Journal
NEUROSCIENCE RESEARCH
Volume 75, Issue 2, Pages 138-149Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2012.11.003
Keywords
Brainstem; Suckling; NMDA; In vitro; Rhythm generation; Mouse
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Funding
- Japan Society for the Promotion of Science [19791373, 20592186, 21791814]
- Grants-in-Aid for Scientific Research [24791984, 20592186, 21791814, 19791373, 23592750] Funding Source: KAKEN
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Suckling is a rhythmic jaw movement that is symmetrical on the left and right side and is highly coordinated with tongue movement. Thus, we investigated the neuronal mechanisms of the left/right and jaw/tongue coordinations during N-methyl-u-aspartate (NMDA)-induced fictive suckling using isolated brainstem-spinal cord preparations obtained from neonatal mice. We observed synchronous low-frequency rhythmic activity in the left/right trigeminal motor nerves, which differed from respiration, and high-frequency rhythmic trigeminal activity, which was side-independent. The low-frequency rhythmic trigeminal activity was also synchronized with the hypoglossal nerve activity. After a complete midline separation of the preparation or a partial midline transection of the brainstem from the anterior inferior cerebellar artery to the junction of the vertebral artery, the low-frequency rhythmic trigeminal activity disappeared, whereas the high-frequency rhythmic trigeminal activity and low-frequency rhythmic hypoglossal activity still remained. These results suggest that the neuronal network that generates low-frequency rhythmic activity likely contributes to the synchronized activity of the left/right jaw muscles and to the jaw/tongue muscles, where it sends its command to the trigeminal motoneurons mainly via the commissural pathway that crosses the transected midline region. Such a neuronal network may underlie the coordinated movements of the jaw and tongue during suckling. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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