Article
Clinical Neurology
Gabriela S. Gilmour, Davide Martino, Karen Hunka, Pia Lawrence, Zelma H. T. Kiss, Veronica Bruno
Summary: In this study, it was found that patients with ET-plus had similar tremor outcomes after VIM DBS compared to those with ET, without the development of new neurological issues. This suggests that patients with ET-plus can still be considered good candidates for VIM DBS treatment of tremor.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal, Erik H. Middlebrooks
Summary: The optimal targets for deep brain stimulation in essential tremor and dystonic tremor remain unknown. This study suggests that DBS targeting the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable treatment option for medication-refractory dystonic tremor and essential tremor patients. Our findings highlight the involvement of cerebello-thalamo-cortical and basal ganglia-thalamo-cortical networks in the pathophysiology of dystonic tremor.
Article
Clinical Neurology
Claire Olivier, Jean-Charles Lamy, Zuzana Kosutzka, Angele Van Hamme, Saoussen Cherif, Brian Lau, Marie Vidailhet, Carine Karachi, Marie-Laure Welter
Summary: This study investigated the effects of high-frequency non-invasive cerebellar transcranial alternating current stimulation (tACS) on patients with severe essential tremor (ET) who had previously undergone deep brain stimulation (DBS). The results showed that active-tACS significantly improved tremor amplitude and severity in the VIM-DBS group, while sham-tACS had no effect. In the non-VIM-DBS group, active-tACS also improved tremor amplitude and severity. These findings support the safety and potential efficacy of high-frequency cerebellar tACS in reducing ET amplitude and severity.
Article
Clinical Neurology
Shenghong He, Fahd Baig, Abteen Mostofi, Alek Pogosyan, Jean Debarros, Alexander L. Green, Tipu Z. Aziz, Erlick Pereira, Peter Brown, Huiling Tan
Summary: The study proposed an innovative approach for essential tremor treatment by detecting tremor-provoking movements and delivering stimulation in real-time, achieving effective therapeutic outcomes. Results showed a high percentage of stimulation time when tremors were triggered, with tremor suppression achieved while conserving energy.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Kaltra Dhima, Julia Biars, Efstathios Kondylis, Sean Nagel, Xin Xin Yu, Darlene P. Floden
Summary: This study examined neuropsychological outcomes following thalamic VIM DBS in patients with ET, finding no significant cognitive decline at the group level but subtle declines in verbal memory at the individual level. Factors related to cognitive decline included DBS settings, age of onset, intracranial complications, and postoperative medication reduction. Symptoms of depression and anxiety remained stable. Further research is needed to explore associations with electrode lateralization and disease progression.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Stephanie Cernera, Jose D. Alcantara, Enrico Opri, Jackson N. Cagle, Robert S. Eisinger, Zachary Boogaart, Leena Pramanik, Madison Kelberman, Bhavana Patel, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz
Summary: The study aimed to establish a physiology-driven responsive DBS system for personalized therapy in ET based on EMG signals. Results showed that EMG-driven rDBS provides clinically equivalent tremor suppression compared to traditional cDBS, while delivering less total electrical energy, leading to increased battery life of the INS.
Article
Neuroimaging
Bastian E. A. Sajonz, Marvin L. Frommer, Isabelle D. Walz, Marco Reisert, Christoph Maurer, Michel Rijntjes, Tobias Piroth, Nils Schroter, Carolin Jenkner, Peter C. Reinacher, Joachim Brumberg, Philipp T. Meyer, Ganna Blazhenets, Volker A. Coenen
Summary: Delayed therapy escape after thalamic deep brain stimulation (DBS) is a serious condition. This study aimed to identify clinical and neuroimaging markers of delayed therapy escape. The rebound frequency of postural tremor seems to be a good diagnostic marker, and increased glucose metabolism in the thalamus and dentate nucleus may be associated with this phenomenon.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Daniel Kroneberg, Bassam Al-Fatly, Tanja Schmitz-Huebsch, Florin Gandor, Doreen Gruber, Georg Ebersbach, Andreas Horn, Andrea A. Kuehn
Summary: This study investigates the temporal dynamics and clinical effects of an overnight unilateral withdrawal of deep brain stimulation (DBS) on gait disturbances. The results show that cessation of stimulation leads to improvement in gait performance and helps identify stimulation-induced gait disturbances.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Alexandra Boogers, Jana Peeters, Tine Van Bogaert, Boateng Asamoah, Philippe De Vloo, Wim Vandenberghe, Bart Nuttin, Myles Mc Laughlin
Summary: This study aimed to investigate the effect of anodic and symmetric biphasic pulses on the therapeutic window in essential tremor patients. The results showed that anodic stimulation and symmetric biphasic stimulation could increase the therapeutic window in ET patients.
Article
Clinical Neurology
AnneMarie Brinda, Julia P. Slopsema, Rebecca D. Butler, Salman Ikramuddin, Thomas Beall, William Guo, Cong Chu, Remi Patriat, Henry Braun, Mojgan Goftari, Tara Palnitkar, Joshua Aman, Lauren Schrock, Scott E. Cooper, Joseph Matsumoto, Jerrold L. Vitek, Noam Harel, Matthew D. Johnson
Summary: By using ultra-high field MRI, researchers developed subject-specific pathway activation models for directional DBS leads. The study found that the efficacy and side effects of DBS therapy for Essential Tremor were associated with the activation of different pathways in the brain, and the degree of activation was significantly correlated with the suppression of tremor and the severity of side effects. Therefore, a model-based programming approach can achieve more selective activation of specific regions in the brain.
Review
Neurosciences
Tomasz M. Fraczek, Benjamin I. Ferleger, Timothy E. Brown, Margaret C. Thompson, Andrew J. Haddock, Brady C. Houston, Jeffrey G. Ojemann, Andrew L. Ko, Jeffrey A. Herron, Howard J. Chizeck
Summary: Deep Brain Stimulation (DBS) is an important tool for treating pharmacologically resistant neurological movement disorders, but the current open-loop design may limit its potential. The research demonstrated the feasibility of fully implanted, cortically driven aDBS as a treatment for pharmacologically resistant essential tremor. The use of feedback in adaptive DBS systems allows for a response to the patient's therapeutic needs, outperforming open-loop approaches in certain cases.
FRONTIERS IN NEUROSCIENCE
(2021)
Letter
Clinical Neurology
Paul Reker, Stefanie T. Jost, Petra Schiller, Alexandra Gronostay, Gereon R. Fink, Veerle Visser-Vandewalle, Keyoumars Ashkan, Alexandra Rizos, Pablo Martinez-Martin, Lena Strobel, Afsar Sattari, Lars Timmermann, Anna Sauerbier, K. Ray Chaudhuri, Elke Kalbe, Haidar S. Dafsari
Summary: Deep brain stimulation (DBS) is an effective treatment for essential tremor (ET). Gender differences have been observed in DBS for Parkinson's disease, and this systematic chart review also found gender differences in DBS treatment for ET. The main reason for this is the underrepresentation of women in referrals for surgical evaluation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Cherry H. Yu, Daniel H. Lench, Christine Cooper, Nathan C. Rowland, Istvan Takacs, Gonzalo Revuelta
Summary: The study aimed to investigate the optimal stimulation sites and their overlap with white matter tracts in different subtypes of essential tremor (ET) and essential tremor plus syndrome (ET-plus). The results showed no significant differences in optimal stimulation site or white-matter tract overlap between ET, ET-plus, and ET-plus subgroups. This suggests that VIM DBS therapy is equally effective for ET and ET-plus patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Jack Shen, Luca Marsili, Alok K. Dwivedi, Gregory Kuhlman, Andrew P. Duker, Alberto J. Espay, Abhimanyu Mahajan
Summary: This study found no correlation between head tremor and postural instability in patients with essential tremor who underwent bilateral ventral intermediate nucleus deep brain stimulation.
Article
Clinical Neurology
Jimmy C. Yang, Katie L. Bullinger, Faical Isbaine, Abdulrahman Alwaki, Enrico Opri, Jon T. Willie, Robert E. Gross
Summary: CM deep brain stimulation (DBS) shows promise in treating drug-resistant generalized epilepsy and bifrontal epilepsy, with a significant reduction in seizure frequency observed in patients. Further studies are needed to explore the optimal use of CM DBS in different types of epilepsy and its impact on treatment outcomes.
JOURNAL OF NEUROSURGERY
(2022)
