Review
Biochemistry & Molecular Biology
Guangshan Hao, Pinar Eser, Jun Mo
Summary: Intracranial hypertension is a common phenomenon in patients with aneurysmal subarachnoid hemorrhage and is associated with unfavorable outcomes. Recent research suggests that oxidative stress may play a crucial role in the physio-pathological changes leading to increased intracranial pressure.
Article
Clinical Neurology
Hugo Gonzalez Gomez, Jude P. J. Savarraj, Atzhiry S. Paz, Xuefang Ren, Hua Chen, Louise D. McCullough, Huimahn A. Choi, Aaron M. Gusdon
Summary: This study found that an increase in peripheral eosinophil counts after non-traumatic subarachnoid hemorrhage (SAH) is associated with worse clinical outcomes. The study suggests that a delayed increase in eosinophil counts after SAH may impact patients' functional outcomes.
FRONTIERS IN NEUROLOGY
(2023)
Article
Critical Care Medicine
Joshua Kahan, Hanley Ong, Hailan Elnaas, Judy H. H. Ch'ang, Santosh B. B. Murthy, Alexander E. E. Merkler, Mert R. R. Sabuncu, Ajay Gupta, Hooman Kamel
Summary: Intracranial hypertension is a serious complication of acute brain injury that can lead to stroke, herniation, and death. Previous studies have examined the use of optic nerve diameter measurements on CT scans to identify those at risk, but little is known about its accuracy. In this study, we aimed to validate the use of optic nerve diameter measurements on CT scans as a screening tool for intracranial hypertension in a large group of patients with brain injury. Our findings suggest that while CT-derived optic nerve diameter can be sensitive in identifying intracranial hypertension, it is not specific and overall correlation is weak.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Surgery
Mark Broadwin, Puja Patel, Tara Stansbury, Jeffrey B. Brown, Anh Hoang, Hope M. Kincaid, Shae Duka, Mark Cipolle
Summary: This study investigated the characteristics of patients with isolated traumatic subarachnoid hemorrhage (itSAH) and found that patients with high Glasgow Coma Scale (GCS) scores may be safely observed without neurosurgical consultation. Factors associated with worsening repeat computed tomography head (CTH) included injury severity, neurological deficit, length of stay, and certain medical histories. These findings may help identify patients who require transfer for intensive care.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Critical Care Medicine
Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincon-Gutierrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone
Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.
Article
Medicine, General & Internal
Min Li, Rui Wang, Qi-Xing Fang, Yi-Xuan He, Ying-Wu Shi, Shun-Nan Ge, Rui-Na Ma, Yan Qu
Summary: This retrospective study investigates the association between the severity of traumatic subarachnoid hemorrhage (tSAH) and acute respiratory failure (ARF) in patients with moderate-to-severe traumatic brain injury (M-STBI). The study findings suggest that high Fisher grade tSAH on admission is associated with ARF in M-STBI patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yingchi Shan, Yihua Li, Xuxu Xu, Junfeng Feng, Xiang Wu, Guoyi Gao
Summary: This study aimed to establish a noninvasive method for assessing ICP levels in TBI patients through investigating CT HU features. The HU model showed the highest ability to predict intracranial hypertension, especially in patients with unilateral injury. It achieved the highest F1 score in different classifications of ICP levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Wiley Gillam, Nikhil Godbole, Shourya Sangam, Alyssa Detommaso, Marco Foreman, Brandon Lucke-Wold
Summary: This review aimed to explore how neurologic injury can lead to Post-Traumatic Stress Disorder (PTSD), focusing on traumatic brain injury, subarachnoid hemorrhage, and stroke as common neurologic injuries. The altered activity in the limbic system may be associated with characteristic symptoms of PTSD. However, early diagnosis and appropriate treatment are lacking in these patients.
Article
Clinical Neurology
Bradley J. Macintosh, Qinghui Liu, Till Schellhorn, Mona K. Beyer, Inge Rasmus Groote, Pal C. Morberg, Joshua M. Poulin, Maiken N. Selseth, Ragnhild C. Bakke, Aina Naqvi, Amir Hillal, Teresa Ullberg, Johan Wasselius, Ole M. Ronning, Per Selnes, Espen S. Kristoffersen, Kyrre Eeg Emblem, Karoline Skogen, Else C. Sandset, Atle Bjornerud
Summary: This study evaluates the application of a three-dimensional deep learning AI model developed using non-contrast computed tomography (CT) imaging data in diagnosing intracerebral hemorrhage. The results show that the model can accurately assess the location and volume of the hemorrhage, with high accuracy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Critical Care Medicine
Agnieszka Kazimierska, Agnieszka Uryga, Cyprian Mataczynski, Marek Czosnyka, Erhard W. Lang, Magdalena Kasprowicz
Summary: This study investigates the relationship between intracranial pressure pulse shape and CT features in traumatic brain injury patients. The results reveal that pulse shape index is associated with intracranial mass lesions (including midline shift and space-occupying lesions) and correlates significantly with the extent of the lesions and CT scores.
Article
Critical Care Medicine
Yihua Li, Guoqing Zhang, Yingchi Shan, Xiang Wu, Jiaqi Liu, Yajun Xue, Guoyi Gao
Summary: This study aimed to evaluate intracranial hypertension in patients with traumatic brain injury non-invasively using computed tomography (CT) radiomic features. The study found that second-order features had the most robust ability to predict intracranial hypertension. The findings demonstrate the potential of radiomic feature analysis in clinical practice and further research.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medicine, General & Internal
Daniel P. Whitehouse, Miguel Monteiro, Endre Czeiter, Thijs Vande Vyvere, Fernanda Valerio, Zheng Ye, Krisztina Amrein, Konstantinos Kamnitsas, Haiyan Xu, Zhihui Yang, Jan Verheyden, Tilak Das, Evgenios N. Kornaropoulos, Ewout Steyerberg, Andrew I. R. Maas, Kevin K. W. Wang, Andras Buki, Ben Glocker, David K. Menon, Virginia F. J. Newcombe
Summary: The relationship between serum biomarker concentration and lesion type and volume in TBI is primarily determined by the severity of injury and intracranial disease burden, rather than the pathoanatomical type of injury.
Article
Immunology
Nicholas Caffes, Katherine Hendricks, John S. Bradley, Nancy A. Twenhafel, J. Marc Simard
Summary: The neurological sequelae of Bacillus anthracis infection, including intracranial hemorrhage, can lead to rapidly progressive fulminant meningoencephalitis. This review discusses the toxic role of intracranial hemorrhage in anthrax meningoencephalitis and explores potential treatments targeting the hemorrhage. The use of minocycline, an antimicrobial with neuroprotective properties, is also examined.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Daisu Abe, Motoki Inaji, Takeshi Hase, Shota Takahashi, Ryosuke Sakai, Fuga Ayabe, Yoji Tanaka, Yasuhiro Otomo, Taketoshi Maehara
Summary: This study aimed to develop a prehospital triage system to stratify patients with head trauma according to trauma severity using machine learning techniques and to evaluate the predictive accuracy of these techniques. Results showed that among several machine learning algorithms, extreme gradient boosting (XGBoost) achieved the highest ROC-AUC and PR-AUC in cross-validation studies and exhibited accurate performance in the testing set.
Review
Immunology
Xinpeng Deng, Yiwen Wu, Ziliang Hu, Shiyi Wang, Shengjun Zhou, Chenhui Zhou, Xiang Gao, Yi Huang
Summary: Subarachnoid hemorrhage (SAH) is a severe cerebrovascular accident associated with poor prognosis. Within 72 hours of SAH, early brain injury (EBI) occurs, characterized by blood-brain barrier breakdown, cerebral edema, and reduced cerebrovascular flow. It has been found that ferroptosis, an iron-dependent form of programmed cell death, is involved in EBI and is strongly correlated with poor prognosis. This review summarizes the current understanding of ferroptosis in EBI and highlights its potential as a target for future research on SAH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Edward W. Swanson, Hsu-Tang Cheng, Srinivas M. Susarla, Georgia C. Yalanis, Denver M. Lough, Owen Johnson, Anthony P. Tufaro, Paul N. Manson, Justin M. Sacks
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2016)
Article
Surgery
Karan Chopra, Edward W. Swanson, Srinivas Susarla, Sarah Chang, W. Grant Stevens, Devinder P. Singh
AESTHETIC SURGERY JOURNAL
(2016)
Article
Surgery
Edward W. Swanson, Devin T. Miller, Srinivas M. Susarla, Joseph Lopez, Denver M. Lough, James W. May, Richard J. Redett
ANNALS OF PLASTIC SURGERY
(2016)
Article
Surgery
Srinivas M. Susarla, Zoe M. MacIsaac, Edward Swanson, Edward Davidson, Anand Kumar
JOURNAL OF CRANIOFACIAL SURGERY
(2017)
Article
Education, Scientific Disciplines
Srinivas M. Susarla, Erin M. Rada, Joseph Lopez, Edward W. Swanson, Devin Miller, Richard J. Redett, Anand R. Kumar
JOURNAL OF SURGICAL EDUCATION
(2017)
Article
Surgery
Srinivas M. Susarla, Edward W. Swanson, Sheri Slezak, Scott D. Lifchez, Richard J. Redett
PLASTIC AND RECONSTRUCTIVE SURGERY
(2017)
Article
Surgery
Srinivas M. Susarla, Gerhard S. Mundinger, Christopher C. Chang, Edward W. Swanson, Denver Lough, S. Alex Rottgers, Richard J. Redett, Anand R. Kumar
PLASTIC AND RECONSTRUCTIVE SURGERY
(2017)
Article
Surgery
Denver Lough, Edward Swanson, Nikolai A. Sopko, Christopher Madsen, Devin Miller, Howard Wang, Qiongyu Guo, Srinivas M. Sursala, Anand R. Kumar
PLASTIC AND RECONSTRUCTIVE SURGERY
(2017)
Article
Surgery
Denver M. Lough, Nikolai A. Sopko, Hotaka Matsui, Devin Miller, Edward W. Swanson, Rachel Bluebond-Langner, Gerald Brandacher, Arthur L. Burnett, Trinity J. Bivalacqua, Richard J. Redett
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Dermatology
Gerhard S. Mundinger, Mark W. Stalder, James Lee, Charles W. Patterson, Silpa Sharma, Daniel J. Womac, Nikolai A. Sopko, Edward W. Swanson
Summary: Lower extremity traumatic wounds in pediatric patients present challenges that can be overcome with the use of AHSC, which has shown the ability to cover exposed structures and achieve wound closure.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Biology
Jiakun Jiang, Wei Yang, Erin M. Schnellinger, Stephen E. Kimmel, Wensheng Guo
Summary: In this article, a dynamic logistic state space model is proposed to continuously update parameters for better prediction accuracy. The model allows for both time-varying and time-invariant coefficients, with time-varying coefficients modeled using smoothing splines and smoothing parameters chosen by maximum likelihood. The model is updated using batch data to approximate the underlying binomial density function. Simulation results show significantly higher prediction accuracy compared to existing methods. The method is applied to predict 1 year survival after lung transplantation using United Network for Organ Sharing data.
Article
Health Care Sciences & Services
Wei Yang, Jiakun Jiang, Erin M. Schnellinger, Stephen E. Kimmel, Wensheng Guo
Summary: The Brier score is a popular measure for predicting binary outcomes, but its interpretation is not straightforward due to its dependence on outcome prevalence. To address this issue, we propose a modification to the Brier score that removes the influence of outcome variance. We demonstrate through simulation that this new measure is more sensitive for comparing different prediction models. We also introduce a standardized performance improvement measure based on this criterion.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Urology & Nephrology
Jia Hwei Ng, Wei Yang, Laura M. Dember, HFM Study Grp
Summary: A lack of standardized criteria for fistula maturation is a barrier to improving outcomes. Using data from the HFM Study, we determined the performance characteristics of multiple candidate criteria for maturation.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Surgery
Stephen Milner, Mark Granick, Edward Swanson, Nikolai Sopko
Summary: Autologous keratinocyte culture and various combinations play a crucial role in repairing full-thickness skin defects. The ideal treatment for such defects should focus on restoring the structure and function of the skin to actively participate in biological processes.
SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH
(2021)
Article
Surgery
Gerhard S. Mundinger, David G. Armstrong, David J. Smith, Alexander M. Sailon, Abhishek Chatterjee, Greg Tamagnini, Joanna Partridge, Nicholas Baetz, Pratima Labroo, Edward W. Swanson, Nikolai A. Sopko, Mark S. Granick
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)