Review
Clinical Neurology
Zelong Zheng, Qi Wang, Shujie Sun, Jinbiao Luo
Summary: Spontaneous intracerebral hemorrhage is one of the most devastating types of stroke, with high mortality and morbidity. The optimal management of this condition remains controversial, and conventional surgical interventions and medical management have shown limited benefit. However, minimally invasive surgery for intracerebral hemorrhage has shown promising results in early phase clinical trials.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Hitoshi Kobata, Naokado Ikeda
Summary: Surgical treatment for intracerebral hemorrhage has shown potential benefits in reducing mortality, especially when using minimally invasive procedures. The reduction of ICH volume during surgery is associated with functional improvement, highlighting the importance of early hematoma evacuation for better outcomes. Ongoing trials using emerging minimally invasive techniques are expected to provide further insights into the optimal treatment for ICH.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Theodore C. Hannah, Rebecca Kellner, Christopher P. Kellner
Summary: Intracerebral hemorrhage (ICH) presents high morbidity and mortality rates, requiring prompt intervention to prevent further neuronal damage. Minimally invasive surgery (MIS) techniques offer potential benefits, but further research is needed to fully evaluate their efficacy.
Article
Cardiac & Cardiovascular Systems
Michael Kim, Jared Cooper, Fawaz Al-Mufti, Chirag Gandhi, Christian Bowers
Summary: Spontaneous intracerebral hemorrhage is a common, disabling, and high-mortality disease, with no significant effective treatment available. Traditional open craniotomy for SICH evacuation has not shown significant clinical benefits, so minimally invasive surgery has become a focus of research.
CARDIOLOGY IN REVIEW
(2021)
Review
Engineering, Biomedical
Mishek J. Musa, Austin B. Carpenter, Christopher Kellner, Dimitri Sigounas, Isuru Godage, Saikat Sengupta, Chima Oluigbo, Kevin Cleary, Yue Chen
Summary: Intracerebral hemorrhage is a common and serious cause of morbidity and mortality worldwide, but there is currently no specific treatment that has been proven effective. Surgical hematoma evacuation, despite promising preclinical studies, has not shown clear benefits over medical management. Minimally invasive treatment options are still in early-stage clinical trials. Robotics has the potential to improve treatment outcomes and play a significant role in the future of stroke treatment.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Clinical Neurology
Colton J. Smith, Christina P. Rossitto, Michael Manhart, Imke Fuhrmann, Julie DiNitto, Turner Baker, Muhammad Ali, Marily Sarmiento, J. Mocco, Christopher P. Kellner
Summary: Cerebral blood volume changes in the perihematomal and pericavity parenchyma after minimally invasive intracerebral hemorrhage evacuation were studied using pre- and post-operative CT imaging and intraoperative perfusion imaging. The results showed a significant increase in blood volume in the pericavity region after surgery, with a 21.6% increase at 3 mm and a 9.1% increase at 6 mm from the lesion border. This study demonstrates the significant increase in pericavity cerebral blood volume after minimally invasive ICH evacuation.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Duanlu Hou, Ying Lu, Danhong Wu, Yuping Tang, Qiang Dong
Summary: This study found through a meta-analysis that minimally invasive surgery (MIS) provides certain benefits for patients with intracerebral hemorrhage (ICH) in both short-term and long-term follow-up compared to other treatments, including open surgery (CT) and conventional medication (Me).
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Tao Zhu, Shan Jiang, Zhiyong Yang, Zeyang Zhou, Yuhua Li, Shixing Ma, Jie Zhuo
Summary: The study proposed an AR-based neuroendoscopic navigation system to assist surgeons in locating and clearing intracerebral hemorrhage. It has been validated to have high accuracy and feasibility.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Editorial Material
Clinical Neurology
Muhammad Ali, Kurt Yaeger, Luis Ascanio, Zachary Troiani, J. Mocco, Christopher P. Kellner
Summary: Intracerebral hemorrhage is the most deadly form of stroke with no effective treatment currently available. The SCUBA technique allows for effective clot removal and cauterization of active arterial bleeding, potentially improving outcomes for patients.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Jingchen Li, Zhiyong Li, Lin Zhao, Yuanyu Wang, Jiankai Yang, Yan Feng, Xiaowei Zhang, Xiuwen Wu
Summary: This retrospective study compared the outcomes of hypertensive cerebral hemorrhage patients who underwent stereotactic drainage at conventional timing (within 12 hours of admission) and those who underwent the procedure at a customized surgical timing. The results showed that the customized timing group had better prognosis, higher hematoma clearance rate, and lower recurrent hemorrhage rate compared to the conventional timing group. Therefore, customized timing of stereotactic drainage may be a better option to reduce post-surgery complications and promote recovery.
NEUROLOGY AND THERAPY
(2023)
Article
Clinical Neurology
Christopher P. Kellner, Rui Song, Muhammad Ali, Dominic A. Nistal, Milan Samarage, Neha S. Dangayach, John Liang, Ian McNeill, Xiangnan Zhang, Joshua B. Bederson, J. Mocco
Summary: This retrospective analysis of 90 patients undergoing minimally invasive endoscopic intracerebral hemorrhage evacuation found that younger age, absence of intraventricular hemorrhage, lobar location, and early time to evacuation were independently associated with good long-term functional outcomes. The odds ratio for time to evacuation suggests a 5% reduction in the odds of achieving a favorable outcome for each additional hour.
Article
Clinical Neurology
Likun Wang, Sheng Luo, Siying Ren, Hui Yu, Guiquan Shen, Guofeng Wu, Qingwu Yang
Summary: This study found that irregular-shaped hematoma was an independent predictor of postoperative rehemorrhage after sMIS, which can be used to assess the risk of rehemorrhage in patients before surgery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Chiu-Hao Hsu, Sheng-Chieh Chou, Lu-Ting Kuo, Sheng-Jean Huang, Shih-Hung Yang, Dar-Ming Lai, Abel Po-Hao Huang
Summary: A retrospective analysis showed that early endoscopic-assisted evacuation is safe and effective for selected patients with ICH. Minimally invasive neurosurgery (MIN) has lower rebleeding, morbidity, and mortality rates compared to traditional craniotomy, offering potential improvements in functional outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Muhammad Ali, Xiangnan Zhang, Luis C. Ascanio, Zachary Troiani, Colton Smith, Neha S. Dangayach, John W. Liang, Magdy Selim, J. Mocco, Christopher P. Kellner
Summary: In this study, the authors investigated factors associated with long-term functional independence in patients with spontaneous intracerebral hemorrhage (ICH) who underwent minimally invasive endoscopic evacuation. They found that NIHSS score on presentation, lack of intraventricular hemorrhage (IVH), and shorter time to evacuation were independently associated with functional independence at 6 months.
JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
Qiang Cai, Wenju Wang, Zhiyang Li, Ping Song, Long Zhou, Li Cheng, Hangyu Wei, Pan Lei, Qianxue Chen, Zhaohui Yang
Summary: A new clinical surgery approach, termed the two-in-one technique, combining neuroendoscopy with stereotactic aspiration, was developed for the treatment of spontaneous supratentorial intracerebral hemorrhage (SSICH). This technique effectively reduces intracranial pressure and avoids temporary increases caused by transparent sheath insertion. It offers the advantages of neuroendoscopy and has shown promising effectiveness and safety in the surgical treatment of SSICH.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Gina Li, Nicolas Bonamici, Mahua Dey, Maciej S. Lesniak, Irina V. Balyasnikova
EXPERT OPINION ON DRUG DELIVERY
(2018)
Review
Clinical Neurology
Rimas V. Lukas, Jing Wu, Mahua Dey, Robin A. Buerki, Richard W. Byrne, George J. Dohrmann
JOURNAL OF CLINICAL NEUROLOGY
(2018)
Article
Oncology
Anna Filley, Mario Henriquez, Tanmoy Bhowmik, Brij Nath Tewari, Xi Rao, Jun Wan, Margaret A. Miller, Yunlong Liu, R. Timothy Bentley, Mahua Dey
JOURNAL OF NEURO-ONCOLOGY
(2018)
Review
Immunology
Dana Mitchell, Sreenivasulu Chintala, Mahua Dey
JOURNAL OF NEUROIMMUNOLOGY
(2018)
Article
Oncology
Wei X. Huff, Namita Agrawal, Scott Shapiro, James Miller, Charles Kulwin, Mitesh Shah, Jesse J. Savage, Troy Payner, Alexander Vortmeyer, Gordon Watson, Mahua Dey
RADIATION ONCOLOGY
(2018)
Article
Cell Biology
Tanwir Hasan, Seamus P. Caragher, Jack M. Shireman, Cheol H. Park, Fatemeh Atashi, Shivani Baisiwala, Gina Lee, Donna Guo, Jennifer Y. Wang, Mahua Dey, Meijing Wu, Maciej S. Lesniak, Craig M. Horbinski, C. David James, Atique U. Ahmed
CELL DEATH & DISEASE
(2019)
Review
Biochemistry & Molecular Biology
Wei X. Huff, Jae Hyun Kwon, Mario Henriquez, Kaleigh Fetcko, Mahua Dey
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Dana Mitchell, Sreenivasulu Chintala, Kaleigh Fetcko, Mario Henriquez, Brij N. Tewari, Atique Ahmed, R. Timothy Bentley, Mahua Dey
FRONTIERS IN ONCOLOGY
(2019)
Article
Biochemical Research Methods
Hannah Marie Brown, Fan Pu, Mahua Dey, James Miller, Mitesh V. Shah, Scott A. Shapiro, Zheng Ouyang, Aaron A. Cohen-Gadol, R. Graham Cooks
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2019)
Article
Neurosciences
Teresa P. Easwaran, Nicola Lancki, Mario Henriquez, Alexander O. Vortmeyer, Nicholas M. Barbaro, Denise M. Scholtens, Atique U. Ahmed, Mahua Dey
Summary: This study investigated the association between molecular classification of gliomas and seizure presentation as well as post-operative seizure control. It found that the presence of IDH mutation is associated with seizures at presentation, while IDH-mutant tumors are associated with worse post-operative seizure outcomes.
NEUROMOLECULAR MEDICINE
(2021)
Review
Clinical Neurology
D. K. Mitchell, H. J. Kwon, P. A. Kubica, W. X. Huff, R. O'Regan, M. Dey
Summary: Brain metastasis is the most common malignant intracranial neoplasm in adults, with an increasing incidence due to improved surveillance, effective systemic therapy, and an aging population. Timely and accurate diagnosis is crucial for improving long-term outcomes. Treatment approaches should be based on the type and molecular profile of the primary tumor, as well as the size, number, and location of metastatic lesions.
Review
Health Care Sciences & Services
Sudarshawn Damodharan, Montserrat Lara-Velazquez, Brooke Carmen Williamsen, Jeffrey Helgager, Mahua Dey
Summary: Diffuse intrinsic pontine glioma (DIPG) is a type of brainstem tumor that occurs primarily in children and is characterized by high infiltrative capacity and multiple genetic mutations. Advances in molecular understanding, including the categorization of tumors with the H3 K27M mutation and the development of treatment options, have improved our knowledge of this disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Jack M. Shireman, Nikita Gonugunta, Lei Zhao, Akshita Pattnaik, Emily Distler, Skyler Her, Xiaohu Wang, Rahul Das, Jaques Galipeau, Mahua Dey
Summary: Age-related immune dysfunctions have close connections with pathologies like cancers and lack of vaccine efficacy among the elderly. An engineered fusokine, GIFT-7, has the potential to reverse aging-related lymphoid organ atrophy. In experiments using aged mouse models of glioblastoma, peripheral vaccination with GIFT-7TVax resulted in thymic regeneration, long-term antitumor immunity, increased pro-inflammatory cytokines, enhanced T-cell trafficking to the brain, and robust T-cell formation.
Review
Oncology
Jack M. Shireman, Simon Ammanuel, Jens C. Eickhoff, Mahua Dey
Summary: This study reveals significant differences in immunobiology between males and females, which also affect the overall response to immunotherapy in GBM treatment.
NEURO-ONCOLOGY ADVANCES
(2022)
Article
Psychology, Multidisciplinary
Stefan Petranek, Jennifer Pencek, Mahua Dey
BEHAVIORAL SCIENCES
(2018)
