Strategies for treatment in Alexander disease

Drug screening to identify suppressors of GFAP expression

(2010) Woosung Cho et al.   HUMAN MOLECULAR GENETICS

Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition

(2010) Guomei Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

(2010) Rujin Tian et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

(2009) Fiona M. Menzies et al.   BRAIN

Proteasome Regulators: Activators and Inhibitors

(2009) Li Huang et al.   CURRENT MEDICINAL CHEMISTRY

Suppression of GFAP toxicity by αB-crystallin in mouse models of Alexander disease

(2009) Tracy L. Hagemann et al.   HUMAN MOLECULAR GENETICS

Dysfunctions of neuronal and glial intermediate filaments in disease

(2009) Ronald K.H. Liem et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual transgenic reporter mice as a tool for monitoring expression of glial fibrillary acidic protein

(2009) Woosung Cho et al.   JOURNAL OF NEUROCHEMISTRY

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

(2009) S. E. Lutz et al.   JOURNAL OF NEUROSCIENCE

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceftriaxone has a therapeutic role in Alexander disease

(2009) GianPietro Sechi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Mild functional effects of a novel GFAP mutant allele identified in a familial case of adult-onset Alexander disease

(2008) Tiziana Bachetti et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice

(2008) Woosung Cho et al.   EXPERIMENTAL CELL RESEARCH

Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways

(2008) G. Tang et al.   HUMAN MOLECULAR GENETICS

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1

(2008) Amanda L. Sheldon et al.   NEUROCHEMISTRY INTERNATIONAL

A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

(2008) Nico Melzer et al.   PLoS One

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester

(2007) Bala T.S. Susarla et al.   NEUROCHEMISTRY INTERNATIONAL