Article
Genetics & Heredity
Jingwen Yin, Xudong Luo, Qian Peng, Susu Xiong, Dong Lv, Zhun Dai, Jiawu Fu, Ying Wang, Yaxue Wei, Chunmei Liang, Xusan Xu, Dandan Zhang, Lulu Wang, Dongjian Zhu, Xia Wen, Xiaoqing Ye, Zhixiong Lin, Juda Lin, You Li, Jiafeng Wang, Guoda Ma, Keshen Li, Yajun Wang
Summary: The study found that polymorphisms within the MIR137 gene are associated with the risk of schizophrenia, especially in a Han Chinese population where a female-specific association was reported.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Qingqing Xu, Yaojing Li, Mo Li, Shengying Qin, Ailing Ning, Ruixue Yuan, Yingmei Fu, Dongxiang Wang, Ran Zhang, Duan Zeng, Wenjuan Yu, Huafang Li, Shunying Yu
Summary: This study revealed an association between the rs2088885 and rs7627954 SNPs of the TNIK gene and risperidone treatment response.
Article
Genetics & Heredity
Xianglai Liu, Hailing Xie, Zejuan Fu, Qiankun Yao, Tianming Han, Dafei Zhan, Zhan Lin, Hong Zhu
Summary: The study revealed a correlation between MAD1L1 and TSNARE genetic polymorphisms and susceptibility to schizophrenia, suggesting a protective role. Replication experiments in cohorts with larger sample sizes are needed to confirm these findings.
BMC MEDICAL GENOMICS
(2021)
Article
Genetics & Heredity
Ruimei Liu, Wei Tang, Weiping Wang, Feikang Xu, Weixing Fan, Yi Zhang, Chen Zhang
Summary: The study did not find a significant association between the NLRP3 gene and susceptibility to schizophrenia, but suggested a potential involvement in cognitive impairment, particularly attention deficits, in the disorder.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Cristina Delgado-Sallent, Pau Nebot, Thomas Gener, Amanda B. Fath, Melina Timplalexi, M. Victoria Puig
Summary: Neural synchrony and functional connectivity are disrupted in schizophrenia. Atypical antipsychotic drugs, but not typical antipsychotic drugs, can reduce prefrontal and cortical-hippocampal hypersynchrony induced by psychosis-like states, suggesting that atypical antipsychotic drugs target prefrontal-hippocampal pathways for antipsychotic action. Serotonin receptors may play a selective role in the distinct effects of atypical antipsychotic drugs compared to typical antipsychotic drugs.
Article
Endocrinology & Metabolism
Yang Sun, Ye Lv, Hui-Wen Ren, Guan-Yu Wang, Li-Na Xuan, Yi-Yang Luo, Zhi-Lin Luan
Summary: The study found a significant association between MAP3K4 and schizophrenia in the Northeast Chinese Han population, with certain SNPs showing strong correlation with the disease.
METABOLIC BRAIN DISEASE
(2022)
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xianglai Liu, Tianming Han, Hailing Xie, Zejuan Fu, Qiankun Yao, Zhan Lin, Hong Zhu, Dafei Zhan
Summary: This study found a significant association between rs4380187 SNP and schizophrenia, with specific genotype variations potentially decreasing the risk of the disease.
JOURNAL OF GENE MEDICINE
(2021)
Article
Medicine, General & Internal
Lu Shen, Xiaoying Lv, Hailiang Huang, Mo Li, Cong Huai, Xi Wu, Hao Wu, Jingsong Ma, Luan Chen, Ting Wang, Jie Tan, Yidan Sun, Lixing Li, Yi Shi, Chao Yang, Lei Cai, Yana Lu, Yan Zhang, Saizheng Weng, Shaobin Tai, Na Zhang, Lin He, Chunling Wan, Shengying Qin
Summary: The study proposed a loci inheritance frequency model for characterization of differential methylated regions as SCZ biomarkers. Functional enrichment analysis revealed that multiple differentially methylated genes (DMGs) were involved in various signaling pathways, including Notch/HH/Wnt signaling, MAPK signaling, GPCR signaling, and immune response signaling.
Article
Cell Biology
Maolan Wu, Xiangrong Zheng, Juan Huang, Xiaolei Hu
Summary: Polymorphisms of the IL33-IL1RL1-IL1RAP complex are associated with childhood asthma susceptibility, eosinophilic airway inflammation, and response to ICS treatment in Chinese Han children in Hunan. Certain genetic variants are linked to asthma risk, airway inflammation severity, and responsiveness to ICS treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yuxin Wang
Summary: The study revealed that LRRC3B gene polymorphisms were associated with the risk of breast cancer, suggesting that LRRC3B variants might be helpful in predicting breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Xi Wang, Lin Xiao, Zhiyuan Wang, Liqiang Zhi, Qiang Li
Summary: This study found a strong association between SNP rs11177 of the GNL3 gene and susceptibility to hand OA. The rs11177 polymorphism was also associated with clinical features of hand OA patients.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Fei Wang, Defan Luo, Jianxiang Chen, Cuiqing Pan, Zhongyao Wang, Housheng Fu, Jianbing Xu, Meng Yang, Shaowei Mo, Liying Zhuang, Weifu Wang
Summary: This study found that HTR1A-rs6295 and TPH2-rs11178996 are associated with the risk of premature ejaculation in the Chinese Han population.
Article
Genetics & Heredity
Baoping Hu, Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Dongya Yuan, Yongjun He, Tianbo Jin, Shumei He
Summary: By studying the northwest Chinese Han population, this research identified the relationships between polymorphisms in or near the SLC11A1 gene and age- and sex-specific tuberculosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Virology
Yinan Yao, Yan Shen, Haifeng Shao, Yuchang Liu, Yan Ji, Guoming Du, Xiangyu Ye, Peng Huang, Haiming Chen
Summary: RLRs, specifically the DDX58 rs3824456, DHX58 rs2074160, and IFIH1 rs2111485 SNPs, may be predictive markers for spontaneous clearance of HBV in the Chinese Han population.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Neurosciences
Jingsong Ma, Mingzhe Zhao, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Ting Wang, Hao Wu, Na Zhang, Zhiruo Zhang, Lin He, Shengying Qin
Summary: The study used meta-analysis to demonstrate a significant association between COMT Val158Met polymorphism and antipsychotic response, which was consistent in both Caucasian and Asian patient populations. Genotyping of patients for predicting antipsychotic response may be relevant for future randomized clinical trials.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mo Li, Yi Hu, Baihui Zhao, Luan Chen, Hailiang Huang, Cong Huai, Xiaoqing Zhang, Jinghong Zhang, Wei Zhou, Lu Shen, Qi Zhen, Bao Li, Wenjun Wang, Lin He, Shengying Qin
Summary: A two-stage study identified genetic markers associated with TB susceptibility in 616 TB patients and 709 healthy controls. The study confirmed 6 nominally significant SNPs and a HLA-II allele as predisposing factors for TB. The research provides insight into the genetic variants linked to TB susceptibility and sheds light on tuberculosis pathogenesis.
Article
Cell Biology
Liang Gao, Qian Yu, Huasheng Zhang, Zhengting Wang, Tianyu Zhang, Jinnan Xiang, Shuxiang Yu, Shaoyang Zhang, Hongguang Wu, Yizhou Xu, Zhuo Wang, Lu Shen, Gang Shu, Ye-Guang Chen, Huijuan Liu, Lei Shen, Baojie Li
Summary: The study reveals an active immune pathway in colitic inflammation that may be targeted to treat patients with IBD with defects in PGE(2) production.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xi Wu, Cong Huai, Lu Shen, Mo Li, Chao Yang, Juan Zhang, Luan Chen, Wenli Zhu, Lingzi Fan, Wei Zhou, Qinghe Xing, Lin He, Chunling Wan, Shengying Qin
Summary: The study found that patients with schizophrenia in Chinese families carried more duplications compared to healthy family members and controls, and identified new CNV loci associated with schizophrenia. Two genes within these CNVs showed significant relevance to schizophrenia, supporting the role of CNVs in schizophrenia etiology and providing new insights into the pathogenesis of schizophrenia.
Meeting Abstract
Clinical Neurology
Lu Shen
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mingzhe Zhao, Jingsong Ma, Mo Li, Yingtian Zhang, Bixuan Jiang, Xianglong Zhao, Cong Huai, Lu Shen, Na Zhang, Lin He, Shengying Qin
Summary: Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play crucial roles in drug detoxification, cellular metabolism, and homeostasis. In addition to their basic metabolic functions, CYPs can also influence drug responses by affecting drug action, safety, bioavailability, and drug resistance through metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lu Shen, Xiaoying Lv, Hailiang Huang, Mo Li, Cong Huai, Xi Wu, Hao Wu, Jingsong Ma, Luan Chen, Ting Wang, Jie Tan, Yidan Sun, Lixing Li, Yi Shi, Chao Yang, Lei Cai, Yana Lu, Yan Zhang, Saizheng Weng, Shaobin Tai, Na Zhang, Lin He, Chunling Wan, Shengying Qin
Summary: The study proposed a loci inheritance frequency model for characterization of differential methylated regions as SCZ biomarkers. Functional enrichment analysis revealed that multiple differentially methylated genes (DMGs) were involved in various signaling pathways, including Notch/HH/Wnt signaling, MAPK signaling, GPCR signaling, and immune response signaling.
Article
Genetics & Heredity
Wei Zhou, Luan Chen, Hao Wu, Ting Wang, Gang Ma, Baocheng Wang, Cong Wang, Na Zhang, Yingtian Zhang, Lin He, Shengying Qin, Xiaofang Sun, Hai Zhang, Lu Shen
Summary: This study investigated the role of miRNAs in BDA1 through miRNA profiling, identifying miR-135a-1-3p as a key player in the pathogenesis of BDA1. Dual-luciferase reporter gene experiment revealed Hoxd10 as a potential target gene of miR-135a-1-3p. Pathway analysis showed that the targets of miRNAs were closely related to Runx1/2, Notch, and collagen-related pathways.
Article
Neurosciences
Jing Sun, Xiaoya Zhang, Qijie Cong, Dong Chen, Zhenghui Yi, Hailiang Huang, Cong Wang, Mo Li, Rongsen Zeng, Yunxi Liu, Cong Huai, Luan Chen, Chuanxin Liu, Yan Zhang, Yong Xu, Lingzi Fan, Guoqiang Wang, Chuanfu Song, Muyun Wei, Huihui Du, Jinhang Zhu, Lin He, Shengying Qin
Summary: This study found that NRG-1 deficiency-induced mitochondrial dysfunction is associated with the therapeutic outcomes of olanzapine in TRS patients. MiR143-3p was identified as a critical target of NRG-1, with levels in neural stem cells correlating with the severity of olanzapine resistance in TRS patients. Treatments targeting the NRG-1/miR143-3p axis may provide novel biomarkers and treatment strategies for TRS.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Genetics & Heredity
Yunfeng Ruan, Yen-Feng Lin, Yen-Chen Anne Feng, Chia-Yen Chen, Max Lam, Zhenglin Guo, Lin He, Akira Sawa, Alicia R. Martin, Shengying Qin, Hailiang Huang, Tian Ge
Summary: PRS-CSx is a method that improves cross-population polygenic prediction by integrating GWAS summary statistics from multiple populations. It can enhance the predictive performance of polygenic risk scores in non-European populations and reduce healthcare disparities.
Article
Psychiatry
Mingzhe Zhao, Jingsong Ma, Mo Li, Wenli Zhu, Wei Zhou, Lu Shen, Hao Wu, Na Zhang, Shaochang Wu, Chunpeng Fu, Xianxi Li, Ke Yang, Tiancheng Tang, Ruoxi Shen, Lin He, Cong Huai, Shengying Qin
Summary: This study explored the genetic underpinnings of treatment response to risperidone in schizophrenia patients through GWAS and WES, highlighting the potential role of the GPCR gene family and GPCR signaling pathway in the etiology of treatment response. The findings may contribute to personalized medicine for schizophrenia patients.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Xi Wu, Lu Wang, Lu Shen, Kefu Tang
Summary: This meta-analysis evaluated the immune response to COVID-19 vaccines in patients with multiple sclerosis (pwMS) receiving disease-modifying therapies (DMTs). The study found that pwMS receiving anti-CD20 and sphingosine-1-phosphate receptor modulator (S1PRM) treatments had attenuated serologic response after full vaccination. No significant associations were found between other treatments and humoral response. As for T-cell response, no significant difference was found between pwMS on anti-CD20 and those without DMTs, while S1PRM was marginally associated with impaired cellular response.
Article
Biochemistry & Molecular Biology
Wei Zhou, Jing Sun, Cong Huai, Yunxi Liu, Luan Chen, Zhenghui Yi, Qinyu Lv, Chuanfu Song, Wenli Zhu, Chuanxin Liu, Saizheng Weng, Hao Wu, Yidan Sun, Runshuai Zhang, Lianfeng Wu, Mo Li, Jinhang Zhu, Yingtian Zhang, Muyun Wei, Yujian Guo, Sijia Huang, Na Zhang, Ruoxi Shen, Ying Zhang, Huihui Du, Hailiang Huang, Lin He, Xiaofang Sun, Lu Shen, Shengying Qin
Summary: In this study, the genetic and epigenetic factors of antipsychotic-induced metabolic syndrome were analyzed through genome-wide and whole-exome sequencing as well as epigenome-wide association studies. The findings suggest an imbalance of rare functional variants in the leptin and peroxisome proliferator-activated receptors gene sets between the APs-induced Mets and Non-Mets cohorts. Moreover, hypermethylation in ABCG1 region was associated with higher TC and TG levels, and several candidate genes were verified to be associated with olanzapine-induced fat deposit. Overexpression of PTPN11 gene resulted in compromised glucose responses and insulin resistance, which could be protected by pharmacologic inhibition of PTPN11.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
