Article
Physiology
Mohammed R. Alwatban, Stacey E. Aaron, Carolyn S. Kaufman, Jill N. Barnes, Patrice Brassard, Jaimie L. Ward, Kathleen B. Miller, Anna J. Howery, Lawrence Labrecque, Sandra A. Billinger
Summary: This study reveals that the rate of change in middle cerebral artery blood velocity (MCAv) and flow pulsatility index (PI) is significantly higher in females compared to males. These findings suggest that sex-specific trajectories with aging play a role in cerebrovascular function and highlight the need for further investigation into sex differences in cerebrovascular disease prevalence.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Burak T. Cilhoroz, Jacob P. DeBlois, Wesley K. Lefferts, Allison P. Keller, Patricia Pagan Lassalle, Michelle L. Meyer, Lee Stoner, Kevin S. Heffernan
Summary: The association between large artery function, neurovascular coupling (NVC), and cognitive performance in young women was explored. It was found that NVC was associated with cognitive function in young women, and carotid artery function may contribute to optimal NVC by regulating blood flow delivery and pulsatility.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemical Research Methods
Alberto Gonzalez Olmos, Zaka Humlesen, Vladimir Matchkov, Dmitry D. Postnov
Summary: Laser speckle contrast imaging is used to provide physiological information about vascular topology and blood flow dynamics. This study presents a new method for contrast calculation that preserves fine temporal dynamics and structural features, resulting in improved estimation of blood flow dynamics. Simulations and in vivo experiments demonstrate the effectiveness of the proposed method compared to standard spatial and temporal contrast calculations.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Physiology
Tom G. Bailey, Timo Klein, Annelise L. Meneses, Kayla B. Stefanidis, Stefanie Ruediger, Daniel J. Green, Tim Stuckenschneider, Stefan Schneider, Christopher D. Askew
Summary: This study compared cerebrovascular and systemic vascular function between older adults with and without mild cognitive impairment (MCI), and found that changes in systemic vascular stiffness and endothelial function may contribute to altered cerebrovascular hemodynamics and impaired cognitive function in individuals with MCI.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Keisei Kosaki, Takashi Tarumi, Shoya Mori, Masahiro Matsui, Jun Sugawara, Takeshi Sugaya, Makoto Kuro-O, Chie Saito, Kunihiro Yamagata, Koichiro Oka, Seiji Maeda
Summary: This study compared cerebral and renal blood flow parameters between non-CKD adults and CKD patients and identified common predictors of hemodynamics in both the brain and kidneys, including pressure pulsatility and several cardiovascular risk factors.
HYPERTENSION RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Grant S. Roberts, Anthony Peret, Erin M. Jonaitis, Rebecca L. Koscik, Carson A. Hoffman, Leonardo A. Rivera-Rivera, Karly A. Cody, Howard A. Rowley, Sterling C. Johnson, Oliver Wieben, Kevin M. Johnson, Laura B. Eisenmenger
Summary: This study used four-dimensional flow MRI to comprehensively evaluate cerebral hemodynamics in middle-aged and older adults, and found that age and sex have an impact on blood flow and pulsatility.
Article
Cell Biology
Ilaria Alice Crippa, Paolo Pelosi, Armin Alvaro Quispe-Cornejo, Antonio Messina, Francesco Corradi, Fabio Silvio Taccone, Chiara Robba
Summary: Impaired cerebral autoregulation may increase the risk of brain hypoperfusion in septic patients. Our study found that pupillary light reflex measurement can potentially be used to assess autonomic nervous system function and evaluate cerebral autoregulation in septic patients.
Article
Obstetrics & Gynecology
Meirav Segev, Alina Weissmann-Brenner, Tal Weissbach, Eran Kassif, Boaz Weisz
Summary: The study evaluated the intra-observer variability of MCA and UA Doppler measurements in term, uncomplicated pregnancies. MCA indices showed higher intra-rater/observer agreement compared to UA pulsatility index. MCA-PI was significantly correlated with fetal biometric parameters and birthweight.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Wesley K. Lefferts, Krista S. Reed, Rachel E. Rosonke, Jacqueline A. Augustine, Kerrie L. Moreau
Summary: The mechanisms underlying sex differences in brain aging are still unclear but may be related to changes in cerebral pulsatile blood flow. This study found that women exhibit accelerated increases in cerebral pulsatility during midlife, likely driven by exaggerated increases in carotid stiffness and pulse pressure compared with men.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Stephen Contag, Silvia Visentin, Katherine Goetzinger, Erich Cosmi
Summary: The study compared the effectiveness of cerebral-placental ratio (CPR) and cerebral-renal ratio (CRR) in predicting adverse neonatal outcomes among growth-restricted fetuses. The results showed that the umbilical artery pulsatility index performed the best in detecting composite adverse neonatal outcomes, with no additional benefit from using CRR compared to CPR. The data did not support the use of renal artery Doppler as a useful clinical test for identifying fetuses at risk for adverse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Duygu Adiyaman, Bahar Konuralp Atakul, Melda Kuyucu, Hakan Golbasi, Atalay Ekin
Summary: The study found significant differences in PSV between near and far-field MCA, especially in women with a normal BMI. However, no differences were observed in women with a BMI higher than 25, or in groups categorized according to gestational weeks.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2021)
Article
Biophysics
Arkadiusz Ziolkowski, Agata Pudelko, Agnieszka Kazimierska, Zofia Czosnyka, Marek Czosnyka, Magdalena Kasprowicz
Summary: The study examined the utility of the ratio of pulse slopes (RPS) in assessing intracranial compliance. Findings showed changes in RPS and ICP pulse morphology during infusion tests, with a significant correlation between baseline RPS and intracranial elasticity.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Geriatrics & Gerontology
Andrew G. Pearson, Kathleen B. Miller, Adam T. Corkery, Nicole A. Eisenmann, Anna J. Howery, Karly A. Cody, Nathaniel A. Chin, Sterling C. Johnson, Jill N. Barnes
Summary: This study found that lower sympathoexcitatory responses to isometric handgrip exercise are associated with greater white matter hyperintensities burden in middle-aged to older adults.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Marius Causemann, Vegard Vinje, Marie E. Rognes
Summary: The study presents a computational platform for modelling and simulation of intracranial dynamics, successfully predicting the complex interplay between intracranial pressure, cerebrospinal fluid (CSF) flow, and brain tissue movement. The model is well-aligned with clinical observations and provides a qualitative and quantitative platform for investigating intracranial dynamics under various conditions.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Multidisciplinary Sciences
Eman M. Khedr, Mohammed A. Abbas, Ayman Gamea, Mohamed A. Sadek, Ahmed F. Zaki
Summary: The aim of this study was to determine if there are any alterations in anterior and posterior circulation in tension-type headache and migraine with or without aura compared to normal volunteers. The results showed that patients with chronic tension-type headache had lower peak systolic velocity (PSV) and mean flow velocity (MFV) in the middle cerebral artery (MCA) compared to controls, while patients with migraine without aura had higher EDV and MFV in the anterior cerebral artery (ACA) compared to controls.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Johan Gasslander, Nina Sundstrom, Anders Eklund, Lars-Owe D. Koskinen, Jan Malm
Summary: Male sex, antiplatelet medication, and a lower opening pressure at surgery were identified as risk factors for SDH in iNPH patients with shunts in this Swedish-based registry study. Anti-siphoning devices did not prevent SDH, but allowed for lower opening pressures without increasing the risk of SDH.
JOURNAL OF NEUROSURGERY
(2021)
Article
Anesthesiology
Nina Sundstrom, Camilla Brorsson, Marcus Karlsson, Urban Wiklund, Lars-Owe D. Koskinen
Summary: Refeeding syndrome (RFS) is a rare and potentially life-threatening condition, characterized by seizures, acute encephalopathy and serious deviations in homeostasis in malnourished patients starting refeeding. This study described the course of disease, treatment and multimodal monitoring output in a comatose RFS patient. Despite the severe clinical state, cerebral autoregulation and compensatory reserve were generally normal during neuro-intensive care treatment.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Ophthalmology
Anders Wahlin, Petter Holmlund, Abigail M. Fellows, Jan Malm, Jay C. Buckey, Anders Eklund
Summary: The study revealed that spaceflight can cause optic nerve lengthening and anterior movement of the optic nerve head, which are associated with SANS. Additionally, upward displacement of the optic chiasm was observed, but it could not be linked to SANS.
Article
Clinical Neurology
Jenny Larsson, Hanna Israelsson, Anders Eklund, Lillemor Lundin-Olsson, Jan Malm
Summary: Patients with idiopathic normal pressure hydrocephalus (INPH) experience issues with falls, fear of falling, and confidence in avoiding falls. While there is improvement after shunt surgery, they still do not reach the levels of the control group. Recurrent fallers are more likely to have low quality of life and symptoms of depression.
Article
Neurosciences
Beatrice M. Magnusson, Emil Isaksson, Lars-Owe D. Koskinen
Summary: This study aimed to map the epidemiological and demographic features of TBI patients in Umea county, Sweden. The results showed that patients with GCS scores of 13-15 had higher frequencies of abnormal CT findings, need for neurosurgical intervention, and hospital admission than previously reported.
Article
Critical Care Medicine
Linda Hagglund, Magnus Olivecrona, Lars-Owe D. Koskinen
Summary: This study investigated the correlation between brain and subcutaneous glycerol levels in sTBI patients, as well as the impact of this correlation on brain tissue damage. Results showed a positive relationship between glycerol(brain/sc) and S-100B and NSE levels, suggesting that damaged blood-brain barrier may alter concentrations of various substances in the brain. These findings emphasize the importance of considering the effects of blood-brain barrier integrity on data interpretation in clinical settings and research.
NEUROCRITICAL CARE
(2022)
Article
Clinical Neurology
Gabriel Simander, Per Olof Eriksson, Peter Lindvall, Lars-Owe D. Koskinen
Summary: This study found that intrasellar pressure (ISP) is positively correlated with tumor volume and diameter in patients with pituitary adenoma, with the coronal tumor diameter having the strongest influence on ISP elevation. Adenomas classified as parasellar invasive showed higher mean ISP than non-invasive adenomas.
Article
Clinical Neurology
Conny Johansson, Lars-Owe D. Koskinen, Rickard L. Sjoberg, Peter Lindvall
Summary: This study investigated the correlation between serum myo-inositol (MI) levels and long-term clinical outcome in patients with spontaneous subarachnoid hemorrhage (SAH). The results showed that MI levels decreased over time and the decrease was more significant in patients with unfavorable outcomes. Additionally, the MI value on day 7 was able to predict favorable outcome after 1 year.
Article
Multidisciplinary Sciences
Priyantha Wijayatunga, Lars-Owe D. Koskinen, Nina Sundstrom
Summary: This study aimed to develop a model that could predict future intracranial pressure (ICP) levels of individual patients in the intensive care unit (ICU) in order to warn treating clinicians. The model, based on a probabilistic Markov model and a prediction enhancement method, was able to reliably predict increases in ICP and had a straightforward expandability.
SCIENTIFIC REPORTS
(2022)
Correction
Critical Care Medicine
Emanuele Rezoagli, Matteo Petrosino, Paola Rebora, David Menon, Stefania Mondello, D. James Cooper, Andrew I. R. Maas, Eveline J. A. Wiegers, Stefania Galimberti, Giuseppe Citerio, Cecilia Ackerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Gerard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras M. Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana D. Castano-Leon, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Veronique Keyser, Vincent Degos, Francesco Della Corte, Hugo Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Duliere, Ari Ercole, Erzsebet Ezer, Martin Fabricius, Kelly Foks, Shirin A. Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro Gomez, Benjamin J. Gravesteijn, Francesca Grossi, Deepak Gupta, Iain Haitsma, Raimund G. Helbok, Eirik Helseth, Jilske Huijben, Peter Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos Kolias, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noemi Kovacs, Ana Kowark, Alfonso Lagares, Steven Laureys, Aurelie Lejeune, Fiona Lecky, Didier Ledoux, Roger Lightfoot, Hester Lingsma, Alex Manara, Hugues Marechal, Costanza Martino, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Jozsef Nyiradi, Fabrizio Ortolano, Jean-Francois Payen, Vincent Perlbarg, Paolo P. Persona, Wilco Peul, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Oddrun Sandrod, Kari Schirmer-Mikalsen, Rico Frederik W. Schou, Charlie Sewalt, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Ewout Steyerberg, Nino Stocchetti, Nina Sundstroem, Riikka Takala, Viktoria Tamas, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils A. Valeinis, Shirley Vallance, Zoltan Vamos, Gregory Steen, T. J. M. van Dijck Jeroen, Thomas Essen, Roel Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Peter Vulekovic, Eveline A. Wiegers, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick Zeiler, Agate Ziverte, Tommaso V. Zoerle, Russel Gruen, Lynette Murray, Dinesh Varma, Christopher MacIsaac, Andrea Jordan
INTENSIVE CARE MEDICINE
(2023)
Article
Clinical Neurology
Sanna A. Eklund, Hanna Israelsson, Mattias Brunstrom, Karin Forsberg, Jan Malm
Summary: This study found that idiopathic normal pressure hydrocephalus (iNPH) patients treated with CSF shunting had a shorter life expectancy. Cardiovascular comorbidities and fatal falls contributed to the increased mortality in iNPH, suggesting the importance of treating iNPH in supplementary ways to reduce mortality.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Gabriel Simander, Per Dahlqvist, Louise Oja, Per Olof Eriksson, Peter Lindvall, Lars-Owe D. Koskinen
Summary: The aim of this study was to investigate the association between intraoperative intrasellar pressure (ISP) and pre-and postoperative endocrine disturbances in patients with pituitary tumors, focusing on hyperprolactinemia and hypopituitarism. The study included 100 patients who underwent transsphenoidal surgery and had their ISP measured intraoperatively. The results showed that ISP was associated with preoperative hyperprolactinemia in nonprolactinoma pituitary tumor patients, but not with postoperative hypopituitarism at 3 months after surgery.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Conny Johansson, Helena Aineskog, Lars-Owe D. Koskinen, Andreas Gunnarsson, Peter Lindvall
Summary: This study investigates the correlation between serum levels of neurofilament light (NFL) and cerebrospinal fluid (CSF) levels, as well as long-term clinical outcome in patients with aneurysmal subarachnoid haemorrhage (SAH). The results show a significant correlation between serum and CSF-NFL levels, and suggest that serum NFL may be used as a prognostic marker for clinical outcome in SAH.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Helena Aineskog, Conny Johansson, Robert Nilsson, Lars-Owe D. Koskinen, Peter Lindvall
Summary: This study found a significant correlation between protein S100B and blood clearance and health-related quality of life after 1 year of aneurysmal subarachnoid hemorrhage (aSAH). Peak S100B can be used as a prognostic factor for predicting unfavorable outcome in aSAH.
ACTA NEUROCHIRURGICA
(2022)
Correction
Clinical Neurology
Ulrika Sandvik, Lars-Owe Koskinen, Anders Lundquist, Patric Blomstedt