Targeted therapy for malignant glioma patients: Lessons learned and the road ahead

Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors

(2011) Arkaitz Carracedo et al.   CELL CYCLE

EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

(2009) Q.-W. Fan et al.   Science Signaling

Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for Dimerization

(2008) Judith Schmiedel et al.   CANCER CELL

S6K1 Plays a Key Role in Glial Transformation

(2008) J. L. Nakamura et al.   CANCER RESEARCH

Identification of p18INK4c as a Tumor Suppressor Gene in Glioblastoma Multiforme

(2008) D. A. Solomon et al.   CANCER RESEARCH

Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas

(2008) C.-H. Kwon et al.   CANCER RESEARCH

p53 Small-Molecule Inhibitor Enhances Temozolomide Cytotoxic Activity against Intracranial Glioblastoma Xenografts

(2008) E. B. Dinca et al.   CANCER RESEARCH

DNA repair and cancer stem-like cells – Potential partners in glioma drug resistance?

(2008) Tor-Christian Aase Johannessen et al.   CANCER TREATMENT REVIEWS

Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2

(2008) T. Martens et al.   CLINICAL CANCER RESEARCH

Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments

(2008) A. A. Brandes et al.   CLINICAL CANCER RESEARCH

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

(2008) K. Yoshimoto et al.   CLINICAL CANCER RESEARCH

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Validation of Patient's Self-Reported Social Functioning As an Independent Prognostic Factor for Survival in Metastatic Colorectal Cancer Patients: Results of an International Study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer

(2008) Fabio Efficace et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase II Study of Vandetanib Alone or With Paclitaxel and Carboplatin as First-Line Treatment for Advanced Non–Small-Cell Lung Cancer

(2008) John V. Heymach et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Imatinib in Patients With Recurrent Gliomas of Various Histologies: A European Organisation for Research and Treatment of Cancer Brain Tumor Group Study

(2008) Eric Raymond et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I/II Trial of Erlotinib and Temozolomide With Radiation Therapy in the Treatment of Newly Diagnosed Glioblastoma Multiforme: North Central Cancer Treatment Group Study N0177

(2008) Paul D. Brown et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma

(2008) Teri N. Kreisl et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcription-Dependent Epidermal Growth Factor Receptor Activation by Hepatocyte Growth Factor

(2008) T. E. Reznik et al.   MOLECULAR CANCER RESEARCH

Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity

(2008) F. Yamoutpour et al.   MOLECULAR CANCER THERAPEUTICS

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

(2008) Hongwu Zheng et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

(2008) Jinyan Du et al.   NATURE BIOTECHNOLOGY

VEGF Trap induces antiglioma effect at different stages of disease

(2008) Candelaria Gomez-Manzano et al.   NEURO-ONCOLOGY

EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors

(2008) Li Li et al.   NEURO-ONCOLOGY

The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility

(2008) J. J. Lammerts van Bueren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4

(2008) Kunio Matsumoto et al.   PROTEOMICS

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE