Article
Clinical Neurology
Cristian Deana, Sara Pez, Tamara Ius, Davide Furlan, Annacarmen Nilo, Miriam Isola, Maria De Martino, Stefano Mauro, Lorenzo Verriello, Christian Lettieri, Barbara Tomasino, Mariarosaria Valente, Miran Skrap, Luigi Vetrugno, Giada Pauletto
Summary: This study compared the effect of DEX and propofol on intraoperative seizures (IOSs) during awake craniotomy for brain tumor resection. The results showed that patients receiving DEX had a higher incidence of IOSs compared to those receiving propofol. However, at the 1-year follow-up, both groups had similar epilepsy outcomes.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
A. M. de Sain, M. H. M. Mantione, I. M. C. Huenges Wajer, M. J. E. van Zandvoort, P. W. A. Willems, P. A. Robe, C. Ruis
Summary: The aim of this study was to compare preoperative, early postoperative, and late postoperative cognitive functioning in patients with suspected gliomas who underwent awake brain tumor surgery. The results showed that overall cognitive functioning remained stable in the early and late postoperative phase, except for the inhibition task.
ACTA NEUROCHIRURGICA
(2023)
Review
Clinical Neurology
Mohammad Mofatteh, Mohammad Sadegh Mashayekhi, Saman Arfaie, Yimin Chen, Kasra Hendi, Angela Tian Hui Kwan, Faraz Honarvar, Arad Solgi, Xuxing Liao, Keyoumars Ashkan
Summary: This systematic review found that in experienced hands, awake craniotomy (AC) does not cause an increase in stress, anxiety, and depression in patients. However, the psychiatric impact of AC should not be underestimated.
Article
Oncology
Diana Cristina Ghinda, Ben Lambert, Junfeng Lu, Ning Jiang, Eve Tsai, Adam Sachs, Jin-Song Wu, Georg Northoff
Summary: The study demonstrated distinct power law exponent features in the tumoral tissue for the first time, potentially providing a novel electrophysiological marker in the future. The significant features observed in the peritumoral tissue of gliomas indicate the area where both the onset of epileptiform activity and the tumor infiltration occur.
FRONTIERS IN ONCOLOGY
(2021)
Review
Clinical Neurology
Mohammad Mofatteh, Mohammad Sadegh Mashayekhi, Saman Arfaie, Hongquan Wei, Arshia Kazerouni, Georgios P. Skandalakis, Ahmad Pour-Rashidi, Abed Baiad, Lior Elkaim, Jack Lam, Paolo Palmisciano, Xiumei Su, Xuxing Liao, Sunit Das, Keyoumars Ashkan, Aaron A. Cohen-Gadol
Summary: Awake craniotomy (AC) during pregnancy is important for the preservation of neurological functions and minimizing the use of anesthesia. Existing studies have shown that AC in pregnant patients is safe and feasible, with no adverse effects on pregnancy outcomes when performed by experienced surgeons.
NEUROSURGICAL REVIEW
(2023)
Article
Oncology
Yah-Yuan Wu, Ko-Ting Chen, Yi-Chuan Chu, Chun-Chang Yeh, Wei-Chia Chen, Pin-Yuan Chen, Wei-Han Chang, Kuo-Chen Wei, Yi-Chun Chen
Summary: In this study, we evaluated the characteristics of patients with primary brain tumors and compared the neuropsychological deficits between patients who had awake craniotomy with left- or right-sided tumors. We also analyzed the association between white matter tracts and neuropsychological deficits in patients with right-sided tumors.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Yah-Yuan Wu, Ko-Ting Chen, Yi-Chuan Chu, Chun-Chang Yeh, Wei-Chia Chen, Pin-Yuan Chen, Wei-Han Chang, Kuo-Chen Wei, Yi-Chun Chen
Summary: Neuroplasticity is important for maintaining neural circuit function, especially in patients with brain tumors. This study evaluated the characteristics of primary brain tumor patients and compared neuropsychological deficits in patients undergoing different types of surgeries. The association between white matter tracts and neuropsychological deficits in patients with right-sided tumors was also analyzed.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Borys M. Kwinta, Aneta M. Myszka, Monika M. Bigaj, Roger M. Krzyewski, Anna Starowicz-Filip
Summary: Intra- and postoperative adverse events were observed in the majority of awake craniotomy cases for intrinsic supratentorial brain tumors, with the most common intraoperative adverse events being hypertension, discomfort, pain, and tachycardia. The most frequent postoperative adverse events were new language deficits and new motor deficits.
NEUROLOGICAL SCIENCES
(2021)
Article
Oncology
Eric Plitman, Tumul Chowdhury, Gabriel Paquin-Lanthier, Hirokazu Takami, Sudhakar Subramaniam, Kok Weng Leong, Abigail Daniels, Mark Bernstein, Lashmi Venkatraghavan
Summary: In patients undergoing awake craniotomy, the use of benzodiazepine-based sedation is associated with a higher incidence of postoperative neurological deficits compared to benzodiazepine-free sedation. Preoperative neurological symptoms are also related to postoperative neurological deficits in the benzodiazepine-based sedation group.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Collin J. Larkin, Ketan Yerneni, Constantine L. Karras, Zachary A. Abecassis, Guangyu Zhou, Christina Zelano, Ashley N. Selner, Jessica W. Templer, Matthew C. Tate
Summary: This study found that the duration and number of stimulations have a significant impact on the frequency of perioperative seizures in neurosurgical patients. Lesions located within the insula were associated with increased incidence of afterdischarge.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Brin E. Freund, Anteneh M. Feyissa, Aafreen Khan, Joseph I. Sirven, Sanjeet S. Grewal, David Sabsevitz, Diogo Moniz-Garcia, Alfredo Quinones-Hinojosa, William O. Tatum
Summary: This study found that using a novel circular grid for ECoG during awake craniotomy can improve the detection of ictal and interictal activity compared to a standard strip electrode. Additionally, the study discovered an association between PFEDs and intraoperative seizures.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
K. Steininger, K. H. Kahl, I Konietzko, C. Wolfert, S. Motov, P. E. Krauss, T. Broecheler, M. Hadrawa, B. Sommer, G. Stueben, E. Shiban
Summary: This study presents preliminary results of intraoperative radiotherapy (IORT) in awake craniotomies for tumor resection. Through retrospective analysis, the study found that the combination of awake craniotomy and IORT is feasible and safe for the treatment of brain tumors.
NEUROSURGICAL REVIEW
(2022)
Review
Neurosciences
Pablo R. Kappen, Tobia Beshay, Arnaud J. P. E. Vincent, Djaina Satoer, Clemens M. F. Dirven, Johannes Jeekel, Markus Klimek
Summary: Mapping musical function during awake craniotomy is feasible and can identify specific brain regions relevant for music production, with no decline in musical function observed during follow-up.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Juan Silvestre G. Pascual, Kathleen Joy O. Khu, Yves P. Starreveld
Summary: This study presents a systematic review and two case studies on multilingual brain tumor patients, revealing the heterogeneity of language areas in the brain. The findings suggest that the location and number of language areas vary in different situations, which is crucial for neurosurgical interventions and treatment.
Article
Clinical Neurology
Ryohei Otani, Ryoji Yamada, Kei Kawaguchi, Miyu Kikuchi, Yoshihiro Kushihara, Nobusada Shinoura
Summary: The serum concentration of levetiracetam during awake craniotomy is inversely correlated with the patient's body surface area and estimated glomerular filtration rate. Levetiracetam shows superior correlation between serum concentration and dosage adjusted for body surface area and estimated glomerular filtration rate compared to phenytoin. Additionally, monitoring serum levetiracetam concentration may be useful in predicting seizure risk and calibrating dosage accurately to prevent intraoperative seizures during awake craniotomy.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ori Barzilai, Natalie DiStefano, Eric Lis, Yoshiya Yamada, D. Michael Lovelock, Andrew N. Fontanella, Mark H. Bilsky, Ilya Laufer
JOURNAL OF NEUROSURGERY-SPINE
(2018)
Article
Clinical Neurology
Ibrahim Hussain, Ori Barzilai, Anne S. Reiner, Natalie DiStefano, Lily McLaughlin, Shahiba Ogilvie, Mark Bilsky, Ilya Laufer
Article
Clinical Neurology
Ori Barzilai, Lily McLaughlin, Mary-Kate Amato, Anne S. Reiner, Shahiba Q. Ogilvie, Eric Lis, Yoshiya Yamada, Mark H. Bilsky, Ilya Laufer
Editorial Material
Clinical Neurology
Ori Barzilai
WORLD NEUROSURGERY
(2018)
Article
Oncology
Ori Barzilai, Anne L. Versteeg, Arjun Sahgal, Laurence D. Rhines, Mark H. Bilsky, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Peter Pal Varga, Stefano Boriani, Chetan Bettegowda, Michael G. Fehlings, Yoshiya Yamada, Michelle J. Clarke, Paul M. Arnold, Ziya L. Gokaslan, Charles G. Fisher, Ilya Laufer
Review
Clinical Neurology
Patrick D. Kelly, Scott L. Zuckerman, Yoshiya Yamada, Eric Lis, Mark H. Bilsky, Ilya Laufer, Ori Barzilai
NEUROSURGICAL REVIEW
(2020)
Article
Oncology
Ori Barzilai, Anne L. Versteeg, C. Rory Goodwin, Arjun Sahgal, Laurence D. Rhines, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Aron Lazary, Michael G. Fehlings, Michelle J. Clarke, Paul M. Arnold, Stefano Boriani, Chetan Bettegowda, Ziya L. Gokaslan, Charles G. Fisher, Ilya Laufer
Article
Clinical Neurology
Robert J. Rothrock, Ori Barzilai, Anne S. Reiner, Eric Lis, Adam M. Schmitt, Daniel S. Higginson, Yoshiya Yamada, Mark H. Bilsky, Ilya Laufer
Summary: The study found that postoperative survival among patients with spinal metastases has improved over the past 20 years, particularly in patients with kidney, breast, lung, and colon tumors metastatic to the spine. Patients with synchronous metastatic disease had better survival compared to those with metachronous disease. These results emphasize the need for long-term outcome consideration in treatment decisions for patients undergoing surgery for spinal metastatic tumors.
Article
Clinical Neurology
William C. Newman, John Berry-Candelario, Jemma Villavieja, Anne S. Reiner, Mark H. Bilsky, Ilya Laufer, Ori Barzilai
Summary: Surgical resection of benign intradural extramedullary spine tumors results in significant improvement in symptom control, including pain severity, pain interference, and overall pain experience. The study found rapid and durable improvements in patient-reported outcomes following surgery.
Article
Clinical Neurology
Benjamin Rapoport, Christina Sze, Xi Chen, Ibrahim Hussain, Mark H. Bilsky, Ilya Laufer, Alvin C. Goh, Ori Barzilai
Summary: The study described a robot-assisted retroperitoneal approach for lumbar nerve sheath tumor resection, achieving complete en bloc tumor removal without bone removal or spinal fusion. This minimally invasive alternative involved interdisciplinary collaboration and adjunctive technologies such as intraoperative ultrasound and neurophysiologic monitoring.
OPERATIVE NEUROSURGERY
(2021)
Article
Oncology
Ori Barzilai, Axel Martin, Anne S. Reiner, Ilya Laufer, Adam Schmitt, Mark H. Bilsky
Summary: This study compares the genomic tumor landscape between spinal metastases and the corresponding primary tumors as well as between spinal metastases and visceral metastases. The results show a high concordance rate for genetic alterations between spinal metastases and primary tumors, especially for driver mutations.
Article
Clinical Neurology
Vikram B. Chakravarthy, Ben Schachner, Anubhav Amin, Anne S. Reiner, Yoshiya Yamada, Adam Schmitt, Daniel S. Higginson, Ilya Laufer, Mark H. Bilsky, Ori Barzilai
Summary: This study evaluates the clinical outcomes of hybrid therapy for spinal metastases from colorectal cancer (CRC). The results show that hybrid therapy can effectively control the disease, but patients may experience disease progression outside the treated level.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Ori Barzilai, Stefano Boriani, Charles G. Fisher, Arjun Sahgal, Jorrit Jan Verlaan, Ziya L. Gokaslan, Aron Lazary, Chetan Bettegowda, Laurence D. Rhines, Ilya Laufer
GLOBAL SPINE JOURNAL
(2019)
Article
Clinical Neurology
Ori Barzilai, Mary-Kate Amato, Lily McLaughlin, Anne S. Reiner, Shahiba Q. Ogilvie, Eric Lis, Yoshiya Yamada, Mark H. Bilsky, Ilya Laufer
NEURO-ONCOLOGY PRACTICE
(2018)
Article
Clinical Neurology
Ori Barzilai, Mark H. Bilsky, Ilya Laufer
GLOBAL SPINE JOURNAL
(2020)