabriel J. E. Rinkel, Craig S. Anderson
Summary: Blood pressure is an important factor in managing intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage. However, there are controversies surrounding the management of blood pressure for these conditions. Current research involves analyzing patient data to determine the strength and direction of blood pressure changes and provide recommendations for clinical practice and future research.
Article
Clinical Neurology
Joseph P. Broderick, James C. Grotta, Andrew M. Naidech, Thorsten Steiner, Nikola Sprigg, Kazunori Toyoda, Dar Dowlatshahi, Andrew M. Demchuk, Magdy Selim, J. Mocco, Stephan Mayer
Summary: Research in the acute management of intracerebral hemorrhage (ICH) over the past 35 years has shown that early treatment to control bleeding and minimize brain injury is crucial. However, current medical and surgical interventions have not yet shown significant benefits in large-scale trials, emphasizing the need for further research and improvement in the delivery of ICH therapies for better outcomes.
Article
Clinical Neurology
Maximilian Spruegel, Joji B. Kuramatsu, Stefan T. Gerner, Jochen A. Sembill, Dominik Madzar, Caroline Reindl, Tobias Bobinger, Tamara Mueller, Philip Hoelter, Hannes Luecking, Tobias Engelhorn, Hagen B. Huttner
Summary: This study examined the impact of age on bleeding characteristics and clinical outcomes in different types of intracerebral hemorrhage. Results showed that elderly patients had worse functional outcomes at three months, with oral anticoagulant patients having larger baseline hemorrhage volumes and hematoma enlargement compared to non-OAC patients.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Mohammad Anadani, Adnan Qureshi, Sarah Menacho, Ramesh Grandhi, Shadi Yaghi, Mouhammad A. Jumaa, Adam de Havenon
Summary: The study suggests an interaction between race/ethnicity and response to blood pressure lowering treatment after intracerebral hemorrhage, with White patients showing a potential association between intensive treatment and worse outcomes, while this association was not observed in non-White patients.
EUROPEAN STROKE JOURNAL
(2021)
Article
Clinical Neurology
Ellis S. van Etten, Kanishk Kaushik, Wilmar M. T. Jolink, Emma A. Koemans, Merel S. Ekker, Ingeborg Rasing, Sabine Voigt, Floris H. B. M. Schreuder, Suzanne C. Cannegieter, Gabriel J. E. Rinkel, Willem M. Lijfering, Catharina J. M. Klijn, Marieke J. H. Wermer
Summary: This study identifies several trigger factors, such as caffeine consumption, lifting weights, sexual activity, and Valsalva maneuvers, that increase the risk of spontaneous intracerebral hemorrhage (ICH). These findings provide new insights into the pathophysiology of vessel rupture resulting in ICH.
Article
Medicine, General & Internal
Laurent Puy, Adrian R. R. Parry-Jones, Else Charlotte Sandset, Dar Dowlatshahi, Wendy Ziai, Charlotte Cordonnier
Summary: Intracerebral haemorrhage (ICH) is a serious condition caused by the rupture of a cerebral vessel and the entry of blood into the brain parenchyma. It is a major cause of stroke-related mortality and dependency, with limited treatment options available. This Primer provides a comprehensive overview of the epidemiology, pathophysiology, diagnosis, and treatment of ICH, highlighting the importance of prevention and management of haematoma expansion and long-term vascular risk.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Clinical Neurology
Ronda Lun, Vignan Yogendrakumar, Greg Walker, Michel Shamy, Robert Fahed, Adnan Qureshi, Dar Dowlatshahi
Summary: The study validates revised definitions of hematoma expansion incorporating intraventricular hemorrhage expansion for predicting poor outcome, outperforming conventional definitions even after accounting for care limitations.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Lotte Sondag, Axel Wolsink, Wilmar M. T. Jolink, Sabine Voigt, Marianne A. A. van Walderveen, Marieke J. H. Wermer, Catharina J. M. Klijn, Floris H. B. M. Schreuder
Summary: This study investigated the association between blood pressure variability and the development of perihematomal edema after intracerebral hemorrhage. The results suggest that blood pressure variability is not associated with edema development, indicating that other mechanisms such as inflammatory processes may play a more important role.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Marcin Wiacek, Maciej Szymanski, Klaudia Walewska, Halina Bartosik-Psujek
Summary: This study aimed to evaluate the association of periprocedural blood pressure changes with symptomatic intracranial hemorrhage (sICH) and malignant brain edema (MBE) in patients undergoing endovascular treatment (EVT) for anterior circulation ischemic stroke. The results showed that a decrease in mean arterial blood pressure (MAP) during the procedure was associated with a higher risk of MBE occurrence, and a decrease in MAP over 40% was associated with a higher incidence of both MBE and sICH. Additionally, post-treatment elevation of systolic blood pressure (SBP) and MAP increased the risk of sICH.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Ernst Mayerhofer, Livia Parodi, Savvina Prapiadou, Rainer Malik, Jonathan Rosand, Marios K. Georgakis, Christopher D. Anderson
Summary: Integrating a genetic risk score into a clinical risk score can improve risk stratification for anticoagulation-related intracerebral hemorrhage. A prediction score incorporating genomic information is superior to a clinical risk score alone for risk stratification in anticoagulant users.
Article
Clinical Neurology
Weidong Liu, Xianbo Zhuang, Liyong Zhang
Summary: This meta-analysis of prospective studies found that increased systolic blood pressure variability is associated with a higher risk of poor functional outcomes in patients with intracerebral hemorrhage, regardless of the method used for assessment. The results suggest that systolic blood pressure variability can be a predictor of poor outcomes in this patient population.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Michael T. Mullen, Craig S. Anderson
Summary: Blood pressure is the most important modifiable risk factor for intracerebral hemorrhage. Early use of medication to achieve blood pressure control is beneficial for acute ICH recovery. Long-term use of oral antihypertensive drugs can achieve lower blood pressure goals. Sustained reduction in blood pressure is more important than the choice of antihypertensive agents.
