Article
Clinical Neurology
Hung Yang Chien, Yao Chun Yang, Min Hong Hsieh, Chang Chen Yang
Summary: This study evaluated bone-cement binding for thoracolumbar fractures using a new assessment method and found that patients who underwent early PVP had better bone-cement integration and fewer adjacent fractures.
WORLD NEUROSURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Haowen Dai, Yang Liu, Qing Han, Aobo Zhang, Hao Chen, Yang Qu, Jincheng Wang, Jianwu Zhao
Summary: This study compared the biomechanical differences between unilateral percutaneous vertebroplasty (UPVP) and bilateral percutaneous vertebroplasty (BPVP) using finite element analysis. The results showed that BPVP could balance vertebral body stress, reduce intervertebral disc stress, and offer stability advantages compared to UPVP. Therefore, BPVP has the potential to reduce postoperative complications and provide promising clinical effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Bing Peng, Zepeng Zhang, Jiangping Chen, Jianqiang Zhang, Zhexiang Wang
Summary: This study investigated the correlation between bone cement distribution and adjacent vertebral fractures after percutaneous vertebroplasty. By retrospectively analyzing patient data and comparing different evaluation methods, a simple and accurate evaluation method was derived.
WORLD NEUROSURGERY
(2023)
Article
Engineering, Biomedical
Saulo Martelli, Mario Giorgi, Enrico Dall'Ara, Egon Perilli
Summary: Analysis of microstructural deformation and fracture behavior of elderly femora revealed that cortical elastic instability promotes bone fracture behavior, enhancing load bearing capacity, toughness, and damage tolerance. These findings will contribute to the advancement of current methods for predicting hip fragility.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Felix N. Schmidt, Michael Hahn, Kilian E. Stockhausen, Tim Rolvien, Constantin Schmidt, Tobias Knopp, Christian Schulze, Klaus Pueschel, Michael Amling, Bjorn Busse
Summary: Doses of irradiation above 25 kGy are known to cause irreversible mechanical decay in bone tissue. However, the impact of irradiation doses absorbed in a clinical setting on the mechanical properties of bone remains unclear. This study investigated high irradiation doses of 31.2 kGy and found that they severely alter the mechanical properties of bone, while doses below 30 Gy do not have an impact on mechanical bending-behavior of bone.
MATERIALS TODAY BIO
(2022)
Article
Endocrinology & Metabolism
Chengqiang Zhou, Shaolong Huang, Yifeng Liao, Han Chen, Yazhong Zhang, Hua Li, Ziqiang Zhu, Yunqing Wang
Summary: This study investigates the correlation between the larger side bone cement volume/vertebral body volume ratio (LSBCV/VBV%) and adjacent vertebral compression fracture (AVCF) in percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fracture (OVCF). The results show that bone mineral density (BMD), bone cement disc leakage, and LSBCV/VBV% are independent risk factors for AVCF after PVP.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ergonomics
Narayan Yoganandan, Jamie Baisden, Aditya Vedantam, Vicky Varghese, Anjishnu Banerjee
Summary: The purpose of this study was to measure the bone mineral densities (BMDs) of the C1 and C2 vertebrae using computed tomography and discuss their implications for autonomous vehicles and vulnerable road users. Nine elderly female cadaver specimens were used to determine BMDs at specific regions. The findings can provide valuable information for developing female-specific finite element models to enhance understanding of load paths, injuries, mechanisms, and tolerance.
ACCIDENT ANALYSIS AND PREVENTION
(2023)
Article
Clinical Neurology
Luca Denaro, Umile Giuseppe Longo, Rocco Papalia, Sergio De Salvatore, Laura Ruzzini, Ilaria Piergentili, Vincenzo Denaro
Summary: The study aimed to determine the trends in PV procedures and evaluate the yearly national costs in Italy. Data from 2009 to 2015 showed a high number of PV surgeries in Italy, with females being the majority of patients. The median length of hospital stay was 4.15 days, and the mean hospital reimbursement for each PV hospitalization was 4,629 euros.PV costs were relatively lower compared to other countries.
EUROPEAN SPINE JOURNAL
(2021)
Article
Surgery
Jingchi Li, Yimin Xie, Shenglu Sun, Congyang Xue, Wenqiang Xu, Chen Xu, Zhipeng Xi
Summary: This study found that the differences in bone mineral density (BMD) between the inner cortex and cancellous bone of the vertebral body can increase the risk of adjacent vertebral fracture (AVF) after percutaneous vertebroplasty (PVP) by deteriorating the local biomechanical environment. Therefore, it is suggested that the maximum differences in BMD should be routinely measured to predict the risk of AVF.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Wei Wei, Xianping Du, Na Li, Yunjie Liao, Lifeng Li, Song Peng, Wei Wang, Pengfei Rong, Yin Liu
Summary: Changes in T1 tilt may alter biomechanical loadings of cervical spine segments, especially of the adjacent segments after ACF surgery. Extension may be more susceptible to T1 tilt changes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
An-Jhih Luo, Jen-Chung Liao, Lih-Hui Chen, Po-Liang Lai
Summary: High-viscosity bone cement (HVBC) and low-viscosity bone cement (LVBC) have similar clinical outcomes in the treatment of thoracic vertebral compression fractures, but HVBC has less cement leakage, a larger injection volume, and better postoperative pain relief.
Review
Medicine, General & Internal
Ming Chen, Cekai Yang, Zhuoyan Cai, Youtao Liu, Hao Liu, Jianchao Cui, Zhensong Yao, Yuan Chen
Summary: This study aimed to explore the influencing factors of adjacent vertebral re-fracture after percutaneous vertebroplasty (PVP) for osteoporosis vertebral compression fractures (OVCFs). The clinical data of 55 patients with adjacent vertebral re-fracture after PVP operation for OVCFs were retrospectively analyzed. The study found that a higher dose of bone cement, greater cross-sectional area asymmetry (CSAA) and fat infiltration rate (FIR) of multifidus, and higher CSAA of erector spinae were independent risk factors for recurrent fractures of adjacent vertebrae after PVP.
FRONTIERS IN MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Francois Zot, Estelle Ben-Brahim, Mathieu Severyns, Yann Ledoux, Michel Mesnard, Laetitia Caille, Cecile Swennen, Simon Teyssedou, Abdollah-Yassine Moufid, Arnaud Germaneau, Tanguy Vendeuvre
Summary: Lumbar disc arthroplasty is a surgical procedure used to treat degenerative disc disease. This study compared the mechanical response of ball-and-socket and elastic prostheses using finite element models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Fei Feng, Mengmeng Chen, Xuan Wang, Hongwei Zhang, Hongtao Nie, Hai Tang
Summary: This study investigated the product translation of a spinal acrylic bone cement (ABC) in China. The newly marketed product demonstrated similar properties to the existing product and passed verification tests. It showed good performance in non-clinical and animal experiments, and proved to be safe and effective in a clinical investigation.
BIOACTIVE MATERIALS
(2022)
Article
Medicine, Research & Experimental
Shen-Yun Fang, Ji-Lin Dai, Ji-Kang Min, Wei-Li Zhang
Summary: The study investigated risk factors for vertebral re-fracture post-PKP for OVCF. Age, number of operative vertebral bodies, degenerative scoliosis, and anti-osteoporosis treatment were significantly associated with re-fracture. Degenerative lateral curvature was identified as an independent risk factor and possible risk factor for re-fracture post-PKP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Amir Lavi, Gadi Pelled, Wafa Tawackoli, Nardi Casap, Dan Gazit, Zulma Gazit
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2017)
Article
Cell Biology
Maxim Bez, Dmitriy Sheyn, Wafa Tawackoli, Pablo Avalos, Galina Shapiro, Joseph C. Giaconi, Xiaoyu Da, Shiran Ben David, Jayne Gavrity, Hani A. Awad, Hyun W. Bae, Eric J. Ley, Thomas J. Kremen, Zulma Gazit, Katherine W. Ferrara, Gadi Pelled, Dan Gazit
SCIENCE TRANSLATIONAL MEDICINE
(2017)
Article
Cell & Tissue Engineering
Doron Cohn Yakubovich, Dmitriy Sheyn, Maxim Bez, Yeshai Schary, Eran Yalon, Afeef Sirhan, May Amira, Alin Yaya, Sandra De Mel, Xiaoyu Da, Shiran Ben-David, Wafa Tawackoli, Eric J. Ley, Dan Gazit, Zulma Gazit, Gadi Pelled
STEM CELL RESEARCH & THERAPY
(2017)
Article
Biotechnology & Applied Microbiology
Maxim Bez, Thomas J. Kremen, Wafa Tawackoli, Pablo Avalos, Dmitriy Sheyn, Galina Shapiro, Joseph C. Giaconi, Shiran Ben David, Jess G. Snedeker, Zulma Gazit, Katherine W. Ferrara, Dan Gazit, Gadi Pelled
Article
Multidisciplinary Sciences
Maxim Bez, Zhengwei Zhou, Dmitriy Sheyn, Wafa Tawackoli, Joseph C. Giaconi, Galina Shapiro, Shiran Ben David, Zulma Gazit, Gadi Pelled, Debiao Li, Dan Gazit
SCIENTIFIC REPORTS
(2018)
Article
Orthopedics
Thomas J. Kremen, Maxim Bez, Dmitriy Sheyn, Shiran Ben-David, Xiaoyu Da, Wafa Tawackoli, Shawn Wagner, Dan Gazit, Gadi Pelled
AMERICAN JOURNAL OF SPORTS MEDICINE
(2019)
Article
Cell & Tissue Engineering
Gadi Pelled, Raphael Lieber, Pablo Avalos, Doron Cohn-Schwartz, Wafa Tawackoli, Joseph Roth, Emma Knapp, Edward M. Schwarz, Hani A. Awad, Dan Gazit, Zulma Gazit
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Orthopedics
Thomas J. Kremen, Tina Stefanovic, Wafa Tawackoli, Khosrowdad Salehi, Pablo Avalos, Derek Reichel, Manuel J. Perez, Juliane D. Glaeser, Dmitriy Sheyn
AMERICAN JOURNAL OF SPORTS MEDICINE
(2020)
Article
Orthopedics
Jorge Chahla, Angela Papalamprou, Virginia Chan, Yasaman Arabi, Khosrawdad Salehi, Trevor J. Nelson, Orr Limpisvasti, Bert R. Mandelbaum, Wafa Tawackoli, Melodie F. Metzger, Dmitriy Sheyn
Summary: The study found resident mesenchymal progenitor cells in all three zones of healthy adult donor menisci, with a higher prevalence in the white-white zone. Additionally, differences in vasculature distribution were observed between the zones, with larger vessels spanning towards the red-white zone and smaller arterioles and venules sprouting from the red-red zone.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Juliane D. Glaeser, Derek Ju, Wafa Tawackoli, Jae H. Yang, Khosrowdad Salehi, Tina Stefanovic, Linda E. A. Kanim, Pablo Avalos, Giselle Kaneda, Stephen Stephan, Melodie F. Metzger, Hyun W. Bae, Dmitriy Sheyn
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell & Tissue Engineering
Juliane D. Glaeser, Phillip Behrens, Tina Stefanovic, Khosrowdad Salehi, Angela Papalamprou, Wafa Tawackoli, Melodie F. Metzger, Samuel Eberlein, Trevor Nelson, Yasaman Arabi, Kevin Kim, Robert H. Baloh, Shiran Ben-David, Doron Cohn-Schwartz, Robert Ryu, Hyun W. Bae, Zulma Gazit, Dmitriy Sheyn
Summary: The study showed that coating allografts with iNCC-MPCs for mouse cranial defect repair resulted in a better integration compared to BM-MSCs, indicating the potential use of iNCC-MPCs as a cell source for cranial bone repair.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Juliane D. Glaeser, Xianchao Bao, Giselle Kaneda, Pablo Avalos, Phillip Behrens, Khosrowdad Salehi, Xiaoyu Da, Angel Chen, Chloe Castaneda, Pawel Nakielski, Wensen Jiang, Wafa Tawackoli, Dmitriy Sheyn
Summary: Cranial bone loss is a clinical challenge for craniofacial reconstruction. Induced pluripotent stem cells (iPSCs) can differentiate into mesenchymal stromal cells (MSCs) which show potential for bone regeneration. Overexpression of BMP6 in iPSC-derived cells via neural crest or mesoderm, embedded in 3D printable bio-ink, can generate viable bone graft alternatives for cranial reconstruction.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Thomas Spater, Giselle Kaneda, Melissa Chavez, Julia Sheyn, Jacob Wechsler, Victoria Yu, Patricia Del Rio, Dave Huang, Melodie Metzger, Wafa Tawackoli, Dmitriy Sheyn
Summary: The study found that xenotransplantation of human cells into immunocompetent rats did not result in elevated immune responses compared to immunocompromised rats. This suggests that immunocompetent rats are suitable animal models for xenotransplantation studies targeting immunoprivileged sites.
BIOENGINEERING-BASEL
(2023)
Article
Orthopedics
Juliane D. Glaeser, Wafa Tawackoli, Derek G. Ju, Jae H. Yang, Linda E. A. Kanim, Khosrowdad Salehi, Victoria Yu, Evan Saidara, Jean-Phillipe Vit, Zhanna Khnkoyan, Zachary NaPier, Laura S. Stone, Hyun W. Bae, Dmitriy Sheyn
Article
Medicine, Research & Experimental
Dmitriy Sheyn, Shiran Ben-David, Wafa Tawackoli, Zhengwei Zhou, Khosrawdad Salehi, Maxim Bez, Sandra De Mel, Virginia Chan, Joseph Roth, Pablo Avalos, Joseph C. Giaconi, Haneen Yameen, Lena Hazanov, Dror Seliktar, Debiao Li, Dan Gazit, Zulma Gazit