Article
Oncology
Yavuz Samanci, Uluman Sisman, Alara Altintas, Sebile Sarioglu, Samira Sharifi, Ali Ihsan Atasoy, Yasemin Bolukbasi, Selcuk Peker
Summary: The study analyzed the efficacy and safety of frameless hypofractionated Gamma Knife radiosurgery in the management of unresected, large metastatic brain tumors. The results showed high local control rate, no radiation necrosis observed, and clinical parameters significantly associated with progression-free survival and overall survival.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Article
Oncology
Yavuz Samanci, Fatih Karakose, Sukran Senyurek, Selcuk Peker
Summary: This study compared the clinical outcomes of sfSRS versus hfSRS GKRS in patients with unresected small METs, and found that hfGKRS had advantages in terms of local control and toxicity.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Article
Oncology
Francesco Inserra, Fabio Barone, Paolo Palmisciano, Gianluca Scalia, Valerio Da Ros, Ahmed Abdelsalam, Antonio Crea, Maria Gabriella Sabini, Santino O. Tomasi, Gianluca Ferini, Rosario Maugeri, Lidia Strigari, Giuseppe Emmanule Umana
Summary: This study investigated the outcomes and complications of hypofractionated Gamma Knife radiosurgery (GKRS) for the treatment of benign and malignant intracranial tumors. The results showed that the protocol was effective in achieving local tumor control without acute radiation toxicity.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Daisuke Kawahara, Xueyan Tang, Chung K. Lee, Yasushi Nagata, Yoichi Watanabe
Summary: This study proposed a model using machine learning and radiomics features to predict the response of brain metastases treated by Gamma knife radiosurgery. By analyzing radiomics features of 157 tumors and using a neural network classifier, the model showed higher accuracy, sensitivity, and AUC compared to visual evaluation method.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sten Myrehaug, John Hudson, Hany Soliman, Mark Ruschin, Chia-Lin Tseng, Jay Detsky, Zain Husain, Julia Keith, Eshetu G. Atenafu, Pejman Maralani, Chris Heyn, Sunit Das, Nir Lipsman, Arjun Sahgal
Summary: This study aimed to report mature image-based outcomes for MLC-Linac HSRT, focusing on clinical and dosimetric factors associated with local failure (LF). The results showed that daily 5-fraction 30Gy HSRT treatment can achieve optimal local control, irrespective of tumor volume and histology, with an acceptable risk of radiation necrosis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Clinical Neurology
Baha'eddin A. Muhsen, Krishna C. Joshi, Bryan S. Lee, Bicky Thapa, Hamid Borghei-Razavi, Xuefei Jia, Gene H. Barnett, Samuel T. Chao, Alireza M. Mohammadi, John H. Suh, Michael A. Vogelbaum, Lilyana Angelov
Summary: In this study, Gamma Knife radiosurgery (GKRS) was shown to be effective in reducing tumor size and peritumoral edema (PTE) in patients with large posterior fossa brain metastases (LPFMs). The treatment also resulted in significant opening of the fourth ventricle, with patients tolerating the procedure well.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Matthew Gallitto, Michelle Savacool, Albert Lee, Tony J. C. Wang, Michael B. Sisti
Summary: This study reports on the feasibility of using GammaKnife ICON for five-fraction SRS in the management of newly diagnosed GBM. Progression free survival was comparable to historical data without significant radiation-induced toxicities.
Article
Clinical Neurology
Yuki Shinya, Hirotaka Hasegawa, Masahiro Shin, Mariko Kawashima, Takehiro Sugiyama, Osamu Ishikawa, Satoshi Koizumi, Yuichi Suzuki, Hirofumi Nakatomi, Nobuhito Saito
Summary: Integrating RA into GKRS for treating BAVMs can shorten obliteration time, improve obliteration rate, with no significant difference in hemorrhage rates post-GKRS between the two groups. There is a trend of more signal changes in the early period in the RA-GKRS group.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zekun Jiang, Bao Wang, Xiao Han, Peng Zhao, Meng Gao, Yi Zhang, Ping Wei, Chuanjin Lan, Yingchao Liu, Dengwang Li
Summary: Multimodality MRI-based radiomics models can predict the posttreatment response of LCBM to GKRS.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Filippo Gagliardi, Pierfrancesco De Domenico, Silvia Snider, Edoardo Pompeo, Francesca Roncelli, Lina Raffaella Barzaghi, Michele Bailo, Martina Piloni, Alfio Spina, Andrei Fodor, Giulia Berzero, Nadia Di Muzio, Massimo Filippi, Gaetano Finocchiaro, Pietro Mortini
Summary: The standard treatment for surgically inaccessible low-grade brainstem gliomas is external-beam radiotherapy, but Gamma Knife radiosurgery plays an increasingly important role in treatment. This meta-analysis compared different treatment methods for these tumors and evaluated their effects on patient survival, clinical outcomes, tumor control, and complications.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Clinical Neurology
Nourou Dine Adeniran Bankole, Adyl Melhaoui, Yasser Arkha, Semmar Afaf, Khalid Bouyakhlef, Mahjouba Boutarbouch, Mohamed Jiddane, Abdeslam El Khamlichi
Summary: This study retrospectively evaluated the outcomes of patients with brain metastases treated with Leksell Gamma Knife stereotactic radiosurgery (GKSR) between 2008 and 2021. The results showed that GKSR provides good overall survival (OS) and better quality of life for patients with single or multiple brain metastases. Tumor stability and retreatment influenced the OS of patients with brain metastases.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Eline Verhaak, Wietske C. M. Schimmel, Karin Gehring, Wilco H. M. Emons, Patrick E. J. Hanssens, Margriet M. Sitskoorn
Summary: The study found that over 9 months, patients' physical well-being worsened while emotional well-being improved at group level. However, at individual level, most patients experienced declines in physical well-being and improvements in emotional well-being. Overall, aspects of HRQoL remained stable except for emotional well-being and physical well-being varied considerably at the individual patient level.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Elaine A. C. Albers, Michiel B. B. de Ruiter, Lonneke V. V. van de Poll-franse, Laura G. G. Merckel, Annette Compter, Sanne B. B. Schagen
Summary: This prospective study aimed to assess neurocognitive decline in patients with brain metastases (BM) after treatment with stereotactic radiosurgery (SRS). The results showed that high age is a risk factor for neurocognitive decline.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Marie Cantaloube, Mohamed Boucekine, Anne Balossier, Xavier Muracciole, Mickael Meyer, Christine Delsanti, Romain Carron, Yassine Mohamed Beltaifa, Domnique Figarella-Branger, Jean Regis, Laetitia Padovani
Summary: This study confirms that postoperative Gamma Knife radiosurgery (GK) after resection of brain metastases is an effective and well-tolerated technique for treating tumors of all sizes. In cases of intracranial relapse, iterative stereotactic radiosurgery (SRS) or salvage whole brain radiotherapy (WBRT) can be performed to delay the potential side effects of WBRT.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Yasunori Sato, Masaaki Yamamoto, Toru Serizawa, Kei-ichiro Yamada, Yoshinori Higuchi, Hidetoshi Kasuya
Summary: A grading system for brain metastases patients treated with stereotactic radiosurgery and surviving long has been developed in this study. Through analysis of clinical factors, five factors correlated with survival of more than 3 years were identified and used to categorize patients into four grades, with significant differences in mean survival times among the grades. The model was shown to be useful in predicting survival time for patients undergoing aggressive treatment options.
RADIOTHERAPY AND ONCOLOGY
(2021)