Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Review
Biochemistry & Molecular Biology
Maria Ricci, Andrea Cimini, Maria Rosaria Grivet Fojaja, Mariacristina Ullo, Bruno Carabellese, Viviana Frantellizzi, Ennio Lubrano
Summary: This review focuses on imaging aspects of fibromyalgia, particularly novel approaches in molecular imaging, with an emphasis on neuroimaging. The potential role of functional MRI and different PET tracers in the field of fibromyalgia has been discussed, serving as a comprehensive guide for novel imaging options in research and clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Na Niu, Haiqun Xing, Meiqi Wu, Yanru Ma, Yimin Liu, Jiantao Ba, Shikun Zhu, Fang Li, Li Huo
Summary: The meta-analysis aimed to evaluate the clinical use value of C-11-FMZ and F-18-FDG in PET for localizing the epileptogenic zone. The pooled concordance rates of FDG-PET, FMZ-PET, and FDG-PET/MRI were calculated to be 0.67, 0.75, and 0.93, respectively, showing that FDG-PET/MRI had the highest concordance rate. The overall sensitivity and specificity of F-18-FDG-PET were 0.66 and 0.71, while C-11-FMZ-PET had a sensitivity of 0.62 and specificity of 0.73.
EUROPEAN RADIOLOGY
(2021)
Article
Veterinary Sciences
Taesik Yun, Yoonhoi Koo, Hakhyun Kim, Wonguk Lee, Soochong Kim, Dong-In Jung, Mhan-Pyo Yang, Byeong-Teck Kang
Summary: A 15.5-year-old neutered male domestic shorthair cat presented with neurologic dysfunctions, showing improvement in symptoms following treatment with hydroxyurea and prednisolone, and a hypermetabolic region was found in the lesion on F-18-FDG-PET scan.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sung Soo Ahn, Soonmee Cha
Summary: Advances in molecular and genetic characterization of CNS tumors have led to a new era of tumor classification and imaging plays a critical role in preoperative diagnosis, surgical planning, molecular marker prediction, targeted treatment planning, and post-therapy assessment.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jing Wang, Chentao Jin, Jinyun Zhou, Rui Zhou, Mei Tian, Hyeon Jeong Lee, Hong Zhang
Summary: Alzheimer's disease is the most common dementia worldwide, and there is currently no exact etiology and effective treatment. Due to the complexity and heterogeneity of the disease, a range of biomarkers should be established to evaluate its severity and prognosis. Positron emission tomography is an effective imaging technique that allows for comprehensive observation and evaluation of Alzheimer's disease from diverse perspectives.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Oncology
Rahul M. Nikam, Xuyi Yue, Gurcharanjeet Kaur, Vinay Kandula, Abdulhafeez Khair, Heidi H. Kecskemethy, Lauren W. Averill, Sigrid A. Langhans
Summary: Brain tumors are the second most common cancers in children after leukemias. Early and accurate diagnosis is crucial for improving patient outcomes. Advanced neuroimaging techniques, beyond conventional CT and MRI, are being used to enhance the early detection and differential diagnosis of central nervous system tumors. This review provides an overview of recent developments in neuroimaging techniques for pediatric brain tumors.
Editorial Material
Clinical Neurology
Tore Eid
Summary: By using ex vivo and in vivo nuclear magnetic resonance spectroscopy (MRS) methods, researchers found that GABA is significantly increased in the epileptogenic zone (EZ) of mesiotemporal lobe epilepsy (MTLE) mouse model, confirming it as the best metabolite to discriminate the EZ. This increase in GABA was specific to the injected hippocampus of mice with MTLE and not reversed by antiepileptic drug exposure.
Review
Immunology
Rafael Roesler, Simone Afonso Dini, Gustavo R. Isolan
Summary: Brain tumors and metastases lead to changes in brain tissue remodeling, immunosuppression, and inflammatory responses, affecting invasion and metastasis. Radiotherapy may cause neuroinflammatory and necrotic lesions. GBM is the most aggressive primary malignant brain tumor in adults.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Immunology
Yuan Gao, Caixia Wu, Xueqi Chen, Linlin Ma, Xi Zhang, Jinzhi Chen, Xuhe Liao, Meng Liu
Summary: This review provides a comprehensive overview of the importance of positron emission tomography/computed tomography (PET/CT) imaging in cancer immunotherapy, particularly immune-checkpoint inhibitors (ICIs). It highlights the role of PET/CT in evaluating the tumor microenvironment, discovering immune-related adverse events, assessing therapeutic efficacy, and predicting therapeutic prognosis. The review also discusses the future development direction and potential challenges of PET/CT imaging, and summarizes research on novel PET molecular probes for precise application of ICIs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Luca Giovanella, Desiree' Deandreis, Alexis Vrachimis, Alfredo Campenni, Petra Petranovic Ovcaricek
Summary: Molecular imaging plays a crucial role in the evaluation and management of thyroid cancer, contributing to the optimization of treatment decisions and the improvement of risk stratification models. Different molecular imaging techniques can be used to detect various types of thyroid cancer, and new theragnostic approaches offer promising prospects for treatment.
Article
Biology
Benjamin Haenisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff, Juergen Dukart, Bratislav Misic, Sofie Louise Valk
Summary: This study investigates the role of neurotransmitter transporter and receptor molecules in the structure-function relationships in the human brain. Using positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors, the researchers discovered three main spatial gradients of chemoarchitectural similarity in the cortical and subcortical regions of the brain. The findings show that the organization of the receptome shares similarities with functional and structural brain anatomy.
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinming Zhang, Yi Liao, Xiawan Wang, Teng Zhang, Jianhua Feng, Jianing Deng, Kexin Shi, Lin Chen, Liu Feng, Mindi Ma, Le Xue, Haifeng Hou, Xiaofeng Dou, Congcong Yu, Lei Ren, Yao Ding, Yufei Chen, Shuang Wu, Zexin Chen, Hong Zhang, Cheng Zhuo, Mei Tian
Summary: The study developed a novel deep learning framework for accurate and efficient identification of epileptic foci in pediatric patients with temporal lobe epilepsy, outperforming traditional visual assessment and other analysis methods.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biochemical Research Methods
Jason L. J. Dearing, Brett M. Paterson, Vamsidhar Akurathi, Soledad Betanzos-Lara, S. Ted Treves, Stephan D. Voss, Jonathan M. White, James S. Huston, Suzanne V. Smith, Paul S. Donnelly, Alan B. Packard
BIOCONJUGATE CHEMISTRY
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Frederic H. Fahey, Sonja I. Ziniel, Dacie Manion, S. Ted Treves
JOURNAL OF NUCLEAR MEDICINE
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Frederic H. Fahey, Sonja I. Ziniel, Dacie Manion, Amanda Baker, S. Ted Treves
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kitiwat Khamwan, Donika Plyku, Shannon E. O'Reilly, Alison Goodkind, Xinhua Cao, Frederic H. Fahey, S. Ted Treves, Wesley E. Bolch, George Sgouros
Article
Clinical Neurology
Catherine Stamoulis, Nishant Verma, Himanshu Kaulas, Jonathan J. Halford, Frank H. Duffy, Phillip L. Pearl, S. Ted Treves
Article
Radiology, Nuclear Medicine & Medical Imaging
Frederic H. Fahey, Alison Goodkind, Robert D. MacDougall, Leah Oberg, Sonja I. Ziniel, Richard Cappock, Michael J. Callahan, Neha Kwatra, S. Ted Treves, Stephan D. Voss
JOURNAL OF NUCLEAR MEDICINE
(2017)
Review
Radiology, Nuclear Medicine & Medical Imaging
Frederic H. Fahey, Alison B. Goodkind, Donika Plyku, Kitiwat Khamwan, Shannon E. O'Reilly, Xinhua Cao, Eric C. Frey, Ye Li, Wesley E. Botch, George Sgouros, S. Ted Treves
SEMINARS IN NUCLEAR MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Frederic Fahey, Katherine Zukotynski, David Zurakowski, Robert Markelewicz, Anthony Falone, Marie Vitello, Xinhua Cao, Frederick Grant, Laura Drubach, A. Hans Vija, Manojeet Bhattacharya, Xinhong Ding, Zvi Bar-Sever, Michael Gelfand, S. Ted Treves
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2014)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
S. Ted Treves, Michael Lassmann
JOURNAL OF NUCLEAR MEDICINE
(2014)
Article
Pediatrics
Frederick D. Grant, Michael J. Gelfand, Laura A. Drubach, S. Ted Treves, Frederic H. Fahey
PEDIATRIC RADIOLOGY
(2015)
Review
Radiology, Nuclear Medicine & Medical Imaging
S. Ted Treves, Anthony E. Falone, Frederic H. Fahey
SEMINARS IN NUCLEAR MEDICINE
(2014)
Review
Radiology, Nuclear Medicine & Medical Imaging
Diego De Palma, Luigi Mansi, S. Ted Treves
CLINICAL AND TRANSLATIONAL IMAGING
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
S. Ted Treves, Alison Goodkind, F. D. Grant
CLINICAL AND TRANSLATIONAL IMAGING
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
S. Ted Treves, Michael J. Gelfand, Alison Goodkind, Frederic H. Fahey, Michael Lassmann
CLINICAL AND TRANSLATIONAL IMAGING
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephanie E. Spottswood, Thomas Pfluger, Stephen P. Bartold, David Brandon, Nanci Burchell, Dominique Delbeke, Darlene M. Fink-Bennett, Pamela K. Hodges, Paul R. Jolles, Michael Lassmann, Alan H. Maurer, James E. Seabold, Michael G. Stabin, S. Ted Treves, Marina Vlajkovic
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY
(2014)
Article
Clinical Neurology
Ankit N. Khambhati
Summary: RNS is a powerful tool for personalized treatment of drug-resistant, focal epilepsy, effectively reducing seizures. The stored chronic electrophysiology and therapy data in the RNS System can optimize device parameters. Emerging research can uncover complex relationships between stimulation, brain network physiology, and clinical outcomes, accelerating efficacy for a broader population with focal epilepsy.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Angelique C. Paulk, Pariya Salami, Rina Zelmann, Sydney S. Cash
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Vasileios Kokkinos
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Editorial Material
Clinical Neurology
Vivek P. Buch, Josef Parvizi
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Rory J. Piper, George M. Ibrahim, Martin M. Tisdall
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Saadi Ghatan
Summary: Pediatric epilepsy surgery has gained recognition for its safety and effectiveness in treating epilepsy in children. Advances in diagnostic and treatment techniques, such as minimally invasive procedures and neuroimaging, have contributed to its rapid growth potential.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
Article
Clinical Neurology
Pranav Nanda, R. Mark Richardson
Summary: The MGH surgical epilepsy group's shift towards a seizure network paradigm has led to improvements in invasive monitoring methods, with more hypothesis-driven implantations, dominant use of sEEG depth electrodes, wider population coverage, and increased targeting of thalamic nuclei, optimizing the delineation of patients' seizure networks and critical treatment nodes.
NEUROSURGERY CLINICS OF NORTH AMERICA
(2024)
