Article
Biochemistry & Molecular Biology
Yuki Yasumoto, Milan Stoiljkovic, Jung Dae Kim, Matija Sestan-Pesa, Xiao-Bing Gao, Sabrina Diano, Tamas L. Horvath
Summary: The study revealed a novel interaction between microglia and neurons in the ventral hippocampus, which plays a role in regulating synaptic number, reactive oxygen species production, and neuronal circuit functions, ultimately influencing anxiety-like behavior.
MOLECULAR PSYCHIATRY
(2021)
Article
Behavioral Sciences
Erin P. Harris, Andrew J. McGovern, Thieza G. Melo, Aaron Barron, Yvonne M. Nolan, Olivia F. O'Leary
Summary: Stress during childhood is a significant risk factor for depression, with higher prevalence in women suggesting biological sex plays a role. This study aimed to investigate whether stress during the prepubertal period induces sex-specific changes in anxiety-like behavior, anhedonia, and antidepressant-like behavior in adulthood. The results showed that juvenile stress led to long-lasting effects on antidepressant-like and reward-seeking behavior, potentially due to alterations in catecholaminergic innervation of the medial prefrontal cortex.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Danilo Benette Marques, Rafael Naime Ruggiero, Lezio Soares Bueno-Junior, Matheus Teixeira Rossignoli, Joao Pereira Leite
Summary: The perception of control over a stressful experience may determine its impacts and generate resistance against future stressors. The study on male rats suggests that hippocampal-prefrontal network theta activity supports cognitive mechanisms of stress coping and is associated with escape performance and vulnerability to stress-related disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Rachelle Larivee, Natalie Johnson, Natalie R. Freedgood, Heather A. Cameron, Timothy J. Schoenfeld
Summary: Stressors during adolescence can affect brain development and have long-lasting impacts on behavior. This study used a transgenic neurogenesis ablation rat model to investigate the functional effects of reduced hippocampal neurogenesis during adolescence. The results showed that long-term neurogenesis ablation starting in adolescence can lead to hippocampal atrophy and increased behavioral caution and despair in stressful environments.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Cell Biology
Shan Shao, Yawen Zheng, Zibing Fu, Jiaxin Wang, Yu Zhang, Cheng Wang, Xuetao Qi, Tingting Gong, Longyu Ma, Xi Lin, Haitao Yu, Shulu Yuan, You Wan, Haolin Zhang, Ming Yi
Summary: Chronic pain is a major global medical problem. Recent evidence suggests that the hippocampus plays a role in modulating chronic pain, but the exact mechanisms remain unknown. In this study, a neural ensemble in the ventral hippocampal CA1 region was found to respond to noxious stimuli and become hypersensitive after peripheral inflammation. Manipulating the activity of these neurons in mice induced chronic pain-like behaviors or reduced pain-related behaviors, depending on the context. Additionally, specific pathways from the ventral hippocampus to the basolateral amygdala and infralimbic cortex were found to be involved in pain modulation at different stages of chronic inflammatory pain.
Review
Immunology
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen
Summary: This review explores the roles of adult hippocampal neurogenesis and microglia in the etiology of depression, and discusses the mechanisms by which microglia regulate adult hippocampal neurogenesis in depression and potential drugs for improving neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiuting Yao, Chenxi Yang, Conghui Wang, Hong Li, Jingyi Zhao, Xiaomin Kang, Zhuodong Liu, Lingyan Chen, Xinyu Chen, Tianshu Pu, Qinyang Li, Lijie Liu
Summary: Adolescence is a critical period for brain development, and high-fat diet consumption can negatively affect emotional health. This study found that high-fat diet in adolescence led to increased depression and anxiety, decreased neurogenesis in the hippocampus, and excessive microglial activation. Additionally, abnormal microglial engulfment of newborn neurons was observed in the high-fat diet group. These findings contribute to our understanding of the mechanisms underlying high-fat diet-related affective disorders in young people.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Ya-Xin Sun, Yun-Ai Su, Qi Wang, Jia-Ya Zheng, Chen-Chen Zhang, Ting Wang, Xiao Liu, Yu-Nu Ma, Xue-Xin Li, Xian-Qiang Zhang, Xiao-Meng Xie, Xiao-Dong Wang, Ji-Tao Li, Tian-Mei Si
Summary: Early-life stress can lead to long-lasting deficits of hippocampus-dependent learning and memory in adult mice, which may be associated with the hypofunction of the BDNF-TrkB pathway. In this study, the causal involvement of the BDNF-TrkB pathway in ELS-induced cognitive deficits was examined, and the therapeutic effects of the TrkB agonist (7,8-DHF) were demonstrated.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Nahoko Kuga, Ryota Nakayama, Shota Morikawa, Haruya Yagishita, Daichi Konno, Hiromi Shiozaki, Natsumi Honjoya, Yuji Ikegaya, Takuya Sasaki
Summary: This study found that stressful memories are a potential factor in inducing psychiatric symptoms, and stress susceptibility is related to memory consolidation mechanisms in the ventral hippocampus (vHC). The vHC plays a crucial role in emotional memory. Through transcriptome analysis and neuronal population dynamics research in male mice, it was discovered that intrinsic calbindin expression in the vHC is associated with susceptibility to social defeat stress. The activation of ventral hippocampal sharp wave ripples (SWRs) after stress triggers the synchronous reactivation of stress memory-encoding neuronal ensembles and facilitates information transfer to the amygdala, while suppression of these SWRs can prevent social behavior deficits.
NATURE COMMUNICATIONS
(2023)
Review
Biology
Tarek Amer, Lila Davachi
Summary: Pattern separation is the process by which highly similar stimuli or experiences in memory are represented by non-overlapping neural ensembles. It has been traditionally attributed to the hippocampus, but recent evidence suggests that it involves a network of brain regions. The 'cortico-hippocampal pattern separation' (CHiPS) framework proposes that cognitive control regions play a significant role in pattern separation, either by resolving interference in sensory regions or by directly modulating hippocampal processes.
Article
Biochemistry & Molecular Biology
Jessica Marie Perez, Stefano Berto, Kelly Gleason, Subroto Ghose, Chunfeng Tan, Tae-Kyung Kim, Genevieve Konopka, Carol A. Tamminga
Summary: The study demonstrates unique molecular changes in hippocampal subfields of individuals with schizophrenia, suggesting different biological functions in each subfield which may help identify potential hippocampal-based therapeutic targets for schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Kornrawee Suwannakot, Nataya Sritawan, Ram Prajit, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
Summary: Melatonin has neuroprotective effects against 5-FU-induced oxidative stress by restoring antioxidant enzyme levels and protein expression in the rat hippocampus and PFC.
Article
Psychiatry
David P. Herzog, Diego Pascual Cuadrado, Giulia Treccani, Tanja Jene, Verena Opitz, Annika Hasch, Beat Lutz, Klaus Lieb, Inge Sillaber, Michael A. Van der Kooij, Vijay K. Tiwari, Marianne B. Mueller
Summary: The study revealed differentially expressed genes associated with paroxetine treatment and candidate mechanisms related to good treatment response, such as neuropeptide signaling and synaptic transmission. The results suggest that general paroxetine effects can be distinguished from treatment response-associated molecular signatures, offering potential new targets for future antidepressant treatments.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Biological
Michael K. Yeung, Tsz L. Lee, Agnes S. Chan
Summary: The study found that depressive and anxiety symptoms in older people are associated with decreased functioning of the lateral prefrontal cortex during cognitive control tasks, particularly in the n-back task.
BIOLOGICAL PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
C. E. Matisz, M. Patel, N. S. Hong, R. J. McDonald, A. J. Gruber
Summary: Chronic inflammatory diseases are often associated with anxiety in humans. This study found that prolonged gut inflammation is sufficient to induce anxiety-related behaviors in mice. The research suggests that chronic inflammation may affect memory consolidation processes, leading to the generalization of negative associations and fearful responses in inappropriate contexts.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Mariele Lino Silva, Lais Bhering Martins, Luana Caroline dos Santos, Gilberto Simeone Henriques, Antonio Lucio Teixeira, Ana Maria dos Santos Rodrigues, Adaliene Versiani Matos Ferreira
Summary: This study suggests that patients with migraine have lower plasma levels of minerals and lower dietary intake of minerals compared to individuals without migraine. It highlights the importance of dietary intervention to ensure adequate mineral intake as a therapeutic strategy for migraine.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibanez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Pina-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suarez, Bernardo Barra, Maria Isabel Behrens, SoniaM. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farias, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nunez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula Franca Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Summary: Limited knowledge and funding, as well as inadequate infrastructure, present significant barriers to dementia biomarker research in Latin American and Caribbean countries. However, the region shows great potential for advancements in this field.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Lais B. Martins, Ana L. M. Silveira, Antonio L. Teixeira
Summary: This study aims to provide a comprehensive overview of the involvement of the kynurenine pathway (KP) in the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD) and discuss potential therapeutic opportunities. The results showed altered levels of KP metabolites in the brains of AD and PD patients, and associations between peripheral levels of KP metabolites and cognitive function in these patients.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimaraes Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcilia Aparecida Silva
Summary: This systematic review examined the potential association between anxiety and depression and chemo/radiotherapy-induced oral mucositis. The results showed that there is a connection between anxiety and depression and the severity of oral mucositis in a significant number of participants. However, the limited number of cases and heterogeneity in the data hindered a conclusive conclusion about this association.
Article
Clinical Neurology
Kelly Santana, Eduardo Franca, Joao Sato, Ana Silva, Maria Queiroz, Julia de Farias, Danniely Rodrigues, Iara Souza, Vanessa Ribeiro, Egas Caparelli-Daquer, Antonio L. Teixeira, Leigh Charvet, Abhishek Datta, Marom Bikson, Suellen Andrade
Summary: This study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCs) combined with a rehabilitation program for the management of PASC-related fatigue. The results showed that active HD-tDCS significantly reduced fatigue, decreased anxiety, and improved quality of life compared to sham HD-tDCS.
Article
Neurosciences
Haitham Salem, Robert Suchting, Mitzi M. Gonzales, Sudha Seshadri, Antonio L. Teixeira
Summary: This study aimed to detect conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and determine the effect of apathy on the progression to AD in patients with MCI. The study found that 17.3% of individuals had conversion from MCI to AD over a period of 8.21 years. Patients with apathy had a higher conversion rate and shorter time-to-conversion. Age and cognitive performance were found to moderate the relationship between apathy and time-to-conversion.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Eliana C. B. Toscano, Erica L. M. Vieira, Lea T. Grinberg, Natalia P. Rocha, Joseane A. S. Brant, Regina S. Paradela, Alexandre V. Giannetti, Claudia K. Suemoto, Renata E. P. Leite, Ricardo Nitrini, Milene A. Rachid, Antonio L. Teixeira
Summary: Temporal lobe epilepsy (TLE) is associated with cognitive deficits, and this study investigates the underlying neuronal basis. The researchers found that an increase in p-tau burden is potentially involved in cognitive deficits in mesial TLE, particularly attention impairment and seizure frequency.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychiatry
Izabela Guimaraes Barbosa, Flavia da Mata Chiacchio Leite, Maxime Bertoux, Henrique Cerqueira Guimaraes, Luciano Inacio Mariano, Leandro Boson Gambogi, Antonio Lucio Teixeira, Paulo Caramelli, Leonardo Cruz de Souza
Summary: This study found that bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) have similar deficits in social cognition functions. The results of the Facial Emotion Recognition (FER) and Modified Faux-Pas (mFP) tests can be used to differentiate between the two disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Natalia Pessoa Rocha, Eduarda Xavier Carreira, Ana Carolina de Almeida Prado, Fabiola Tavares, Mayra Tavares, Francisco Cardoso, Antonio Jaeger, Leonardo Cruz de Souza, Antonio Lucio Teixeira
Summary: The International Parkinson's Disease and Movement Disorder Society (MDS) developed diagnostic criteria for mild cognitive impairment (MCI) and dementia in Parkinson disease (PD). However, the applicability of these criteria was limited for PD patients with low levels of formal education in Brazil. There is a need for revision of the guidelines to account for differences among populations, especially related to educational level.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Multidisciplinary Sciences
Parnian Shobeiri, Sanam Alilou, Mehran Jaberinezhad, Farshad Zare, Nastaran Karimi, Saba Maleki, Antonio L. Teixeira, George Perry, Nima Rezaei
Summary: This systematic review evaluated the accuracy of long non-coding RNAs (lncRNAs) in identifying Alzheimer's disease (AD) through meta-analysis. The results showed that lncRNAs had high accuracy in identifying AD and could be considered a promising diagnostic biomarker for the disease.
Review
Medicine, General & Internal
Lijin Jose, Lais Bhering Martins, Thiago M. Cordeiro, Keya Lee, Alexandre Paim Diaz, Hyochol Ahn, Antonio L. Teixeira
Summary: This systematic review aims to investigate the effectiveness of noninvasive neuromodulation in HD-associated motor, cognitive, and behavioral symptoms. 19 studies were identified, exploring the use of ECT, TMS, and tDCS in the treatment of HD. The results showed improvement in HD symptoms, particularly depression and psychosis after ECT protocols, although the impact on cognitive and motor symptoms is more controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Karina Braga Gomes, Ramon Goncalves Pereira, Alexandre Alberto Braga, Henrique Cerqueira Guimaraes, Elisa de Paula Franca Resende, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Wagner Meira Junior, Maria das Gracas Carvalho, Paulo Caramelli
Summary: This study used machine learning algorithms to assess the ability of routine laboratory variables in predicting cognitive and functional decline in older adults. The random forest model was found to be the most accurate in predicting cognitive decline, including variables such as triglycerides, glucose, and hemoglobin. For functional decline, platelet count, hemoglobin, and cortisol were identified as important features. The findings suggest that routine laboratory variables can be used to predict cognitive and functional decline in older populations using machine learning algorithms.
Article
Medicine, Research & Experimental
Antonio L. Teixeira, Lais Bhering Martins, Thiago Macedo e Cordeiro, Lijin Jose, Robert Suchting, Holly M. Holmes, Ron Acierno, Hyochol Ahn
Summary: This study aims to evaluate the feasibility, safety, and efficacy of home-based transcranial direct current stimulation (tDCS) for the treatment of apathy in Alzheimer's disease (AD). A randomized, sham-controlled pilot clinical trial will be conducted involving 40 subjects with AD, with their caregivers administering tDCS at home under remote televideo supervision. The findings from this study will contribute to the development of non-pharmacological treatment strategies and have great potential for clinical translation.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Behavioral Sciences
Melissa A. Ribeiro, Rafael P. Aguiar, Franciele F. Scarante, Eduardo J. Fusse, Rubia M. W. de Oliveira, Francisco S. Guimara, Alline C. Campos
Summary: Several pieces of evidence suggest that the monoaminergic theory of depression cannot fully explain all behavioral and neuroplastic changes observed after antidepressant chronic treatment. Other molecular targets, such as the endocannabinoid system, have been associated with the chronic effects of these drugs. In this study, the researchers hypothesized that the behavioral and neuroplastic effects observed after repeated treatment with antidepressants depend on CB1 receptor activation. However, their results showed that chronic blockade of the CB1 receptor does not attenuate the antidepressant or anxiolytic effects of the antidepressants ESC or VFX, indicating that CB1 receptors are not involved in the observed effects.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
