Article
Medicine, Research & Experimental
Candace E. Hobson, Joe Saliba, Nopawan Vorasubin, Robert H. Lyles, Bill Mastrodimos, Roberto A. Cueva
Summary: This study shows that the position of vestibular schwannoma relative to the IAC axis can be used along with tumor size to predict postoperative facial outcomes. A greater proportion of tumor posterior to the IAC axis was associated with significantly better facial outcomes.
Editorial Material
Clinical Neurology
Ufuk Erginoglu, Walid Elshamy, Mustafa K. Baskaya
Summary: Preserving facial nerve function is crucial in translabyrinthine approach for vestibular schwannoma surgery. Anatomical variations in the facial nerve are rare but can be associated with congenital abnormalities. We present a rare case of vestibular schwannoma with a bifurcated facial nerve. The patient had a successful postoperative recovery with Grade I outcome. This case highlights the importance of identifying and preserving the facial nerve during vestibular schwannoma resection.
WORLD NEUROSURGERY
(2022)
Article
Otorhinolaryngology
Yin Ren, Bridget MacDonald, Kareem O. Tawfik, Marc S. Schwartz, Rick A. Friedman
Summary: Clinical predictors of facial nerve outcomes after microsurgical resection of vestibular schwannoma were identified, indicating excellent outcomes can be achieved with this procedure. Gross total resection and >= 100-mu V intraoperative FN electromyographic response were found to predict excellent FN outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Nickalus R. Khan, Turki Elarjani, Aria M. Jamshidi, Stephanie H. Chen, Clifford S. Brown, Josh Abecassis, Michael A. Silva, Victor M. Lu, Eva Wu, Monica Diaz-Kanelidis, Rita Bhatia, Michael E. Hoffer, Adrien A. Eshraghi, Christine T. Dinh, Simon I. Angeli, Fred F. Telischi, Jacques J. Morcos
Summary: This study retrospectively evaluated the clinical and surgical outcomes of a large surgical series of vestibular schwannoma in North America over 20 years. The study found that facial nerve outcomes were correlated with cerebellopontine angle extension, tumor volume, facial nerve stimulation threshold, facial nerve consistency, preoperative facial nerve function, and history of a prior resection. The data supports a continuation of a strategy of gross total resection, modifiable by intraoperative findings and judgment.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Michael A. Silva, Henry Chang, Ashish H. Shah, Nickalus R. Khan, Clifford S. Brown, Christine T. Dinh, Adrien A. Eshraghi, Fred F. Telischi, Simon Angeli, Jacques J. Morcos
Summary: Intracisternal papaverine irrigation during vestibular schwannoma resection can safely improve immediate postoperative facial nerve outcomes, maintain similar long-term facial nerve outcomes, and is not associated with a significant increase in complications.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Yang Sun, Jianhua Yang, Tang Li, Kaiming Gao, Xiaoguang Tong
Summary: This study has established a new nomogram for predicting the rates of poor facial nerve outcomes after vestibular schwannoma surgery, which includes significant prognostic factors. The nomogram showed good discrimination and calibration in the validation cohort.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Gang Xiao, Bin Huang, Ming Guo, Chaoxin Long, Pingan Li, Bin Zhong, Chuncheng Guan
Summary: BRCAT54 is an anti-tumor lncRNA that is downregulated in lung cancer and its role in vestibular schwannoma (VS) is unclear. This study found that BRCAT54 interacts with miR-21 and suppresses cell proliferation in VS.
Article
Medicine, General & Internal
Natalia Carasek, Danielle Cristovao, Lucas Alves Teixeira Oliveira, Fernanda Ferreira Caldas, Fernando Massa Correia, Thais Gomes Abrahao Elias, Rivadavio Amorim, Fayez Bahmad Jr
Summary: This study describes a case in which simultaneous surgical treatments for vestibular schwannoma and middle ear cholesteatoma were performed on a female patient, followed by cochlear implantation. The surgical approach was successful, with preservation of the auditory nerve and cochlea, and positive postoperative results were observed with the cochlear implant in both silent and noisy environments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kuan-Wei Chiang, Sanford P. C. Hsu, Tsui-Fen Yang, Mao-Che Wang
Summary: This study investigated the impact of the extent of internal acoustic meatus tumor removal on large acoustic neuroma surgery outcomes, finding a correlation with poor postoperative facial function. Younger age, larger tumors requiring radiosurgery, and more extensive tumor removal were associated with better tumor control.
Article
Otorhinolaryngology
Catherine Sobieski, Daniel E. Killeen, Samuel L. Barnett, Bruce E. Mickey, Jacob B. Hunter, Brandon Isaacson, Joe Walter Kutz
Summary: Facial nerve outcomes one year after microsurgical resection are poorer in patients with NF2 tumors compared to sporadic tumors, particularly for tumors with a volume greater than 3 cm³ and those classified as NF2 tumors.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Stephen A. Chan, Robert J. Macielak, Amy M. Tuchscherer, Brian A. Neff, Colin L. W. Driscoll, Maria Peris-Celda, Jamie J. Van Gompel, Michael J. Link, Matthew L. Carlson
Summary: This study evaluated the optimal dose and timing of sodium fluorescein (SF) administration for selective fluorescence of sporadic vestibular schwannoma (VS) during microsurgery. The results showed that SF and YE560 could achieve selective fluorescence of the tumor approximately 30 minutes after administration, facilitating better visualization and differentiation of the tumor from surrounding nerves.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Clinical Neurology
Felix Arlt, Johannes Kasper, Dirk Winkler, Katja Jaehne, Michael Karl Fehrenbach, Juergen Meixensberger, Caroline Sander
Summary: Intraoperative neurophysiological monitoring is crucial in vestibular schwannoma surgery to prevent nerve injury. Repeated direct nerve stimulation and a detected decreased amplitude might show facial nerve function deterioration.
FRONTIERS IN NEUROLOGY
(2022)
Review
Health Care Sciences & Services
Bruno Sergi, Stefano Settimi, Gaia Federici, Costanza Galloni, Carla Cantaffa, Eugenio De Corso, Daniela Lucidi
Summary: Management of vestibular schwannoma (VS) is a complex process that requires consideration of factors such as patient age, tumor size, and hearing preservation. An individualized treatment approach is preferable over a single standard method.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Michel Heide Talebnasab, Dan Dupont Hougaard
Summary: Vestibular schwannoma is the most common type of intracranial schwannoma, accounting for about 8% of all intracranial tumors in adults with an estimated incidence rate of around 1.3/100,000. The incidence rates of facial nerve schwannomas and cochlear nerve schwannomas are not well-documented. These three types of nerve tumors often present with unilateral hearing loss, tinnitus, and disequilibrium. Facial nerve palsy is common in facial nerve schwannomas but rare in vestibular schwannomas. The symptoms are usually persistent and progressive, leading to interventions that may cause significant morbidity such as deafness and imbalance.
Article
Clinical Neurology
Robert J. Macielak, Christine M. Lohse, Katherine P. Wallerius, Skye K. Lawlor, Brian A. Neff, Maria Peris Celda, Jamie J. Van Gompel, Colin L. W. Driscoll, Michael J. Link, Matthew L. Carlson
Summary: Younger age and better immediate postoperative HB grade were found to be significantly associated with complete recovery of facial nerve function to HB Grade I after microsurgical resection of sporadic vestibular schwannoma.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Otorhinolaryngology
Ellen Andries, Annick Gilles, Vedat Topsakal, Olivier Vanderveken, Paul Van de Heyning, Vincent Van Rompaey, Griet Mertens
Summary: The study found that HRQoL scores measured with HUI significantly improved after cochlear implantation in users aged 55 and older, but the multi-attribute scores remained worse than those of the control group. Vestibular loss was significantly related to decreases in HUI multi-attribute and emotion scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Griet Mertens, Paul Van de Heyning, Olivier Vanderveken, Vedat Topsakal, Vincent Van Rompaey
Summary: The study demonstrates that there is a significant linear correlation between frequency-to-place mismatch and speech perception in noise six months after cochlear implantation. Minimizing this mismatch can lead to better initial speech perception outcomes for cochlear implant recipients. However, the effect seems to disappear after twelve months of experience with the cochlear implant. Additional research is needed to explore tonotopic fitting strategies based on postoperative CT images of electrode contact locations.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Genetics & Heredity
Allan Thomas Hojland, Lisse J. M. Tavernier, Isabelle Schrauwen, Manou Sommen, Vedat Topsakal, Isabelle Schatteman, Ingeborg Dhooge, Alex Huber, Diego Zanetti, Henricus P. M. Kunst, Alexander Hoischen, Michael B. Petersen, Guy Van Camp, Erik Fransen
Summary: This study identified significant associations between ACAN gene variants and otosclerosis risk, with multiple independent signals. The variants include both predisposing and protective alleles, spanning different populations. Exonic variants in the ACAN gene are mainly located in the CS domain, with a wide range of effect sizes and population frequencies.
Article
Surgery
Ahmet M. Tekin, Ahmed N. Elsamanody, Ismail M. Ali, Vedat Topsakal
Summary: In Somalia, urban violence has caused stray bullet injuries in the pterygopalatine fossa. Endoscopic endonasal approach has shown to be efficient and safe for the removal of foreign bodies in this area, regardless of age and anatomical dimensions.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Psychology, Multidisciplinary
Kaat De Raedemaeker, Ina Foulon, Roberta Vella Azzopardi, Elke Lichtert, Ronald Buyl, Vedat Topsakal, Ingo Beyer, Ivan Bautmans, Olaf Michel, Frans Gordts
Summary: This study examined hearing thresholds in senior adults aged 80 years and older and compared the results with the current ISO 7029 reference values. The findings revealed that both male and female participants in the study had worse hearing thresholds than expected based on the ISO reference values. Given the significant impact on individuals and society, this is a problem that requires attention.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Health Care Sciences & Services
Vedat Topsakal, Sumit Agrawal, Marcus Atlas, Wolf-Dieter Baumgartner, Kevin Brown, Iain A. Bruce, Stefan Dazert, Rudolf Hagen, Luis Lassaletta, Robert Mlynski, Christopher H. Raine, Gunesh P. Rajan, Joachim Schmutzhard, Georg Mathias Sprinzl, Hinrich Staecker, Shin-ichi Usami, Vincent Van Rompaey, Mario Zernotti, Paul van de Heyning
Summary: This study investigated the opinions of experienced cochlear implant surgeons on surgical techniques and materials that can best preserve residual hearing after surgery. The results were compared to a previous survey conducted in 2010. The findings showed a preference for round window insertion, slow array insertion, and the use of systematic antibiotics. The importance of insertion depth and choosing electrode arrays with minimal trauma was also highlighted. While there was agreement on certain aspects, there was disagreement on whether the middle ear should be flushed with a non-aminoglycoside antibiotic solution and whether a sheath or insertion tube should be used. The study provides insight into the changing beliefs and areas of consensus and disagreement in cochlear implant surgery since 2010.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Otorhinolaryngology
Mohammad Al Saadi, Emilie Heuninck, Leo De Raeve, Paul Van de Heyning, Vedat Topsakal
Summary: This study reports the experience of using an image-guided and navigation-based robot arm as an assistive surgical tool for cochlear implantation. The results show that RACIS can provide an efficient way to access the inner ear, which is helpful for dealing with intra cochlear ossifications and achieving full insertion of the cochlear implant.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Neurosciences
Mona Khan, Marnick Clijsters, Sumin Choi, Wout Backaert, Michiel Claerhout, Floor Couvreur, Laure Van Breda, Florence Bourgeois, Kato Speleman, Sam Klein, Johan Van Laethem, Gill Verstappen, Ayse Sumeyra Dereli, Seung-Jun Yoo, Hai Zhou, Thuc Nguyen Dan Do, Dirk Jochmans, Lies Laenen, Yves Debaveye, Paul De Munter, Jan Gunst, Mark Jorissen, Katrien Lagrou, Philippe Meersseman, Johan Neyts, Dietmar Rudolf Thal, Vedat Topsakal, Christophe Vandenbriele, Joost Wauters, Peter Mombaerts, Laura Van Gerven
Summary: The study investigated the possibility of SARS-CoV-2 invading the brain through the olfactory projection. The researchers obtained tissue and fluid samples from deceased COVID-19 patients and found no evidence of viral invasion in the olfactory bulb and frontal lobe. Instead, they identified anatomical barriers between the olfactory epithelium and the olfactory nerve.
Article
Medicine, General & Internal
Gill Verstappen, Olaf Michel, Stijn Halewyck, Vedat Topsakal, Antje Possneck
Summary: Gout is a common inflammatory arthritis characterized by the deposition of monosodium urate crystals. If not adequately treated, it can lead to the development of gout tophi at various locations, such as the septal cartilage and nasal tip.
CLINICAL CASE REPORTS
(2022)
Article
Genetics & Heredity
Ahmet M. Tekin, Hermine Baelen, Emilie Heuninck, Yildirim A. Bayazit, Griet Mertens, Vincent van Rompaey, Paul van de Heyning, Vedat Topsakal
Summary: Cochlear implantation (CI) for deafblindness has a greater impact than for non-syndromic hearing loss. Minimally invasive robotically assisted cochlear implant surgery (RACIS) is a safe and beneficial intervention for deafblindness due to an optic atrophy 1 (OPA1) mutation, as it minimizes surgical trauma and possible failures.
Article
Pediatrics
Gill Verstappen, Ina Foulon, Kelsey van den Houte, Emilie Heuninck, Bart Van Overmeire, Frans Gordts, Vedat Topsakal
Summary: This study aimed to assess the different etiologies, risk factors, and hearing results of infants with permanent hearing loss, as well as evaluate the efficacy and consequences of different screening devices over the past 21 years. The results showed that only a limited number of infants had permanent hearing loss, with genetic causes and anatomical abnormalities being the common etiologies for bilateral and unilateral sensorineural hearing loss, respectively.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Yasar Kemal Duymaz, Ahmet M. Tekin, Patrick D'Haese, Samil Sahin, Burak Erkmen, Ahmet Adnan Cirik, Vedat Topsakal
Summary: This study investigated the readability of online sources on hereditary hearing impairment (HHI). The results showed that all analyzed websites required higher reading levels than sixth grade, indicating that not all patients and parents can comprehend the information they seek for on these websites.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Hermine Baelen, Anne-Marie Esschendal, Yannick De Brucker, Ina Foulon, Vedat Topsakal, Frans Gordts
Summary: This study presents the common comorbidities of congenital facial nerve palsy and their detection and treatment, particularly focusing on ENT problems like hearing loss. The study includes a literature review and research on 16 children with congenital facial nerve palsy. The findings indicate that congenital facial nerve palsy can be associated with Moebius syndrome and often presents with bilateral and severe symptoms, including hearing loss and other abnormalities such as dysfunction of the abducens nerve and ophthalmological problems. Radiological imaging is recommended for diagnostic and therapeutic purposes.
FRONTIERS IN PEDIATRICS
(2023)
Article
Otorhinolaryngology
Jaouad Abari, Emilie Heuninck, Mohammad Al Saadi, Vedat Topsakal
Summary: By utilizing image guided and robot-assisted surgery, it is possible to achieve correct insertion of the electrode array without the need to open the tympanomeatal flap. After a series of cases and optimization of the insertion angles and planning software, a new clinical routine for robotic-assisted cochlear implant surgery, based on image guided surgery without opening a tympanomeatal flap, has been developed.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Furkan Yaz, Michael Buttner, Ahmet M. Tekin, Ilhan Bahsi, Vedat Topsakal
Summary: This study aims to analyze the evolutions and developments in the scientific output relating to tinnitus. The results showed an increasing trend in tinnitus research from 1980 to 2020, with a focus on treatment and pathogenic mechanisms. The findings provide new insights for future tinnitus research.
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
(2023)