Journal
NEUROSCIENCE LETTERS
Volume 576, Issue -, Pages 17-21Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2014.05.046
Keywords
Apolipoprotein E; Polymorphism; Cognitive function; Aged
Categories
Funding
- Kaohsiung Veterans General Hospital [VGHNSU101-01]
- Taipei Veterans General Hospital, Taiwan [VGHUST102-G1-2-1]
- National Science Council, Taiwan [NSC 102-2314-B-075B-001]
Ask authors/readers for more resources
Apolipoprotein E (APOE) gene polymorphism has been reported to be associated with cognitive dysfunction in healthy individuals, however the results were controversial in the very old elderly. The aim of this study is to assess the possible association of the APOE polymorphism with cognitive dysfunction in people aged 75 years and over. Four hundred and twenty-five aged Chinese veteran men without dementia were enrolled for APOE genotyping and neuropsychological tests including Mini-Mental Status Examination (MMSE), Digit Span Forward and Backward, and Cognitive Ability Screening Instrument Chinese language version (CASI C-2.0) were evaluated in these subjects. Among the elderly veterans, people who carry APOE epsilon 4 were found to have worse performance on the total CASI scores, the abstraction/judgment subscores and the list-generating fluency subscores. This study suggests that the APOE epsilon 4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available