Review
Oncology
Luigi Albano, Marco Losa, Lina Raffaella Barzaghi, Ajay Niranjan, Zaid Siddiqui, John C. Flickinger, Lawrence Dade Lunsford, Pietro Mortini
Summary: A systematic review and meta-analysis of outcomes of Gamma Knife radiosurgery for pituitary tumors over the past twenty years showed that it is safe and effective, with good tumor control and remission rates for both non-secreting and secreting tumors.
Article
Oncology
Yanli Li, Lisha Wu, Tingting Quan, Junyi Fu, Linhui Cao, Xi Li, Shunyao Liang, Minyi Huang, Yinhui Deng, Jinxiu Yu
Summary: This study aimed to report the characteristic of tumor regrowth after gamma knife radiosurgery (GKRS) and outcomes of repeat GKRS in nonfunctioning pituitary adenomas (NFPAs). The study found that parasellar invasion and tumor margin dose (<12 Gy) were independent risk factors for tumor regrowth after GKRS. Repeat GKRS might be effective on tumor control for selected patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Felix Ehret, Markus Kufeld, Christoph Fuerweger, Alfred Haidenberger, Paul Windisch, Susanne Fichte, Ralph Lehrke, Carolin Senger, David Kaul, Daniel Ruess, Maximilian Ruge, Christian Schichor, Joerg-Christian Tonn, Guenter Stalla, Alexander Muacevic
Summary: In addition to surgery and medication, robotic radiosurgery is an effective and safe treatment option for growth hormone-secreting tumors of the pituitary gland infiltrating surrounding tissue structures, achieving biochemical disease control or remission in most patients with decreasing hormone levels. The treatment also demonstrates favorable risk and safety profiles.
Article
Oncology
Junyi Fu, Yanli Li, Lisha Wu, Xin Yang, Tingting Quan, Xi Li, Jiamin Zeng, Yinhui Deng, Jinxiu Yu
Summary: This study aimed to investigate the incidence, risk factors, and prognosis of pituitary hemorrhage in pituitary adenomas treated with gamma knife radiosurgery. It was found that nonfunctioning pituitary adenomas were an independent risk factor for new or worsened pituitary hemorrhage after gamma knife radiosurgery.
Review
Clinical Neurology
Shota Yamashita, Atsushi Saito, Hidefumi Jokura, Tomohiro Kawaguchi, Miki Fujimura, Yoshikazu Ogawa, Teiji Tominaga
Summary: So far, only two cases of aneurysm formation in the internal carotid artery after gamma knife radiosurgery (GKRS) for pituitary adenomas have been reported. However, at least five out of 482 patients who underwent GKRS for pituitary adenomas at our institute developed aneurysms within the area of high single-dose irradiation. This suggests that the rate of aneurysm formation in such conditions may be higher than previously thought.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Yang Wu, Mengqi Wang, Yangyang Xu, Rong Wen, Xiaowei Liu, Yuan Gao, Yifeng Shi, Wei Pan, Hao Deng, Wei Wang
Summary: The study compared the efficacy and safety of primary GKS and postoperative GKS for acromegaly and found no significant differences in endocrine remission, biochemical recurrence, imaging regression, imaging progression, radiation-induced complications. Base nadir GH after OGTT was identified as a predictor of durable endocrine remission.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Oncology
Nidan Qiao, Damin Yu, Guoqing Wu, Qilin Zhang, Boyuan Yao, Min He, Hongying Ye, Zhaoyun Zhang, Yongfei Wang, Hanfeng Wu, Yao Zhao, Jinhua Yu
Summary: This study utilized artificial intelligence approaches to analyze pathological images and predict endocrine outcomes in patients with active acromegaly after stereotactic radiosurgery. The model showed strong predictive power and outperformed established prognostic markers.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Natasha Ironside, Harrison Snyder, Zhiyuan Xu, David Schlesinger, Ching-Jen Chen, Mary Lee Vance, Gregory K. Hong, John A. Jane, Jason P. Sheehan
Summary: This study investigated the relationship between the distance from the hypothalamic-pituitary axis to the treatment target and anterior pituitary function preservation after stereotactic radiosurgery (SRS) for pituitary adenomas. The results showed that a greater distance between the normal pituitary gland and the SRS target was associated with anterior pituitary function preservation.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
I. Jonathan Pomeraniec, Zhiyuan Xu, Cheng-Chia Lee, Huai-Che Yang, Tomas Chytka, Roman Liscak, Roberto Martinez-Alvarez, Nuria Martinez-Moreno, Luca Attuati, Piero Picozzi, Douglas Kondziolka, Monica Mureb, Kenneth Bernstein, David Mathieu, Michel Maillet, Akiyoshi Ogino, Hao Long, Hideyuki Kano, L. Dade Lunsford, Brad E. Zacharia, Christine Mau, Leonard C. Tuanquin, Christopher Cifarelli, David Arsanious, Joshua Hack, Ronald E. Warnick, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Herwin Speckter, Samir Patel, Dale Ding, Darrah Sheehan, Kimball Sheehan, Svetlana Kvint, Love Y. Buch, Alexander R. Haber, Jacob Shteinhart, Mary Lee Vance, Jason P. Sheehan
Summary: Stereotactic radiosurgery (SRS) is an effective treatment for pituitary adenomas, but the mechanism of delayed endocrine deficits is not well understood. This multicenter study aimed to evaluate radiation tolerance and identify predictors of delayed hypopituitarism after SRS for these tumors. The study found that tumor control was achieved in a high percentage of patients, but a significant number developed new loss of pituitary function, with certain factors such as tumor type, age, and radiation dose playing a role.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Charles Ashton, Suhn K. Rhie, John D. Carmichael, Gabriel Zada
Summary: Profiling of human pituitary adenoma DNA methylome identified KCNAB2 as differentially methylated between NFPAs and GH-secreting PAs. Modulation of Kcnab2 expression in GH3 cells affected GH secretion, and quinidine administration reduced GH secretion in a dose-dependent manner. These findings suggest potential new therapeutic targets for acromegaly.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Adomas Bunevicius, Darrah Sheehan, Mary Lee Vance, David Schlesinger, Jason P. Sheehan
Summary: This study found that technological advancements and growing center experience were important factors for improved endocrine remission rates in patients with CD.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
Valentina Pinzi, Marcello Marchetti, Anna Viola, Irene Tramacere, Irene Cane, Cecilia Iezzoni, Laura Fariselli
Summary: Radiosurgery is a safe and effective technique for treating intracranial meningiomas. However, when targeting large-volume or critically located lesions, single-fraction radiosurgery can lead to high toxicity rates. This study found that a fractionated RS schedule of 25 Gy in 5 fractions (hypo-RS) is a well-tolerated option for the treatment of large and/or critically located benign meningiomas, with favorable local control.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Clinical Neurology
Yasuyuki Kinoshita, Akira Taguchi, Atsushi Tominaga, Kazunori Arita, Fumiyuki Yamasaki
Summary: Recovery from AGHD after initial TSS is more likely in younger female patients with higher peak GH levels assessed by preoperative PPT. Patients aged <= 62.2 years and with a peak GH level of >= 0.74 μg/L based on preoperative PPT are likely to recover from AGHD.
JOURNAL OF NEUROSURGERY
(2021)
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Nathan C. Rowland, Coralie De Hemptinne, Nicole C. Swann, Salman Qasim, Svjetlana Miocinovic, Jill L. Ostrem, Robert T. Knight, Philip A. Starr
FRONTIERS IN HUMAN NEUROSCIENCE
(2015)
Editorial Material
Engineering, Biomedical
Francesco Sammartino, Nathan Rowland, Mojgan Hodaie, Suneil K. Kalia, Andres M. Lozano, Clement Hamani
EXPERT REVIEW OF MEDICAL DEVICES
(2016)
Review
Clinical Neurology
Nathan C. Rowland, Francesco Sammartino, Andres M. Lozano
MOVEMENT DISORDERS
(2017)
Article
Clinical Neurology
Ethan A. Winkler, Nathan C. Rowland, John K. Yue, Harjus Birk, Alp Ozpinar, Bobby Tay, Christopher P. Ames, Praveen V. Mummaneni, Ivan H. El-Sayed
WORLD NEUROSURGERY
(2016)
Review
Medicine, Research & Experimental
Nathan C. Rowland, Suneil K. Kalia, Lorraine V. Kalia, Paul S. Larson, Daniel A. Lim, Krystof S. Bankiewicz
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2016)
Article
Clinical Neurology
Pratik Y. Chhatbar, Steven A. Kautz, Istvan Takacs, Nathan C. Rowland, Gonzalo J. Revuelta, Mark S. George, Marom Bikson, Wuwei Feng
Review
Clinical Neurology
Irene E. Harmsen, Nathan C. Rowland, Richard A. Wennberg, Andres M. Lozano
Article
Oncology
Ahmed J. Awad, Nathan Christopher Rowland, Matthew Mian, Annie Hiniker, Matthew Tate, Manish Kumar Aghi
JOURNAL OF NEURO-ONCOLOGY
(2014)
Letter
Clinical Neurology
Griffin R. Baum, Nathan C. Rowland, Joshua J. Chern, Andrew Reisner
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2014)
Article
Clinical Neurology
Nathan C. Rowland, Philip A. Starr, Paul S. Larson, Jill L. Ostrem, William J. Marks, Daniel A. Lim
MOVEMENT DISORDERS
(2015)
Article
Neurosciences
Nathan C. Rowland, Kai J. Miller, Philip A. Starr
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2014)
Letter
Clinical Neurology
Philippe De Vloo, Gaddum Duemani Reddy, Nathan Rowland, Francesco Sammartino, Maheleth Llinas, Darcia Paul, Brian J. Murray, Anthony E. Lang, Alfonso Fasano, Renato P. Munhoz, Suneil K. Kalia
MOVEMENT DISORDERS
(2019)
Article
Clinical Neurology
Ezequiel Gleichgerrcht, Adam S. Greenblatt, Tanja S. Kellermann, Nathan Rowland, W. Alexander Vandergrift, Jonathan Edwards, Kathryn A. Davis, Leonardo Bonilha
Summary: The study aimed to explore the association between seizure spread directionality and specific cerebral white matter tracts in patients with temporal lobe epilepsy. Results showed that patients with anterior-posterior seizures had higher fractional anisotropy along different white matter pathways compared to those with medial-lateral seizures, indicating a structural reinforcement of supporting pathways in temporal lobe epilepsy.
Review
Clinical Neurology
Veena Sheshadri, Nathan C. Rowland, Jigesh Mehta, Marina Englesakis, Pirjo Manninen, Lashmi Venkatraghavan
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2017)
Article
Anesthesiology
Melissa Brockerville, Zoe Unger, Nathan C. Rowland, Francesco Sammartino, Pirjo H. Manninen, Lashmi Venkatraghavan
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2018)