Article
Clinical Neurology
Baris Kucukyuruk, Taha Sukru Korkmaz, Kelvin Nemayire, Fatma Ozlen, Ali Metin Kafadar, Ziya Akar, Mehmet Yasar Kaynar, Galip Zihni Sanus
Summary: FNa-VA provides real-time assessment of the surgical field in treating intracranial aneurysms, with a satisfactory clip application rate of 98.74%. Postoperative angiography reveals good results, with no ischemic events due to artery occlusion during surgery.
WORLD NEUROSURGERY
(2021)
Article
Surgery
Fernando Dip, Emanuele Lo Menzo, Michael Bouvet, Rutger M. Schols, Danny Sherwinter, Steven D. Wexner, Kevin P. White, Raul J. Rosenthal
Summary: This study conducted Delphi surveys of international experts to summarize the use of intraoperative fluorescence imaging in different surgical scenarios. The results showed that indocyanine green dye is safe and can significantly enhance anatomical visualization and reduce procedural risk. However, the dosing and timing of indocyanine green vary between procedures, and further research is needed for optimization.
Article
Clinical Neurology
Tomaz Smigoc, Ninna Kozorog, Janez Ravnik
Summary: In this article, five cases of cerebral vascular malformations were presented, demonstrating the use of intraoperative neuromonitoring and angiography in reducing the risk and improving outcomes. Intraoperative neuromonitoring measured brain hypoperfusion, while angiography helped identify residual aneurysms and blood flow. The application of these techniques showed significant improvements in treatment outcomes.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Article
Clinical Neurology
Mostafa Shahein, Daniel M. Prevedello, Thomas L. Beaumont, Khalid Ismail, Radwan Nouby, Marilly Palettas, Luciano M. Prevedello, Bradley A. Otto, Ricardo L. Carrau
Summary: The study found a strong correlation between gland/blood fluorescence ratios to gland/ICA SI in pituitary adenoma, as well as tumor/blood fluorescence ratios to tumor/ICA SI in various pathologies. ICG fluorescence was able to assess perfusion in pituitary gland and nasoseptal flaps, as well as visualize surrounding vasculature.
JOURNAL OF NEUROSURGERY
(2021)
Review
Medicine, Research & Experimental
Shankhaneel Ghosh, Wireko Andrew Awuah, Hareesha Rishab Bharadwaj, Favour Tope Adebusoye, Brian M. Ou Yong, Jack Wellington, Toufik Abdul-Rahman, Denys Ovechkin
Summary: Intraoperative indocyanine green video angiography (ICG-VA) is a valuable tool in the surgical management of intracranial aneurysms, providing real-time visualization of aneurysmal blood flow and aiding in surgical planning. However, its implementation in low- and middle-income countries is hindered by financial constraints and limited access to training and expertise.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Clinical Neurology
Karol P. Budohoski, Kunal Raygor, Daniel A. Tonetti, Kazim H. Narsinh, Ethan A. Winkler, Christopher Dowd, Adib A. Abla
Summary: This study describes a simple method of intraoperative angiography (IOA) that can be applied during surgery of paraclinoid aneurysms and can be performed in a normal operating room without the need to navigate the aortic arch.
WORLD NEUROSURGERY
(2022)
Article
Optics
Daewoon Seong, Won Ki, Pilun Kim, Jaeyul Lee, Sangyeob Han, Soojin Yi, Hong Kyun Kim, Mansik Jeon, Jeehyun Kim
Summary: This study developed a virtual intraoperative OCT angiography integrated surgical microscope, which can simultaneously visualize the morphological tissue structure and microvasculature data of the surgical region, demonstrating its potential application in in vivo imaging and simulated surgeries of small animals.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Clinical Neurology
Gregor Durner, Hellen Wahler, Michael Braun, Thomas Kapapa, Christian Rainer Wirtz, Ralph Koenig, Andrej Pala
Summary: The study evaluated the additional value of ioDSA in a hybrid operating room equipped with an Artis Zeego robotic c-arm for neurovascular procedures. Results showed that ioDSA was able to detect certain neurovascular issues that could not be visualized by ICG angiography, highlighting its potential benefits in selected cases.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Surgery
Kuan-Cheng Chen, Chih-Hsun Lin, Hsu Ma, Tien-Hsiang Wang, Yu-Chung Shih, Mei-Chun Chen, Yu-Jen Chiu, Ching-En Chen
Summary: This study evaluated the outcomes of intraoperative ICG angiography in free flap surgery for head and neck cancer. The results showed that the use of intraoperative ICG angiography significantly reduced the total flap failure rate and increased the flap salvage rate, but did not significantly affect the re-exploration rate.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Medicine, General & Internal
Shigeyuki Yamashita, Kazuto Shibuya, Kanetsugu Nagao, Toshio Doi, Shigeki Yokoyama, Akio Yamashita, Kazuaki Fukahara, Tsutomu Fujii, Naoki Yoshimura
Summary: Intraoperative blood flow evaluation using ICG angiography revealed no abnormalities, however, postoperative CT angiography detected anastomotic stenosis, suggesting the need for more precise intraoperative evaluation methods.
CLINICAL CASE REPORTS
(2021)
Article
Clinical Neurology
Wojciech Swiatnicki, Jaroslaw Szymanski, Anna Szymanska, Piotr Komunski
Summary: This study aimed to compare the incidence of surgery-related complications in patients who underwent fluorescein video angiography versus those who did not. The study found that intraoperative fluorescein video angiography successfully identified aneurysm remnants and vessel occlusions, leading to better outcomes in the FL-VA group compared to the control group.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Clinical Neurology
Naoki Kato, Tohru Terao, Takuya Ishii, Emiko Saito, Yusuke Hirokawa, Shotaro Michishita, Yuichi Sasaki, Satoshi Tani, Yuichi Murayama
Summary: This study evaluated the hemodynamic changes of the subclavian artery during thoracic outlet syndrome surgery using ICG videoangiography. A significant decrease in subclavian artery flow velocity was observed after decompression.
OPERATIVE NEUROSURGERY
(2022)
Article
Clinical Neurology
Dong Hoon Lee, Jong Hyeok Park, Jung Jae Lee, Jong Beom Lee, Ho Jin Lee, Il Sup Kim, Jung Woo Hur, Jae Taek Hong
Summary: The study evaluated the usefulness of ICG angiography and Doppler sonography in monitoring the vertebral artery during CVJ surgery, finding that the combined use of these two techniques can effectively reduce the incidence of vertebral artery injury, thus enhancing surgical safety and success rates.
NEUROSURGICAL FOCUS
(2021)
Article
Surgery
Gabrielle LeBlanc, Caitlin Takahashi, Jamie Huston, Ravi Shridhar, Kenneth Meredith
Summary: The study examined the impact of indocyanine green (ICYG) in a surgeon's decision-making during esophagectomy. The results showed that the use of ICYG did not significantly improve the rate of anastomotic leaks, but in 80% of cases, the surgeon's decision-making was impacted, resulting in additional resection of the gastric conduit.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Clinical Neurology
Martin N. Stienen, Christian F. Freyschlag, Karl Schaller, Torstein Meling
ACTA NEUROCHIRURGICA
(2020)
Article
Neurosciences
Julia Velz, Giuseppe Esposito, Luca Regli
Summary: Traumatic intracranial aneurysms of the distal anterior cerebral artery are rare and present therapeutic challenges. This study discussed the mechanisms of their formation and treatment strategies, emphasizing the importance of trapping and revascularization as well as the potential use of intra-to-intracranial bypass procedures.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Review
Clinical Neurology
Basil E. Gruter, Lazar Tosic, Stefanos Voglis, Flavio Vasella, Valentino Mutschler, Oliver Bichsel, Natalie Scherrer, Luca Regli, Giuseppe Esposito
Summary: The study analyzed clinical research on cerebral bypass surgery over the past few decades, finding that flow augmentation and flow preservation bypasses were the main focus. Asian countries, particularly Japan, were most active in researching moyamoya disease.
CEREBROVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Martina Sebok, Christiaan Hendrik Bas van Niftrik, Niklas Lohaus, Giuseppe Esposito, Mohamad El Amki, Sebastian Winklhofer, Susanne Wegener, Luca Regli, Jorn Fierstra
Summary: For patients with symptomatic unilateral ICA occlusion, impaired CVR may be associated with collateral activation, particularly leptomeningeal collateral. Patients with activated secondary collaterals exhibit more impaired BOLD-CVR values, and activation of leptomeningeal collateral is strongly correlated with severely impaired BOLD-CVR.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Clinical Neurology
Sina Finkenstaedt, Lelio Guida, Luca Regli, Giuseppe Esposito
Summary: The systematic review analyzed surgical revascularization techniques for flow-augmentation in children with Moyamoya vasculopathy (MMV). Combined and indirect techniques were found to be effective, with recommendations to reduce surgical risks by avoiding certain exposures. Further studies are needed to determine the optimal technique for this specific pediatric population.
JOURNAL OF NEUROSURGICAL SCIENCES
(2021)
Editorial Material
Clinical Neurology
Giuseppe Esposito, Luca Regli
JOURNAL OF NEUROSURGICAL SCIENCES
(2021)
Review
Clinical Neurology
Lelio Guida, Martina Sebok, Susanne Wegener, Jorn Fierstra, Bas van Niftrik, Andreas R. Luft, Luca Regli, Giuseppe Esposito
Summary: This study systematically analyzed the literature on flow augmentation bypass for the treatment of acute ischemic stroke and found limited and heterogeneous evidence. Further research is encouraged to explore the potential use of EC-IC bypass in highly selected patients.
JOURNAL OF NEUROSURGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Martina Sebok, Christiaan Hendrik Bas van Niftrik, Sebastian Winklhofer, Susanne Wegener, Giuseppe Esposito, Christoph Stippich, Andreas Luft, Luca Regli, Jorn Fierstra
Summary: Comprehensive hemodynamic impairment mapping using BOLD CVR can identify hemodynamically relevant symptomatic unilateral carotid artery stenosis or occlusion. Patients with occlusion showed lower CVR values compared to healthy subjects and those with stenosis, with only 58% of the cohort exhibiting significant CVR impairment.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Martina Seboek, Patricia Blum, Johannes Sarnthein, Jorn Fierstra, Menno R. Germans, Carlo Serra, Niklaus Krayenbuehl, Luca Regli, Giuseppe Esposito
Summary: Microsurgery is important in managing unruptured intracranial aneurysms (UIAs). The Clavien-Dindo classification system, which rates deviations from normal postoperative course, was found to be applicable in patients undergoing microsurgery for UIAs. Patients with complex aneurysms had a higher risk of developing new neurological deficits.
NEUROSURGICAL FOCUS
(2021)
Editorial Material
Clinical Neurology
Elisa Colombo, Giuseppe Esposito, Luca Regli, Johannes Sarnthein
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Surgery
Giuseppe E. Umana, S. Ottavio Tomasi, Paolo Palmisciano, Gianluca Scalia, Valerio Da Ros, Rahman Al-Schameri, Stefano M. Priola, Lara Brunasso, Giuseppe Roberto Giammalva, Federica Paolini, Roberta Costanzo, Lapo Bonosi, Rosa Maria Gerardi, Rosario Maugeri, Lidia Strigari, Philip E. Stieg, Giuseppe Esposito, Michael T. Lawton, Christoph J. Griessenauer, Peter A. Winkler
Summary: This study aims to analyze morphological changes in cerebral veins of patients with aneurysmal subarachnoid hemorrhage (aSAH). The study collects arterial and venous CT angiograms and analyzes the changes in veins. The results will be correlated with clinical outcomes and compared with a healthy control group.
FRONTIERS IN SURGERY
(2022)
Article
Neurosciences
Sami Barrit, Mejdeddine Al Barajraji, Salim El Hadweh, Olivier Dewitte, Nathan Torcida, Joachim Andre, Fabio Silvio Taccone, Sophie Schuind, Elisa Gouvea Bogossian
Summary: PbtO(2)-guided therapy can improve the neurological outcome of traumatic brain injury patients. A retrospective analysis was conducted on severe TBI patients, comparing the outcomes of those who received ICP-guided therapy versus those who received ICP/PbtO(2) guided therapy. Significant differences were found in the occurrence of ICP, ICU length of stay, and Glasgow Coma Scale at ICU discharge.
Article
Clinical Neurology
Martina Seboek, Giuseppe Esposito, Christiaan Hendrik Bas van Niftrik, Jorn Fierstra, Tilman Schubert, Susanne Wegener, Jeremia Held, Zsolt Kulcsar, Andreas R. Luft, Luca Regli
Summary: Using a flowchart based on multimodal MRI, this study aims to select highly selected patients with acute large vessel occlusion who could benefit from urgent bypass surgery due to persistent inadequate collateral flow.
JOURNAL OF NEUROSURGERY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Elisa Colombo, Tim Fick, Giuseppe Esposito, Menno Germans, Luca Regli, Tristan van Doormaal
Summary: This review analyzed the current techniques for 3D segmentation and visualization of brain arteriovenous malformations (bAVMs). The results showed a trend towards using machine learning algorithms for segmentation, with unsupervised fuzzy-based algorithms being a potential preferred strategy. Further research is needed to improve algorithms and find innovative tools for tridimensional visualization.
Article
Clinical Neurology
Christiaan H. B. van Niftrik, Martina Sebok, Susanne Wegener, Giuseppe Esposito, Matthias Halter, Aimee Hiller, Christoph Stippich, Andreas R. Luft, Luca Regli, Jorn Fierstra
Summary: The study demonstrated that increased ipsilateral transcranial doppler PCA-P2 systolic flow velocity independently correlates with BOLD-CVR based hemodynamic failure in patients with symptomatic unilateral steno-occlusive disease. A cutoff value of 85 cm/second appears to indicate hemodynamic failure stage 2.