Article
Neurosciences
Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Marian Henryk Lewandowski
Summary: Circadian rhythms are regulated by a set of brain structures, one of which is the IGL that integrates various stimuli influencing rhythmicity through the norepinephrinergic system. Norepinephrine affects different types of IGL neurons, exerting multiple effects on them. This is the first study to confirm the effects of norepinephrine on the activity of the IGL network.
Article
Pharmacology & Pharmacy
Qi Xu, Lihong Sun, Wenxin Zhang, Hui Wu, Cuicui Jiao, Lili Xu, Xiaowei Qian, Huaqi Yao, Qing Chen, Fang Xu, Feng Fu, Ying Feng, Luyang Wang, Xinzhong Chen
Summary: This study established a rat model of pain induced by uterine cervix inflammation, with a novel pain score derived from specific behaviors and c-Fos expression in the spinal cord. The highest pain score and c-Fos expression were found in the 0.9 mg capsaicin group. Intrathecal morphine significantly reduced both the pain score and c-Fos expression in the spinal cord.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Felipe P. Fiuza, Jose Pablo G. Queiroz, Antonio Carlos Q. Aquino, Diego A. Camara, Luiz Eduardo M. Brandao, Ramon H. Lima, Jose Rodolfo L. P. Cavalcanti, Rovena Clara G. J. Engelberth, Jeferson S. Cavalcante
Summary: This study found that aging affects the daily changes in the number of calretinin (CR) neurons in the inter-geniculate leaflet (IGL) and ventral lateral geniculate nucleus (vLGN) in rats. CR cells decreased with age in the IGL and retinorecipient part of vLGN, and age-related CR loss was observed in all nuclei during the light to dark transition. CR expression showed daily rhythms in these regions, with no specific spatial restrictions for age-related changes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ehsan Ranaei Pirmardan, Aliaa Barakat, Yuanlin Zhang, Marzieh Naseri, Ali Hafezi-Moghadam
Summary: This study conducted a longitudinal investigation into diabetic cataract in Nile grass rats, identifying various types of cataracts and elucidating the mechanisms underlying their development. The research offers insights into early stages of diabetic cataract and highlights the suitability of Nile grass rats as a model for mechanistic studies in the context of metabolism, diabetes, and aging.
Article
Neurosciences
Jagoda S. Jeczmien-Lazur, Anna M. Sanetra, Kamil Pradel, Gabriela Izowit, Lukasz Chrobok, Katarzyna Palus-Chramiec, Hugh D. Piggins, Marian H. Lewandowski
Summary: The intergeniculate leaflet and ventral lateral geniculate nucleus (IGL/VLG) play an important role in entraining the brain's circadian system to various cues. We investigated the sensitivity of IGL/VLG neurons to metabolism-related peptides and found that they responded to most of the substances tested, suggesting their involvement in the body's energy homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Veronika Bodi, Vivien Csikos, Timea Majer, Attila Toth, Arpad Dobolyi, Ildiko Vilagi, Petra Varro
Summary: Zearalenone (ZEA), a mycotoxin produced by Fusarium species, has acute effects on neuronal functions in rats, altering excitability in the neocortex and inhibiting long-term potentiation in the hippocampus. Systemic administration of ZEA to male rats had minimal impact on neuronal activation and evoked potentials, although a small neuronal population was activated in the somatosensory cortex. This suggests that ZEA may have a limited ability to cross the blood-brain barrier in sufficient concentrations to affect certain brain areas.
Article
Pharmacology & Pharmacy
Jia Rong Gao, Miao Miao Shi, Hui Jiang, Xiao Li Zhu, Liang Bing Wei, Xiu Juan Qin
Summary: This study found that miR-339-5p can inhibit the proliferation and inflammation of mesangial cells in glomerulonephritis by regulating the Syk/Ras/c-Fos signaling pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Alexa Brown, Franz R. Villaruel, Nadia Chaudhri
Summary: Extinction is a fundamental form of inhibitory learning that is important for adapting to changing environmental contingencies. This study aimed to generate an extensive brain activation map of extinction learning in a rat model of appetitive Pavlovian conditioning. The findings provide novel evidence for the contribution of different brain areas and neural networks in the recall versus extinction of appetitive Pavlovian conditioned responding.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Javier Orihuel, Laura Gomez-Rubio, Claudia Valverde, Roberto Capellan, David Roura-Martinez, Marcos Ucha, Emilio Ambrosio, Alejandro Higuera-Matas
Summary: The study suggests that adolescent exposure to cannabis may increase the risk of cocaine use in adulthood. It found that adolescent THC exposure alters the cellular activation patterns induced by cocaine in rats, resulting in a stronger cocaine-induced activation in certain brain regions. Sex-dependent interactions were also observed, with cocaine inducing more robust cellular activation in females exposed to THC during adolescence compared to males.
Article
Acoustics
James Matchynski, Rayyan Manwar, Karl J. Kratkiewicz, Rajtarun Madangopal, Veronica A. Lennon, Kassem M. Makki, Abbey L. Reppen, Alexander R. Woznicki, Bruce T. Hope, Shane A. Perrine, Alana C. Conti, Kamran Avanaki
Summary: The study developed a functional and molecular photoacoustic tomography system for direct imaging of neuronal ensembles in Fos-LacZ transgenic rats, enabling measurement of neuroactivity underlying complex behaviors. The results demonstrate successful and direct detection of Fos-expressing neuronal ensembles using this approach, suggesting its potential use in monitoring neuronal activity underlying a range of behavioral processes.
Article
Neurosciences
Tiemo Friedrich, Martha Anna Schalla, Miriam Goebel-Stengel, Peter Kobelt, Matthias Rose, Andreas Stengel
Summary: This study aimed to investigate the effects of LPS-induced inflammatory stress on the activity of brain nuclei-expressing phoenixin. It was found that LPS stress significantly increased c-Fos and phoenixin expression in multiple brain nuclei, which was distinctively different from restraint stress.
Article
Green & Sustainable Science & Technology
David Fernandez-Quezada, Sonia Luquin, Yaveth Ruvalcaba-Delgadillo, Joaquin Garcia-Estrada, Fernando Jauregui-Huerta
Summary: This study investigated the effects of environmental noise on male and female rats. It was found that noise exposure differentially increased the serum corticosterone levels in male and female rats. Various brain regions outside the auditory circuits showed a high expression of c-fos, with females exhibiting less intense expression in most areas.
Article
Endocrinology & Metabolism
Sachie Sasaki-Hamada, Yoshimichi Maeno, Mizuki Yabe, Hitoshi Ishibashi
Summary: The study revealed that NMU receptors were co-localized more with neuronal nuclei than with astrocyte markers in the CA1 region. Additionally, NMU application enhanced excitatory postsynaptic potentials in rat hippocampal slices and increased Fos-IR while reducing colocalization with a GABA neuron marker. These findings suggest that NMU receptor activation contributes to GABAergic neuronal activity in the CA1 region of the hippocampus.
Article
Urology & Nephrology
Ezidin G. Kaddumi, AbdulFattah S. Fararjeh, Manal Udwan
Summary: Although there is increasing evidence concerning urinary bladder innervation by vagal afferents, the functional aspects and conditions at which these afferents are recruited are still unclear. In this study, the neuronal responses of nodose ganglion were investigated following cystometry under different models of urinary bladder irritation. The results demonstrate the innervation of vagus afferents to the urinary bladder and suggest a possible role of the vagus nerve during urinary bladder pathology.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Po-Chun Chu, Chen-Syuan Huang, Pi-Kai Chang, Rou-Shayn Chen, Ko-Ting Chen, Tsung-Hsun Hsieh, Hao-Li Liu
Summary: This study demonstrates the potential of weak ultrasound stimulation to induce long-lasting neuromodulatory effects and explores its application in future clinical neuromodulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Lily Yan, Laura Smale, Antonio A. Nunez
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Behavioral Sciences
Lily Yan, Joseph S. Lonstein, Antonio A. Nunez
HORMONES AND BEHAVIOR
(2019)
Article
Behavioral Sciences
Garrett M. Fogo, Alyssa M. Goodwin, Ohanes S. Khacherian, Brandi J. Ledbetter, Andrew J. Gall
JOURNAL OF COMPARATIVE PSYCHOLOGY
(2019)
Article
Biology
Dorela D. Shuboni-Mulligan, Breyanna L. Cavanaugh, Anne Tonson, Erik M. Shapiro, Andrew J. Gall
CHRONOBIOLOGY INTERNATIONAL
(2019)
Article
Neurosciences
Garrett M. Fogo, Dorela D. Shuboni-Mulligan, Andrew J. Gall
Article
Behavioral Sciences
Widya Adidharma, Sean P. Deats, Tomoko Ikeno, Jack W. Lipton, Joseph S. Lonstein, Lily Yan
HORMONES AND BEHAVIOR
(2019)
Article
Biology
Andrew J. Gall, Alyssa M. Goodwin, Ohanes S. Khacherian, Laura B. Teal
JOURNAL OF BIOLOGICAL RHYTHMS
(2020)
Article
Neurosciences
Andrew J. Gall, Peter J. Vollbrecht, Tristan Tobias
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Joseph S. Lonstein, Katrina Linning-Duffy, Yuping Tang, Anna Moody, Lily Yan
Summary: The study showed that daytime light intensity can alter the central orexin system of both male and female grass rats, sometimes in a sex-specific manner, providing insights into how daytime light intensity impacts functions regulated by orexin.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Joel E. Soler, Hang Xiong, Faiez Samad, Fredric P. Manfredsson, Alfred J. Robison, Antonio A. Nunez, Lily Yan
Summary: Environmental lighting conditions play a key role in cognitive function, affecting hippocampal function in diurnal mammals like the Nile grass rats. Studies have shown that the hypothalamic orexin system may mediate the effects of daylight intensity on hippocampal function, with orexin A peptide treatment improving spatial memory performance and hippocampal OX1R knockdown leading to deficits in memory and dendritic spine density.
Article
Microbiology
A. J. Gall, G. D. Griffin
Summary: Prebiotics stimulate bacterial growth in the gut, while probiotics replace or restore beneficial bacteria in the digestive tract. Studies have shown that prebiotics can reduce anxiety-like behaviors but do not affect spatial memory performance in healthy rats.
BENEFICIAL MICROBES
(2021)
Article
Biology
Huishi Toh, Atefeh Bagheri, Colin Dewey, Ron Stewart, Lili Yan, Dennis Clegg, James A. Thomson, Peng Jiang
Summary: This study developed a new comparative species RNA-seq data analysis tool called CRSP, which can be used for species lacking sequenced genomes and reference transcripts. The tool was validated using RNA-seq data from Nile rats, providing a gene expression reference for this species. The CRSP tool is not limited to Nile rats and can be applied to any species without prior genomic knowledge.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Article
Biology
Antony B. Kim, Emma M. Beaver, Stephen G. Collins, Lance J. Kriegsfeld, Steven W. Lockley, Kwoon Y. Wong, Lily Yan
Summary: Through multielectrode array recordings, this study found that non-image-forming effects mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) are able to stably encode irradiance. These effects include entrainment of daily rhythms and light-induced arousal, and stimulating S-cones is found to be important in these processes.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Geriatrics & Gerontology
Dorela D. Shuboni-Mulligan, Demarrius L. Young, Julianie De La Cruz Minyety, Elizabeth Vera, Jeeva Munasinghe, Andrew J. Gall, Mark R. Gilbert, Terri S. Armstrong, DeeDee K. Smart
Summary: This study revealed that older mice show disruptions in sleep, circadian rhythms, and masking behaviors which are associated with significant volume alterations in the non-image forming visual system. These findings suggest that brain atrophy in specific non-image forming regions may contribute to circadian and sleep dysfunction in older individuals when faced with diseases or treatments.
NPJ AGING AND MECHANISMS OF DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Loren Toussaint, Andrew J. Gall, Alyssa Cheadle, David R. Williams
PSYCHOLOGY & HEALTH
(2020)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)