Article
Medicine, General & Internal
Marta Villadoniga, Lidia Cabanes-Martinez, Laura Lopez-Vinas, Samira Fanjul, Marta del Alamo, Ignacio Regidor
Summary: Deep brain stimulation of the subthalamic nucleus is an efficient treatment for motor symptoms in patients with Parkinson's disease, but its effects on gait and balance remain controversial. Researchers have considered alternative targets, such as the pedunculopontine nucleus and the pars reticulata of substantia nigra, to improve gait disorders. Compared to conventional subthalamic stimulation, combined stimulation of the substantia nigra and subthalamic nucleus leads to better outcomes in improving gait.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Karen Wendt, Majid Memarian Sorkhabi, Charlotte J. Stagg, Melanie K. Fleming, Timothy Denison, Jacinta O'Shea
Summary: This study compared the effects of monophasic and biphasic iTBS using a custom-made device and found that monophasic iTBS induced a stronger increase in motor corticospinal excitability, suggesting its potential for greater functional impact.
Article
Neurosciences
Srestha Mazumder, Anita Y. Bahar, Claire E. Shepherd, Asheeta A. Prasad
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra and aggregation of alpha-synuclein. Deep brain stimulation of the subthalamic nucleus is commonly used to treat motor symptoms in Parkinson's disease. However, the cellular changes in the subthalamic nucleus during Parkinson's disease and the impact of deep brain stimulation on the subthalamic nucleus and substantia nigra are not well understood.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Tao Xue, Shu Wang, Shujun Chen, Huizhi Wang, Chong Liu, Lin Shi, Yutong Bai, Chunkui Zhang, Chunlei Han, Jianguo Zhang
Summary: This study found that deep brain stimulation of the subthalamic nucleus (STN-DBS) can reduce seizure activity by inhibiting the STN-SNr circuit. Activation of this circuit, on the other hand, increases seizure activity. Furthermore, the use of specific orexin receptor antagonists also shows potential in suppressing motor seizure activity.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil
Summary: Stimulation of the zona incerta can reduce heat pain perception, but does not affect warmth perception or pressure pain. These findings provide a mechanistic explanation for sensory changes observed in Parkinsonian patients undergoing subthalamic deep brain stimulation and identify the zona incerta as a potential target for neuromodulation of pain.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Yuhan Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study aimed to evaluate optimal stimulation parameters for treating dystonia with STN-DBS. Results showed that the optimal parameters vary among patients, with improvement rate being linearly dependent on stimulation parameters. Adverse effects include dyskinesia and depression.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Martin A. Horn, Alessandro Gulberti, Ute Hidding, Christian Gerloff, Wolfgang Hamel, Christian K. E. Moll, Monika Poetter-Nerger
Summary: This study assessed the effects of footwear and different DBS modes on gait kinematics in patients with Parkinson's disease. The results showed that both footwear and DBS mode influenced gait characteristics in patients with PD. Interestingly, the effects of DBS on gait were specific to different gait tasks, with STN+SN DBS showing the most significant effects during gait with increased cognitive load.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Leon A. Steiner, Andrea A. Kuhn, Jorg R. P. Geiger, Henrik Alle, Milos R. Popovic, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, William D. Hutchison, Luka Milosevic
Summary: This study aims to explore the local synaptic dynamics in the subthalamic nucleus (STN) and the neighboring substantia nigra pars reticulata (SNr) during external stimulation. The results show that inhibitory input in the STN persists during high frequency stimulation, while it does not occur in the SNr. This indicates a local synaptic mechanism in the STN during high frequency stimulation, which is associated with the regulation of neuronal firing.
Article
Clinical Neurology
Lin Shi, Shiying Fan, Tianshuo Yuan, Huaying Fang, Jie Zheng, Zunyu Xiao, Yu Diao, Guanyu Zhu, Quan Zhang, Huanguang Liu, Hua Zhang, Fangang Meng, Jianguo Zhang, Anchao Yang
Summary: Microstimulation near the bottom of STN is an effective method to identify the boundary between STN and SNr, leading to better lead placement and therapeutic outcomes in STN-DBS surgery. This study provides clinical evidence supporting the routine use of microstimulation for optimal lead placement.
FRONTIERS IN NEUROLOGY
(2021)
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Neurosciences
Roxanne Lofredi, Cem-Georg Auernig, Siobhan Ewert, Friederike Irmen, Leon A. Steiner, Ute Scheller, Bernadette C. M. van Wijk, Simon Oxenford, Andrea A. Kuhn, Andreas Horn
Summary: Lead-DBS is a reliable and easy-to-use software tool for precise localization of deep brain stimulation electrodes. This study investigates the differences introduced by different raters and imaging types in the manual refinement process of electrode localization using Lead-DBS. The results show similar outcomes for all users, with an increase in variability when using postoperative MRI and standard space normalization. These findings contribute to the understanding of Lead-DBS and its potential use in formal training and imaging research in the field of deep brain stimulation.
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Yue Yuan, Lvpiao Zheng, Zhouyan Feng, Gangsheng Yang
Summary: The experiment on rat hippocampal CA1 region reveals that high-frequency monophasic pulses can induce abnormal neuron activity, while high-frequency biphasic pulses lead to persisting attenuation of neuronal excitability, indicating potential damages caused by monophasic stimulations in brain tissues.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Review
Biochemistry & Molecular Biology
Napoleon Torres, Jenny Molet, Cecile Moro, John Mitrofanis, Alim Louis Benabid
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Medicine, Research & Experimental
Thomas Costecalde, Tetiana Aksenova, Napoleon Torres-Martinez, Andriy Eliseyev, Corinne Mestais, Cecile Moro, Alim Louis Benabid
Article
Neurosciences
Florian Reinhart, Nabil El Massri, Napoleon Torres, Claude Chabrol, Jenny Molet, Daniel M. Johnstone, Jonathan Stone, Alim-Louis Benabid, John Mitrofanis, Cecile Moro
NEUROSCIENCE RESEARCH
(2017)
Article
Neurosciences
Cecile Moro, Napoleon Torres, Katerina Arvanitakis, Karen Cullen, Claude Chabrol, Diane Agay, Fannie Darlot, Alim-Louis Benabid, John Mitrofanis
EXPERIMENTAL BRAIN RESEARCH
(2017)
Article
Neurosciences
Nabil El Massri, Ana P. Lemgruber, Isobel J. Rowe, Cecile Moro, Napoleon Torres, Florian Reinhart, Claude Chabrol, Alim-Louis Benabid, John Mitrofanis
EXPERIMENTAL BRAIN RESEARCH
(2017)
Article
Clinical Neurology
Pantaleo Romanelli, Marco Piangerelli, David Ratel, Christophe Gaude, Thomas Costecalde, Cosimo Puttilli, Mauro Picciafuoco, Alim Benabid, Napoleon Torres
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
Laurent Goetz, Manik Bhattacharjee, Murielle U. Ferraye, Valerie Fraix, Carina Maineri, Daniela Nosko, Albert J. Fenoy, Brigitte Piallat, Napoleon Torres, Alexandre Krainik, Eric Seigneuret, Olivier David, Martin Parent, Andre Parent, Pierre Pollak, Alim-Louis Benabid, Bettina Debu, Stephan Chabardes
Article
Neurosciences
Nabil El Massri, Karen M. Cullen, Sebastian Stefani, Cecile Moro, Napoleon Torres, Alim-Louis Benabid, John Mitrofanis
EXPERIMENTAL BRAIN RESEARCH
(2018)
Article
Engineering, Biomedical
Napoleon Torres-Martinez, David Ratel, Celine Cretallaz, Christophe Gaude, Sandrine Maubert, Jean-Louis Divoux, Christine Henry, David Guiraud, Fabien Sauter-Starace
JOURNAL OF NEURAL ENGINEERING
(2019)
Article
Neurosciences
F. Sauter-Starace, D. Ratel, C. Cretallaz, M. Foerster, A. Lambert, C. Gaude, T. Costecalde, S. Bonnet, G. Charvet, T. Aksenova, C. Mestais, Alim-Louis Benabid, N. Torres-Martinez
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Napoleon Torres-Martinez, Celine Cretallaz, David Ratel, Pascal Mailley, Christophe Gaude, Thomas Costecalde, Clement Hebert, Philippe Bergonzo, Emmanuel Scorsone, Jean-Paul Mazellier, Jean-Louis Divoux, Fabien Sauter-Starace
BIOELECTROCHEMISTRY
(2019)
Article
Clinical Neurology
Alim Louis Benabid, Thomas Costecalde, Andrey Eliseyev, Guillaume Charvet, Alexandre Verney, Serpil Karakas, Michael Foerster, Aurelien Lambert, Boris Moriniere, Neil Abroug, Marie-Caroline Schaeffer, Alexandre Moly, Fabien Sauter-Starace, David Ratel, Cecile Moro, Napoleon Torres-Martinez, Lilia Langar, Manuela Oddoux, Mircea Polosan, Stephane Pezzani, Vincent Auboiroux, Tetiana Aksenova, Corinne Mestais, Stephan Chabardes
Article
Neurosciences
Aurelie Davin, Stephan Chabardes, Annaelle Devergnas, Caroline Benstaali, Claire-Anne N. Gutekunst, Olivier David, Napoleon Torres-Martinez, Brigitte Piallat
Summary: Patients with Parkinson's disease often experience excessive daytime sleepiness which can greatly affect their quality of life. This study investigates the potential use of deep brain stimulation in the pedunculopontine nucleus area to alleviate excessive daytime sleepiness in Parkinson's disease patients. The results show that low-frequency stimulation of the pedunculopontine nucleus area can effectively reduce daytime sleepiness and partially restore daytime wakefulness architecture in nonhuman primates, offering insights for the development of new therapeutic strategies.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Luke C. Gordon, Kristy L. Martin, Napoleon Torres, Alim-Louis Benabid, John Mitrofanis, Jonathan Stone, Cecile Moro, Daniel M. Johnstone
Summary: Photobiomodulation (PBM) can mitigate neuropathology in rodent models of Parkinson's disease (PD). The optimal peripheral tissue target for remote PBM is currently unclear. This study compared the neuroprotective efficacy of remote PBM targeting the abdomen or leg with transcranial PBM, and found that both remote targets provided significant neuroprotection.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Masaharu Imai, Yoshinori Takeuchi, Jun Ohta, Gregg Jorgen Suaning, Chung-Yu Wu, Napoleon Torres-Martinez
2017 22ND ASIA AND SOUTH PACIFIC DESIGN AUTOMATION CONFERENCE (ASP-DAC)
(2017)