Journal
NEUROSURGERY CLINICS OF NORTH AMERICA
Volume 23, Issue 2, Pages 237-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2012.01.011
Keywords
EGFR; EGFRvIII; PTEN; MGMT; Glioblastoma
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The purpose of this article is to update the neurosurgical field on current molecular markers important to glioblastoma biology, treatment, and prognosis. The highlighted biologic markers in this article include epidermal growth factor receptor (EGFR), EGFR variant Ill (EGFRvIII), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and O6-methylguanine-DNA methyltransferase (MGMT).
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