Article
Cell & Tissue Engineering
Andreas Bruzelius, Isabel Hidalgo, Antonio Boza-Serrano, Anna-Giorgia Hjelmer, Amelie Tison, Tomas Deierborg, Johan Bengzon, Tania Ramos-Moreno
Summary: A study identified a stromal microglial progenitor (STR-MP) in human bone marrow that can generate microglia-like cells in vitro, potentially for use in cell-based therapies and disease modeling. These stromal microglia (STR-M) cells exhibit phagocytic ability, classical activation, and survival in human brain tissue. This finding suggests that bone marrow harbors a source of microglia-like precursors that can be utilized in patient-centered rapid derivative approaches.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Lena Batoon, Amy J. Koh, Rahasudha Kannan, Laurie K. McCauley, Hernan Roca
Summary: This study introduced a novel inducible caspase-9 (iCasp9) mouse model that allowed targeted cell apoptosis and further investigation of efferocytosis. The unique feature of this model, controlled by any Cre-expressing mouse lines, holds extensive potential applications and provides more insights into the diversity of mechanisms and cellular effects induced by apoptosis.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Weihan Wang, Hao Zhang, Changkai Hou, Quanlei Liu, Shuyuan Yang, Zhen Zhang, Weidong Yang, Xinyu Yang
Summary: The downregulation of ADAMTS-5 in human IA suggests a potential role in the pathophysiology of IA. Compensatory administration of ADAMTS-5 inhibits IA development and rupture, highlighting important implications for treating this cerebrovascular disease.
Review
Cell Biology
Daniel Hernandez-Barrientos, Rosana Pelayo, Hector Mayani
Summary: This review discusses the important role of hematopoietic niches in the development of blood cell lineages, and explores the cellular identity, structural organization, and interconnecting mechanisms of these niches within the hematopoietic microenvironment.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Cornelia Lee-Thedieck, Peter Schertl, Gerd Klein
Summary: This review provides a comprehensive overview of the extracellular matrix (ECM) in hematopoietic stem cell (HSC) niches and highlights its importance in regulating cellular function and niche structure. The role of different classes of ECM molecules and their interactions with cells are discussed, along with the significance of matrix remodeling and biophysics in HSC niche function. The review also examines the application of current knowledge of ECM in artificial HSC niches for HSC expansion, targeted differentiation, and drug testing.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Hematology
Albert J. Pedroza, Alex R. Dalal, Rohan Shad, Nobu Yokoyama, Ken Nakamura, Paul Cheng, Robert C. Wirka, Olivia Mitchel, Michael Baiocchi, William Hiesinger, Thomas Quertermous, Michael P. Fischbein
Summary: This study provides a detailed characterization of aortic root smooth muscle cells (SMCs) in Marfan syndrome (MFS), revealing the involvement of SMCs derived from both the second heart field (SHF) and neural crest in the formation of aortic root aneurysms. The study also highlights the subtly distinct transcriptional responses between these two lineages and suggests that TWIST1 may play a key role in the enriched collagen synthesis in SHF-derived SMCs in MFS.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Claire Fielding, Andres Garcia-Garcia, Claudia Korn, Stephen Gadomski, Zijian Fang, Juan L. Reguera, Jose A. Perez-Simon, Berthold Gottgens, Simon Mendez-Ferrer
Summary: Cholinergic signals in the bone marrow preserve haematopoietic stem cell quiescence and self-renewal under proliferative stress.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Mateusz Adamiak, Kamila Bujko, Arjun Thapa, Valentina Pensato, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Daryl L. Davies, Henning Ulrich, Magda Kucia, Mariusz Z. Ratajczak
Summary: Recent evidence suggests that extracellular adenosine triphosphate (eATP) plays a crucial role in regulating the mobilization and homing of hematopoietic stem progenitor cells (HSPCs) through activation of P2X4 and P2X7 receptors. Deficiency in either receptor impairs chemotaxis of HSPCs and affects their homing and engraftment post transplantation.
Article
Physiology
Kyu Hwan Kwack, Natalie A. Lamb, Jonathan E. Bard, Elliot D. Kramer, Lixia Zhang, Scott Abrams, Keith L. Kirkwood
Summary: The study revealed defects in myeloid differentiation in mandibular bone marrow cells but enhanced immunosuppressive activity. There was a significant decrease in granulocyte-monocyte progenitors and monocyte progenitors in mandibular bone marrow, along with differences in T lymphocyte and B lymphocyte populations. Single cell RNA sequencing showed distinct differences in transcriptomic profiles of myeloid populations between mandible and femur bone marrow, highlighting previously unrecognized aspects of mandibular bone marrow populations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Obstetrics & Gynecology
Ramanaiah Mamillapalli, Levent Mutlu, Hugh S. Taylor
Summary: The study showed that bone marrow-derived stem cells can differentiate into various uterine cell types while retaining stem cell properties in a mouse model.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Bellenghi, Giovanna Talarico, Laura Botti, Rossella Puglisi, Claudio Tabolacci, Paola Portararo, Annamaria Piva, Giada Pontecorvi, Alessandra Care, Mario P. Colombo, Gianfranco Mattia, Sabina Sangaletti
Summary: Dysregulated fatty acid metabolism interacts with oncogenic signals, worsening tumor aggressiveness. Overexpression of SCD5 gene reduces SPARC secretion, leading to decreased aggressiveness and reversal of Epithelial to Mesenchymal Transition (EMT) status in the metastatic clone of 4T1.
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Oncology
Hyun-Jaung Sim, Yong-Chan Kim, Govinda Bhattarai, Sae-Young Won, Jeong-Chae Lee, Byung-Hoon Jeong, Sung-Ho Kook
Summary: PrPC-derived prion disease primarily affects neurodegeneration, but its impact on hematopoietic stem progenitor cells (HSPCs) has been poorly understood. In a study involving mice infected with prions, the presence of misfolded prion protein (PrPSc) was observed in bone marrow cells derived from infected mice, and these cells showed prion infectivity. Following infection, there was a significant decrease in the number of HSPCs, mainly due to increased apoptotic cell death in PrPC-positive HSPCs. Both PrPC-positive and PrPC-negative HSCs underwent cellular senescence, affecting their repopulation and self-renewal capacities. This study provides new evidence that prion infection modulates HSC fate through both cell-autonomous and non-autonomous mechanisms.
Article
Immunology
Lisiena Hysenaj, Berengere de Laval, Vilma Arce-Gorvel, Mile Bosilkovski, Gabriela Gonzalez-Espinoza, Guilhaume Debroas, Michael H. Sieweke, Sandrine Sarrazin, Jean-Pierre Gorvel
Summary: So far, hematopoietic stem cells (HSC) have been believed to be the source of mature immune cells. However, recent evidence shows that HSC can also directly sense cytokines released during infection/inflammation and interact with pathogen-associated molecular patterns, contributing to an efficient immune response. The study demonstrates that HSC can directly sense B. abortus pathogenic bacteria via the interaction of CD150 with the bacterial outer membrane protein Omp25, leading to committed myeloid lineage development.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Summary: The article provides a detailed characterization of senescent skeletal cells in vivo, identifying a population of senescent cells associated with age and increased in late osteoblasts/osteocytes and CD24(high) osteolineage cells. The authors also establish CD24 as a marker for skeletal cells cleared by senolytics.
NATURE COMMUNICATIONS
(2023)