Article
Clinical Neurology
Thandar Aung, Olesya Grinenko, Jian Li, John C. Mosher, Patrick Chauvel, Jorge Gonzalez-Martinez
Summary: The correlation between seizure outcomes in patients with drug-resistant epilepsy (DRE) who underwent laser interstitial thermal therapy (LITT) and the extent of laser ablation was studied. The complete removal of seizure onset zone (SOZ) and epileptogenic zone (PEZ) was found to be associated with the duration of seizure freedom (SF).
Article
Psychology, Multidisciplinary
Lilia Maria Morales Chacon, Judith Gonzalez Gonzalez, Martha Rios Castillo, Sheila Berrillo Batista, Karla Batista Garcia-Ramo, Aisel Santos Santos, Nelson Quintanal Cordero, Marilyn Zaldivar Bermudez, Randis Garbey Fernandez, Barbara Estupinan Diaz, Zenaida Hernandez Diaz, Juan E. Bender del Busto, Abel Sanchez Coroneux, Margarita M. Baez Martin, Lourdes Lorigados Pedre
Summary: This study presented the postsurgical outcome of ExTLE patients undergoing preoperative multimodal evaluation and intraoperative sequential ECoG. Results indicated that using SISCOM and ESI data alongside intraoperative ECoG allowed for seizure control in pharmacoresistant ExTLE epilepsy patients.
BEHAVIORAL SCIENCES
(2021)
Article
Clinical Neurology
Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Summary: By comparing the interictal magnetoencephalography (MEG) band power from patients with surgical failure to normative maps, we were able to identify patient-specific abnormalities and propose three mechanisms contributing to poor surgical outcome. We developed markers of these mechanisms and validated them against patient outcomes.
Article
Clinical Neurology
Benjamin Edmonds, Makoto Miyakoshi, Luigi Gianmaria Remore, Samuel Ahn, H. Westley Phillips, Atsuro Daida, Noriko Salamon, Ausaf Bari, Raman Sankar, Joyce H. Matsumoto, Aria Fallah, Hiroki Nariai
Summary: This study aimed to characterize the ictal EEG changes in the CM and AN of the thalamus using SEEG recordings in pediatric-onset neocortical drug-resistant epilepsy patients. Visual and quantitative analysis showed consistent detection of ictal EEG changes in both CM and AN, with low-voltage fast activity being the most common pattern. The results suggest the feasibility of using a closed-loop system in the thalamus for detecting and modulating seizure activity in neocortical epilepsy.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Christopher W. Beatty, Stephanie M. Ahrens, Kristen H. Arredondo, Anto Bagic, Shasha Bai, Kevin E. Chapman, Michael A. Ciliberto, Dave F. Clarke, Mariah Eisner, Nathan B. Fountain, Jay R. Gavvala, M. S. Perry, Kyle C. Rossi, Lily C. Wong-Kisiel, Susan T. Herman, Adam P. Ostendorf
Summary: This study examines the variations in evaluation and treatment choices for epilepsy surgery, highlighting the need for comparative trials in the surgical management of drug-resistant epilepsy.
Review
Clinical Neurology
Niravkumar Barot, Kavita Batra, Jerry Zhang, Mary Lou Klem, James Castellano, Jorge Gonzalez-Martinez, Anto Bagic
Summary: MRgLITT is an effective and safe intervention for drug-resistant epilepsy with different disease etiologies. The seizure freedom outcome is overall comparable between extratemporal and temporal lobe epilepsy; and highest with patients having hypothalamic hamartomas.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Alessandra Maccabeo, Maryse A. Van't Klooster, Eline Schaft, Matteo Demuru, Willemiek Zweiphenning, Peter Gosselaar, Tineke Gebbink, Wim M. Otte, Maeike Zijlmans
Summary: In this study, the distribution of spikes and HFOs recorded during intraoperative electrocorticography (ioECoG) was investigated to predict the postsurgical outcomes of patients with lateral neocortical temporal lobe epilepsy (TLE) whose mesiotemporal structures are left in situ. The results showed that low rates of mesiotemporal post-ioECoG ripples and older age at epilepsy onset were predictors of good seizure outcomes. HFOs in ioECoG may be helpful in informing the success chance of hippocampus-sparing resection in patients with lateral neocortical TLE.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Heiko J. Luhmann
Summary: This review article provides an overview of the molecular, cellular, and network mechanisms underlying focal seizures in neocortical networks with developmental malformations. Neocortical malformations are a large variety of structural abnormalities associated with epilepsy and other neurological and psychiatric disorders. Animal models and state-of-the-art techniques have contributed to our understanding of neocortical hyperexcitability in developmental disorders. Additionally, molecular biological and electro-physiological techniques have provided insights into the subcellular, cellular, and network mechanisms of focal seizures.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Mehdi Khan, Aswin Chari, Kiran Seunarine, Christin Eltze, Friederike Moeller, Felice D'Arco, Rachel Thornton, Krishna Das, Stewart Boyd, J. Helen Cross, M. Zubair Tahir, Martin M. Tisdall
Summary: This study aimed to investigate the association between the proportion of resected putative seizure onset zone (SOZ) contacts and seizure outcome in children undergoing stereoelectroencephalography (SEEG)-guided resective epilepsy surgery. The results showed that in children, the percentage of resected SOZ contacts was not associated with seizure freedom after surgery.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Graham W. Johnson, Leon Y. Cai, Saramati Narasimhan, Hernan F. J. Gonzalez, Kristin E. Wills, Victoria L. Morgan, Dario J. Englot
Summary: By developing a supervised machine learning technique using diffusion-weighted imaging, we successfully classified the seizure onset sites and surgical outcomes of patients with temporal lobe epilepsy. The results of the study demonstrated high accuracy in distinguishing patients from healthy controls and identifying seizure onset sites.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Ceren Alis, Cihan Isler, Deniz Alis, Mustafa Uzan, Cigdem Ozkara
Summary: This study aimed to identify predictive factors for seizure recurrence after epilepsy surgery in patients with lesional posterior cortex epilepsy (PCE). It was found that more than half of the patients were seizure-free at long-term follow-up, but bilateral findings on interictal EEG and gliosis were associated with recurrent seizures after surgery.
WORLD NEUROSURGERY
(2023)
Article
Neurosciences
Victor Karpychev, Alexandra Balatskaya, Nikita Utyashev, Nikita Pedyash, Andrey Zuev, Olga Dragoy, Tommaso Fedele
Summary: High-frequency oscillations (HFO) are a valuable biomarker for identifying epileptogenic tissue. This study validated the predictive power of HFO rates and examined their morphological features. The findings support the use of HFO in epilepsy surgery and contribute to the understanding of HFO morphology.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Georgia Ramantani, Dorottya Cserpan, Martin Tisdall, Willem M. Otte, Georg Dorfmuller, J. Helen Cross, Monique van Schooneveld, Pieter van Eijsden, Frauke Nees, Gitta Reuner, Niklaus Krayenbuhl, Josef Zentner, Christine Bulteau, Kees P. J. Braun
Summary: This study retrospectively investigated the functional outcomes after hemispherotomy in a cohort of 455 children, and identified the determinants of these outcomes. The results showed that the use of antiseizure medication and independent walking ability were good, but language ability and voluntary grasping with the hemiplegic hand were affected by certain factors.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Karina A. Gonzalez Otarula, Yee-Leng Tan, Jeffery A. Hall, Edward F. Chang, Jose A. Correa, Francois Dubeau, Viviane Sziklas, Jean-Paul Soucy, Marie -Christine Guiot, Robert C. Knowlton, Eliane Kobayashi
Summary: This study aimed to report the postsurgical seizure outcome of temporal lobe epilepsy patients with normal or subtle, nonspecific MRI findings and to identify prognostic factors related to seizure control after surgery. The study found that a favorable outcome can be achieved in a good proportion of TLE patients with normal or subtle, non-specific MRI findings, particularly when presurgical investigation suggests a rather circumscribed generator. Presurgical factors such as the presence of focal nonmotor aware seizures and unilateral or no spikes on interictal EEG may indicate a higher probability of seizure freedom.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Margherita A. G. Matarrese, Alessandro Loppini, Lorenzo Fabbri, Eleonora Tamilia, M. Scott Perry, Joseph R. Madsen, Jeffrey Bolton, Scellig S. D. Stone, Phillip L. Pearl, Simonetta Filippi, Christos Papadelis
Summary: Neurosurgical intervention is the best treatment for patients with drug resistant epilepsy, and surgical planning requires biomarkers that can accurately identify the epileptogenic zone. Interictal spikes recorded with electrophysiological techniques are considered biomarkers, but they lack specificity due to their propagation across brain areas. Understanding the relationship between interictal spike propagation and functional connections among brain areas may help develop more precise biomarkers for delineating the epileptogenic zone.
Editorial Material
Clinical Neurology
Dario J. Englot, Andre H. Lagrange
Article
Neurosciences
Yayue Gao, Guanpeng Chen, Pengfei Teng, Xin Zhang, Fang Fang, Dario J. Englot, Guoming Luan, Xiongfei Wang, Qian Wang
Summary: PVNH is a developmental disorder characterized by failed neuronal migration, forming ectopic neuronal nodules along the ventricular walls. This study used MEG and sEEG recordings to investigate the functional communication between PVNH tissue and the neocortex. The results showed that PVNH tissue is functionally integrated into cognition-related cortical circuits and can modulate local neural activity in sensory areas.
Editorial Material
Clinical Neurology
Dario J. Englot
Article
Clinical Neurology
Graham W. Johnson, Derek J. Doss, Victoria L. Morgan, Danika L. Paulo, Leon Y. Cai, Jared S. Shless, Aarushi S. Negi, Abhijeet Gummadavelli, Hakmook Kang, Shilpa B. Reddy, Robert P. Naftel, Sarah K. Bick, Shawniqua Williams Roberson, Benoit M. Dawant, Mark T. Wallace, Dario J. Englot
Summary: Why are people with epilepsy not continuously having seizures? Johnson et al. use intracranial electrical recordings to analyse brain network interactions in people with epilepsy, and provide evidence that the seizure-onset network is actively suppressed by the rest of the brain during interictal states.
Article
Biology
Yue Liu, Shunxing Bao, Dario J. Englot, Victoria L. Morgan, Warren D. Taylor, Ying Wei, Ipek Oguz, Bennett A. Landman, Ilwoo Lyu
Summary: This paper proposes a novel particle method for establishing dense shape correspondence between pre- and post-surgical surfaces in temporal lobe resection. The method can handle partial structural abnormality involving non-rigid changes. Unlike existing particle methods, explicit particle adjacency is considered to establish a smooth correspondence. Moreover, hierarchical optimization of particles is proposed to avoid the trappings of locally optimal particle update.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Shengchao Zhang, Sarah E. Goodale, Benjamin P. Gold, Victoria L. Morgan, Dario J. Englot, Catie Chang
Summary: Patterns in fMRI data can reflect dynamic changes in the brain and are related to individual and group differences in behavior, cognition, and clinical traits. Detecting vigilance states in fMRI data without external measurements is challenging. This study shows that vigilance levels can be detected in the low-dimensional structure of fMRI data, even within individual time frames.
Editorial Material
Clinical Neurology
Dario J. Englot
Summary: Approximately one in five patients with newly diagnosed focal epilepsy may have an MRI finding that is likely causative and may alter treatment options, while an additional one in five patients may have abnormalities of unknown significance. This information is crucial for patient counseling, prognosis, and management.
Review
Behavioral Sciences
Henry C. Skrehot, Dario J. Englot, Zulfi Haneef
Summary: This meta-analysis compared the efficacy of vagus nerve stimulation (VNS), responsive neurostimulation (RNS), and deep brain stimulation (DBS) for reducing seizures in drug-resistant focal epilepsy. The study found that RNS and DBS had similar seizure reduction efficacy, which was greater than that of VNS, especially in the first year post-implantation.
EPILEPSY & BEHAVIOR
(2023)
Editorial Material
Clinical Neurology
Dario J. Englot
Summary: Loss of consciousness is a significant feature of epileptic seizures and can lead to serious consequences. This study compared brain activities during focal impaired awareness and focal to bilateral tonic-clonic seizures, revealing differences in the mechanisms of loss of consciousness. These findings have important implications for clinical outcomes and neuromodulation therapies.
Editorial Material
Clinical Neurology
Dario J. Englot
Summary: This study aimed to evaluate the prevalence and risk factors for pharmacoresistance in pediatric FCD-related epilepsy. The results showed that failure of only one antiseizure medication is significantly associated with the risk of pharmacoresistance. These data support an operational re-definition of pharmacoresistance for surgical planning and indicate the potential benefits of early, curative surgery to improve outcomes in patients with FCD-related epilepsy.
Article
Cell Biology
Aditya Nanda, Graham W. Johnson, Yu Mu, Misha B. Ahrens, Catie Chang, Dario J. Englot, Michael Breakspear, Mikail Rubinov
Summary: Much of systems neuroscience explores the significance of scale-free brain activity patterns, which lack natural scales. This study reconciles different explanations for scale-free activity across species and modalities, by linking estimates of excitation-inhibition balance with time-resolved correlation of brain activity. The results provide a simpler understanding of scale-free brain activity and establish strict tests for future theories.
Article
Clinical Neurology
T. Campbell Arnold, Lohith G. Kini, John M. Bernabei, Andrew Y. Revell, Sandhitsu R. Das, Joel M. Stein, Timothy H. Lucas, Dario J. Englot, Victoria L. Morgan, Brian Litt, Kathryn A. Davis
Summary: This study proposes a semi-automated method to quantify structural changes after epilepsy surgery and compares the remote effects of two surgical approaches (anterior temporal lobectomy and selective amygdalohippocampectomy) on brain structure.
Editorial Material
Clinical Neurology
Dario J. Englot
Letter
Clinical Neurology
Robert J. Dambrino, Scott L. Zuckerman, Dario J. Englot, Reid C. Thompson, William O. Cooper
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Graham W. Johnson, Leon Y. Cai, Derek J. Doss, Jasmine W. Jiang, Aarushi S. Negi, Saramati Narasimhan, Danika L. Paulo, Hernan F. J. Gonzalez, Shawniqua Williams Roberson, Sarah K. Bick, Catie E. Chang, Victoria L. Morgan, Mark T. Wallace, Dario J. Englot
Summary: This study demonstrates the use of a deep learning framework to accurately classify seizure onset zones in patients with drug-resistant temporal lobe epilepsy. The findings highlight the importance of temporal evolution of evoked responses within 350 msec in accurately classifying the onset zones.
JOURNAL OF NEUROSURGERY
(2022)